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Zhonghua Bing Li Xue Za Zhi = Chinese... Apr 2021
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fibrocystic Breast Disease; Humans
PubMed: 33832010
DOI: 10.3760/cma.j.cn112151-20200704-00523 -
Histopathology Apr 2000
Comparative Study
Topics: Adenocarcinoma; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Male; Middle Aged; S100 Proteins; Sinusitis
PubMed: 10841649
DOI: 10.1046/j.1365-2559.2000.0855b.x -
The American Journal of Surgical... Apr 2009Microglandular adenosis (MGA) is an uncommon, benign breast lesion that is characterized by a proliferation of small uniform, round glands lined by a single layer of...
Microglandular adenosis (MGA) is an uncommon, benign breast lesion that is characterized by a proliferation of small uniform, round glands lined by a single layer of epithelial cells around open lumina with haphazard infiltrative growth in fibrous and fatty breast tissue. Although MGA usually has an indolent course, there is morphologic evidence that MGA can be a precursor for the development of intraductal and invasive ductal carcinoma. To investigate the possibility of such a transition, we studied 17 cases of MGA or atypical MGA some of which had given rise to carcinoma in situ (CIS) and/or invasive ductal carcinoma using the reticulin stain, immunohistochemistry (S-100, p63, Ki-67, and p53), and a molecular approach involving microdissection and high-resolution comparative genomic hybridization and MYC chromogenic in situ hybridization. MGA and carcinomas arising from MGA were typically negative for p63 and positive for S-100 and Ki-67 and occasionally positive for p53. High-resolution comparative genomic hybridization identified recurrent gains and losses in MGA (2q+, 5q-, 8q+, and 14q-) and atypical MGA (1q+, 5q-, 8q+, 14q-, and 15q-). Some examples of MGA and carcinomas arising from MGA harbored few gross chromosomal abnormalities whereas others had considerable genetic instability with widespread aberrations affecting numerous chromosomal arms. Such widespread genetic changes, together with recurrent loss of 5q and gain of 8q were reminiscent of those reported specifically for basal-like, estrogen receptor-negative, and BRCA1-associated breast tumors. Concordant genetic alterations were identified between MGA, atypical MGA, and higher risk lesions (CIS and invasive ductal carcinoma) and in some cases there was an accumulation of genetic alterations as cases "progressed" from MGA to atypical MGA, CIS, and invasive ductal carcinoma. The molecular data suggests that MGA, atypical MGA, and carcinoma arising in MGA in a single case were clonally related. This result implicates MGA as a nonobligate precursor for the development of intraductal and invasive ductal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Chromosome Aberrations; Comparative Genomic Hybridization; DNA, Neoplasm; Disease Progression; Female; Fibrocystic Breast Disease; Humans; Immunoenzyme Techniques; In Situ Hybridization; Karyotyping; Microdissection; Middle Aged
PubMed: 19047897
DOI: 10.1097/PAS.0b013e31818af361 -
Histopathology May 2012Microglandular adenosis (MGA) is a proliferative breast lesion, which has been proposed to be a potential precursor of triple-negative breast cancers. The aims of...
AIMS
Microglandular adenosis (MGA) is a proliferative breast lesion, which has been proposed to be a potential precursor of triple-negative breast cancers. The aims of this study were to determine whether MGAs harbour genetic alterations and if any such genetic aberrations found in MGAs are similar to those found in matched invasive carcinomas.
METHODS AND RESULTS
Twelve cases of MGA and/or atypical MGA (AMGA), 10 of which were associated with invasive carcinoma, were evaluated. Immunohistochemical profiling revealed that all invasive carcinomas were of triple-negative phenotype and expressed S100, cytokeratins 8/18 and 'basal' markers. The morphologically distinct components of each case (MGA, AMGA and/or invasive carcinoma) were microdissected and subjected to microarray comparative genomic hybridization. Apart from three typical MGAs, all samples harboured genetic alterations. The percentage of the genome affected by copy number aberrations in MGA/AMGA ranged from 0.5 to 61.9%, indicating varying levels of genetic instability. In three cases, MGA/AMGA displayed copy number aberrations similar to those found in matched invasive components, providing strong circumstantial evidence that MGA may constitute the substrate for the invasive carcinoma development.
CONCLUSIONS
Our results support the contention that MGA can be a clonal lesion and non-obligate precursor of triple-negative breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cluster Analysis; Comparative Genomic Hybridization; Female; Fibrocystic Breast Disease; Humans; Precancerous Conditions
PubMed: 22486256
DOI: 10.1111/j.1365-2559.2012.04207.x -
American Journal of Clinical Pathology Nov 1993Breast carcinoma arose in or in conjunction with microglandular adenosis (MGA) in 14 of 60 (23%) patients with MGA listed in the authors' files. This article describes...
Breast carcinoma arose in or in conjunction with microglandular adenosis (MGA) in 14 of 60 (23%) patients with MGA listed in the authors' files. This article describes the clinicopathologic and immunohistochemical features and prognosis of these carcinomas. The median patient age was 47 years (range, 26-68 years). All patients had a mass. Six (43%) had a family history of breast carcinoma. Lymph node metastases were found in 3 of 11 axillary dissections. Ten patients treated by mastectomy were recurrence-free, with a median follow-up of 57 months (range, 3-108 months). Two of three patients treated by excisional surgery were recurrence-free 12 and 105 months later. The third woman had bone metastases at 51 months and was alive 98 months after treatment. Carcinoma arose in the MGA in 13 patients. In these patients, in situ carcinoma was found in expanded MGA glands composed of cells with vesicular poorly differentiated nuclei. One patient with benign MGA had carcinoma develop in the opposite breast that was not associated with MGA. When it arose in MGA, basement membranes were present in benign MGA and in situ carcinoma but tended to be disrupted in invasive foci that appeared to be formed by coalescent MGA glands. Strong immunoreactivity for cytokeratin, S-100, and cathepsin D was detected in carcinomas. Two carcinomas had nuclear progesterone receptors, and one of these had estrogen receptors. One carcinoma had positive findings for HER-2neu, and four had immunoreactivity for p53 protein. The following conclusions were drawn from these observations: (1) carcinomas arising in MGA have a distinctive histopathologic pattern; (2) the carcinomas are composed of epithelial cells (cytokeratin positive, actin negative) that are strongly immunoreactive for S-100 protein and cathepsin D; and (3) with a median follow-up of nearly 5 years, patients with these carcinomas had a relatively favorable prognosis, despite histopathologic and immunohistochemical features usually associated with a poor prognosis.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma; Combined Modality Therapy; Family; Female; Fibrocystic Breast Disease; Follow-Up Studies; Humans; Keratins; Lymphatic Metastasis; Middle Aged; Treatment Outcome
PubMed: 7504394
DOI: 10.1093/ajcp/100.5.507 -
Human Pathology Jun 1985A case of microglandular adenosis of the breast in a 75-year-old woman is presented, with emphasis on the ultrastructural features. While the tumor was histologically...
A case of microglandular adenosis of the breast in a 75-year-old woman is presented, with emphasis on the ultrastructural features. While the tumor was histologically similar to those reported previously in the literature, certain microscopic aspects suggested malignant change. Ultrastructurally, the characteristic findings were villus interdigitation between epithelial cells, thick basement membranes around individual tubules, and abundant apical lysosomal granules.
Topics: Aged; Cytoplasmic Granules; Female; Fibrocystic Breast Disease; Humans; Microscopy, Electron
PubMed: 3997141
DOI: 10.1016/s0046-8177(85)80115-5 -
Nederlands Tijdschrift Voor Geneeskunde 2013Diabetic mastopathy is a rare condition, which is clinically not easily to differentiate from breast cancer.
BACKGROUND
Diabetic mastopathy is a rare condition, which is clinically not easily to differentiate from breast cancer.
CASE DESCRIPTION
A 32-year-old woman, with a long-standing history of insulin-dependent diabetes mellitus presented at the breast outpatient clinic with a firm palpable, painless mass in her right breast. Mammography and ultrasound examination showed, respectively, slight asymmetry with dense glandular tissue and a hypoechoic area with posterior shadowing. MR mammography showed no suspicious abnormalities. Histopathological examination revealed fibrous tissue with lymphocytic inflammation. The combination of clinical presentation, history of diabetes mellitus, and histological findings led to a diagnosis of diabetic mastopathy.
CONCLUSION
A palpable breast abnormality in a woman with diabetes mellitus can be caused by diabetic mastopathy. Knowledge of this condition by the disciplines involved can prevent over-diagnosis and unnecessary interventions.
Topics: Adult; Diabetes Mellitus, Type 1; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Mammography; Ultrasonography, Mammary
PubMed: 23425712
DOI: No ID Found -
Zhonghua Bing Li Xue Za Zhi = Chinese... Aug 2017To study the clinicopathologic, immunohistochemical features, differential diagnoses and prognosis of mammary microglandular adenosis with carcinoma (MGACA) with...
To study the clinicopathologic, immunohistochemical features, differential diagnoses and prognosis of mammary microglandular adenosis with carcinoma (MGACA) with micropapillary pattern. Five cases of MGACA were collected from 2010 to 2016 and reviewed for their clinical, histologic features and outcome.EnVision method were done for S-100 protein, cytokeratin (CK), p63, Calponin, smooth muscle myosin heavy chain (SMMHC), PR, ER and HER2. Histologically, microglandular adenosis(MGA), atypical MGA (AMGA) and invasive carcinoma were seen in all five cases of MGACA. The invasive component was metaplastic carcinoma in one case and ductal in four cases. All epithelial cells were S-100 and CK positive in MGA, AMGA and invasive carcinoma. p63, Calponin and SMMHC negativity confirmed the lack of a myoepithelial cell layer in MGA, AMGA and MGACA. PR was weakly focally positive in one case, but ER and HER2 were negative in all cases (four cases were triple negative). Ki-67 index was 20% to 40%. Laminin and collagen Ⅳ staining showed the presence of basement membrane in MGA and AMGA, except MGACA. The follow-up time ranged from 3 months to 6 years, and all patients were alive without recurrence or distant metastasis. MGACA is a rare tumor with distinct morphological and IHC features. Compared to most triple-negative breast cancers, MGACA seems to have a relatively favorable outcome.
Topics: Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Immunohistochemistry; Keratins; Neoplasm Proteins; Neoplasm Recurrence, Local; S100 Proteins; Triple Negative Breast Neoplasms
PubMed: 28810292
DOI: 10.3760/cma.j.issn.0529-5807.2017.08.003 -
Gynakologische Rundschau 1981
Topics: Breast Neoplasms; Female; Fibrocystic Breast Disease; Humans; Mastectomy
PubMed: 7239336
DOI: No ID Found -
Current Opinion in Obstetrics &... Aug 1991Perhaps the most remarkable trend relevant to benign breast disease during the past year is the relative paucity of new investigations. This interesting trend is... (Review)
Review
Perhaps the most remarkable trend relevant to benign breast disease during the past year is the relative paucity of new investigations. This interesting trend is reflected in one of the most remarkable recent texts on this subject. In The Breast: Comprehensive Management of Benign and Malignant Disorders (Bland et al., eds. WB Saunders, 1991), only 70 of 1100 pages are devoted to benign breast disease. The majority of recent reports have focused on three issues: symptomatic treatment of breast pain, expectant management of clinically benign masses in younger women, and cytologic differentiation of benign and precancerous cystic lesions.
Topics: Biopsy, Needle; Breast Diseases; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Pain; Pain Management; Radiography
PubMed: 1878515
DOI: No ID Found