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Physiotherapy Theory and Practice Dec 2020: The 10-meter walk test (10MWT) is commonly used to reflect a walking speed, health status, and functional ability of many individuals. However, the test is currently...
: The 10-meter walk test (10MWT) is commonly used to reflect a walking speed, health status, and functional ability of many individuals. However, the test is currently applied using various timing protocols and distance covered that may affect data interpretation with a standard value, and comparisons among the studies. : This study investigated the influence of timing protocols and distance covered on the outcomes of the 10MWT in 78 participants who walked at various speeds, including healthy adults (n = 33), healthy elderly (n = 29), and clinical samples with impaired walking ability (walked slower than 0.8 m/s, n = 16). : The participants were timed while they walked (1) over a 10-meter walkway using static and flying starts; and (2) over 4 and 10 meters using a flying start. The comparisons for outcomes of the timing protocols (static and flying starts), and distance covered (4 and 10 meters) for each group of participants was executed using the dependent samples t-test. : A walking speed using a static start was slower than that using a flying start approximately 0.05-0.11 m/s for each group (p < 0.001). On the contrary, the outcomes of a flying start over 4 and 10 meters showed no significant differences (p > 0.05). : The findings clearly confirmed the influence of timing protocols on the outcomes of the 10MWT in individuals with various walking speeds, and a flying start over 4 meters in the middle of a 10-meter walkway can be applied as an alternative protocol of the 10MWT when area limits.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Walk Test; Walking Speed
PubMed: 30704332
DOI: 10.1080/09593985.2019.1570577 -
Respiratory Care Sep 2005The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the... (Review)
Review
The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the pMDI device (propellants, formulation, metering valve, and actuator) all play roles in the formation of the spray, and in determining drug delivery to the lungs. Hence the opportunity exists to design a pMDI product by adjusting the formulation, metering-valve size, and actuator nozzle diameter in order to obtain the required spray characteristics and fine-particle dose. Breath-actuated pMDIs, breath-coordinated pMDIs, spray-velocity modifiers, and spacer devices may be useful for patients who cannot use a conventional press-and-breathe pMDI correctly. Modern pMDI devices, which contain non-ozone-depleting propellants, should allow inhalation therapy via pMDI to extend well into the 21st century for a variety of treatment indications.
Topics: Administration, Inhalation; Aerosol Propellants; Chemistry, Pharmaceutical; Equipment Design; Humans; Inhalation Spacers; Metered Dose Inhalers; Respiratory Mechanics
PubMed: 16122401
DOI: No ID Found -
Diabetes Care Oct 2018Blood glucose monitoring is fundamental for hyperglycemia management during pregnancy, but are the devices up to the job? Studies assessing the accuracy of 10... (Review)
Review
Blood glucose monitoring is fundamental for hyperglycemia management during pregnancy, but are the devices up to the job? Studies assessing the accuracy of 10 commercially available glucose meters during pregnancy showed that although >98-99% of the meter values were in the acceptable zones of the error grid for the majority of the meters, the meter performance varied, with the majority showing positive bias and a few showing minimal negative bias. The mean difference between meter and laboratory plasma values varied between -0.33 and 0.73 mmol/L. Three meters showed deviations from laboratory results with a change in maternal hematocrit levels. No meters had a total analytical error <5%, and no studies evaluated meters using recent International Organization for Standardization 15197:2013 criteria. The Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT) recently showed that an antenatal continuous glucose monitoring system (CGMS), as an adjunct to capillary monitoring, was associated with a lower incidence of large-for-gestational-age babies, fewer neonatal intensive care unit admissions (>24 h), and a lower incidence of neonatal hypoglycemia. The flash glucose monitoring system shows good accuracy in pregnant women but has not been marketed widely in the U.S. We suggest that meters cannot be assumed to be sufficiently accurate during pregnancy and that manufacturers should ensure a total error <5%, with bias and imprecision <2% during pregnancy. Large studies are needed to evaluate the usefulness of CGMS among pregnant women with type 2 diabetes and gestational diabetes mellitus.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Monitoring, Physiologic; Pregnancy; Pregnancy in Diabetics; Reference Standards; Reproducibility of Results
PubMed: 30237233
DOI: 10.2337/dc18-0833 -
Journal of the American Pharmaceutical... 1998To provide an overview of several blood glucose meters that will enhance practicing pharmacists' knowledge and understanding of these devices to allow education of the... (Review)
Review
OBJECTIVE
To provide an overview of several blood glucose meters that will enhance practicing pharmacists' knowledge and understanding of these devices to allow education of the patient with diabetes.
DATA SOURCES
Original and review articles, blood glucose meter package inserts and manuals.
DATA SYNTHESIS
Careful blood glucose control is essential to prevent long-term complications of diabetes. Newer blood glucose meters have a broad variety of features, including small size, extended memory capacity, blood glucose manipulation techniques, and computer downloading capabilities. The decision to choose a blood glucose meter should be based on a number of criteria, including the patient's needs, ease of use, and affordability.
CONCLUSION
Pharmacists must position themselves to differentiate among the numerous blood glucose meters available on the market and make appropriate recommendations based on patient-specific needs.
Topics: Blood Glucose Self-Monitoring; Blood Specimen Collection; Calibration; Counseling; Humans
PubMed: 9654849
DOI: 10.1016/s1086-5802(16)30317-5 -
Journal of Diabetes Science and... Sep 2013Maintaining appropriate glycemic control in critically ill patients reduces morbidity and mortality. The use of point-of-care (POC) glucose devices is necessary to...
BACKGROUND
Maintaining appropriate glycemic control in critically ill patients reduces morbidity and mortality. The use of point-of-care (POC) glucose devices is necessary to obtain rapid results at the patient's bedside. However, the devices should be thoroughly tested in the intended population before implementation. The use of POC glucose meters in critically ill patients has been questioned both in the literature and by regulatory agencies. The aim of this study was to determine if the ACCU-CHEK® Inform II system (Roche Diagnostics) POC glucose meter demonstrated the desired accuracy and precision, as defined by Clinical and Laboratory Standards Institute guideline POCT12-A3, in a large number of critically ill patients from multiple intensive care settings at two academic medical centers.
METHODS
A total of 1200 whole blood meter results from 600 patients were compared with central laboratory plasma values. Whole blood aliquots from venous samples were used to obtain duplicate meter results with the remaining sample being processed to obtain plasma for central laboratory testing within 5 min of meter testing.
RESULTS
A total of 1185 (98.8%) of the new meter's glucose values were within ± 12.5% (± 12 mg/dl for values ≥ 100 mg/dl) of the comparative laboratory glucose values, and 1198 (99.8%) were within ± 20% (± 20 mg/dl for values <100 mg/dl).
CONCLUSIONS
Considering the large number of patients from numerous critical care units examined, the new glucose meter system appears to have sufficient analytic accuracy for use in critically ill patients.
Topics: Blood Glucose; Critical Care; Humans; Hyperglycemia; Intensive Care Units; Point-of-Care Systems
PubMed: 24124955
DOI: 10.1177/193229681300700518 -
Sensors (Basel, Switzerland) Sep 2021Automatic meter infrastructure (AMI) systems using remote metering are being widely used to utilize water resources efficiently and minimize non-revenue water. We...
Automatic meter infrastructure (AMI) systems using remote metering are being widely used to utilize water resources efficiently and minimize non-revenue water. We propose a convolutional neural network-long short-term memory network (CNN-LSTM)-based solution that can predict faulty remote water meter reading (RWMR) devices by analyzing approximately 2,850,000 AMI data collected from 2762 customers over 360 days in a small-sized city in South Korea. The AMI data used in this study is a challenging, highly unbalanced real-world dataset with limited features. First, we perform extensive preprocessing steps and extract meaningful features for handling this challenging dataset with limited features. Next, we select important features that have a higher influence on the classifier using a recursive feature elimination method. Finally, we apply the CNN-LSTM model for predicting faulty RWMR devices. We also propose an efficient training method for ML models to learn the unbalanced real-world AMI dataset. A cost-effective threshold for evaluating the performance of ML models is proposed by considering the mispredictions of ML models as well as the cost. Our experimental results show that an F-measure of 0.82 and MCC of 0.83 are obtained when the CNN-LSTM model is used for prediction.
Topics: Cost-Benefit Analysis; Memory, Long-Term; Neural Networks, Computer; Remote Sensing Technology; Water
PubMed: 34577436
DOI: 10.3390/s21186229 -
Journal of Dairy Science Feb 2018Accurate cow-side blood β-hydroxybutyrate (BHB) detection meters are valuable tools for rapid diagnosis of hyperketonemia. The main objective of this study was to...
Accurate cow-side blood β-hydroxybutyrate (BHB) detection meters are valuable tools for rapid diagnosis of hyperketonemia. The main objective of this study was to compare the blood BHB measured in whole blood by the BHBCheck meter (PortaCheck, Moorestown, NJ) to a previously validated meter, Precision Xtra meter (Abbott Laboratories, Abbott Park, IL) and a colorimetric laboratory assay. Samples (n = 426) were collected from postpartum primiparous and multiparous Holstein cows (n = 79 cows) enrolled in 1 of 2 experiments (Exp) with different sampling schedules (Exp 1: n = 39 cows, 58 samples; Exp 2: n = 40 cows, 368 samples). In both Exp, whole-blood samples were collected from the coccygeal vessels after morning milking, before morning feeding. Blood samples were used immediately for BHB quantification via the BHBCheck meter and the Precision Xtra meter. Blood was also collected into evacuated tubes containing no additive (Exp 1) or potassium oxalate/sodium fluoride (Exp 2), which were centrifuged for serum or plasma separation and stored at -20°C for subsequent analysis. Laboratory quantification of BHB concentration was done by the BHB LiquiColor Assay (EKF Diagnostics-Stanbio, Boerne, TX; certified for serum and plasma). Data were analyzed by UNIVARIATE, CORR, FREQ, REG, and LOGISTIC procedures of SAS 9.4 (SAS Institute Inc., Cary, NC). Within this sample set, average parity was 3.3 lactations and DIM was 14 d. The proportion of samples classified as hyperketonemia (BHB ≥1.2 mmol/L) was 25, 28, and 31% as determined by the colorimetric assay, BHBCheck meter, and Precision Xtra meter, respectively. The correlation for BHBCheck meter BHB concentration compared with the colorimetric assay concentrations was r = 0.96, with a sensitivity of 91% and specificity of 93%. Correlation, sensitivity, and specificity of the Precision Xtra meter concentrations were 0.97, 98%, and 92%, respectively. Bland-Altman plots demonstrated minimal bias for both meters. Area under the receiver operator characteristic curve suggests adequate diagnostic accuracy of both meters. Overall, accuracy, sensitivity, and specificity of the BHBCheck meter was similar to the Precision Xtra meter and laboratory assay, indicating the BHBCheck meter is appropriate for use as a cow-side diagnostic test for hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Ketosis; Parity; Point-of-Care Systems; Pregnancy; ROC Curve; Sensitivity and Specificity
PubMed: 29224868
DOI: 10.3168/jds.2017-13583 -
Nature Feb 2022The sensing of gravity has emerged as a tool in geophysics applications such as engineering and climate research, including the monitoring of temporal variations in...
The sensing of gravity has emerged as a tool in geophysics applications such as engineering and climate research, including the monitoring of temporal variations in aquifers and geodesy. However, it is impractical to use gravity cartography to resolve metre-scale underground features because of the long measurement times needed for the removal of vibrational noise. Here we overcome this limitation by realizing a practical quantum gravity gradient sensor. Our design suppresses the effects of micro-seismic and laser noise, thermal and magnetic field variations, and instrument tilt. The instrument achieves a statistical uncertainty of 20 E (1 E = 10 s) and is used to perform a 0.5-metre-spatial-resolution survey across an 8.5-metre-long line, detecting a 2-metre tunnel with a signal-to-noise ratio of 8. Using a Bayesian inference method, we determine the centre to ±0.19 metres horizontally and the centre depth as (1.89 -0.59/+2.3) metres. The removal of vibrational noise enables improvements in instrument performance to directly translate into reduced measurement time in mapping. The sensor parameters are compatible with applications in mapping aquifers and evaluating impacts on the water table, archaeology, determination of soil properties and water content, and reducing the risk of unforeseen ground conditions in the construction of critical energy, transport and utilities infrastructure, providing a new window into the underground.
PubMed: 35197616
DOI: 10.1038/s41586-021-04315-3 -
Annals of Clinical Biochemistry Jan 2014To assess glucose meter performance in a diabetes antenatal clinic, focussing on clinical and pre-analytical factors that might impact on the quantification of meter...
BACKGROUND
To assess glucose meter performance in a diabetes antenatal clinic, focussing on clinical and pre-analytical factors that might impact on the quantification of meter accuracy and precision.
METHODS
The Freestyle Lite and the Performa glucose meters were assessed by trained researchers. Finger stick glucose was measured and compared with plasma venous glucose, obtained from a concomitantly collected antecubital fossa sample. Venous plasma was separated on-site then sent to the laboratory for measurement of glucose using the hexokinase method (comparative method). Additional data collected included: (i) timing of and also (ii) quantity of last carbohydrate intake; (iii) time periods between collection, preparation and analysis of the venous sample; (iv) the haemolysis index of the plasma sample and (v) haematocrit.
RESULTS
There were 104 participants. Both meters fulfilled ISO 15197 standards, with 99% and 97% of Freestyle Lite and Performa results, respectively, falling within acceptable limits for this standard. Both meters showed minor proportional bias, reading low at higher glucose values. Consensus error grid analysis showed 100% of results from the Freestyle Lite and 99% from the Performa falling within Zone A, thus the observed differences in measured capillary and venous plasma glucose were sufficiently minor that they would have little effect on clinical action. No association was observed between [capillary-plasma] glucose difference and the five variables outlined above.
CONCLUSIONS
The two glucose meters tested showed a reassuringly acceptable level of performance, when assessed by a research team in the setting of a diabetes antenatal clinic.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Clinical Laboratory Techniques; Diabetes, Gestational; Female; Humans; Pregnancy; Pregnancy Complications; Prenatal Diagnosis
PubMed: 24003257
DOI: 10.1177/0004563213487893 -
ISA Transactions Jul 2019In recent years, the Coriolis mass flow meters (CMF), devices based on the Coriolis effect over a vibrating pipe, have developed better metrological performance and they...
In recent years, the Coriolis mass flow meters (CMF), devices based on the Coriolis effect over a vibrating pipe, have developed better metrological performance and they are now a reasonable alternative for the custody transfer measurements. Nowadays, many custody transfer operations require measurement of the net volume (volume measured at a certain reference temperature) and, therefore, it is not feasible to use the CMF as a mass flow meter. However, the actual CMF can be used as net volume meters because they have special equipment to measure density and temperature, and a flow computer. In this work, firstly a mathematical simplification of the physical model is proposed for the CMF. We part from the dimensional analysis of the flow-phase relationship produced by the Coriolis force, the main physical principle behind these devices. A simplified formula is obtained and it permits identifying the magnitudes of influence of the CMF as a mass meter. Secondly, its metrological properties are characterized. For such purpose, a 4" straight tube commercial meter has been calibrated in volume, in the 50 to 165 m/h range against a standard container and a bidirectional prover, employing gas oil and kerosene (JET-A1). These calibrations have turned out to be compatible with the ones performed by the manufacturer in mass and using water. Then it is verified that the CMF fulfills the requisites of the legal metrology: maximum error allowed, linearity and repeatability. Skewness is observed in the relative error (expressed in %) of the CMF and it has been researched to be due to systematic effects related to constructive parameters of the meter. Lineal correlation is verified between relative error and temperature, and between relative error and flow rate, with negative slopes of -0.03% °C and -0.001% h/m respectively.
PubMed: 30711341
DOI: 10.1016/j.isatra.2019.01.007