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Chemistry (Weinheim An Der Bergstrasse,... Jul 2022Carbon cloth electrode modified by covalently attaching a manganese organometallic catalyst is used as cathode for the electrochemical reduction of CO in methanol...
Carbon cloth electrode modified by covalently attaching a manganese organometallic catalyst is used as cathode for the electrochemical reduction of CO in methanol solutions. Six different industrial amines are employed as co-catalyst in millimolar concentrations to deliver a series of new reactive system. While such absorbents were so far believed to provide a CO reservoir and act as sacrificial proton source, we herein demonstrate that this role can be played by methanol, and that the adduct formed between CO and the amine can act as an effector or inhibitor toward the catalyst, thereby enhancing or reducing the production of formate. Pentamethyldiethylentriamine (PMDETA), identified as the best effector in our series, converts CO in wet methanolic solution into bisammonium bicarbonate. Computational studies revealed that this adduct is responsible for a barrierless transformation of CO to formate by the reduced form of the Mn catalyst covalently bonded to the electrode surface. As a consequence, selectivity can be switched on demand from CO to formate anion, and in the case of (PMDETA) an impressive TON of 2.8×10 can be reached. This new valuable knowledge on an integrated capture and utilization system paves the way toward more efficient transformation of CO into liquid fuel.
Topics: Amines; Carbon Dioxide; Electrodes; Formates; Methanol
PubMed: 35471768
DOI: 10.1002/chem.202104377 -
Drug Design, Development and Therapy 2017The authors designed and synthesized 17 (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives to find a new chemical scaffold, showing excellent...
The authors designed and synthesized 17 (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives to find a new chemical scaffold, showing excellent tyrosinase-inhibitory activity. Their tyrosinase-inhibitory activities were evaluated against mushroom tyrosinase at 50 μM, and five of the PDTM derivatives (PDTM3, PDTM7-PDTM9, and PDTM13) were found to inhibit mushroom tyrosinase more than kojic acid or arbutin, the positive controls. Of seventeen PDTMs, PDTM3 (half-maximal inhibitory concentration 13.94±1.76 μM), with a 2,4-dihydroxyphenyl moiety, exhibited greatest inhibitory effects (kojic acid half-maximal inhibitory concentration 18.86±2.14 μM). Interestingly, PDTM compounds with no hydroxyl group, PDTM7-PDTM9, also had stronger inhibitory activities than kojic acid. In silico studies of interactions between tyrosinase and the five PDTMs suggested their binding affinities were closely related to their tyrosinase-inhibitory activities. Cell-based experiments performed using B16F10 mouse-skin melanoma cells showed that PDTM3 effectively inhibited melanogenesis and cellular tyrosinase activity. A cell-viability study conducted using B16F10 cells indicated that the antimelanogenic effect of PDTM3 was not attributable to its cytotoxicity. Kinetic studies showed PDTM3 competitively inhibited tyrosinase, indicating binding to the tyrosinase-active site. We found that PDTM3 with a new chemical scaffold could be a promising candidate for skin-whitening agents, and that the 1,3-dithiolane ring could be used as a chemical scaffold for potent tyrosinase inhibition.
Topics: Agaricales; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Methanol; Molecular Structure; Monophenol Monooxygenase; Structure-Activity Relationship
PubMed: 28352157
DOI: 10.2147/DDDT.S131538 -
Polski Tygodnik Lekarski (Warsaw,...
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Drug Metabolism and Disposition: the... Oct 1996Methanol toxicokinetics were examined in pregnant Sprague-Dawley rats and CD-1 mice to explore the possibility of gestational-associated alterations in metabolism and... (Comparative Study)
Comparative Study
Methanol toxicokinetics were examined in pregnant Sprague-Dawley rats and CD-1 mice to explore the possibility of gestational-associated alterations in metabolism and disposition. In vitro biotransformation of methanol in rat and mouse fetal livers also was examined to assess the capability of the near-term rodent fetus to metabolize methanol. In the in vivo studies, rats received a single dose (100 or 2,500 mg/kg) of methanol either orally (by gavage) or intravenously; mice received a single oral or intravenous 2500-mg/kg dose. The maximal rate of methanol elimination (Vmax) in vivo decreased at term in both rodent species; Vmax in near-term rats and mice was only 65-80% of that in nonpregnant animals. Gestation also affected intercompartmental transfer rate constants, although there was no obvious relationship between these changes and gestational stage. In vitro metabolism studies supported the in vivo data; adult near-term rodent livers metabolized methanol with a Vmax of approximately 85% that in livers from nonpregnant rodents (p < 0.05). Fetal rodent liver was capable of metabolizing methanol in vitro, but only at a rate < 5% of respective adult livers. Data generated in these experiments demonstrate that alterations in methanol disposition associated with gestational stage must be accounted for in the development of a toxicokinetic model for methanol in pregnant mammals.
Topics: Administration, Oral; Animals; Female; Formaldehyde; Infusions, Intravenous; Methanol; Mice; Pregnancy; Rats; Rats, Sprague-Dawley; Species Specificity
PubMed: 8894506
DOI: No ID Found -
Annals of Emergency Medicine Aug 1999
Topics: Adult; Humans; Injections, Intravenous; Male; Methanol; Retina; Suicide, Attempted
PubMed: 10425062
DOI: 10.1016/s0196-0644(99)70259-3 -
Water Science and Technology : a... 2001An overview on methanol conversion in high-rate anaerobic reactors is presented, with the focus on technological as well as microbiological aspects. The simple...
An overview on methanol conversion in high-rate anaerobic reactors is presented, with the focus on technological as well as microbiological aspects. The simple C1-compound methanol can be degraded anaerobically in a complex way, in which methanogens, sulfate reducing bacteria and homoacetogens interact cooperatively or competitively at substrate level. This interaction has large technological implications as it determines the final product of methanol mineralization, methane or carbon dioxide. The degradation route of methanol may be entirely different when environmental conditions change. Direct methanogenesis from methanol seems the predominant mineralization route under mesophilic conditions both in the absence and the presence of sulfate. Under thermophilic conditions methanol oxidation to carbon dioxide and hydrogen appears to play an important role. The UASB technology for mesophilic digestion of methanolic waste has presently reached full-scale maturity. The potential of methanol as feedstock for anaerobic processes is discussed.
Topics: Bacteria, Anaerobic; Biodegradation, Environmental; Bioreactors; Methanol; Oxidation-Reduction; Waste Disposal, Fluid
PubMed: 11730139
DOI: No ID Found -
The Journal of the Florida Medical... Jul 1993A 46-year-old male presented to the emergency room seven hours after consuming a large container of sterno. He could not see and complained of abdominal and back pain....
A 46-year-old male presented to the emergency room seven hours after consuming a large container of sterno. He could not see and complained of abdominal and back pain. He was tachypneic, tachycardic, hypertensive and hypothermic. Laboratory results were significant for a severe metabolic acidosis, a serum osmolality of 465 and serum methanol level of 493 mg/dl. Aggressive treatment included ethanol drip, bicarbonate and hemodialysis. He survived and regained his eyesight in spite of this degree of elevation of the serum methanol level. The literature does not reveal a similar report.
Topics: Acidosis; Charcoal; Humans; Male; Methanol; Middle Aged; Osmolar Concentration; Sodium Bicarbonate
PubMed: 8089646
DOI: No ID Found -
Bioresource Technology Feb 2009Methanol vapours were treated in a biotrickling filter (BTF) packed with inert polypropylene spheres. The effects of the nitrogen concentration in the nutrient solution,...
Methanol vapours were treated in a biotrickling filter (BTF) packed with inert polypropylene spheres. The effects of the nitrogen concentration in the nutrient solution, the empty bed residence time (EBRT) and the methanol inlet concentration, on the BTF performance, were all examined. The elimination capacity (EC), the biomass and the carbon dioxide production rates were all increased with the rising of the nitrogen concentration and the EBRT. The EC also rose with increasing methanol inlet load (IL) when the methanol inlet concentration and the EBRT were varied, from 0.3 to 37.0 g m(-3), and from 20 to 65 s, respectively. The BTF reached its maximum EC level of 2160 g m(-3) h(-1) when it was operated at an IL level of 3700 g m(-3) h(-1). The input methanol was removed through two mechanisms: biodegradation and absorption in the liquid phase. The partition coefficient for the methanol in the BTF was determined at five EBRTs and along the packed bed. It generally followed the Henry model, having an average value of 2.64 x 10(-4)[mol L(-1)](gas)/[mol L(-1)](liquid).
Topics: Biomass; Filtration; Methanol; Nitrogen; Solutions; Temperature; Time Factors; Volatilization
PubMed: 18977135
DOI: 10.1016/j.biortech.2008.08.049 -
American Journal of Clinical Pathology Sep 1955
Topics: Blood; Body Fluids; Ethanol; Humans; Methanol
PubMed: 13248833
DOI: 10.1093/ajcp/25.9_ts.1071 -
Acta Anaesthesiologica Scandinavica Jul 2007
Topics: Administration, Cutaneous; Epilepsy; Fatal Outcome; Female; Glasgow Coma Scale; Humans; Methanol; Middle Aged
PubMed: 17567277
DOI: 10.1111/j.1399-6576.2007.01332.x