-
Archives Des Maladies Du Coeur Et Des... Jun 1999The coronary circulation has a protective regulation system which, in extreme haemodynamic conditions, compensates increased myocardial oxygen demand. The coronary... (Review)
Review
The coronary circulation has a protective regulation system which, in extreme haemodynamic conditions, compensates increased myocardial oxygen demand. The coronary reserve, based on this concept defines the capacity of the system to increase flow temporally, and, thereby, myocardial oxygen supply. The introduction of new methods of investigating the coronary microcirculation has enabled the study of this phenomenon in several cardiovascular pathologies. Two types of investigation are used currently for studying the coronary microcirculation: 1) invasive methods, especially the recently developed intracoronary Doppler and pressure guide, 2) non-invasive methods, and, in particular, contrast echocardiography, position emission tomography and magnetic nuclear resonance. These investigations allow measurement of the coronary reserve or the assessment of the myocardial consequences of abnormalities of the microcirculation. Some workers use these methods to investigate pathological coronary microcirculation in different cardiomyopathies, in the presence of different cardiovascular risk factors (hypertension, diabetes, smoking, hypercholesterolaemia) and after cardiac transplantation.
Topics: Coronary Circulation; Humans; Microcirculation
PubMed: 10410813
DOI: No ID Found -
Annals of the Academy of Medicine,... Jul 1999The study of the microcirculation by intravital microscopy represents a sophisticated research tool to analyse complex biological interactions and disease mechanisms as... (Review)
Review
The study of the microcirculation by intravital microscopy represents a sophisticated research tool to analyse complex biological interactions and disease mechanisms as well as to develop and test novel prophylactic and therapeutic approaches aimed at the prevention or attenuation of manifestation of disease-associated microvascular disorders and cellular dysfunction. This may include pathogenesis of atherosclerosis and thrombosis, fibrosis and cirrhosis as well as hypertension, diabetes and tumorogenesis. In addition, using the microscopic technique, circulatory and cellular disorders in surgical diseases and procedures, such as shock and resuscitation, ischaemia/reperfusion and transplantation, trauma, sepsis and inflammation, as well as burn injury and wound healing, may be analysed. With the background of the increasing knowledge of molecular and cellular mechanisms of disease evaluated in vitro, the technique of intravital microscopy ideally allows to bridge over from those in vitro observations to test their potential relevance in vivo.
Topics: Animals; Humans; Microcirculation; Microscopy; Prostheses and Implants; Surgical Flaps; Vascular Diseases
PubMed: 10561769
DOI: No ID Found -
Microcirculation (New York, N.Y. : 1994) 2005This special edition of Microcirculation brings together the proceedings from the Symposium held in the spring of 2004 in the Natcher Auditorium on the campus of the...
This special edition of Microcirculation brings together the proceedings from the Symposium held in the spring of 2004 in the Natcher Auditorium on the campus of the National Institutes of Health to commemorate the 50th Anniversary of the Microcirculatory Society, Inc. Twelve brief reviews are introduced with the goals being to present a collective sense of the history of research in microcirculation, provide insight into where established topics of inquiry stand today, and to define emerging topics of investigation for future research efforts.
Topics: Animals; Endothelium, Vascular; Humans; Lymphatic System; Microcirculation; Research; Societies, Medical
PubMed: 15804969
DOI: 10.1080/10739680590907114 -
Fiziolohichnyi Zhurnal (Kiev, Ukraine :... 2002Peculiarities of the morphofunctional state of skin, to a large extent, depend on the state of microcirculation. As the skin nutrition is provided by the microvessels,... (Review)
Review
Peculiarities of the morphofunctional state of skin, to a large extent, depend on the state of microcirculation. As the skin nutrition is provided by the microvessels, the question arises if the disturbances in microcirculation affect the parametres of the morphofunctional state of the skin. The main clinical investigations on microcirculation are represented in this review: the influences of systemic and local microcirculatory disturbances on the physiological parameters of skin, as well as the age changes of microcirculation and their influences on the dermatosis have been elucidated. The main questions on physiology and pathology of the skin microcirculation and methods of their study have been described.
Topics: Aging; Humans; Microcirculation; Skin; Skin Diseases, Vascular; Skin Physiological Phenomena
PubMed: 12125278
DOI: No ID Found -
Annals of the New York Academy of... 1982
Topics: Humans; Microcirculation; Pulmonary Circulation
PubMed: 6953812
DOI: 10.1111/j.1749-6632.1982.tb21356.x -
Graefe's Archive For Clinical and... May 2014Orthogonal polarization spectral (OPS) imaging is an optical imaging technique that uses a handheld microscope and green polarized light to visualize the red blood cells...
PURPOSE
Orthogonal polarization spectral (OPS) imaging is an optical imaging technique that uses a handheld microscope and green polarized light to visualize the red blood cells in the microcirculation of organ surfaces. The purpose of this study was to evaluate whether OPS imaging can be used for the functional and morphological evaluation of microcirculation in the conjunctiva.
METHODS
To accomplish the aforementioned purpose, 21 eyes of 21 volunteer patients were examined. OPS images of the vasculature of the inferior conjunctiva and the nasal part of the bulbar conjunctiva were taken from each eye. The images were subsequently analyzed using a computer, and the following parameters were assessed: red blood cell velocity, blood vessel diameter, and functional capillary density. In addition, distinct qualitative aspects of the conjunctival microvasculature were characterized.
RESULTS
OPS imaging facilitated both the observation of red blood cells that were flowing through conjunctival vessels on a white background, and the measurement of other quantitative and qualitative microvascular parameters. Significant differences between several measures of the inferior and nasal bulbar conjunctival microcirculations were found, including differences in the configurations of the vessel segments, the number of vessel segments, the number of bifurcations, the mean diffusion distance, and the functional capillary density.
CONCLUSIONS
OPS imaging can be used to measure the diameters of microvessels, functional capillary density, and other parameters. Significant differences between the microcirculations of the inferior conjunctiva and the nasal bulbar conjunctiva were found, which indicates the necessity of using a standardized approach to examine the conjunctival vasculature. OPS imaging is suitable for both the functional and morphological evaluation of the conjunctival microcirculation.
Topics: Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Blood Vessels; Conjunctiva; Female; Humans; Male; Microcirculation; Microscopy, Polarization; Middle Aged; Regional Blood Flow; Young Adult
PubMed: 24627137
DOI: 10.1007/s00417-014-2603-9 -
Journal of Hypertension. Supplement :... Jul 1992To review experimental findings on the importance of the microcirculation in hypertension. (Review)
Review
PURPOSE
To review experimental findings on the importance of the microcirculation in hypertension.
RESULTS OF DATA ANALYSIS
A significant part of the increase in vascular resistance found in hypertension involves alterations in the arteriolar network. Changes in vascular reactivity and amplification of normal microvascular autoregulatory loops are among the mechanisms involved in these microvascular alterations. Depending on the organ and the type of hypertension, different types of changes have been observed, including (1) changes in resting arteriolar diameter and increased tone, either throughout the arteriolar network or localized to certain arteriolar segments; (2) temporary closure of a significant fraction of the terminal arteriolar bed; and (3) degenerative processes in terminal arterioles and capillaries inducing anatomical rarefaction of the microvessels.
CONCLUSIONS
Microvascular changes are responsible for only a portion of the increased resistance but they are extremely important in the global understanding of the hypertensive process, as they are potentially responsible for tissue damage and may be related to the increased risk of organ failure in hypertension.
Topics: Animals; Hypertension; Microcirculation; Rats; Vascular Resistance
PubMed: 1403235
DOI: 10.1097/00004872-199207005-00009 -
Critical Care (London, England) Mar 2018This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at... (Review)
Review
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
Topics: Administration, Intravenous; Decision Support Techniques; Fluid Therapy; Humans; Intensive Care Units; Microcirculation
PubMed: 29558989
DOI: 10.1186/s13054-018-1993-1 -
No Shinkei Geka. Neurological Surgery Sep 1978
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cerebrovascular Circulation; Microcirculation
PubMed: 714234
DOI: No ID Found -
Phlebologie 1990