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Obstetrics and Gynecology Clinics of... Sep 1994Most women have fibrocystic changes in their breasts. Patients with proliferative changes with atypia are at an increased risk of breast cancer. The management of... (Review)
Review
Most women have fibrocystic changes in their breasts. Patients with proliferative changes with atypia are at an increased risk of breast cancer. The management of mastalgia is the challenge most frequently encountered in patients with fibrocystic changes. Clinically, the types and variants of fibrocystic changes are sometimes difficult to distinguish. When the diagnosis of fibrocystic changes is unclear, a histologic evaluation biopsy, open surgical biopsy, should be performed.
Topics: Adult; Biopsy; Breast Neoplasms; Danazol; Female; Fibrocystic Breast Disease; Humans; Incidence; Middle Aged; Risk Factors; Severity of Illness Index
PubMed: 7816405
DOI: No ID Found -
World Journal of Surgery 1989Clinical macrocysts occur in about 7% of adult women. Modern terminology and understanding of benign breast disorders considers microcysts and macrocysts as specific... (Review)
Review
Clinical macrocysts occur in about 7% of adult women. Modern terminology and understanding of benign breast disorders considers microcysts and macrocysts as specific clinical and pathological entities. The terminology and concepts of fibrocystic disease and its many alternative terms have been discarded. Cysts arise as an aberration of normal lobular involution (ANDI) associated with active secretion of apocrine epithelium under hormonal stimulation. They are readily managed in most cases by aspiration alone. Multiple recurrent cysts may constitute a considerable nuisance and justify short-term therapy with danazol. There is increasing evidence that multiple recurrent cysts are associated with a small, but significant increase in breast cancer risk.
Topics: Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans
PubMed: 2696224
DOI: 10.1007/BF01658419 -
Clinical Imaging 2012Diabetic mastopathy (DMP) is an uncommon collection of clinical, radiological, and histological features, classically described in premenopausal women with long-term... (Review)
Review
Diabetic mastopathy (DMP) is an uncommon collection of clinical, radiological, and histological features, classically described in premenopausal women with long-term insulin-dependent diabetes mellitus. This entity can mimic breast carcinoma, but, in the appropriate clinical and imaging setting, the diagnosis can be made by core biopsy, avoiding unnecessary surgeries. We report the case of a 34-year-old female, with a 12-year history of type 1 diabetes, who presented with bilateral breast lumps. Mammography, ultrasonography, and magnetic resonance imaging could not exclude the suspicion of malignancy, and a core biopsy was performed showing the typical histologic features of DMP. The literature is briefly reviewed.
Topics: Breast Neoplasms; Diabetes Mellitus, Type 1; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Magnetic Resonance Imaging; Syndrome; Ultrasonography, Mammary; Young Adult
PubMed: 23154017
DOI: 10.1016/j.clinimag.2012.01.003 -
Singapore Medical Journal Jun 2007Diabetic fibrous mastopathy is reported in a 37-year-old premenopausal woman. A known case of insulin-dependent diabetes mellitus, she presented with bilateral hard...
Diabetic fibrous mastopathy is reported in a 37-year-old premenopausal woman. A known case of insulin-dependent diabetes mellitus, she presented with bilateral hard breast lumps, which were suggestive of malignancy on both ultrasonography and mammography. Fine-needle aspiration cytology and core biopsy showed fibrosis. An incisional biopsy further excluded malignancy and was conclusive for diabetic fibrous mastopathy.
Topics: Adult; Biopsy, Fine-Needle; Diabetes Complications; Female; Fibrocystic Breast Disease; Histocytochemistry; Humans; Mammography; Premenopause; Ultrasonography
PubMed: 17538761
DOI: No ID Found -
Medical Ultrasonography Feb 2018A wide spectrum of breast diseases breast diseases have or exhibit at some point in their natural history a complex cystic aspect. Through the lens of B-mode and... (Review)
Review
A wide spectrum of breast diseases breast diseases have or exhibit at some point in their natural history a complex cystic aspect. Through the lens of B-mode and Doppler ultrasound with sonoelastographic augmentation, conditions ranging from the utterly benign fibrocystic change to the most intricate encysted or cystically degenerated cancerous lesions, are covered in detail in this review. The aim of this paper is to familiarize the practitioner with the ultrasonographic aspects of complex breast cystic masses and to implement a gradual, strategic approach in the diagnostic algorithm.
Topics: Breast; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Ultrasonography, Mammary
PubMed: 29400375
DOI: 10.11152/mu-1163 -
American Family Physician Oct 1987Fibrocystic breast disease is characterized by breast pain, lumpiness or cysts. The few patients who have atypia on breast biopsy are at substantially increased risk for... (Review)
Review
Fibrocystic breast disease is characterized by breast pain, lumpiness or cysts. The few patients who have atypia on breast biopsy are at substantially increased risk for the development of breast cancer. Management of fibrocystic breast disease involves monitoring for breast cancer by repeated physical and mammographic examinations. Alleviation of symptoms may be attempted by reassurance, reduction of methylxanthine intake and treatment with danazol.
Topics: Adult; Breast; Bromocriptine; Danazol; Female; Fibrocystic Breast Disease; Humans; Mammography; Middle Aged; Nutritional Physiological Phenomena; Palpation; Tamoxifen
PubMed: 3314435
DOI: No ID Found -
The Breast Journal 2007Sclerosing lymphocytic lobulitis is strongly associated with type one diabetes, when it is then known as diabetic mastopathy. This very rare benign condition tends to... (Review)
Review
Sclerosing lymphocytic lobulitis is strongly associated with type one diabetes, when it is then known as diabetic mastopathy. This very rare benign condition tends to present in premenopausal women, often with diabetic complications particularly retinopathy. Patients present with clinically suspicious fibrous breast lumps; these are commonly multiple, bilateral, and recurrent. Mammograms show asymmetric densities and no focal mass and ultrasound investigation tends to show ill-defined hypoechoic attenuation with strong posterior acoustic shadowing. Magnetic resonance imaging can be used to further differentiate the lesion from malignancy. However, a core biopsy or excisional biopsy is essential so that a pathologic diagnosis can be made. The constellation of pathologic findings is: lymphocytic lobulitis and ductitis with glandular atrophy, lymphocytic/mononuclear perivascular inflammation which is predominantly B-cell and dense often keloid-like fibrosis, with or without epithelioid-like fibroblasts. A review of the current literature on diabetic mastopathy was carried out as it was noted that there has been no recent review of the literature. Detailed Pubmed and other medical data base searches were carried out and all publications were considered, irrespective of language and date, wherever possible.
Topics: Biopsy, Needle; Breast Neoplasms; Diabetes Complications; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Magnetic Resonance Imaging; Mammography; Rare Diseases; Risk Assessment; Ultrasonography, Mammary; Women's Health
PubMed: 17983405
DOI: 10.1111/j.1524-4741.2007.00489.x -
BioMed Research International 2020Breast cancer is the most diagnosed cancer among women around the world. The development of computer-aided diagnosis tools is essential to help pathologists to... (Review)
Review
Breast cancer is the most diagnosed cancer among women around the world. The development of computer-aided diagnosis tools is essential to help pathologists to accurately interpret and discriminate between malignant and benign tumors. This paper proposes the development of an automated proliferative breast lesion diagnosis based on machine-learning algorithms. We used Tabu search to select the most significant features. The evaluation of the feature is based on the dependency degree of each attribute in the rough set. The categorization of reduced features was built using five machine-learning algorithms. The proposed models were applied to the BIDMC-MGH and Wisconsin Diagnostic Breast Cancer datasets. The performance measures of the used models were evaluated owing to five criteria. The top performing models were AdaBoost and logistic regression. Comparisons with others works prove the efficiency of the proposed method for superior diagnosis of breast cancer against the reviewed classification techniques.
Topics: Algorithms; Breast; Breast Neoplasms; Cell Proliferation; Diagnosis, Computer-Assisted; Female; Fibrocystic Breast Disease; Humans; Image Interpretation, Computer-Assisted; Machine Learning; Neoplasms
PubMed: 32258124
DOI: 10.1155/2020/4671349 -
Acta Medica Austriaca 1997The development of high resolution technology ultrasound allows not only a simple differentiation between cystic and solid lesions. Palpable tumors and subclinical... (Review)
Review
The development of high resolution technology ultrasound allows not only a simple differentiation between cystic and solid lesions. Palpable tumors and subclinical lesions can be detected and characterized with a high degree of accuracy. The specific sonographic appearances of the most common entities are described. The diagnostic criteria for the differentiation have been developed over many years. There is no single parameter which allows the differentiation of all lesions, and a number of criteria must be considered.
Topics: Adult; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Sensitivity and Specificity; Ultrasonography, Mammary
PubMed: 9273805
DOI: No ID Found -
Diagnostic Cytopathology 1993Microglandular adenosis (MGA) recognizes a benign proliferative lesion of the breast that can mimic adenocarcinoma histologically. We describe the fine-needle aspiration...
Microglandular adenosis (MGA) recognizes a benign proliferative lesion of the breast that can mimic adenocarcinoma histologically. We describe the fine-needle aspiration (FNA) biopsy cytology of MGA in two female patients. Smears were characterized by sparse cellularity, and the harvest consisted of a monotonous population of medium-sized cells, with vacuolated clear cytoplasm and round and uniform nuclei with small nucleoli. Clear cells appeared isolated or clustered with spindly fibroblasts. No naked nuclei of myoepithelial origin were present in the background. The differential diagnostic considerations included several breast lesions composed of clear cells. Subsequent surgical histology of lumpectomy revealed MGA. Further studies are needed to determine whether these cytologic features permit the specific identification of MGA, but our observations show that FNA is a sensitive method in recognizing the benign nature of the lesion.
Topics: Adult; Biopsy, Needle; Female; Fibrocystic Breast Disease; Follow-Up Studies; Humans; Middle Aged
PubMed: 8458288
DOI: 10.1002/dc.2840090116