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Pakistan Journal of Pharmaceutical... Jan 2024Hydrophilic drugs could be incorporated into the skin surface by manes of Lipogel. This study aimed to prepare miconazole lipogel with natural ingredients to enhance...
Hydrophilic drugs could be incorporated into the skin surface by manes of Lipogel. This study aimed to prepare miconazole lipogel with natural ingredients to enhance drug permeability using dimethyl Sulfoxide (DMSO). The miconazole lipogels, A1 (without DMSO) and A2 (with DMSO) were formulated and evaluated for organoleptic evaluation, pH, viscosity, stability studies, freeze-thawing, drug release profile and drug permeation enhancement. Results had stated that prepared lipogel's pH falls within the acceptable range required for topical delivery (4 to 6) while both formulations show good results in organoleptic evaluation. The A2 formulation containing DMSO shows better permeation of miconazole (84.76%) on the artificial skin membrane as compared to A1 lipogel formulation (50.64%). In in-vitro drug release studies, A2 for-mulation showed 87.48% drug release while A1 showed just 60.1% drug release from lipogel. Stability studies were performed on model formulations under environmental conditions and both showed good spreadibility, stable pH, free of grittiness and good consistency in formulation. The results concluded that A2 formulation containing DMSO shows better results as compared to DMSO-free drug lipogel.
Topics: Miconazole; Gels; Dimethyl Sulfoxide; Permeability; Drug Liberation; Viscosity; Drug Stability; Hydrogen-Ion Concentration; Skin Absorption; Chemistry, Pharmaceutical; Drug Compounding; Antifungal Agents; Administration, Cutaneous
PubMed: 38741405
DOI: No ID Found -
Zeitschrift Fur Hautkrankheiten Jul 1984In a randomized double blind study on acne the efficacy and tolerance of a combination preparation of benzoyl peroxide and miconazole as a cream formulation was compared... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
In a randomized double blind study on acne the efficacy and tolerance of a combination preparation of benzoyl peroxide and miconazole as a cream formulation was compared with those of benzoyl peroxide and oral tetracyclin. For this study, we selected patients mainly suffering from papulopustular acne of medium to high degree of severity. Efficacy and tolerance were satisfactory in both groups, and there was no statistically significant difference.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Male; Miconazole; Ointments; Peroxides; Tetracycline
PubMed: 6235682
DOI: No ID Found -
Scandinavian Journal of Dental Research Dec 1994An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy and safety of a single application of a miconazole 55 mg/g... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy and safety of a single application of a miconazole 55 mg/g denture lacquer applied once on the mucosal denture surface, as compared with those of a commercially available miconazole 2% gel applied four times daily for 2 wk, in the treatment of Candida-associated denture stomatitis. The efficacy variables were Candida cultures on the Oricult plates taken from the palatal mucosa and the denture surface, erythema of the palatal mucosa, and smears for leukocyte migration into the palatal epithelium taken on entering the study and on days 3, 7, 14, 21, 28, and 35 after commencement of therapy. On entering the study, all patients had positive cultures of yeast in the samples from the palatal mucosa. Within the first 3 days, all gel patients and 88% of the lacquer patients had fewer than 10 colonies. The gel was statistically significantly more efficient than the lacquer on days 7 and 14. In the samples from the denture surface, all patients had more than 100 yeast colonies at inclusion and, on day 3, approximately 80% in both treatment groups had fewer than 10 colonies. From day 7 onward, the gel was statistically significantly more efficient than the lacquer. The reddening of the palatal mucosa was not statistically significantly different in the treatment groups at any of the examinations, but smears for the determination of leukocyte migration indicated that the gel was statistically significantly more efficient than the lacquer on day 7.(ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Administration, Topical; Aged; Candidiasis, Oral; Cell Movement; Colony Count, Microbial; Denture, Complete, Upper; Epithelium; Erythema; Female; Gels; Humans; Lacquer; Leukocytes; Male; Miconazole; Middle Aged; Mouth Mucosa; Stomatitis, Denture
PubMed: 7871360
DOI: 10.1111/j.1600-0722.1994.tb01484.x -
Drug Delivery Dec 2022is the fungus responsible for oral candidiasis, a prevalent disease. The development of antifungal-based delivery systems has always been a major challenge for...
is the fungus responsible for oral candidiasis, a prevalent disease. The development of antifungal-based delivery systems has always been a major challenge for researchers. This study was designed to develop a nanostructured lipid carrier (NLC) of sesame oil (SO) loaded with miconazole (MZ) that could overcome the solubility problems of MZ and enhance its antifungal activity against oral candidiasis. In the formulation of this study, SO was used as a component of a liquid lipid that showed an improved antifungal effect of MZ. An optimized MZ-loaded NLC of SO (MZ-SO NLC) was used, based on a central composite design-based experimental design; the particle size, dissolution efficiency, and inhibition zone against oral candidiasis were chosen as dependent variables. A software analysis provided an optimized MZ-SO NLC with a particle size of 92 nm, dissolution efficiency of 88%, and inhibition zone of 29 mm. Concurrently, the permeation rate of the sheep buccal mucosa was shown to be significantly ( < .05) higher for MZ-SO NLC (1472 µg/cm) as compared with a marketed MZ formulation (1215 µg/cm) and an aqueous MZ suspension (470 µg/cm). Additionally, an efficacy study in terms of the ulcer index against found a superior result for the optimized MZ-SO NLC (0.5 ± 0.50) in a treated group of animals. Hence, it can be concluded that MZ, through an optimized NLC of SO, can treat candidiasis effectively by inhibiting the growth of .
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Oral; Chemistry, Pharmaceutical; Drug Carriers; Drug Liberation; Lipids; Male; Miconazole; Mouth Mucosa; Nanoparticle Drug Delivery System; Particle Size; Random Allocation; Rats; Sesame Oil; Sheep; Solubility; Surface Properties
PubMed: 35014929
DOI: 10.1080/10717544.2021.2023703 -
Journal of AOAC International Oct 2022The combined mixture of miconazole nitrate (MIC) and nystatin (NYS) has proven its efficiency as a prodigious remedy to cure women's frequent infections: vaginal mycosis...
Innovative Earth-Friendly UV-Spectrophotometric Technique for In Vitro Dissolution Testing of Miconazole Nitrate and Nystatin in Their Vaginal Suppositories: Greenness Assessment.
BACKGROUND
The combined mixture of miconazole nitrate (MIC) and nystatin (NYS) has proven its efficiency as a prodigious remedy to cure women's frequent infections: vaginal mycosis and vaginal candidiasis.
OBJECTIVE
A novel green spectrophotometric technique, namely the Fourier self-deconvolution method (FSD), was employed for the quantitative determination of MIC and NYS in their pure and pharmaceutical forms without prior separation. Moreover, the proposed technique was first employed to study the dissolution profile of the cited drugs in their pharmaceutical formulation according to FDA recommendations without excipient interference.
METHOD
The FSD method is based on a simple mathematical manipulation of zero-order spectra of the cited drugs, which suffered from severe overlapping, so zero-order spectra of the cited drugs were deconvoluted using the Fourier wavelet function in spectrophotometer software. The deconvoluted amplitudes for MIC and NYS were measured at 255 nm and 320 nm, respectively.
RESULTS
Linearity ranges were 70-700 µg/mL for MIC and 1-25 µg/mL for NYS. The greenness of the proposed technique was assessed using two assessment tools, namely eco-scale scoring and green analytical procedure index (GAPI), revealing the excellent greenness of this technique. The proposed technique was validated consistent with ICH guidelines and statistically compared to the reported method with no significant differences between them.
CONCLUSIONS
The proposed technique has advantages of being simple, time-saving, and noting need any modification to be suitable for quantitative analysis of MIC and NYS in both pharmaceutical and laboratory mixtures.
HIGHLIGHTS
An innovative FSD method was developed for quantitative analysis of MIC and NYS in their synthetic and pharmaceutical mixtures and applied for in vitro dissolution testing of their pharmaceutical mixture, producing satisfactory results.
Topics: Female; Humans; Miconazole; Nystatin; Suppositories; Solubility; Excipients; Spectrophotometry
PubMed: 35699478
DOI: 10.1093/jaoacint/qsac074 -
Antimicrobial Agents and Chemotherapy Feb 1978Miconazole was compared with amphotericin B in the treatment of murine cryptococcosis. Both subcutaneous and intraperitoneal administration of miconazole produced serum... (Comparative Study)
Comparative Study
Miconazole was compared with amphotericin B in the treatment of murine cryptococcosis. Both subcutaneous and intraperitoneal administration of miconazole produced serum levels higher than the minimum inhibitory concentration for the challenge strain. However, maximal tolerable doses of miconazole gave no increase in survival. When combined with amphotericin B, miconazole demonstrated neither additive nor antagonistic effects on survival. Spleen and brain counts of cryptococci were not lowered by miconazole; also, miconazole did not alter the effect of amphotericin B on reducing tissue counts. In vitro studies confirmed that the strain of Cryptococcus neoformans was quite susceptible to both miconazole and amphotericin B. However, miconazole had a delayed onset of antifungal activity. This was apparent even at miconazole levels 20 times greater than the minimum inhibitory concentration. Also, the antifungal activity of miconazole was markedly inhibited by serum. Delayed antifungal activity and serum inhibition may limit the in vivo effectiveness of miconazole in murine cryptococcosis.
Topics: Amphotericin B; Animals; Cryptococcosis; Cryptococcus neoformans; Drug Therapy, Combination; Imidazoles; Male; Mice; Mice, Inbred BALB C; Miconazole; Microbial Sensitivity Tests
PubMed: 348099
DOI: 10.1128/AAC.13.2.277 -
Archives of Ophthalmology (Chicago,... Sep 1979Data from this in vivo albino rabbit study suggest that miconazole nitrate may penetrate the ocular compartments better than either natamycin or amphotericin B after...
Data from this in vivo albino rabbit study suggest that miconazole nitrate may penetrate the ocular compartments better than either natamycin or amphotericin B after intravenous, subconjunctival, or topical administration. The concentrations of miconazole in cornea and in aqueous humor after either topical or subconjunctival administration were very high, and a further threefold increase in the levels was seen if the corneal epithelium had been removed prior to drug therapy. Miconazole was found in the vitreous in some animals after subconjunctival injections of the drug. Intravenous administration produced high concentrations of miconazole in the aqueous humor, which rapidly fell over eight hours. No signs of toxicity or adverse reactions were found in these short-term experiments. Miconazole may be a useful addition in our methods of treating keratomycosis and oculomycosis.
Topics: Administration, Topical; Animals; Aqueous Humor; Conjunctiva; Cornea; Eye; Female; Imidazoles; Injections, Intravenous; Male; Miconazole; Rabbits; Vitreous Body
PubMed: 475641
DOI: 10.1001/archopht.1979.01020020271017 -
Mycoses Sep 2010Miconazole (MICON) has long been used for the topical treatment of mucosal candidiasis. However, the preponderance of MICON susceptibility data was generated before...
Miconazole (MICON) has long been used for the topical treatment of mucosal candidiasis. However, the preponderance of MICON susceptibility data was generated before standard methodology was established, and prior to the emergence of fluconazole (FLU)-resistant strains. The objective of this study was to determine the antifungal activity of MICON and comparators against recent clinical isolates of Candida spp. using standard Clinical and Laboratory Standards Institute methodology. One hundred and fifty isolates, consisting of 25 strains each of Candida albicans, C. krusei, C. glabrata, C. tropicalis, C. parapsilosis and C. dubliniensis, were tested. Of these, twenty-two strains were known to be FLU-resistant. Minimum inhibitory concentrations (MICs) were determined for MICON, amphotericin B (AM), caspofungin (CAS), clotrimazole (CLOT), FLU, itraconazole (ITRA), nystatin (NYS) and voriconazole (VOR). MICON demonstrated potent inhibitory activity against all of the strains tested. The MIC(90) for MICON was 0.12 microg ml(-1) against FLU-susceptible strains, which was comparable to that of AM, CAS, CLOT, ITRA and VOR. The MICON MIC(90) against FLU-resistant strains was 0.5 microg ml(-1), which was 12-fold lower than the FLU MIC(90). Our study showed that MICON possesses potent activity against all of the Candida isolates tested, including those with known FLU resistance. This indicates that recent clinical isolates remain susceptible to this antifungal and that MICON could be used as first-line treatment for oropharyngeal candidiasis.
Topics: Antifungal Agents; Candida; Candidiasis, Oral; Drug Resistance, Fungal; Fluconazole; Humans; Miconazole; Microbial Sensitivity Tests
PubMed: 19531099
DOI: 10.1111/j.1439-0507.2009.01728.x -
Mycoses Mar 1988
Topics: Adult; Candidiasis, Vulvovaginal; Drug Administration Schedule; Female; Humans; Miconazole; Middle Aged
PubMed: 3393169
DOI: No ID Found -
American Journal of Ophthalmology Oct 1986
Topics: Animals; Humans; Keratitis; Ketoconazole; Miconazole; Mycoses; Rabbits
PubMed: 3766681
DOI: 10.1016/0002-9394(86)90103-0