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Archives of Neurology Jul 1978Eight patients with fungal meningitis (5 with the coccidioidal type, 2 with cryptococcal, and 1 with histoplasmosis) were treated with intravenous (IV) and intrathecal...
Eight patients with fungal meningitis (5 with the coccidioidal type, 2 with cryptococcal, and 1 with histoplasmosis) were treated with intravenous (IV) and intrathecal (IT) miconazole after previous therapy with amphotericin B proved unsuccessful. Miconazole was well tolerated with both IV and IT administration. The CSF concentration of miconazole one hour after an IV infusion of 800 mg was 0.1 to 0.3 microgram/ml. When 20 mg of miconazole was administered intrathecally via lumbar injection in patients with coccidioidal meningitis, 6.5, 2.4, 0.77, and 0.24 microgram/ml, respectively, was found in the CSF at the cisternal level at 12, 24, 48, and 72 hours, respectively. Miconazole is apparently an effective fungistatic drug of low toxicity and is a potentially useful agent in the treatment of systemic mycoses and fungal meningitis, in particular.
Topics: Adult; Aged; Arachnoiditis; Cerebral Hemorrhage; Cisterna Magna; Coccidioidomycosis; Cryptococcosis; Histoplasmosis; Humans; Imidazoles; Injections, Intravenous; Injections, Spinal; Male; Meningitis; Miconazole; Middle Aged; Mycoses
PubMed: 580889
DOI: 10.1001/archneur.1978.00500310045009 -
Cornea Jan 1991A case of miconazole corneal toxicity is reported. This was seen in a patient who had had a penetrating keratoplasty for Acanthamoeba keratitis; the patient was treated...
A case of miconazole corneal toxicity is reported. This was seen in a patient who had had a penetrating keratoplasty for Acanthamoeba keratitis; the patient was treated with miconazole postoperatively. The miconazole toxicity manifested itself as a row of pinpoint vesicular elevations in the corneal epithelium associated with surrounding superficial punctate keratitis. Stopping the miconazole led to the resolution of the corneal epithelial changes.
Topics: Acanthamoeba Keratitis; Adult; Female; Humans; Keratitis; Keratoplasty, Penetrating; Miconazole; Postoperative Care
PubMed: 2019117
DOI: No ID Found -
Proceedings of the Royal Society of... 1977
Topics: Adult; Aged; Candidiasis; Female; Humans; Lung Diseases, Fungal; Male; Miconazole
PubMed: 122649
DOI: No ID Found -
Archives of Disease in Childhood Apr 1983
Topics: Candidiasis; Humans; Imidazoles; Infant, Newborn; Infant, Premature, Diseases; Male; Miconazole
PubMed: 6847238
DOI: 10.1136/adc.58.4.319 -
British Dental Journal May 2004Miconazole oral gel is frequently prescribed for the treatment of oral Candidal infections. Its ability to be systemically absorbed and interact with other drugs has...
Miconazole oral gel is frequently prescribed for the treatment of oral Candidal infections. Its ability to be systemically absorbed and interact with other drugs has previously been recorded but is not universally known. As a reminder, a further case of derangement of anticoagulation following concomitant use of warfarin and miconazole is reported. Other potential drug interactions of miconazole and fluconazole are highlighted.
Topics: Administration, Topical; Anticoagulants; Antifungal Agents; Drug Interactions; Gels; Hematuria; Humans; Male; Miconazole; Middle Aged; Warfarin
PubMed: 15131616
DOI: 10.1038/sj.bdj.4811224 -
Journal of Microencapsulation 2012In this article, we report the development of chitosan/miconazole nitrate microcapsules. Four miconazole nitrate ratios including 12.5, 25, 50 and 100 mg were...
In this article, we report the development of chitosan/miconazole nitrate microcapsules. Four miconazole nitrate ratios including 12.5, 25, 50 and 100 mg were performed in the chitosan-based microencapsulation system. Chitosan microcapsules with the drug input of 25 mg showed the highest encapsulation efficiency (52.47%) and acceptable mean particle size (5.65 µm) when compared with those of 12.5, 50 and 100 mg. Fourier transform infrared spectroscopic spectrum proved the entrapment of miconazole nitrate into chitosan microcapsules. The antifungal result demonstrated that microcapsules containing 75 µg miconazole nitrate possessed comparable anti-Aspergillus niger activity as the commercial ointment. The growth inhibition of miconazole nitrate containing chitosan microcapsules towards human skin keratinocytes was found to be dose dependent. A total of 75 µg of miconazole nitrate containing microcapsules revealed about 25% of growth inhibition while that of 150 µg showed approximately 70% of growth inhibition. Special monitoring should be taken if a higher dose of miconazole nitrate was used to develop the microcapsules.
Topics: Antifungal Agents; Aspergillosis; Aspergillus niger; Capsules; Cell Line; Chitosan; Drug Compounding; Humans; Keratinocytes; Miconazole; Particle Size
PubMed: 22172026
DOI: 10.3109/02652048.2011.642017 -
Drug Testing and Analysis Oct 2021This article reports the results obtained from the investigation of the influence of miconazole administration on the physiological fluctuation of the markers of the... (Comparative Study)
Comparative Study
This article reports the results obtained from the investigation of the influence of miconazole administration on the physiological fluctuation of the markers of the steroid profile included in the "steroidal module" of the Athlete Biological Passport. Urines collected from male Caucasian subjects before, during, and after either systemic (i.e., oral and buccal) or topical (i.e., dermal) treatment with miconazole were analyzed according to validated procedures based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) (to determine the markers of the steroid profile) or liquid chromatography coupled to MS/MS (LC-MS/MS) (to determine miconazole urinary levels). The results indicate that only after systemic administration, the markers of the steroid profile were significantly altered. After oral and buccal administration, we have registered (i) a significant increase of the 5α-androstane-3α,17β-diol/5β-androstane-3α,17β-diol ratio and (ii) a significant decrease of the concentration of androsterone, etiocholanolone, 5β-androstane-3α,17β-diol, and 5α-androstane-3α,17β-diol and of the androsterone/etiocholanolone, androsterone/testosterone, and 5α-androstane-3α,17β-diol/epitestosterone ratios. Limited effects were instead measured after dermal intake. Indeed, the levels of miconazole after systemic administration were in the range of 0.1-12.5 μg/ml, whereas after dermal administration were below the limit of quantification (50 ng/ml). Significant alteration started to be registered at concentrations of miconazole higher than 0.5 μg/ml. These findings were primarily explained by the ability of miconazole in altering the kinetic/efficacy of deglucuronidation of the endogenous steroids by the enzyme β-glucuronidase during the sample preparation process. The increase of both incubation time and amount of β-glucuronidase was demonstrated to be effective countermeasures in the presence of miconazole to reduce the risk of uncorrected interpretation of the results.
Topics: Administration, Buccal; Administration, Cutaneous; Administration, Oral; Adult; Athletes; Biomarkers; Chromatography, Liquid; Doping in Sports; Gas Chromatography-Mass Spectrometry; Humans; Male; Miconazole; Middle Aged; Steroids; Tandem Mass Spectrometry; Time Factors; Young Adult
PubMed: 34212529
DOI: 10.1002/dta.3121 -
Nystatin and miconazole: pharmacological and clinical evidence regarding interactions with warfarin.Oral Diseases Nov 2016A retrospective case series published in 2012 concluded that miconazole and nystatin used as topical antifungal drugs appear to interact equally strongly with warfarin....
OBJECTIVE
A retrospective case series published in 2012 concluded that miconazole and nystatin used as topical antifungal drugs appear to interact equally strongly with warfarin. If confirmed, this finding has significant implications for clinical practice. This study evaluates the evidence.
MATERIALS AND METHODS
Evidence from the pharmacology literature, the medical literature and the 'yellow card' adverse drug reaction surveillance reports was analysed regarding possible interactions of nystatin and miconazole with warfarin.
RESULTS
There is strong evidence to support the derangement of warfarin anticoagulation by miconazole oral gel in all areas of evidence studied. No postulated mechanism of interaction, no additional published reported cases and no supportive data from adverse drug reports were identified which would corroborate the case for a significant interaction between nystatin and warfarin.
CONCLUSION
Miconazole and nystatin used as topical antifungal drugs do not interact equally strongly with warfarin. Miconazole oral gel can clearly interact with warfarin to cause derangement of anticoagulation. Nystatin appears unlikely to interact with warfarin.
Topics: Administration, Topical; Anticoagulants; Antifungal Agents; Drug Interactions; Humans; International Normalized Ratio; Miconazole; Nystatin; Retrospective Studies; Warfarin
PubMed: 27416928
DOI: 10.1111/odi.12541 -
Australian and New Zealand Journal of... Nov 1986For the first time comparative efficacy of 1% miconazole in ointment base and drops has been evaluated against Candida, Aspergillus and Fusarium organisms in...
For the first time comparative efficacy of 1% miconazole in ointment base and drops has been evaluated against Candida, Aspergillus and Fusarium organisms in experimental keratomycosis. The findings of the present study reveal that miconazole in ointment drug delivery system has the advantage of being more effective in healing the fungal ulcers and associated lesions. It requires much less frequent application than drops, a parameter of great importance in improving patient compliance. Miconazole ointment was well tolerated by the rabbit eye and produced no ocular or systemic toxicity. The present study confirms that miconazole is a broad-spectrum antifungal agent and it could be a better alternative to presently available drugs to treat human keratomycosis.
Topics: Animals; Aspergillosis; Candidiasis; Corneal Diseases; Corneal Ulcer; Fusarium; Miconazole; Mycoses; Ointments; Ophthalmic Solutions; Rabbits
PubMed: 3814426
DOI: 10.1111/j.1442-9071.1986.tb00474.x -
Thrombosis and Haemostasis May 2000
Review
Topics: Administration, Oral; Aged; Anticoagulants; Antifungal Agents; Drug Synergism; Female; Gels; Hemorrhage; Humans; Intestinal Absorption; Male; Miconazole; Middle Aged; Warfarin
PubMed: 10823285
DOI: No ID Found