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Der Chirurg; Zeitschrift Fur Alle... Apr 2022
Topics: Glucocorticoids; Hepatectomy; Humans; Liver; Methylprednisolone
PubMed: 35244735
DOI: 10.1007/s00104-022-01620-z -
Artificial Cells, Nanomedicine, and... 2016The aim of the present study was to formulate methylprednisolone acetate -Eudragit(®) RS100 nanofibers and nanobeads by the electrospinning method. The physicochemical...
The aim of the present study was to formulate methylprednisolone acetate -Eudragit(®) RS100 nanofibers and nanobeads by the electrospinning method. The physicochemical characteristics of the prepared electrospuns were assessed as well. The particle size and morphology were evaluated using scanning electron microscopy. The crystallinity of the drug in the nanofibers and nanobeads obtained was also studied by X-ray crystallography and differential scanning calorimetry (DSC) thermograms. In addition, FT-IR spectroscopy was applied to investigate any possible chemical interaction between the drug and carrier during the preparation process. The drug release kinetics were considered, to predict the release mechanism. Increasing the concentration of the injected solution resulted in the production of more nanofibers and less nanobeads, with the particle size ranging from 100 to 500 nm. The drug crystallinity was decreased during the electrospinning process; however, no interaction between drug and polymer was observed. The electrospuns showed faster drug release pattern compared to the pure drug. The release data were best fitted to the Weibull model, in which the corresponding shape factor values of the model were less than 0.75 indicating the diffusion mechanism of drug release. In conclusion, electrospinning could be considered as a simple and cost effective method for fabricating the drug: polymer nanofibers and nanobeads.
Topics: Chemical Phenomena; Drug Carriers; Drug Liberation; Electricity; Kinetics; Methylprednisolone; Methylprednisolone Acetate; Nanofibers; Nanotechnology; Polymethacrylic Acids
PubMed: 25289448
DOI: 10.3109/21691401.2014.965309 -
Annales de Medecine Interne 1994
Review
Topics: Humans; Injections, Jet; Methylprednisolone; Rheumatic Diseases
PubMed: 8024178
DOI: No ID Found -
American Journal of Hospital Pharmacy Nov 1994
Comparative Study Review
Topics: Anti-Inflammatory Agents; Back Pain; Controlled Clinical Trials as Topic; Humans; Injections, Epidural; Methylprednisolone; Methylprednisolone Acetate
PubMed: 7856601
DOI: No ID Found -
The Journal of Rheumatology Jun 1997There are numerous reports of hypersensitivity reactions to corticosteroids. However, cases of anaphylactic shock after intraarticular injection of corticosteroids are... (Review)
Review
There are numerous reports of hypersensitivity reactions to corticosteroids. However, cases of anaphylactic shock after intraarticular injection of corticosteroids are exceedingly rare. We describe a case of anaphylaxis in a 31-year-old woman after intraarticular injection of synthetic methylprednisolone acetate. Immediately after injection she developed sneezing, angioedema, tachycardia, and marked hypotension. She responded promptly to treatment with subcutaneous epinephrine. She had received uneventfully one intraarticular injection of the same compound 4 years earlier. Intradermal skin testing showed strong reactivity to methylprednisolone acetate suspension, moderate reactivity to hydrocortisone, and weak reactivity to betamethasone. Tests with dexamethasone, triamcinolone, lidocaine, latex and nonsteroid constituents of the injected suspension including polyethylene glycol, polysorbate 80, mono and dibasic sodium phosphate, and myristyl-gamma-picolinium chloride were negative. This patient had developed anaphylaxis due to methylprednisolone acetate alone. Although such events are very rare, it is advisable to keep injectable epinephrine in the offices of rheumatologists.
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Injections, Intra-Articular; Methylprednisolone; Methylprednisolone Acetate
PubMed: 9195532
DOI: No ID Found -
Drug Metabolism and Disposition: the... 1985Methodology was evolved for comparison of methylprednisolone disposition in man and rabbit. Methylprednisolone, methylprednisone, and methylprednisolone hemisuccinate... (Comparative Study)
Comparative Study
Methodology was evolved for comparison of methylprednisolone disposition in man and rabbit. Methylprednisolone, methylprednisone, and methylprednisolone hemisuccinate ester concentrations in plasma were measured by HPLC methodology after iv administration of each compound to rabbits. Methylprednisolone hemisuccinate is rapidly and completely hydrolyzed to methylprednisolone with a half-life of 10 min. Dosing with the free alcohol or ester produces identical disposition curves for methylprednisolone. Methylprednisolone was found to undergo rapid and reversible metabolism with methylprednisone, a phenomenon also seen in man. Plasma concentrations of methylprednisolone are appreciably greater than the metabolite regardless of the form of steroid given. Administration of the metabolite yields 67% availability of methylprednisolone. The occurrence of reversible metabolism produces an apparent clearance which is about 71% of the value of the "real" elimination clearance for both steroids. Man and rabbit show identical plasma protein binding of methylprednisolone (77%). Small differences in apparent clearance (man, 5.74 ml/min/kg; rabbit, 7.93 ml/min/kg) can be accounted for by the animal scale-up principle (body weight0.89). The rabbit is thus a useful animal model for further assessing mechanisms of drug- or disease-steroid interactions which occur in man.
Topics: Adult; Animals; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Methylprednisolone; Rabbits; Species Specificity
PubMed: 2861987
DOI: No ID Found -
The Medical Journal of Australia Jan 1992
Topics: Anti-Inflammatory Agents; Humans; Injections, Intravenous; Medication Errors; Methylprednisolone; Methylprednisolone Acetate
PubMed: 1736063
DOI: No ID Found -
The New England Journal of Medicine Jun 1986
Topics: Acute Disease; Asthma; Emergencies; Hospitalization; Humans; Methylprednisolone
PubMed: 3713774
DOI: 10.1056/NEJM198606263142610 -
British Journal of Clinical Pharmacology Mar 19891. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
1. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium succinate (MPSS) and an oral dose of 20 mg methylprednisolone as 4 x 5 mg tablets. Plasma concentrations of MP and MPSS were measured by both high performance thin layer (h.p.t.l.c.) and high pressure liquid chromatography (h.p.l.c.). 2. The mean values (+/- s.d.) of half-life, mean residence time (MRT), systemic clearance (CL) and volume of distribution at steady state (Vss) of MP following intravenous administration were 1.93 +/- 0.35 h, 3.50 +/- 1.01 h, 0.45 +/- 0.12 lh-1 kg-1 and 1.5 +/- 0.63 1 kg-1, respectively. There was no evidence of dose-related changes in these values. The plasma MP concentration-time curves were superimposable when normalized for dose. 3. The bioavailability of methylprednisolone from the 20 mg tablet was 0.82 +/- 0.11 (s.d.). 4. In vivo hydrolysis of MPSS was rapid with a half-life of 4.14 +/- 1.62 (s.d.) min, and was independent of dose. In contrast, in vitro hydrolysis in plasma, whole blood and red blood cells was slow; the process continuing for more than 7 days. Sodium fluoride did not prevent the hydrolysis of MPSS.
Topics: Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male; Methylprednisolone; Methylprednisolone Hemisuccinate
PubMed: 2655680
DOI: 10.1111/j.1365-2125.1989.tb05366.x -
American Journal of Cardiovascular... Sep 2022Cardiac arrest is often fatal if not treated immediately by cardiopulmonary resuscitation to restore a normal heart rhythm and spontaneous circulation. We aim to... (Meta-Analysis)
Meta-Analysis
The Effect of Vasopressin and Methylprednisolone on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
INTRODUCTION
Cardiac arrest is often fatal if not treated immediately by cardiopulmonary resuscitation to restore a normal heart rhythm and spontaneous circulation. We aim to evaluate the clinical benefits of vasopressin and methylprednisolone versus placebo for patients with in-hospital cardiac arrest.
DATA SOURCES
We searched PubMed, EMBASE, Scopus, Web of Science, Cochrane Central, and Google Scholar from inception to October 17, 2021, by using search terms included "Vasopressin" AND "Methylprednisolone" AND "Cardiac arrest".
STUDY SELECTION AND DATA EXTRACTION
We included randomized controlled trials (RCTs) that compared vasopressin and methylprednisolone to placebo. The main outcomes were the return of spontaneous circulation (ROSC) and survival to hospital discharge.
DATA SYNTHESIS
A total of three RCTs, with a total of 869 patients, were included. The pooled risk ratios (RRs) were calculated along with their 95% confidence intervals (CIs). Our result showed an increase in ROSC in patients who received vasopressin and methylprednisolone (RR = 1.32; 95% CI = [1.18, 1.47], p < 0.00001) when compared with the placebo group. However, there was no difference between both groups regarding survival to hospital discharge (RR = 1.76; 95% CI = [0.68, 4.56], p= 0.25).
RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE
The current guidelines recommend epinephrine for patients with in-hospital cardiac arrest. Our meta-analysis updates clinicians about using vasopressin and methylprednisolone besides epinephrine, providing them with the best available evidence in managing patients with in-hospital cardiac arrest.
CONCLUSION
Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone besides epinephrine is associated with increased ROSC compared with placebo and epinephrine. However, high-quality RCTs are necessary before drawing a firm conclusion regarding the efficacy of vasopressin and methylprednisolone for patients with in-hospital cardiac arrest.
Topics: Epinephrine; Heart Arrest; Hospitals; Humans; Methylprednisolone; Randomized Controlled Trials as Topic; Return of Spontaneous Circulation
PubMed: 35314927
DOI: 10.1007/s40256-022-00522-z