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Anticancer Research Apr 2023The utility of mismatch repair (MMR) immunohistochemistry (IHC) and microsatellite instability (MSI) testing in uterine mesonephric-like adenocarcinoma (MLA) has seldom...
BACKGROUND/AIM
The utility of mismatch repair (MMR) immunohistochemistry (IHC) and microsatellite instability (MSI) testing in uterine mesonephric-like adenocarcinoma (MLA) has seldom been reported. This study aimed to compare MMR IHC and MSI testing in uterine MLA.
PATIENTS AND METHODS
We analyzed the MMR protein expression of 25 patients with MLA and compared the results with the MSI status.
RESULTS
Of the cases, one (4.0%) was initially interpreted to have a loss of mutS homolog 2 (MSH2) and mutS homolog 6 (MSH6) expression, and eight (32.0%) to have a loss of MSH6 immunoreactivity. Upon re-evaluation of the slides and repeat IHC, all cases were revealed to demonstrate at least focal (5-20%) immunoreactivity for MSH2 or MSH6. MSI testing revealed all cases to be microsatellite stable (MSS).
CONCLUSION
Uterine MLA is an MSS/MMR-proficient tumor. We observed complete concordance between MMR IHC and MSI testing. MMR IHC should be carefully interpreted, and discordant cases must be thoroughly reviewed. Repeat IHC and confirmatory MSI testing may be beneficial in resolving uncertain cases.
Topics: Humans; Microsatellite Instability; DNA Mismatch Repair; Colorectal Neoplasms; MutS Homolog 2 Protein; Adenocarcinoma; DNA-Binding Proteins; MutL Protein Homolog 1
PubMed: 36974792
DOI: 10.21873/anticanres.16332 -
Archives of Pathology & Laboratory... Apr 2010Papillary cystadenoma is a rare benign neoplasm of the epididymis, occurring mainly in young adult males. More than one-third of the cases reported in the literature... (Review)
Review
Papillary cystadenoma is a rare benign neoplasm of the epididymis, occurring mainly in young adult males. More than one-third of the cases reported in the literature have occurred in patients with von Hippel-Lindau disease. Conversely, epididymal nodules presumed to be papillary cystadenomas are found in one-third of males with von Hippel-Lindau disease. The association is stronger for bilateral tumors. The pathogenesis involves loss of the von Hippel-Lindau gene resulting in overexpression of the angiogenic protein "hypoxia-inducible factor." Papillary cystadenoma is of mesonephric derivation. It originates in the efferent ductules of the head of the epididymis in the form of tiny precursor lesions. Histologically, papillary cystadenoma is characterized by cystic spaces with intracystic papillary projections lined by clear cells, with a resultant resemblance to renal cell carcinoma. Immunohistochemical markers may facilitate the distinction between the 2 tumors. Treatment consists of surgical excision and the prognosis is excellent.
Topics: Adolescent; Adult; Aged; Carcinoma, Renal Cell; Cystadenoma, Papillary; Diagnosis, Differential; Epididymis; Humans; Male; Middle Aged; Testicular Neoplasms; Young Adult; von Hippel-Lindau Disease
PubMed: 20367315
DOI: 10.5858/134.4.630 -
International Journal of Gynecological... 2006A second report of an intramural mesonephric adenocarcinoma of the uterus is presented. The histogenesis and clinicopathologic outcome of a surgically staged malignancy... (Review)
Review
A second report of an intramural mesonephric adenocarcinoma of the uterus is presented. The histogenesis and clinicopathologic outcome of a surgically staged malignancy add to the insights and experience of this uncommon disorder.
Topics: Adenocarcinoma; Aged, 80 and over; Biomarkers, Tumor; Calbindin 2; Female; Humans; Immunohistochemistry; Mesonephroma; Neoplasm Invasiveness; S100 Calcium Binding Protein G; Uterine Neoplasms
PubMed: 16803547
DOI: 10.1111/j.1525-1438.2006.00489.x -
International Journal of Gynecological... Oct 2002A number of nonneoplastic glandular lesions of the uterine cervix may be misinterpreted as malignant. Familiarity with their histopathologic features is essential in... (Review)
Review
A number of nonneoplastic glandular lesions of the uterine cervix may be misinterpreted as malignant. Familiarity with their histopathologic features is essential in their recognition and appropriate management. This discussion reviews the clinical and pathologic features of a variety of pseudoneoplastic glandular lesions of the uterine cervix, with an emphasis on those that have been recently described and those that one may encounter more commonly in practice. The entities that will be discussed include tunnel clusters, microglandular hyperplasia, mesonephric hyperplasia, endocervical glandular hyperplasia, and the Arias-Stella reaction.
Topics: Adenocarcinoma; Diagnosis, Differential; Endometrial Hyperplasia; Female; Humans; Uterine Cervical Diseases; Uterine Cervical Neoplasms
PubMed: 12352183
DOI: 10.1097/00004347-200210000-00004 -
Oncology Letters Jan 2016Mesonephric carcinoma of the uterine corpus is an extremely rare malignancy that originates from the mesonephric remnant of the female reproductive tract. There have...
Mesonephric carcinoma of the uterine corpus is an extremely rare malignancy that originates from the mesonephric remnant of the female reproductive tract. There have been no previous reports of mesonephric carcinoma accompanied by a sarcomatous component. The current study presents two cases of uterine corpus mesonephric carcinoma with sarcomatous components that occurred in postmenopausal women. Immunohistochemically, the tumour cells were positive for vimentin and CD10. The tumours of these patients were located in the uterine myometrium; therefore, treatment was similar to that for endometrial cancer. Although the follow-up period was short in the current cases, no metastatic disease was identified in the second case and thus, this may increase clinical knowledge with regard to the biological behavior of these rare malignancies.
PubMed: 26870213
DOI: 10.3892/ol.2015.3886 -
The Journal of Pathology Jan 2024Mesonephric-like adenocarcinoma (MLA) of the female genital tract is an uncommon histotype that can arise in both the endometrium and the ovary. The exact cell of origin...
Mesonephric-like adenocarcinoma harbours characteristic copy number variations and a distinct DNA methylation signature closely related to mesonephric adenocarcinoma of the cervix.
Mesonephric-like adenocarcinoma (MLA) of the female genital tract is an uncommon histotype that can arise in both the endometrium and the ovary. The exact cell of origin and histogenesis currently remain unknown. Here, we investigated whole genome DNA methylation patterns and copy number variations (CNVs) in a series of MLAs in the context of a large cohort of various gynaecological carcinoma types. CNV analysis of 19 MLAs uncovered gains of chromosomes 1q (18/19, 95%), 10 (15/19, 79%), 12 (14/19, 74%), and 2 (10/19, 53%), as well as loss of chromosome 1p (7/19, 37%). Gains of chromosomes 1q, 10, and 12 were also identified in the majority of mesonephric adenocarcinomas of the uterine cervix (MAs) as well as subsets of endometrioid carcinomas (ECs) and low-grade serous carcinomas of the ovary (LGSCs) but only in a minority of serous carcinomas of the uterine corpus (USCs), clear cell carcinomas (CCCs), and tubo-ovarian high-grade serous carcinomas (HGSCs). While losses of chromosome 1p together with gains of chromosome 1q were also identified in both MA and LGSC, gains of chromosome 2 were almost exclusively identified in MLA and MA. Unsupervised hierarchical clustering and t-SNE analysis of DNA methylation data (Illumina EPIC array) identified a co-clustering for MLAs and MAs, which was distinct from clusters of ECs, USCs, CCCs, LGSCs, and HGSCs. Group-wise comparisons confirmed a close epigenetic relationship between MLA and MA. These findings, in conjunction with the established histological and immunophenotypical overlap, suggest bona fide mesonephric differentiation, and support a more precise terminology of mesonephric-type adenocarcinoma instead of MLA in these tumours. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Topics: Female; Humans; Cervix Uteri; DNA Copy Number Variations; DNA Methylation; Carcinoma, Endometrioid; Cystadenocarcinoma, Serous; Carcinoma, Ovarian Epithelial; Ovarian Neoplasms
PubMed: 37850576
DOI: 10.1002/path.6217 -
Clinical Nuclear Medicine Sep 2020We present the case of a 39-year-old woman with vaginal bleeding and abdominal pain. An F-FDG PET/CT showed high F-FDG uptake in a tumor in the pouch of Douglas, in 3...
We present the case of a 39-year-old woman with vaginal bleeding and abdominal pain. An F-FDG PET/CT showed high F-FDG uptake in a tumor in the pouch of Douglas, in 3 lymph nodes in the pelvis, and in the left tuber ischiadicum. Biopsies revealed a mesonephric carcinoma with metastases. Six series of empiric chemotherapy with carboplatin, paclitaxel, and bevacizumab were not sufficient to treat the cancer, and checkpoint immunotherapy with nivolumab and ipilimumab was initialized.
Topics: Adult; Biological Transport; Biopsy; Combined Modality Therapy; Female; Fluorodeoxyglucose F18; Genital Neoplasms, Female; Humans; Immunotherapy; Positron Emission Tomography Computed Tomography
PubMed: 32558718
DOI: 10.1097/RLU.0000000000003134 -
American Journal of Obstetrics and... Dec 1967
Topics: Child; Female; Humans; Mesonephroma; Middle Aged; Urogenital System; Vaginal Neoplasms
PubMed: 6058737
DOI: 10.1016/0002-9378(67)90235-9 -
Chinese Medical Journal 2014
Topics: Adenocarcinoma; Adult; Female; Humans; Mesonephroma; Urethral Neoplasms; Vaginal Neoplasms
PubMed: 24571903
DOI: No ID Found -
International Journal of Surgical... Feb 2017Clear cell urothelial carcinoma (CCUC) is a rare variant of urothelial carcinoma (UC) and its clinical significance has not been well elucidated. Consecutive cases of UC... (Meta-Analysis)
Meta-Analysis
Clear cell urothelial carcinoma (CCUC) is a rare variant of urothelial carcinoma (UC) and its clinical significance has not been well elucidated. Consecutive cases of UC over a period of 5 years were reviewed. Histopathological tumor parameters, including the proportion of tumor cells with clear cell change, and patient outcomes were recorded. Expression of the following immunohistochemical markers was investigated: CK7, CK20, CK5, CD44, and PAX8. We also conducted a review of the literature for case reports/series of CCUC. Ten CCUCs were identified out of a total of 872 cases of UC. The clear cell component was characterized by prominent cytoplasmic membranes and voluminous clear cytoplasm, and accounted for 30% to 90% of the invasive tumor component. Of all the non-CCUC cases reviewed, at least 50% (noninvasive or invasive UC) showed focal areas of clear cell change that accounted for less than 5% of the neoplastic cells. Immunohistochemically, CCUC exhibited positive reactivity for CK5/CD44 (n = 9); CK20 (n = 5), PAX8 (very focal to extensive) (n = 6), and GATA3/CK7 (n = 10). Eight of 10 CCUC were of advanced clinical stage (pT3/pT4) and 6 of 10 experienced tumor recurrence and/or death due to disease. In conclusion, CCUC can be distinguished from non-CCUC by the extensive clear cell change in more than 30% of cells. This variant is associated with rapid progression to muscle invasion and metastasis, with an aggressive clinical course. Expression of CK5/CD44 may represent basal cell features in most CCUC cases, while PAX8 expression is suggestive of mesonephric derivation.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Transitional Cell; Female; Humans; Immunohistochemistry; Male; Middle Aged; Urinary Bladder Neoplasms
PubMed: 27422469
DOI: 10.1177/1066896916660195