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Child's Nervous System : ChNS :... Aug 2001We designed this study to elucidate the associated occult spinal lesions in patients with simple dorsal meningocele. (Comparative Study)
Comparative Study
OBJECT
We designed this study to elucidate the associated occult spinal lesions in patients with simple dorsal meningocele.
METHODS
The study population was comprised of two groups. Group I comprised newly diagnosed patients with dorsal spinal meningocele, and group II comprised patients who had had surgery for meningocele and presented with progressive neurological deficits. Magnetic resonance imaging (MRI) scans of the whole spinal column were done. The associated spinal cord malformations were also treated at the same operation. There were 14 boys and 8 girls, with an age range from birth to 4 years (mean 3.9 months), in group I. Of 20 patients (90%) with associated spinal lesions, 6 had more than one lesion, excluding hydromyelia. Group II was made up of 6 patients who had been previously operated on for a meningocele and who presented with tethered cord syndrome. These were 4 boys and 2 girls, who ranged in age from 4 to 10 years (mean 6 years).
RESULTS
The level of the conus terminalis was lower than L3 in all patients. The other findings on MRI, besides low conus, were as follows: tight filum, split cord malformation, epidermoid, dorsal lipoma and hydromyelia.
CONCLUSIONS
Meningocele frequently camouflages a second, occult, spinal lesion. MRI of the whole spinal column should be performed. An intradural exploration performed with a microneurosurgical technique is needed to detect the fibrous bands that may lead to spinal cord tethering and to release the entrapped nerve roots. The other associated spinal anomalies should be operated on during the same operation.
Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Meningocele; Neural Tube Defects; Prospective Studies; Spinal Cord; Spine
PubMed: 11508539
DOI: 10.1007/s003810100454 -
Child's Brain 1982
Topics: Encephalocele; Female; Humans; Infant; Meningocele
PubMed: 7060413
DOI: 10.1159/000120035 -
AJNR. American Journal of Neuroradiology 2004Intrathoracic meningocele is rare and is usually associated with neurofibromatosis type I. Most of the reported thoracic meningoceles are not strictly anterior in...
Intrathoracic meningocele is rare and is usually associated with neurofibromatosis type I. Most of the reported thoracic meningoceles are not strictly anterior in location, but also lateral or anterolateral. We report a case of true anterior thoracic meningocele with no associated generalized mesenchymal dysplasia.
Topics: Child; Humans; Magnetic Resonance Imaging; Male; Meningocele; Radiography, Thoracic; Thoracic Vertebrae; Tomography, X-Ray Computed
PubMed: 15569757
DOI: No ID Found -
Surgery, Gynecology & Obstetrics May 1968
Topics: Adult; Female; Humans; Male; Meningocele; Middle Aged; Radiography; Sacrum
PubMed: 5652660
DOI: No ID Found -
Journal of Minimally Invasive Gynecology 2006Pelvic meningocele is an uncommon condition and is frequently asymptomatic. The diagnosis easily can be mistaken as ovarian cyst on pelvic sonography. In many reported...
Pelvic meningocele is an uncommon condition and is frequently asymptomatic. The diagnosis easily can be mistaken as ovarian cyst on pelvic sonography. In many reported cases, the diagnosis was made during laparotomy for presumed ovarian cysts. Myelography, computerized tomography (CT), or magnetic resonance imaging (MRI) is useful for definitive diagnosis. A 49-year-old woman, who had a normal diagnostic laparoscopy 3 years prior, was referred for a persistent ovarian cyst. Repeat laparoscopy revealed a retroperitoneal cyst in the left pelvic sidewall. Both ovaries and fallopian tubes were normal. Subsequent CT and MRI were used to diagnose pelvic meningocele. We speculate that pelvic meningoceles can be missed during laparoscopy due to the increased intraperitoneal pressure and the potential reduction in the cerebrospinal fluid pressure at the lumbosacral level.
Topics: Diagnostic Errors; Female; Humans; Laparoscopy; Magnetic Resonance Imaging; Meningocele; Middle Aged; Ovarian Cysts; Tomography, X-Ray Computed; Ultrasonography
PubMed: 16431327
DOI: 10.1016/j.jmig.2005.09.107 -
Journal of Cellular Physiology Jan 2020Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse...
Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse model of LMS (Notch3 ) by introducing a tandem termination codon in the Notch3 locus upstream of the proline (P), glutamic acid (E), serine (S) and threonine (T) domain. Microcomputed tomography demonstrated that Notch3 mice exhibit osteopenia. The cancellous bone osteopenia was no longer observed after the intraperitoneal administration of antibodies directed to the negative regulatory region (NRR) of Notch3. The anti-Notch3 NRR antibody suppressed the expression of Hes1, Hey1, and Hey2 (Notch target genes), and decreased Tnfsf11 (receptor activator of NF Kappa B ligand) messenger RNA in Notch3 osteoblast (OB) cultures. Bone marrow-derived macrophages (BMMs) from Notch3 mutants exhibited enhanced osteoclastogenesis in culture, and this was increased in cocultures with Notch3 OB. Osteoclastogenesis was suppressed by anti-Notch3 NRR antibodies in Notch3 OB/BMM cocultures. In conclusion, the cancellous bone osteopenia of Notch3 mutants is reversed by anti-Notch3 NRR antibodies.
Topics: Abnormalities, Multiple; Animals; Antibodies; Bone and Bones; Female; Genetic Predisposition to Disease; Macrophages; Male; Meningocele; Mice; Mutation; Osteoblasts; Receptor, Notch3; X-Ray Microtomography
PubMed: 31188489
DOI: 10.1002/jcp.28960 -
Ideggyogyaszati Szemle Nov 2006Herniation of the meninges through a defect of the spinal canal is a spinal meningocele, and is usually located dorsally in the lumbosacral region. Meningoceles are...
Herniation of the meninges through a defect of the spinal canal is a spinal meningocele, and is usually located dorsally in the lumbosacral region. Meningoceles are usually part of a complex developmental disorder, or of a systemic disease, or it can be iatrogenic, as well. We report a very rare case of a true anterior thoracic meningocele.
Topics: Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Meningocele; Middle Aged; Myelography; Thoracic Vertebrae
PubMed: 17203884
DOI: No ID Found -
The Journal of Dermatology Apr 2014
Topics: Diseases in Twins; Female; Humans; Infant; Meningocele; Scalp; Twins, Monozygotic
PubMed: 24612009
DOI: 10.1111/1346-8138.12429 -
Rontgen-Blatter; Zeitschrift Fur... Aug 1986The author gives a detailed description of diagnosis and differential diagnosis of a thoracic lateral meningocele associated with known neurofibromatosis (von...
The author gives a detailed description of diagnosis and differential diagnosis of a thoracic lateral meningocele associated with known neurofibromatosis (von Recklinghausen's disease), using plain roentgenography, myelography and computed tomography.
Topics: Female; Humans; Meningocele; Middle Aged; Myelography; Neurofibromatosis 1; Tomography, X-Ray Computed
PubMed: 3092342
DOI: No ID Found -
Revue de Laryngologie - Otologie -... 1973
Topics: Child; Female; Humans; Meningocele; Nose Diseases
PubMed: 4792577
DOI: No ID Found