-
Clinical Pharmacology and Therapeutics Jan 1980The serum levels of methyldopa and its principle metabolites were assessed in 22 hypertensive children, of whom 13 had impaired renal function. A significant correlation...
The serum levels of methyldopa and its principle metabolites were assessed in 22 hypertensive children, of whom 13 had impaired renal function. A significant correlation was found between the magnitude of the renal dysfunction and the serum levels of methyldopa, alpha-methyldopa-sulfate, alpha-methyldopamine, and alpha-methyldopamine-sulfate. The patients were divided into 2 groups: those with normal (serum creatinine less than or equal to 1.0 mg/100 ml) and those with abnormal (serum creatinine greater than 1.0 mg/100 ml) renal function. The serum level of alpha-methyldopa-sulfate and not of methyldopa was elevated in those with renal dysfunction. The serum levels of alpha-methyldopamine and, in particular, its 3-0 sulfate conjugate were markedly elevated in patients with renal disease. These data suggest that the enhanced sensitivity to methyldopa in patients with impaired renal function may be due in part to alpha-methyldopamine.
Topics: Adolescent; Adult; Child; Child, Preschool; Creatinine; Dopamine; Female; Humans; Hypertension; Infant; Kidney Diseases; Male; Methyldopa; Sulfates
PubMed: 7351116
DOI: 10.1038/clpt.1980.6 -
Lancet (London, England) Jan 1971
Topics: Asian People; China; Coombs Test; Humans; Hypertension; Methyldopa
PubMed: 4099260
DOI: 10.1016/s0140-6736(71)90824-5 -
Scandinavian Journal of Clinical and... Apr 1972
Topics: Administration, Oral; Humans; Hypertension; Injections, Intravenous; Kidney; Kidney Failure, Chronic; Methyldopa; Structure-Activity Relationship; Time Factors
PubMed: 5029323
DOI: 10.3109/00365517209081075 -
European Journal of Clinical... Oct 1977
Topics: Administration, Oral; Adult; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Methyldopa; Middle Aged; Time Factors
PubMed: 923625
DOI: 10.1007/BF00645132 -
Journal of the Royal College of... Oct 1981
Topics: Age Factors; Aged; Blood Pressure Determination; Cardiovascular Diseases; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Retrospective Studies; Risk
PubMed: 7320963
DOI: No ID Found -
Lancet (London, England) Apr 1966
Topics: Aged; Anemia, Hemolytic; Female; Humans; Methyldopa
PubMed: 4159738
DOI: 10.1016/s0140-6736(66)90929-9 -
Lancet (London, England) Feb 1966
Topics: Aged; Anemia, Hemolytic; Female; Humans; Methyldopa
PubMed: 4159796
DOI: 10.1016/s0140-6736(66)91439-5 -
Lancet (London, England) Jun 1968
Topics: Africa; Coombs Test; Humans; Hypertension; Methyldopa; Racial Groups
PubMed: 4172174
DOI: 10.1016/s0140-6736(68)92335-0 -
Lancet (London, England) Feb 1968
Topics: Coombs Test; Humans; Hypertension; Methods; Methyldopa
PubMed: 4169998
DOI: 10.1016/s0140-6736(68)91400-1 -
Scandinavian Journal of Clinical and... Apr 1972
Topics: Administration, Oral; Anuria; Creatinine; Glomerular Filtration Rate; Humans; Injections, Intravenous; Kidney; Kidney Failure, Chronic; Methyldopa; Protein Binding
PubMed: 5029324
DOI: 10.3109/00365517209081076