-
Annals of the Rheumatic Diseases Sep 1989
Topics: Arthritis, Rheumatoid; Humans; Methylprednisolone
PubMed: 2802805
DOI: 10.1136/ard.48.9.789-b -
European Journal of Pediatrics Oct 1994
Topics: Drug Administration Schedule; Humans; Infant; Methylprednisolone; Osteopetrosis
PubMed: 7813540
DOI: 10.1007/BF01954503 -
Critical Care Nurse 1983
Topics: Drug Interactions; Humans; Methylprednisolone; Methylprednisolone Hemisuccinate
PubMed: 6354596
DOI: No ID Found -
American Journal of Obstetrics and... Jul 1981Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma...
Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation.
Topics: Female; Humans; Injections, Intravenous; Maternal-Fetal Exchange; Methylprednisolone; Methylprednisolone Hemisuccinate; Pregnancy; Radioimmunoassay
PubMed: 7020419
DOI: 10.1016/0002-9378(81)90207-6 -
Masui. the Japanese Journal of... May 2013Acute respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema resulting from increased capillary permeability. Numerous pharmacologic therapies have... (Review)
Review
Acute respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema resulting from increased capillary permeability. Numerous pharmacologic therapies have been studied for prevention and treatment of ARDS. Although several pharmacological therapies could improve patient's respiratory function, there have been no controlled studies which clearly demonstrated the clinical benefit for ARDS-related mortality. The role of corticosteroids in ARDS remains controversial. Available evidence is against early administration of high-dose corticosteroids (methylprednisolon 120 mg x kg-1 x day - 1). In contrast, low-dose corticosteroid therapy (methylprednisolon 0.5-2.5mgg kg-1 xday-1)remains controversial. With regard to sivelestat sodium, a specific inhibitor of neutrophil elastase, although the effectiveness in decreasing mortality was not clarified, increases in lung oxygenation and ventilator-free days have consistently been revealed. Other probable pharmacologic therapies for ARDS include continuous infusion of cisatracurium. In conclusion, there are not established drugs for ARDS, and further studies are necessary to reveal the clinical effectiveness of the above mentioned and novel pharmacologic therapies.
Topics: Animals; Anticoagulants; Atracurium; Disseminated Intravascular Coagulation; Glycine; Humans; Meta-Analysis as Topic; Methylprednisolone; Neuromuscular Blocking Agents; Protein C; Proteinase Inhibitory Proteins, Secretory; Pulse Therapy, Drug; Randomized Controlled Trials as Topic; Recombinant Proteins; Respiratory Distress Syndrome; Sulfonamides
PubMed: 23772527
DOI: No ID Found -
Anesthesiology Mar 1990Few studies have examined the possible adverse effects that epidural injection of depot corticosteroid preparations may have on meningeal membranes and nervous tissue....
Few studies have examined the possible adverse effects that epidural injection of depot corticosteroid preparations may have on meningeal membranes and nervous tissue. Thirty-six healthy adult white rabbits received 0.3 ml/kg epidural injections of either lactated Ringer's solution (negative control group), 1% lidocaine containing methylprednisolone acetate (study group), or normal saline containing talc (positive control group). Animals were killed either 4 or 10 days after injection and stained sections of the spinal cord and meningeal membranes were examined by light microscopy. In all animals that received either lactated Ringer's solution or lidocaine with methylprednisolone acetate, microscopic examination of specimens taken from the L5-L6 interspace revealed no white cell infiltrates and no fibroblastic activity. All animals that received epidural injections of normal saline containing talc had marked infiltration of tissue macrophages in the epidural space. There was no thickening of the meningeal membranes or nerve roots in any animal. The complete lack of inflammatory changes and meningeal thickening demonstrated in this pilot study helps to confirm the safety of methylprednisolone acetate when injected into the epidural space.
Topics: Animals; Anti-Inflammatory Agents; Epidural Space; Inflammation; Injections, Epidural; Lidocaine; Methylprednisolone; Methylprednisolone Acetate; Rabbits
PubMed: 2310038
DOI: 10.1097/00000542-199003000-00026 -
Developmental Pharmacology and... 1992Disposition of methylprednisolone was characterized in 11 children receiving the high-dose therapy (26.0 mg/kg on average). After intravenous infusion,...
Disposition of methylprednisolone was characterized in 11 children receiving the high-dose therapy (26.0 mg/kg on average). After intravenous infusion, methylprednisolone hemisuccinate was rapidly converted to methylprednisolone with a half-life of about 20 min. Methylprednisolone in serum, eliminated monoexponentially in 8 patients and biexponentially in the remaining three, had the mean residence time of about 3 h, and a terminal half-life of 2.5 h. The volume of distribution at steady state, and the clearance were 1.3 liters/kg and 0.5 liters/kg/h, respectively. Although these average pharmacokinetic parameters were comparable to those determined in other studies with conventional low doses, the clearance values in our data were characterized by 5-fold interindividual difference, suggesting large variations in exposures to methylprednisolone among children on the high-dose pulse therapy.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methylprednisolone
PubMed: 1340442
DOI: 10.1159/000457470 -
The Journal of Bone and Joint Surgery.... May 2009
Topics: Animals; Humans; Injections, Intra-Articular; Methylprednisolone; Nervous System; Vertebral Artery
PubMed: 19411485
DOI: No ID Found -
Journal of Chromatography Jun 1982A sensitive and specific high-performance liquid chromatographic technique is described for the quantitative measurement of the synthetic glucocorticoid...
A sensitive and specific high-performance liquid chromatographic technique is described for the quantitative measurement of the synthetic glucocorticoid methylprednisolone in central nervous tissue (spinal cord) and plasma. Following intravenous administration, methylprednisolone is extracted from spinal cord tissue with diethyl ether-methylene chloride (60:40, v/v). The extract is washed sequentially with alkali, acid and water, concentrated, then chromatographed on an NH2 column using a mobile phase of methylene chloride-isopropanol (85:15, v/v). Steroid elution is monitored with an ultraviolet detector set at 254 nm. Such a system has a detection limit of 2.8 ng methylprednisolone. Extraction of methylprednisolone from spinal cord tissue is linear with tissue concentration and the recovery is around 70%. Endogenous hydrocortisone or other metabolites in the tissue do not interfere with the methylprednisolone peak. A description of the quantitation of methylprednisolone in cat lumbar spinal cord and plasma samples after single intravenous doses of methylprednisolone sodium succinate is given.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Female; Injections, Intravenous; Male; Methylprednisolone; Reference Values; Spinal Cord
PubMed: 7107765
DOI: 10.1016/s0378-4347(00)81427-9 -
Lancet (London, England) Dec 1976
Topics: Adult; Autoimmune Diseases; Humans; Infertility, Male; Male; Methylprednisolone
PubMed: 63058
DOI: 10.1016/s0140-6736(76)91164-8