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International Journal of Gynecological... Jul 2008Mesonephric adenocarcinoma (MA) is a rare tumor of the female genital tract, mainly in the cervix and vagina, which is usually associated with mesonephric remnants or... (Review)
Review
Mesonephric adenocarcinoma (MA) is a rare tumor of the female genital tract, mainly in the cervix and vagina, which is usually associated with mesonephric remnants or mesonephric hyperplasia. In the uterus corpus, MA is as rare as mesonephric structures, and only a few cases have been previously reported. Here, we report a rare case of MA of the uterine corpus. A 73-year-old woman presented with multiple nodules in the bilateral lung. Abdominal computed tomography scan confirmed a uterine tumor measuring 8.6 cm. All tumor markers, including CA125, were within normal limits. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The tumor was confined to the myometrium and showed strong resemblance to cervical MA despite the absence of mesonephric hyperplasia or remnants. The most striking pattern consisted of large sheets of small round tubules, often with densely eosinophilic secretions in the lumen. In addition, the ductal pattern simulating endometrioid adenocarcinoma was also noted. A mixture of tubular and ductal patterns, most predominantly seen, formed more complex tubules and cribriform structures. Other elements consisted of a retiform pattern, serous adenocarcinoma-like papillary budding, and glomeruloid morphology. Immunohistochemically, the tumor cells were positive not only for cytokeratin, epithelial membrane antigen, and vimentin but also for CD10 and calretinin. No staining was identified for estrogen receptor, progesterone receptor, or androgen receptor. Adjuvant chemotherapy was begun for the patient, who is alive with disease 28 months later. We review the previously published cases of MA and discuss the principal differential diagnosis of MA in the uterine corpus.
Topics: Adenocarcinoma; Aged; Female; Humans; Uterine Neoplasms
PubMed: 18580312
DOI: 10.1097/PGP.0b013e318166067f -
Diagnostic Pathology May 2013Carcinosarcoma of the uterine cervix is less common than its counterpart in the uterine corpus. On the other hand, mesonephric adenocarcinoma is also a rare neoplasm in... (Review)
Review
Carcinosarcoma of the uterine cervix is less common than its counterpart in the uterine corpus. On the other hand, mesonephric adenocarcinoma is also a rare neoplasm in the uterine cervix, and it has been reported that mesonephric adenocarcinomas are often accompanied by sarcomatous components. We present a case of mesonephric adenocarcinoma with a sarcomatous component which arose in a 63-year-old postmenopausal woman. The hysterectomy specimen grossly showed an exophytic mass measuring 1.8 cm in the uterine cervix. Histologically, diffuse mesonephric hyperplasia and adenocarcinoma with malignant spindle cell proliferation was recognized, and therefore the tumor was diagnosed as "mesonephric adenocarcinoma with a sarcomatous component." The review of the literature of cervical carcinosarcoma and cervical mesonephric adenocarcinoma revealed that 16% of cervical carcinosarcoma is of mesonephric duct origin, and that mesonephric adenocarcinoma seems to be more likely to have sarcomatous change. We think the presence of a sarcomatous component in the cervical biopsy specimen could be helpful in the diagnosis of mesonephric duct origin.
Topics: Adenosarcoma; Biopsy; Carcinosarcoma; Female; Humans; Hyperplasia; Hysterectomy; Lymph Node Excision; Middle Aged; Mullerian Ducts; Ovariectomy; Salpingectomy; Uterine Cervical Neoplasms; Uterine Neoplasms
PubMed: 23651629
DOI: 10.1186/1746-1596-8-74 -
JPMA. the Journal of the Pakistan... Sep 2015Mesonephric adenocarcinoma is a rare neoplasm of uterine cervix. It originates from the mesonephric ductus remnant or mesonephric hyperplasia area. There have been few... (Review)
Review
Mesonephric adenocarcinoma is a rare neoplasm of uterine cervix. It originates from the mesonephric ductus remnant or mesonephric hyperplasia area. There have been few such cases reported. Our case was 64 years of age and her tumour held the whole endocervical wall. It was around 5cm in diameter, and had exophytic component as well. Bilateral pelvic and paraaortic lymph nodes were negative for metastasis.
Topics: Adenocarcinoma; Diagnosis, Differential; Female; Humans; Mesonephroma; Middle Aged; Uterine Cervical Neoplasms
PubMed: 26338754
DOI: No ID Found -
Diagnostic Cytopathology Feb 2022Mesonephric-like adenocarcinoma is a relatively rare neoplasm with morphology similar to mesonephric adenocarcinoma but unassociated with mesonephric remnants. Its...
Mesonephric-like adenocarcinoma is a relatively rare neoplasm with morphology similar to mesonephric adenocarcinoma but unassociated with mesonephric remnants. Its relatively recent description and rarity make it difficult to diagnose, but it has a high rate of distant metastasis, making distinction from endometrioid carcinoma important. Descriptions of its cytologic features are particularly limited. We describe a case of mesonephric-like adenocarcinoma diagnosed on transbronchial needle aspiration of the lung, that had been misdiagnosed as endometrioid endometrial adenocarcinoma on a prior hysterectomy. We discuss the characteristic cyto and histomorphology, immunoprofile, molecular alterations, and clinical significance of this uncommon tumor.
Topics: Adenocarcinoma; Biopsy, Fine-Needle; Bronchi; Cytodiagnosis; DNA-Binding Proteins; Endometrial Neoplasms; Epithelium; Female; Humans; Mesonephros; Middle Aged; Neoplasm Metastasis; PAX8 Transcription Factor; Transcription Factors
PubMed: 34928073
DOI: 10.1002/dc.24917 -
Gynecologic Oncology Mar 2024Mesonephric (MA) and mesonephric-like (MLA) adenocarcinomas are rare cancers, and data on clinical behavior and response to therapy are limited. We sought to report...
OBJECTIVES
Mesonephric (MA) and mesonephric-like (MLA) adenocarcinomas are rare cancers, and data on clinical behavior and response to therapy are limited. We sought to report molecular features, treatment, and outcomes of MA/MLA from a single institution.
METHODS
Patients with MA (cervix) or MLA (uterus, ovary, other) treated at Memorial Sloan Kettering Cancer Center (MSK) from 1/2008-12/2021 underwent pathologic re-review. For patients with initial treatment at MSK, progression-free survival (PFS1) was calculated as time from initial surgery to progression or death; second PFS (PFS2) was calculated as time from start of treatment for recurrence to subsequent progression or death. Overall survival (OS) was calculated for all patients. Images were retrospectively reviewed to determine treatment response. Somatic genetic alterations were assessed by clinical tumor-normal sequencing (MSK-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]).
RESULTS
Of 81 patients with confirmed gynecologic MA/MLA, 36 received initial treatment at MSK. Sites of origin included cervix (n = 9, 11%), uterus (n = 42, 52%), ovary (n = 28, 35%), and other (n = 2, 2%). Of the 36 patients who received initial treatment at MSK, 20 (56%) recurred; median PFS1 was 33 months (95% CI: 17-not evaluable), median PFS2 was 8.3 months (95% CI: 6.9-14), and median OS was 87 months (95% CI: 58.2-not evaluable). Twenty-six of the 36 patients underwent MSK-IMPACT testing, and 25 (96%) harbored MAPK pathway alterations.
CONCLUSION
Most patients diagnosed with early-stage disease ultimately recurred. Somatic MAPK signaling pathway mutations appear to be highly prevalent in MA/MLA, and therapeutics that target this pathway are worthy of further study.
Topics: Humans; Female; Retrospective Studies; Adenocarcinoma; Mutation; Ovary; Cervix Uteri
PubMed: 38246044
DOI: 10.1016/j.ygyno.2024.01.015 -
Diagnostic Pathology Aug 2017Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus.... (Review)
Review
BACKGROUND
Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the corpus in 1995, only 16 cases have been reported in the English literature. A recent report suggested that MA originates in Müllerian tissue and exhibits the mesonephric differentiation phenotype.
CASE PRESENTATION
An asymptomatic 61-year-old woman was referred to our hospital because of elevated levels of tumor markers. Imaging revealed an intramural lesion of the uterine corpus exhibiting fluorodeoxyglucose uptake. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The tumor was completely confined to the corpus wall and was composed of an intracystic bulky component and an invasive component in the myometrial layer. The tumor exhibited a variety of growth patterns, including a characteristic tubular pattern with dense eosinophilic secretion reminiscent of the thyroid, as well as a variety of morphologies, such as acinar, papillary, and ductal structures. The structures were immunoreactive for CK7, vimentin, CD10, calretinin, PAX8, and GATA3 and almost completely negative for ER/PgR. CA125 and CA19-9 antigen expression was also detected.
CONCLUSION
A case of MA with a unique growth pattern of an intracystic mass within the corpus wall is presented. The histogenesis and differential diagnoses are discussed. The histogenesis of MA is not yet clear. We hypothesize two different pathways involved: 1) direct development from the mesonephric remnants and/or 2) mesonephric transformation of Müllerian adenocarcinoma.
Topics: Adenocarcinoma; Female; Humans; Mesonephroma; Middle Aged; Myometrium; Uterine Neoplasms
PubMed: 28841919
DOI: 10.1186/s13000-017-0655-y -
The Journal of Urology Jul 1973
Topics: Adenoma; Adult; Cystadenoma; Ellis-Van Creveld Syndrome; Female; Humans; Mesonephroma; Retroperitoneal Neoplasms; Urogenital Neoplasms
PubMed: 4713358
DOI: 10.1016/s0022-5347(17)60110-1 -
BMJ Case Reports Dec 2012Mesonephric adenocarcinoma is a rare type of cervical cancer that derives from mesonephric remnants in the uterine cervix. To the best of our knowledge, this is the 34th... (Review)
Review
Mesonephric adenocarcinoma is a rare type of cervical cancer that derives from mesonephric remnants in the uterine cervix. To the best of our knowledge, this is the 34th case of mesonephric adenocarcinoma in adult women documented in the literature. We present an asymptomatic 64-year-old postmenopausal woman presenting with a suspicious-looking cervix as an incidental finding and diagnosed with a stage IB mesonephric adenocarcinoma of the cervix. This case was managed with radical hysterectomy, bilateral salpingoophorectomy and pelvic lymphadenectomy. The rarity of such cases imposes challenges on the management in terms of diagnosis, prognosis and therapeutic options.
Topics: Adenocarcinoma; Female; Humans; Middle Aged; Uterine Cervical Neoplasms
PubMed: 23230242
DOI: 10.1136/bcr.01.2012.5632 -
International Journal of Gynecological... May 2019Mesonephric adenocarcinoma (MNA) is believed to arise from benign mesonephric remnants or hyperplasia located in the lateral walls of the uterine cervix. They are... (Review)
Review
Mesonephric adenocarcinoma (MNA) is believed to arise from benign mesonephric remnants or hyperplasia located in the lateral walls of the uterine cervix. They are uncommon in other sites of the gynecologic tract, and exceptionally rare in the uterine corpus. So far, only 30 cases of uterine MNA have been reported in the literature, as a result, the etiology, clinical behavior, choice of treatment, and histogenesis of uterine MNA are still unclear. In this study, we report 2 cases of MNA of uterine corpus. One case involved the inner half of myometrium with endometrial involvement; the second case involved the outer half of myometrium without endometrial involvement. We also reviewed the clinical and pathologic presentations of this rare entity, and discussed the histogenesis of uterine corpus MNA based on recent molecular findings.
Topics: Adenocarcinoma; Biomarkers, Tumor; Endometrium; Female; Humans; Immunohistochemistry; Middle Aged; Myometrium; Treatment Outcome; Uterine Neoplasms; Uterus
PubMed: 29543603
DOI: 10.1097/PGP.0000000000000493 -
Urology Mar 1983Congenital mesoblastic nephroma is the most common neoplasm in the neonatal age group. It is generally benign in nature and treatment consists solely of complete...
Congenital mesoblastic nephroma is the most common neoplasm in the neonatal age group. It is generally benign in nature and treatment consists solely of complete excision. Congenital mesoblastic nephroma has been mistaken for Wilms tumor and subsequently overtreated. Awareness of congenital mesoblastic nephroma will aid in giving proper therapy.
Topics: Child, Preschool; Diagnosis, Differential; Female; Humans; Kidney Neoplasms; Wilms Tumor
PubMed: 6301131
DOI: 10.1016/0090-4295(83)90093-6