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La Revue Du Praticien Oct 2006Meningiomas account for approximately one-fourth of all primary central nervous system tumour, arising from arachnoidal cells surrounding brain and spinal cord. They... (Comparative Study)
Comparative Study Review
Meningiomas account for approximately one-fourth of all primary central nervous system tumour, arising from arachnoidal cells surrounding brain and spinal cord. They usually affect older adults, particularly women. Ninety percent of meningiomas are slow growing benign tumours. Meningiomas are revealed by various symptoms including neurologic deficits and epileptic seizures. Surgery remains the treatment of choice. Fractionated radiotherapy or stereotactic radiosurgery are used for meningiomas that are recurrent, surgically inacessible, partially excised and either atypical or malignant. Most meningiomas have good long-term prognosis after treatment, some dysplay aggressive clinical behaviour leading to increased patient morbidity and mortality.
Topics: Age Factors; Aged; Angiography; Combined Modality Therapy; Dose Fractionation, Radiation; Epilepsy; Female; Follow-Up Studies; Humans; Incidence; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Radiosurgery; Stereotaxic Techniques; Time Factors
PubMed: 17315505
DOI: No ID Found -
Human Pathology Dec 2002Recently, a number of neoplastic and nonneoplastic entities have been reported that radiographically and clinically mimic meningiomas. Because these lesions occur... (Review)
Review
Recently, a number of neoplastic and nonneoplastic entities have been reported that radiographically and clinically mimic meningiomas. Because these lesions occur infrequently and may resemble a meningioma during intraoperative analysis, they may not be considered in the differential diagnosis. This review (and case illustrations) considers some of the newly recognized and notable lesions that can mimic meningiomas, including solitary fibrous tumors, gliosarcomas, leiomyosarcomas, hemangiopericytomas, melanocytomas, Hodgkin's disease, plasmacytomas, inflammatory pseudotumors, neurosarcoidosis, plasma cell granulomas, Rosai-Dorfman disease, Castleman's disease, xanthomas, rheumatoid nodules, and tuberculomas. Awareness that these lesions involve the dura may facilitate intraoperative recognition and, in some cases, preclude unnecessary additional surgery.
Topics: Adolescent; Adult; Central Nervous System Diseases; Diagnosis, Differential; Dura Mater; Female; Histiocytosis, Sinus; Hodgkin Disease; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meninges; Meningioma; Middle Aged; Neoplasm Metastasis; Sarcoidosis
PubMed: 12514791
DOI: 10.1053/hupa.2002.129200 -
Veterinary Pathology Sep 2022Rhabdoid meningioma is a rare type of meningeal neoplasm in humans. This study reports the clinical, pathological, and ultrastructural features of 4 cases of canine...
Rhabdoid meningioma is a rare type of meningeal neoplasm in humans. This study reports the clinical, pathological, and ultrastructural features of 4 cases of canine meningioma with rhabdoid features. The cases were female and 8 to 12 years of age. Biopsies from complete surgical resections were examined for all cases. The whole brain with tumor recurrence was collected at necropsy in 2 dogs. Histologically, the tumors consisted of discohesive sheets of oval-polygonal cells with abundant eosinophilic cytoplasm and occasional paranuclear hyaline-like inclusions. Cells were intensely immunopositive for vimentin, negative for melan A and S100 protein in all cases, and showed variable immunolabeling for cytokeratin in 2 cases. Focal glial fibrillary acidic protein (GFAP)-immunopositive cells were present in 1 case. Ultrastructurally, the rhabdoid cells in case 1 contained prominent cytoplasmic whorls of intermediate filaments, recapitulating the ultrastructural features of rhabdoid meningioma in humans. In cases 2 and 3, the meningioma cells contained interdigitating cell processes folded in a maze-like fashion resembling rhabdoid-like meningioma in humans. In case 4, the voluminous cytoplasm contained many round-to-flattened mitochondria admixed with rough endoplasmic reticulum, indicating a predominant oncocytic differentiation and not the rhabdoid differentiation suggested by light microscopy. Thus, rhabdoid morphology occurs in different types of meningiomas, and ultrastructural findings are essential for a correct diagnosis.
Topics: Animals; Dog Diseases; Dogs; Female; Humans; Immunohistochemistry; Male; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Rhabdoid Tumor
PubMed: 35674149
DOI: 10.1177/03009858221100436 -
Cancer Dec 1978This paper reviews 8 personally examined cases of primary meningeal mesenchymal chondrosarcoma and 4 similar cases previously reported by others. The clinicopathologic... (Review)
Review
This paper reviews 8 personally examined cases of primary meningeal mesenchymal chondrosarcoma and 4 similar cases previously reported by others. The clinicopathologic features of these extraosseous intracranial and intraspinal examples are similar to those of other extraskeletal mesenchymal chondrosarcomas. The tumor occurred most often in the second and third decades, showed a moderate tendency to local recurrence (5 of 12 cases) and occasionally metastasized to the lungs (1 case). Both intracranial and intraspinal tumors occurred with equal frequency, but the former, probably due to the later onset of symptoms, had the worse prognosis. Microscopically, they are composed of primitive undifferentiated mesenchymal cells and frequently well-defined islands of hyaline cartilage. There is an apparent correlation between the frequency of mitotic figures and the likelihood of recurrence and metastasis. Electron microscopic study of one example revealed morphologic features similar to those previously described by others and supports the conclusion that the neoplastic cells represent primitive precartilaginous mesenchyme displaying focal cartilaginous differentiation.
Topics: Adolescent; Adult; Child; Child, Preschool; Chondrosarcoma; Female; Humans; Male; Meningeal Neoplasms; Middle Aged; Neoplasm Metastasis; Recurrence
PubMed: 365318
DOI: 10.1002/1097-0142(197812)42:6<2744::aid-cncr2820420633>3.0.co;2-l -
Neurologia Medico-chirurgica 2015Meningiomas are the most common intracranial primary neoplasm in adults. Although the spectrum of clinical and molecular genetic issues regarding meningiomas remains... (Review)
Review
Meningiomas are the most common intracranial primary neoplasm in adults. Although the spectrum of clinical and molecular genetic issues regarding meningiomas remains undefined, novel genetic alterations that are associated with tumor morphology, malignancy, or location have recently been discovered. This review focuses on recent advances in understanding of the heterogenous pathology of meningiomas, particularly on associations between the clinical, histological, etiological, epidemiological, and molecular genetical aspects of the neoplasm.
Topics: Humans; Immunohistochemistry; Meningeal Neoplasms; Meningioma; Molecular Biology
PubMed: 25744347
DOI: 10.2176/nmc.ra.2014-0233 -
Journal of Neuro-oncology Apr 2023Surgical resection has long been the treatment of choice for meningiomas and is considered curative in many cases. Indeed, the extent of resection (EOR) remains a... (Review)
Review
INTRODUCTION
Surgical resection has long been the treatment of choice for meningiomas and is considered curative in many cases. Indeed, the extent of resection (EOR) remains a significant factor in determining disease recurrence and outcome optimization for patients undergoing surgery. Although the Simpson Grading Scale continues to be widely accepted as the measure of EOR and is used to predict symptomatic recurrence, its utility is under increasing scrutiny. The influence of surgery in the definitive management of meningioma is being re-appraised considering the rapid evolution of our understanding of the biology of meningioma.
DISCUSSION
Although historically considered "benign" lesions, meningioma natural history can vary greatly, behaving with unexpectedly high recurrence rates and growth which do not always behave in accordance with their WHO grade. Histologically confirmed WHO grade 1 tumors may demonstrate unexpected recurrence, malignant transformation, and aggressive behavior, underscoring the molecular complexity and heterogeneity.
CONCLUSION
As our understanding of the clinical predictive power of genomic and epigenomic factors matures, we here discuss the importance of surgical decision-making paradigms in the context of our rapidly evolving understanding of these molecular features.
Topics: Humans; Meningioma; Meningeal Neoplasms; Neoplasm Recurrence, Local; Neurosurgical Procedures; Retrospective Studies
PubMed: 37010677
DOI: 10.1007/s11060-023-04272-z -
Klinicka Onkologie : Casopis Ceske a... 2019Primary intracranial sarcoma is a rare disease. Due to the scarcity of evidence from randomized clinical trials, we follow the treatment guidelines of their extracranial... (Review)
Review
BACKGROUND
Primary intracranial sarcoma is a rare disease. Due to the scarcity of evidence from randomized clinical trials, we follow the treatment guidelines of their extracranial counterparts or those published in case reports, while taking into consideration the specificity of radiotherapy within the brain, and the limit imposed on chemotherapy by the blood brain barrier. Nevertheless, surgery remains the golden standard of treatment for primary tumours, and also for recurrence. Even though there are usually narrow margins achieved in brain compared with the extracranial sarcomas. Despite significant effort, prognosis remains dismal.
CASE
We present a 69-year old woman who was investigated for psychoorganic syndrome and paresis of the left hand. Magnetic resonance imaging revealed a tumour expansion in her frontal lobe with collateral oedema. Surgical resection was indicated. Histology of the specimen suggested a myxoid meningeal sarcoma. Early disease recurrence 4 months after primary resection was treated by reresection and 50 Gy of adjuvant radiotherapy to the tumour bed. Similarly, another recurrence 19 months after the second surgery was treated using the same approach. Systemic treatment has not been indicated so far. At this time, the patient is without evidence of any disease recurrence and continues with regular follow-up.
CONCLUSION
Myxoid meningeal sarcoma represents a rare disease with a high risk of recurrence. Unfortunately, there is no clear recommendation for treatment algorithm. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
Topics: Aged; Female; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms; Neoplasm Recurrence, Local; Sarcoma
PubMed: 31216855
DOI: 10.14735/amko2019214 -
Cancer Treatment and Research 2005Leptomeningeal dissemination of lymphoma and leukemia differs from that of solid tumors in a number of clinically important aspects. Specific histologic variants of... (Review)
Review
Leptomeningeal dissemination of lymphoma and leukemia differs from that of solid tumors in a number of clinically important aspects. Specific histologic variants of lymphoma and leukemia have such a high incidence of cerebrospinal fluid (CSF) dissemination that assessing CSF cytology at diagnosis is crucial and prophylactic therapy of the CSF compartment is required. Furthermore, while the overall prognosis for patients with leptomeningeal metastases from leukemia and lymphoma is similar to solid tumors, selected patients have excellent response to therapy and attain durable remission. Therefore, aggressive treatment is warranted.
Topics: Humans; Leukemia; Lymphoma; Meningeal Neoplasms; Neoplasm Staging; Survival Analysis
PubMed: 16211883
DOI: 10.1007/0-387-24199-x_4 -
Medicine Mar 2023Meningiomas are mostly benign brain tumors with minimal malignant cases. Anaplastic meningioma has malignant morphological characteristics and a World Health...
RATIONALE
Meningiomas are mostly benign brain tumors with minimal malignant cases. Anaplastic meningioma has malignant morphological characteristics and a World Health Organization grade of III.
PATIENT CONCERNS
The present study reports a case of an occipital meningioma in a patient who initially chose observation and follow-up after diagnosis. The patient ultimately underwent surgery due to the enlargement of the tumor and the development of visual field defects after a decade of imaging follow-up. The postoperative pathology slides indicated the presence of an anaplastic meningioma (World Health Organization-grade III).
DIAGNOSES
The patient's diagnosis was established through cranial magnetic resonance imaging, which revealed an irregular mixed mass in the right occipital region with isointense T1 and hypointense T2 signal, irregular lobulation, and a maximum diameter of approximately 5.4 cm. Heterogenous enhancement was observed in the contrast-enhanced scan.
INTERVENTIONS
The patient opted for surgical intervention to remove the tumor, and the pathology slides of the tumor sample confirmed the diagnosis of anaplastic meningioma. The patient also received radiotherapy (40Gy/15fr).
OUTCOMES
No recurrence was observed during the 9-month follow-up.
LESSONS
This case highlights the potential for low-grade meningiomas to undergo malignant transformation, particularly in the presence of irregular lobulation, peritumoral brain edema, and heterogeneous enhancement on contrast-enhanced scans. Total excision (Simpson grade I) is the preferred treatment option, and long-term imaging follow-up is recommended.
Topics: Humans; Meningioma; Meningeal Neoplasms; Brain Neoplasms; Brain Edema; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Retrospective Studies
PubMed: 37000075
DOI: 10.1097/MD.0000000000033409 -
Chinese Clinical Oncology Jul 2017Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although approximately 80% of the tumors are slow growing and benign, some subtypes are...
Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although approximately 80% of the tumors are slow growing and benign, some subtypes are associated with a less favorable outcome. An adequate classification system aims at providing a tool for estimating recurrence and overall survival of meningioma patients. The 2016 version of the World Health Organization (WHO) classification for CNS tumors constitutes a hallmark for neuropathological tumor classification since genetic alterations and histopathology are combined for a final diagnosis. Although this mainly applies to neuroepithelial tumors in meningioma research and classification the connection of histomorphological features and genetic profiles becomes more and more evident. Here we report on advances and controversies of meningioma classification in the 2016 edition of the WHO classification of CNS tumors. Furthermore we provide an outlook how a future meningioma classification system might look like.
Topics: Humans; Meningeal Neoplasms; Meningioma; Neoplasm Grading; Neoplasm Recurrence, Local; World Health Organization
PubMed: 28595423
DOI: 10.21037/cco.2017.05.02