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Journal of Public Health Management and... 2013
Topics: Anti-Inflammatory Agents; Drug Contamination; Humans; Meningitis, Fungal; Methylprednisolone; Methylprednisolone Acetate; Population Surveillance
PubMed: 23719388
DOI: 10.1097/PHH.0b013e318294f799 -
Deutsche Medizinische Wochenschrift... Dec 1994
Comparative Study Review
[Problems of equivalency points during therapy with glucocorticoids. A comparison of the clinical pharmacokinetics and pharmacodynamics of prednisolone and methylprednisolone].
Topics: Animals; Binding, Competitive; Blood Proteins; Body Fluids; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Hydrocortisone; Metabolic Clearance Rate; Methylprednisolone; Molecular Structure; Prednisolone; Protein Binding
PubMed: 7988369
DOI: 10.1055/s-2008-1058886 -
The Annals of Thoracic Surgery Sep 2016The optimal dose of methylprednisolone during pediatric open heart surgical procedures is unknown. This study compared the antiinflammatory and cardioprotective effects... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
The optimal dose of methylprednisolone during pediatric open heart surgical procedures is unknown. This study compared the antiinflammatory and cardioprotective effects of high and lower doses of methylprednisolone in children undergoing cardiac operations.
METHODS
Thirty children, between 1 and 18 months old and undergoing total correction of tetralogy of Fallot, were randomized in double-blind fashion to receive either 5 or 30 mg/kg of intravenous methylprednisolone after anesthesia induction. Plasma concentrations of methylprednisolone, interleukin-6 (IL-6), IL-8, and IL-10, troponin T, and glucose were measured at anesthesia induction before administration of the study drug, at 30 minutes on cardiopulmonary bypass (CPB), just after weaning from CPB, and at 6 hours after CPB. Troponin T and blood glucose were also measured on the first postoperative morning.
RESULTS
Significantly higher methylprednisolone concentrations were measured in patients receiving 30 mg/kg of methylprednisolone at 30 minutes on CBP, after weaning from CPB and at 6 hours after CPB (p < 0.001). No differences were detected in IL-6, IL-8, IL-10, or troponin concentrations at any time point. Blood glucose levels were significantly higher in patients receiving 30 mg/kg of methylprednisolone at 6 hours after CPB (p = 0.04) and on the first postoperative morning (p = 0.02).
CONCLUSIONS
Based on the measured concentrations of interleukins or troponin T, a 30 mg/kg dose of methylprednisolone during pediatric open heart operations does not offer any additional antiinflammatory or cardioprotective benefit over a 5 mg/kg dose. Higher dose of methylprednisolone exposes patients more frequently to hyperglycemia.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cytokines; Double-Blind Method; Female; Humans; Infant; Male; Methylprednisolone; Tetralogy of Fallot
PubMed: 27154159
DOI: 10.1016/j.athoracsur.2016.02.089 -
Circulation Nov 1979
Topics: Acute Disease; Humans; Methylprednisolone; Myocardial Infarction
PubMed: 487551
DOI: No ID Found -
Heart & Lung : the Journal of Critical... Nov 1991The Second National Acute Spinal Cord Injury Study (NASCIS II), published in 1990, illustrated the benefits of high-dose steroids in the treatment of acute spinal cord... (Review)
Review
The Second National Acute Spinal Cord Injury Study (NASCIS II), published in 1990, illustrated the benefits of high-dose steroids in the treatment of acute spinal cord injury. Research into the use of high-dose steroids is reviewed, and proposed mechanisms of action are addressed. Implications for nursing include method and timing of administration and expected complications. A case study is also provided.
Topics: Acute Disease; Adult; Critical Care; Humans; Male; Methylprednisolone; Spinal Cord; Spinal Cord Injuries
PubMed: 1960072
DOI: No ID Found -
Clinical Pharmacology and Therapeutics May 1985Methylprednisolone in the form of its hemisuccinate ester was injected intravenously in doses of 10 mg/kg and 63.1 mg. Plasma levels of methylprednisolone and of the... (Comparative Study)
Comparative Study
Methylprednisolone in the form of its hemisuccinate ester was injected intravenously in doses of 10 mg/kg and 63.1 mg. Plasma levels of methylprednisolone and of the ester were measured and their kinetics were calculated. Results indicate dose dependency in the kinetics of both. About 10% of the dose was excreted unchanged as hemisuccinate in the urine, indicating incomplete conversion of the prodrug. When methylprednisolone (80 mg) was also taken by mouth, the relative bioavailability of the tablets was 99%. Saliva levels of methylprednisolone were low but paralleled plasma levels in the postdistribution phase. No methylprednisolone hemisuccinate was found in saliva.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Methylprednisolone; Methylprednisolone Hemisuccinate; Middle Aged; Saliva
PubMed: 3886255
DOI: 10.1038/clpt.1985.79 -
Nederlands Tijdschrift Voor Geneeskunde May 1998Ever since the publication in 1990 in The New England Journal of Medicine of a multicentre, randomised, double-blind, placebo-controlled trial on the efficacy of... (Review)
Review
Ever since the publication in 1990 in The New England Journal of Medicine of a multicentre, randomised, double-blind, placebo-controlled trial on the efficacy of methylprednisolone (MP) in the treatment of acute, traumatic spinal cord injury, the advice is to administer MP as soon as possible to every patient presenting a traumatic spinal cord injury. This recommendation has been followed throughout the world, especially by traumatologists, and seems to be above criticism. However, the results of most cited studies, which have had a major influence on the treatment of patients with an acute, traumatic spinal cord lesion, show that the improvements in the neurological condition due to MP cannot be translated into a specific improvement in the functional status. Until it has been proven beyond reasonable doubt that MP can play a significant role in the treatment of these patients, we advise that MP should not be administered to a patient with acute, traumatic spinal cord injury, awaiting the results of more quantitative research. Such research is being performed by the Cochrane Brain and Spinal Cord Injury Group.
Topics: Emergency Treatment; Guidelines as Topic; Humans; Methylprednisolone; Multicenter Studies as Topic; Prospective Studies; Spinal Cord Injuries; Traumatology; Treatment Outcome
PubMed: 9623220
DOI: No ID Found -
Bone Marrow Transplantation Jul 2018
Topics: Adult; Anti-Inflammatory Agents; Female; Hepatic Veno-Occlusive Disease; Humans; Male; Methylprednisolone
PubMed: 29379167
DOI: 10.1038/s41409-018-0087-7 -
Zentralblatt Fur Chirurgie Jun 2018
Topics: Humans; Lung; Methylprednisolone; Pain; Pulmonary Surgical Procedures; Thoracic Surgery, Video-Assisted
PubMed: 29933472
DOI: 10.1055/a-0603-5158 -
Acta Anaesthesiologica Belgica 1987
Review
Topics: Animals; Drug Administration Schedule; Humans; Methylprednisolone; Spinal Cord Injuries
PubMed: 3327343
DOI: No ID Found