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American Review of Tuberculosis Aug 1947
Topics: Humans; Meninges; Meningitis; Tuberculosis; Tuberculosis, Meningeal
PubMed: 20264373
DOI: 10.1164/art.1947.56.2.75 -
Neurological Sciences : Official... Sep 2008A pictorial review was performed (with added acquisition technique optimization guidelines) on CT and MR imaging of intracranial meningeal involvement from infectious or... (Review)
Review
A pictorial review was performed (with added acquisition technique optimization guidelines) on CT and MR imaging of intracranial meningeal involvement from infectious or inflammatory origin, on the inherent main differential diagnoses, and on the topography of contiguous extension of lesions.
Topics: Disease Progression; Humans; Magnetic Resonance Imaging; Meninges; Meningitis; Meningitis, Aseptic; Meningitis, Bacterial; Meningitis, Viral; Skull; Tomography, X-Ray Computed
PubMed: 18690519
DOI: 10.1007/s10072-008-0964-8 -
Neurology Jul 2015To determine the frequency and nature of leptomeningeal contrast enhancement in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated...
OBJECTIVE
To determine the frequency and nature of leptomeningeal contrast enhancement in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated inversion recovery (FLAIR) MRI and 7-tesla postmortem MRI-pathology correlation.
METHODS
Brain MRI, using the postcontrast T2-weighted, FLAIR technique, was prospectively collected in 299 MS cases and 37 age-matched neurologically healthy controls. Expert raters evaluated focal gadolinium enhancement in the leptomeningeal compartment. Two progressive MS cases came to autopsy after in vivo MRI characterization. Pathologic and immunohistochemical examination assessed the association of enhancement with leptomeningeal inflammation and adjacent cortical demyelination.
RESULTS
Focal contrast enhancement was detected in the leptomeningeal compartment in 74 of 299 MS cases (25%) vs 1 of 37 neurologically healthy controls (2.7%; p = 0.001). Enhancement was nearly twice as frequent (p = 0.009) in progressive MS (39/118 cases, 33%) as in relapsing-remitting MS (35/181, 19%). Enhancing foci generally remained stable throughout the evaluation period (up to 5.5 years). Pathology showed perivascular lymphocytic and mononuclear infiltration in the enhancing areas in association with flanking subpial cortical demyelination.
CONCLUSION
Leptomeningeal contrast enhancement occurs frequently in MS and is a noninvasive, in vivo marker of inflammation and associated subpial demyelination. It might therefore enable testing of new treatments aimed at eliminating this inflammation and potentially arresting progressive MS.
Topics: Gadolinium; Humans; Magnetic Resonance Imaging; Meninges; Meningitis; Multiple Sclerosis, Relapsing-Remitting
PubMed: 25888557
DOI: 10.1212/WNL.0000000000001587 -
American Review of Tuberculosis Aug 1947
Topics: Humans; Meninges; Meningitis; Tuberculosis; Tuberculosis, Meningeal
PubMed: 20264374
DOI: 10.1164/art.1947.56.2.95 -
BMC Genomics 2015Meningitis is the inflammation of the meninges in response to infection or chemical agents. While aseptic meningitis, most frequently caused by enteroviruses, is usually... (Comparative Study)
Comparative Study
Comparative proteomics of cerebrospinal fluid reveals a predictive model for differential diagnosis of pneumococcal, meningococcal, and enteroviral meningitis, and novel putative therapeutic targets.
BACKGROUND
Meningitis is the inflammation of the meninges in response to infection or chemical agents. While aseptic meningitis, most frequently caused by enteroviruses, is usually benign with a self-limiting course, bacterial meningitis remains associated with high morbidity and mortality rates, despite advances in antimicrobial therapy and intensive care. Fast and accurate differential diagnosis is crucial for assertive choice of the appropriate therapeutic approach for each form of meningitis.
METHODS
We used 2D-PAGE and mass spectrometry to identify the cerebrospinal fluid proteome specifically related to the host response to pneumococcal, meningococcal, and enteroviral meningitis. The disease-specific proteome signatures were inspected by pathway analysis.
RESULTS
Unique cerebrospinal fluid proteome signatures were found to the three aetiological forms of meningitis investigated, and a qualitative predictive model with four protein markers was developed for the differential diagnosis of these diseases. Nevertheless, pathway analysis of the disease-specific proteomes unveiled that Kallikrein-kinin system may play a crucial role in the pathophysiological mechanisms leading to brain damage in bacterial meningitis. Proteins taking part in this cellular process are proposed as putative targets to novel adjunctive therapies.
CONCLUSIONS
Comparative proteomics of cerebrospinal fluid disclosed candidate biomarkers, which were combined in a qualitative and sequential predictive model with potential to improve the differential diagnosis of pneumococcal, meningococcal and enteroviral meningitis. Moreover, we present the first evidence of the possible implication of Kallikrein-kinin system in the pathophysiology of bacterial meningitis.
Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Kallikrein-Kinin System; Male; Mass Spectrometry; Meninges; Meningitis, Meningococcal; Meningitis, Pneumococcal; Meningitis, Viral; Proteome; Proteomics; Young Adult
PubMed: 26040285
DOI: 10.1186/1471-2164-16-S5-S11 -
Archives of Pediatrics Jan 1948
Topics: Meninges; Tuberculosis; Tuberculosis, Meningeal; Tuberculosis, Miliary
PubMed: 18899723
DOI: No ID Found -
Archives of Pediatrics Jan 1948
Topics: Humans; Meninges; Tuberculosis; Tuberculosis, Meningeal; Tuberculosis, Pulmonary
PubMed: 18899721
DOI: No ID Found -
Archives of Pediatrics Feb 1949
Topics: Humans; Meninges; Tuberculosis; Tuberculosis, Meningeal; Tuberculosis, Pulmonary
PubMed: 18114495
DOI: No ID Found -
British Medical Journal Feb 1949
Topics: Early Diagnosis; Meninges; Streptomycin; Tuberculosis; Tuberculosis, Meningeal
PubMed: 18112412
DOI: 10.1136/bmj.1.4599.338 -
Problemy Tuberkuleza 1964
Topics: Arachnoid; Arachnoiditis; Humans; Meningitis; Pia Mater; Tuberculosis; Tuberculosis, Meningeal
PubMed: 14321019
DOI: No ID Found