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BMJ (Clinical Research Ed.) May 2007
Review
Topics: Female; Humans; Metrorrhagia; Practice Guidelines as Topic; Referral and Consultation
PubMed: 17525454
DOI: 10.1136/bmj.39203.399502.BE -
Menopause (New York, N.Y.) Apr 2011Abnormal uterine bleeding in women is a common cause for gynecologic consultation. Physicians must maintain a low threshold for endometrial assessment in abnormal... (Review)
Review
Abnormal uterine bleeding in women is a common cause for gynecologic consultation. Physicians must maintain a low threshold for endometrial assessment in abnormal uterine bleeding. Accurately determining the etiology of the bleeding permits appropriate treatment, minimizes unnecessary delays in therapy, and prevents needless worry in women. There are few national consensus guidelines, best practice guidelines, or treatment algorithms that provide gynecologists with scrupulous data to make concise decisions for the utilization of technology such as endometrial biopsy, transvaginal ultrasound, saline infusion sonography, or hysteroscopy in the evaluation of menstrual aberrations. Using technology that has a high sensitivity to detect a disease allows a physician to make concise decisions for proceeding with minimally invasive procedures or reliance on medical therapies that will probably be effective.
Topics: Biopsy; Female; Humans; Hysteroscopy; Metrorrhagia
PubMed: 21701428
DOI: 10.1097/gme.0b013e31821255cc -
Minerva Ginecologica Feb 2017Abnormal uterine bleeding (AUB) is one of the commonest health problems encountered by women and a frequent phenomenon during menopausal transition. The clinical... (Review)
Review
Abnormal uterine bleeding (AUB) is one of the commonest health problems encountered by women and a frequent phenomenon during menopausal transition. The clinical management of AUB must follow a standardized classification system to obtain the better diagnostic pathway and the optimal therapy. The PALM-COEIN classification system has been approved by the International Federation of Gynecology and Obstetrics (FIGO); it recognizes structural causes of AUB, which can be measured visually with imaging techniques or histopathology, and non-structural entities such as coagulopathies, ovulatory dysfunctions, endometrial and iatrogenic causes and disorders not yet classified. In this review we aim to evaluate the management of nonstructural causes of AUB during the menopausal transition, when commonly women experience changes in menstrual bleeding patterns and unexpected bleedings which affect their quality of life.
Topics: Female; Humans; Metrorrhagia; Perimenopause; Quality of Life; Uterus
PubMed: 27284943
DOI: 10.23736/S0026-4784.16.03944-7 -
Menopause (New York, N.Y.) Apr 2011Research is ongoing into the mechanisms of abnormal uterine bleeding, including bleeding from organic etiologies, where there is an intrinsic uterine lesion. Most of the... (Review)
Review
Research is ongoing into the mechanisms of abnormal uterine bleeding, including bleeding from organic etiologies, where there is an intrinsic uterine lesion. Most of the current studies are focused on abnormalities of angiogenesis. By elucidating these mechanisms, targeted therapies can be developed. This article reviews the literature on pathologic mechanisms involved in bleeding from organic etiologies.
Topics: Female; Humans; Metrorrhagia; Uterine Diseases
PubMed: 21701425
DOI: 10.1097/gme.0b013e3181fe6e41 -
Menopause (New York, N.Y.) May 2011
Topics: Attitude; Elective Surgical Procedures; Female; Humans; Hysterectomy; Metrorrhagia
PubMed: 21378587
DOI: 10.1097/gme.0b013e31820eb3e6 -
Ginekologia Polska Oct 1988
Topics: Adult; Aged; Diagnosis, Differential; Endometriosis; Female; Humans; Leiomyoma; Metrorrhagia; Middle Aged; Uterine Neoplasms
PubMed: 3248756
DOI: No ID Found -
Abnormal uterine bleeding and dysfunctional uterine bleeding in pediatric and adolescent gynecology.Gynecological Endocrinology : the... Jan 2013Abnormal uterine bleeding (AUB), which is defined as excessively heavy, prolonged and/or frequent bleeding of uterine origin, is a frequent cause of visits to the... (Review)
Review
Abnormal uterine bleeding (AUB), which is defined as excessively heavy, prolonged and/or frequent bleeding of uterine origin, is a frequent cause of visits to the Emergency Department and/or health care provider. While there are many etiologies of AUB, the one most likely among otherwise healthy adolescents is dysfunctional uterine bleeding (DUB), which is characterizing any AUB when all possible underlying pathologic causes have been previously excluded. The most common cause of DUB in adolescence is anovulation, which is very frequent in the first 2-3 post-menarchal years and is associated with immaturity of the hypothalamic - pituitary - ovarian axis. Management of AUB is based on the underlying etiology and the severity of the bleeding and primary goals are prevention of complications, such as anemia and reestablishment of regular cyclical bleeding, while the management of DUB can in part be directed by the amount of flow, the degree of associated anemia, as well as patient and family comfort with different treatment modalities. Treatment options for DUB are: combined oral contraceptives (COCs), progestogens, non steroidal anti inflammatory drugs (NSAIDs), tranexamic acid (anti-fibrinolytic), GnRH analogues, Danazol and Levonorgestrel releasing intra uterine system (LNG IUS).
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Child; Contraceptives, Oral, Combined; Estrogen Antagonists; Female; Gonadotropin-Releasing Hormone; Humans; Menorrhagia; Metrorrhagia; Tranexamic Acid
PubMed: 22946701
DOI: 10.3109/09513590.2012.705384 -
Menopause (New York, N.Y.) Apr 2011New therapies for abnormal uterine bleeding have been slow to reach the marketplace for a variety of reasons. These reasons include the availability of cost-effective... (Review)
Review
New therapies for abnormal uterine bleeding have been slow to reach the marketplace for a variety of reasons. These reasons include the availability of cost-effective therapies already available and the extraordinarily difficult and expensive regulatory barriers emphasizing long-term safety. Common comorbidities like bleeding diatheses, adenomyosis, and leiomyomata further complicate clinical development, necessitating large study samples and making it more expensive. Even the accurate measurement of menstrual blood loss adds an additional hindrance to novel drug development. These obstacles and the currently available therapies will be reviewed in the context of developing new methods for approaching this complicated and prevalent clinical problem.
Topics: Female; Forecasting; Humans; Metrorrhagia
PubMed: 21701433
DOI: 10.1097/gme.0b013e3182127b53 -
Revue Francaise de Gynecologie Et... 1955
Topics: Female; Humans; Menorrhagia; Metrorrhagia; Pelvis; Phlebitis
PubMed: 14385409
DOI: No ID Found -
Journal of Pediatric Health Care :... 2009
Review
Topics: Adolescent; Causality; Diagnosis, Differential; Female; Hemoglobins; Humans; Medical History Taking; Metrorrhagia; Nurse Practitioners; Nursing Assessment; Patient Care Planning; Pediatric Nursing; Physical Examination; Practice Guidelines as Topic; Primary Health Care; Severity of Illness Index
PubMed: 19401253
DOI: 10.1016/j.pedhc.2009.02.003