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The American Journal of Surgical... Jul 1991Human breast cystic disease is a common premenopausal benign breast condition. Apocrine metaplasia of normal breast epithelium is the lesion that allows cysts to... (Review)
Review
Human breast cystic disease is a common premenopausal benign breast condition. Apocrine metaplasia of normal breast epithelium is the lesion that allows cysts to develop. Apocrine metaplasia and breast cysts occur frequently in association with other proliferative changes in breast epithelium, especially breast epithelial hyperplasia. Clinical follow-up studies of women with breast cystic disease indicate an increased risk of subsequent development of breast carcinoma. This risk is enhanced when multiple cysts occur. A positive family history of breast carcinoma adds to the increased risk that is associated with breast cystic disease. Biochemical analysis of breast cystic disease fluid shows a unique protein profile. GCDFP-15 (gross cystic disease fluid protein) in breast cystic disease fluid is also found by immunoperoxidase staining to be present in approximately 50% of all breast carcinomas Enhanced production of GCDFP-15 by breast carcinomas has been shown experimentally and clinically with the use of androgens. A hypothesis is presented on the sequence of alterations that relate to the development of breast gross cystic disease and to the development of breast carcinomas with apocrine features.
Topics: Breast Neoplasms; Female; Fibrocystic Breast Disease; Humans; Incidence; Risk Factors
PubMed: 2058763
DOI: 10.1097/00000478-199107000-00010 -
Obstetrics and Gynecology Clinics of... Mar 2002This article describes 25 years of clinical experience in the setting of a Breast Health Center devoted to benign and malignant disease of the breast. During this... (Comparative Study)
Comparative Study Review
This article describes 25 years of clinical experience in the setting of a Breast Health Center devoted to benign and malignant disease of the breast. During this period, more than 100,000 patients have been evaluated and treated for a wide variety of breast problems. This experience has provided an extraordinary opportunity to evaluate the natural history of benign breast disease and the frequent observation that the relevant medical literature does not reflect the entire spectrum of these conditions or the appropriate treatment. Most textbooks on breast disease emphasize breast cancer and the late manifestations of benign breast disease that often require surgical treatment. More than 180,000 cases of breast cancer occur each year in the United States. The number of women with benign breast disease is far greater and can be counted in the millions. For these patients, the well-trained primary care physician can provide appropriate evaluation and treatment, including appropriate recommendations for referral. For most patients with breast symptomatology, the goal is relief of symptoms and resolution of the problem. To accomplish this requires a contemporary knowledgebase combined with adequate time spent with the patient.
Topics: Breast; Breast Diseases; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Pain
PubMed: 11892859
DOI: 10.1016/s0889-8545(03)00048-2 -
Obstetrics and Gynecology Clinics of... Sep 1987The prominence of fibrocystic change of the breast mandates knowledge of pathophysiology, diagnosis, and treatment on the part of all providing primary care to women.... (Review)
Review
The prominence of fibrocystic change of the breast mandates knowledge of pathophysiology, diagnosis, and treatment on the part of all providing primary care to women. This article reviews cystic, epithelial hyperplastic, and fibrotic changes common to fibrocystic change and fibrocystic disease of the breast. Diagnostic modalities including physical examination technique and needle aspiration are presented, together with the rationale for ultrasonography and mammography. A broad spectrum of treatment options is presented for the clinician.
Topics: Biopsy, Needle; Breast; Cell Transformation, Neoplastic; Estrogen Antagonists; Female; Fibrocystic Breast Disease; Fibrosis; Gonadal Steroid Hormones; Humans; Hyperplasia; Mammography; Risk Factors; Ultrasonography
PubMed: 3323971
DOI: No ID Found -
Canadian Journal of Diabetes Oct 2014Diabetic mastopathy is an uncommon, benign breast condition seen in type 1 and less frequently type 2 diabetic patients. It is characterized by a dense fibrous stromal... (Review)
Review
Diabetic mastopathy is an uncommon, benign breast condition seen in type 1 and less frequently type 2 diabetic patients. It is characterized by a dense fibrous stromal proliferation of breast tissue, clinically mimicking cancerous masses, thus leading to worrisome investigations. Clinicians and pathologists must distinguish this benign condition from malignant causes because surgery may worsen the case as these lesions tend to recur more extensively at the site of resection. We present the case of a young woman with type 1 diabetes with typical diabetic mastopathy and summarize the literature to increase awareness of this troublesome but benign disorder.
Topics: Adult; Biopsy, Needle; Diabetes Mellitus, Type 1; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Mammography; Palpation; Rare Diseases; Treatment Outcome; Women's Health
PubMed: 24821390
DOI: 10.1016/j.jcjd.2013.12.008 -
Virchows Archiv. A, Pathological... 1984Adenomyoepithelial adenosis of the breast is a form of adenosis not previously described. It is similar in several ways to microglandular adenosis, but one significant...
Adenomyoepithelial adenosis of the breast is a form of adenosis not previously described. It is similar in several ways to microglandular adenosis, but one significant difference is the presence of myoepithelial cells. The present case originated as adenomyoepithelial adenosis in a 46-year-old woman. In the course of 18 years it proliferated and changed into a low-grade malignant adenomyoepithelioma. Electron microscopy confirmed the presence of myoepithelial cells in the adenosis, and immuno-histochemical study demonstrated cells containing actin (representing myoepithelial cells) in the adenosis as well as in the adenomyoepithelioma.
Topics: Adenocarcinoma; Breast Neoplasms; Female; Fibrocystic Breast Disease; Humans; Microscopy, Electron; Middle Aged; Precancerous Conditions
PubMed: 6438900
DOI: 10.1007/BF00694925 -
The Breast Journal 2003
Topics: Adult; Aged; Biopsy, Needle; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Greece; Humans; Mammography; Middle Aged; Premenopause
PubMed: 12752642
DOI: 10.1046/j.1524-4741.2003.09324.x -
Lancet (London, England) Aug 1985
Topics: Breast Neoplasms; Female; Fibrocystic Breast Disease; Humans
PubMed: 2862426
DOI: No ID Found -
The Medical Journal of Australia Sep 1979
Topics: Breast Diseases; Breast Neoplasms; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Mastectomy
PubMed: 514166
DOI: 10.5694/j.1326-5377.1979.tb127130.x -
Australian Family Physician Apr 2005This is the second article in a series on breast disorders with an emphasis on diagnosis and management in the general practice setting. This article provides an... (Review)
Review
This is the second article in a series on breast disorders with an emphasis on diagnosis and management in the general practice setting. This article provides an overview of the investigation of patients with a breast symptom and discusses the assessment and management of benign breast lesions including localised nodularity, fibroadenomas and breast cysts.
Topics: Adult; Breast Cyst; Breast Diseases; Diagnosis, Differential; Family Practice; Female; Fibroadenoma; Fibrocystic Breast Disease; Humans; Middle Aged
PubMed: 15861746
DOI: No ID Found -
Annals of Diagnostic Pathology Feb 2004Invasive breast carcinomas of special type are composed of up to 35% of all cases, such as tubular carcinoma, mucinous carcinoma, invasive cribriform carcinoma, lobular...
Invasive breast carcinomas of special type are composed of up to 35% of all cases, such as tubular carcinoma, mucinous carcinoma, invasive cribriform carcinoma, lobular carcinoma, metaplastic carcinoma, medullary carcinoma, and other rare variants. They are recognized by their specific growth and morphologic patterns, glandular differentiation, and cytologic and nuclear features. These features are also present as a focal or minor component in many carcinomas of no special type. In addition, there are a number of lesions that are mimickers of invasive carcinoma, which can sometimes create diagnostic difficulties. It is important for pathologists to recognize these histologic variants and mimickers of breast carcinoma, particularly in evaluating needle or core biopsies. We report a case of a 64-year-old woman with breast carcinoma of no special type with areas having features with resemblance to microglandular adenosis. Differential diagnosis and their histologic features are discussed.
Topics: Breast Neoplasms; Carcinoma, Ductal; Diagnosis, Differential; Female; Fibrocystic Breast Disease; Humans; Middle Aged
PubMed: 15129910
DOI: 10.1016/j.anndiagpath.2003.11.009