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Nihon Rinsho. Japanese Journal of... Sep 2000
Review
Topics: Biomechanical Phenomena; Body Water; Capillaries; Exercise; Humans; Microcirculation; Muscles
PubMed: 11085082
DOI: No ID Found -
La Revue de Medecine Interne May 1986
Review
Topics: Body Temperature Regulation; Capillary Permeability; Hemodynamics; Hot Temperature; Humans; Microcirculation; Partial Pressure; Plethysmography; Skin; Skin Temperature
PubMed: 3532252
DOI: 10.1016/s0248-8663(86)80010-8 -
Hypertension (Dallas, Tex. : 1979) Nov 2012
Topics: Animals; Humans; Microcirculation; Phenotype
PubMed: 22966007
DOI: 10.1161/HYPERTENSIONAHA.112.202465 -
Annual Review of Biomedical Engineering 1999The microcirculation represents a region of the circulation in which blood vessels are directly surrounded by the tissue and cells to which they supply nutrients and... (Review)
Review
The microcirculation represents a region of the circulation in which blood vessels are directly surrounded by the tissue and cells to which they supply nutrients and from which they collect metabolites. The cellular elements that make up the microcirculation have now been identified, and a large body of evidence has become available that provides molecular definitions of these elements. The blood flow is in a domain in which viscous stresses dominate, but the viscoelastic and active properties of cells lead to nonlinear problems. The ability of cells to actively control cytoplasmic mechanical properties and shape, as well as their membrane adhesion, leads to unique cell behavior in microvessels that has a direct influence on organ transport and function. There is also increasing evidence that the properties of the cells are in turn influenced by fluid shear stresses. These issues have greatly expanded the scope of microvascular analysis. The microcirculation is one of the sites in which diseases manifest themselves at an early stage. The application of biomechanical analysis of the microcirculation is starting to focus on diseases. The field is rich with problems of high significance.
Topics: Animals; Biomechanical Phenomena; Cell Adhesion; Humans; Leukocytes; Microcirculation; Models, Cardiovascular; Vasoconstriction; Vasodilation
PubMed: 11701483
DOI: 10.1146/annurev.bioeng.1.1.73 -
Indian Journal of Experimental Biology Jan 2007Blood fluidity in the capillaries is affected significantly in diseases such as cardiac and brain infarcts, diabetic gangrene and many others. In view of the importance... (Review)
Review
Blood fluidity in the capillaries is affected significantly in diseases such as cardiac and brain infarcts, diabetic gangrene and many others. In view of the importance of physiology and pathology of capillary circulation, the hemorheological characteristics of the capillary blood flow are discussed in this article. Also, a new diagnosing technique for blood fluidity disorders is proposed. A computerized system for image analysis and determining blood rheological disorders for clinical and experimental use has also been discussed.
Topics: Blood Flow Velocity; Blood Viscosity; Capillaries; Hemorheology; Humans; Microcirculation; Regional Blood Flow; Vascular Diseases
PubMed: 17249325
DOI: No ID Found -
Clinical Hemorheology and... 2006This paper reviews work on microvascular remodeling that has been done over the past years in our lab. It is not our purpose to fully cover the field; rather we explain... (Review)
Review
This paper reviews work on microvascular remodeling that has been done over the past years in our lab. It is not our purpose to fully cover the field; rather we explain our progress in a more or less chronological order. We address physiological and pathological remodeling in resistance vessels, the biomechanics of the vascular wall and the factors that determine vascular caliber. Subsequently, the intimate link between maintained vascular tone and inward remodeling is discussed, and we highlight our view that tone and remodeling form hallmarks in a continuous process of vascular adaptation. Finally, the role of transglutaminases in remodeling is described.
Topics: Adaptation, Physiological; Animals; Humans; Hypertrophy; Microcirculation; Transglutaminases
PubMed: 16543615
DOI: No ID Found -
Blood Vessels 1991Measurements of coronary microvascular parameters in situ are difficult because of the thickness of the heart muscle and cardiac contraction. Both of these problems...
Measurements of coronary microvascular parameters in situ are difficult because of the thickness of the heart muscle and cardiac contraction. Both of these problems hamper the visualization of the coronary microcirculation. We have refined methodological approaches that enable the study of the coronary microcirculation in situ. In the first approach, microvessels can be visualized in the beating heart using a preparation that compensates for cardiac motion by creating an illusion that the heart is motionless. This is accomplished by flashing a stroboscopic light source once per heart cycle at the same point in each cycle and synchronizing a ventilator with the cardiac cycle. Images of microvessels can be obtained using standard intravital video-microscopic techniques. To visualize the intramural and subendocardial microcirculation, studies are completed in isolated hearts. In this preparation, measurements of microvascular diameters and pressures can be performed in both the subepicardial and subendocardial microcirculations. This latter approach allows insight into transmural differences of coronary microvascular regulation.
Topics: Animals; Arterioles; Blood Pressure; Cardiac Catheterization; Coronary Vessels; Dogs; Image Processing, Computer-Assisted; Microcirculation; Microscopy; Swine; Video Recording
PubMed: 2001475
DOI: 10.1159/000158868 -
American Journal of Physiology.... Nov 2018It has been proposed that optical properties of the lens are actively maintained by an internal microcirculation system that utilizes ionic and fluid fluxes to deliver...
It has been proposed that optical properties of the lens are actively maintained by an internal microcirculation system that utilizes ionic and fluid fluxes to deliver nutrients to deeper regions of the lens tissue via the extracellular space faster than would occur by passive diffusion alone. To test this hypothesis, we utilized a range of commercially available magnetic resonance imaging (MRI) reagents of varying molecular sizes that served as tracers of extracellular solute delivery. The penetration of these tracers into bovine lenses incubated in the absence and presence of solutions that inhibit the microcirculation was monitored in real time over a 4-h period using T1-weighted MRI. We found that only the smaller contrast agents were delivered to the core of the lens and that the rate of solute penetration was significantly faster than that calculated simple diffusion. Next, the lenses were first incubated in either high extracellular K to depolarize the lens potential or ouabain to inhibit the Na pump. These two perturbations are known to inhibit the circulating ionic and fluid fluxes that are proposed to drive solute delivery into the lens core. Both perturbations inhibited the delivery of the extracellular tracer molecules to the lens core. Our findings suggest that the microcirculation system can potentially be harnessed to deliver exogenous antioxidants to the lens core to afford mature fiber cells protection against oxidative damage that ultimately manifests as age-related nuclear cataract.
Topics: Animals; Cataract; Cattle; Contrast Media; Diffusion; Extracellular Space; Lens, Crystalline; Magnetic Resonance Imaging; Microcirculation
PubMed: 30156422
DOI: 10.1152/ajpregu.00180.2018 -
Giornale Italiano Di Dermatologia E... 1984
Review
Topics: Adult; Aged; Aging; Arteries; Arteriovenous Anastomosis; Humans; Infant, Newborn; Microcirculation; Skin; Veins
PubMed: 6384032
DOI: No ID Found -
The New England Journal of Medicine May 2007
Topics: Aged; Aging; Coronary Circulation; Heart Diseases; Humans; Microcirculation; Risk Factors
PubMed: 17538094
DOI: 10.1056/NEJMc070666