-
Skeletal Radiology 1984In a review of cases of fibrous cartilaginous dysplasia of bone, five of fibrocartilaginous lesions were found to be different in clinical behavior and radiographic and...
In a review of cases of fibrous cartilaginous dysplasia of bone, five of fibrocartilaginous lesions were found to be different in clinical behavior and radiographic and morphologic features from the others. We have named these previously undescribed tumors "fibrocartilaginous mesenchymomas with low-grade malignancy in the fibrous elements."
Topics: Adolescent; Adult; Bone Neoplasms; Child; Diagnosis, Differential; Female; Fibrous Dysplasia of Bone; Fibula; Humans; Humerus; Male; Mesenchymoma; Metatarsus; Radiography; Ribs; Terminology as Topic
PubMed: 6505732
DOI: 10.1007/BF00349507 -
Surgical Pathology Clinics Mar 2019Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner... (Review)
Review
Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. This leads to a spectrum of clinically and pathologically diverse mesenchymal and nonmesenchymal neoplasms, variably manifesting as small round cell, spindle cell, clear cell or adipocytic tumors, or tumors with distinctive myxoid stroma. This review summarizes the growing list of mesenchymal neoplasms that are associated with EWSR1 gene rearrangements.
Topics: Biomarkers, Tumor; Gene Rearrangement; Humans; Mesenchymoma; Oncogene Proteins, Fusion; RNA-Binding Protein EWS; Soft Tissue Neoplasms; Translocation, Genetic
PubMed: 30709442
DOI: 10.1016/j.path.2018.10.007 -
Journal of the Indian Medical... Mar 1981
Topics: Aged; Humans; Male; Mesenchymoma; Retroperitoneal Neoplasms
PubMed: 7264337
DOI: No ID Found -
Indian Journal of Pathology &... 2011Uterine mesenchymal tumors are a heterogeneous group of neoplasms that can frequently be diagnostically challenging. Differentiation between the benign and malignant... (Review)
Review
Uterine mesenchymal tumors are a heterogeneous group of neoplasms that can frequently be diagnostically challenging. Differentiation between the benign and malignant counterparts of mesenchymal tumors is significant due to differences in clinical outcome, and the role of the surgical pathologist in making this distinction (especially in the difficult cases) cannot be underestimated. Although immunohistochemical stains are supportive toward establishing a final diagnosis, the morphologic features trump all the other ancillary techniques for this group of neoplasms. This review therefore emphasizes the key morphologic features required to diagnose and distinguish uterine mesenchymal tumors from their mimics, with a brief description of the relevant immunohistochemical features.
Topics: Female; Histocytochemistry; Humans; Mesenchymoma; Uterine Neoplasms
PubMed: 21623068
DOI: 10.4103/0377-4929.81582 -
Medicinski Pregled 1997This is a case report on retroperitoneal localization of a tumor formed of mixed-chondromatous tissue, bone tissue, fatty tissue and connective tissue together with...
This is a case report on retroperitoneal localization of a tumor formed of mixed-chondromatous tissue, bone tissue, fatty tissue and connective tissue together with angiomatous areas with blood vessels having unevenly thickened walls, being histopathologically diagnosed as a mesenchymoma. Apart from presenting the tumor, this paper deals with diagnostic dilemmas in cases of mixed tumors of mesenchymal origin because of numerous disagreements in literature data on morphologic characteristics, biological behavior and diverse nomenclature.
Topics: Aged; Humans; Male; Mesenchymoma; Retroperitoneal Neoplasms
PubMed: 9297057
DOI: No ID Found -
Journal of Pediatric Surgery May 1996Mesenchymoma of the chest wall is rare in infancy and can be easily mistaken for a malignant tumor. It is a distinct pathological entity that presents at birth or during...
Mesenchymoma of the chest wall is rare in infancy and can be easily mistaken for a malignant tumor. It is a distinct pathological entity that presents at birth or during infancy as self-limiting expansile intraosseous lesions involving the body of one or more ribs. Histologically, it is a benign focal overgrowth of normal skeletal elements. Two such cases are presented.
Topics: Diagnosis, Differential; Female; Humans; Infant, Newborn; Male; Mesenchymoma; Thoracic Neoplasms; Thoracotomy; Thorax; Tomography, X-Ray Computed
PubMed: 8861494
DOI: 10.1016/s0022-3468(96)90688-0 -
International Journal of Urology :... Mar 1997Sarcomas of the spermatic cord are rare, and malignant mesenchymomas are particularly rare. Only 8 cases of paratesticular mesenchymoma have been described previously.... (Review)
Review
Sarcomas of the spermatic cord are rare, and malignant mesenchymomas are particularly rare. Only 8 cases of paratesticular mesenchymoma have been described previously. We report here the ninth case of malignant mesenchymoma of the spermatic cord, in which there was a local recurrence. We also briefly review the previously reported cases.
Topics: Angiography, Digital Subtraction; Genital Neoplasms, Male; Humans; Male; Mesenchymoma; Middle Aged; Spermatic Cord; Tomography, X-Ray Computed
PubMed: 9179703
DOI: 10.1111/j.1442-2042.1997.tb00177.x -
Langenbecks Archiv Fur Chirurgie 1991We report the case of an 82-year-old male patient with a malignant mesenchymoma. The tumor arose from the parietal peritoneum closely attached to the ascending colon. It... (Review)
Review
We report the case of an 82-year-old male patient with a malignant mesenchymoma. The tumor arose from the parietal peritoneum closely attached to the ascending colon. It consisted of a larger liposarcomatous and a smaller leiomyosarcomatous component which was demonstrated by immunohistochemistry. To our knowledge this is the first report of a malignant mesenchymoma of this histological composition originating from the parietal peritoneum. The tumor was completely removed surgically, which is the treatment of choice for such tumors. In agreement with other authors, we believe that malignant mesenchymomas arise from a primitive mesenchymal cell with the capacity for totipotent differentiation.
Topics: Aged; Aged, 80 and over; Humans; Immunohistochemistry; Leiomyosarcoma; Liposarcoma; Male; Mesenchymoma; Neoplasms, Multiple Primary; Peritoneal Neoplasms; Peritoneum
PubMed: 2034003
DOI: 10.1007/BF00205126 -
The Central African Journal of Medicine Jan 1995A rare case of primary malignant mesenchymoma of the urinary bladder is reported in a 72 year old man. The tumour showed predominantly a leiomyosarcomatous component... (Review)
Review
A rare case of primary malignant mesenchymoma of the urinary bladder is reported in a 72 year old man. The tumour showed predominantly a leiomyosarcomatous component with foci of malignant bone, cartilage and myxomatous areas. The importance of studying multiple sections from the tumour is stressed to arrive at the proper diagnosis.
Topics: Aged; Biopsy; Cystoscopy; Hematuria; Humans; Male; Mesenchymoma; Urinary Bladder Neoplasms
PubMed: 7767934
DOI: No ID Found -
Journal of Clinical Pathology Nov 2001A 24 year old man had a two year history of a painless mass on his right popliteal region. Magnetic resonance imaging demonstrated a 6 x 8 cm tumour mass in the lateral...
A 24 year old man had a two year history of a painless mass on his right popliteal region. Magnetic resonance imaging demonstrated a 6 x 8 cm tumour mass in the lateral gastrocnemius. Histological examination of the tumour resected by radical surgery revealed that it consisted of myoblastic sarcoma and chondrosarcoma. Immunohistochemical studies were positive for Ki-67 and p53 throughout the area and for S-100 protein in the chondrosarcomatous area; in addition, they showed partial positivity for muscle common actin (HHF-35), smooth muscle actin, and myoglobin in the spindle cells. The percentages of Ki-67, p53, and p21/WAF1 positive cells in the spindle cell component were 34%, 65.7%, and < 0.1%, respectively. In addition, staining was negative for pancytokeratin, desmin, and glial fibrillary acidic protein. The SYT-SSX, TLS-CHOP, and EWS-FLI1 fusion genes were not detected using the reverse transcription polymerase chain reaction. Given the results, the definitive histological diagnosis is malignant mesenchymoma. This is the first report of malignant mesenchymoma of the lower leg with immunohistochemical and molecular studies.
Topics: Adult; Biomarkers, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Humans; Ki-67 Antigen; Leg; Magnetic Resonance Imaging; Male; Mesenchymoma; Muscle Neoplasms; S100 Proteins; Tumor Suppressor Protein p53
PubMed: 11684725
DOI: 10.1136/jcp.54.11.877