-
Annual Review of Microbiology Sep 2017The ability to predict the evolutionary trajectories of antibiotic resistance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the... (Review)
Review
The ability to predict the evolutionary trajectories of antibiotic resistance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the duration of their usefulness. Useful prediction of resistance evolution requires information about (a) the mutation supply rate, (b) the level of resistance conferred by the resistance mechanism, (c) the fitness of the antibiotic-resistant mutant bacteria as a function of drug concentration, and (d) the strength of selective pressures. In addition, processes including epistatic interactions and compensatory evolution, coselection of drug resistances, and population bottlenecks and clonal interference can strongly influence resistance evolution and thereby complicate attempts at prediction. Currently, the very limited quantitative data on most of these parameters severely limit attempts to accurately predict trajectories of resistance evolution.
Topics: Anti-Bacterial Agents; Bacteria; Drug Resistance, Bacterial; Evolution, Molecular; Genetic Fitness; Genetics, Microbial; Molecular Biology; Mutation
PubMed: 28697667
DOI: 10.1146/annurev-micro-090816-093813 -
Current Genetics Feb 2021
Topics: Genetics; Genetics, Microbial; Humans; Peer Review, Research
PubMed: 33331952
DOI: 10.1007/s00294-020-01131-6 -
Research in Microbiology Jun 2014
Topics: Gene Expression Regulation, Bacterial; Genetics, Microbial; History, 20th Century; Molecular Biology; Operon
PubMed: 24859146
DOI: 10.1016/j.resmic.2014.05.018 -
Research in Microbiology Dec 2007
Topics: Bacteria; Genetics, Microbial; Genome, Bacterial; Genomics
PubMed: 18082580
DOI: 10.1016/j.resmic.2007.10.003 -
Yi Chuan = Hereditas Sep 2016In 2015, there are significant progresses in many aspects of the microbial genetics in China. To showcase the contribution of Chinese scientists in microbial genetics,... (Review)
Review
In 2015, there are significant progresses in many aspects of the microbial genetics in China. To showcase the contribution of Chinese scientists in microbial genetics, this review surveys several notable progresses in microbial genetics made largely by Chinese scientists, and some key findings are highlighted. For the basic microbial genetics, the components, structures and functions of many macromolecule complexes involved in gene expression regulation have been elucidated. Moreover, the molecular basis underlying the recognition of foreign nucleic acids by microbial immune systems was unveiled. We also illustrated the biosynthetic pathways and regulators of multiple microbial compounds, novel enzyme reactions, and new mechanisms regulating microbial gene expression. And new findings were obtained in the microbial development, evolution and population genetics. For the industrial microbiology, more understanding on the molecular basis of the microbial factory has been gained. For the pathogenic microbiology, the genetic circuits of several pathogens were depicted, and significant progresses were achieved for understanding the pathogen-host interaction and revealing the genetic mechanisms underlying antimicrobial resistance, emerging pathogens and environmental microorganisms at the genomic level. In future, the genetic diversity of microbes can be used to obtain specific products, while gut microbiome is gathering momentum.
Topics: Bacteria; China; Gene Expression Regulation, Bacterial; Genetics, Microbial; Genome, Bacterial; Host-Pathogen Interactions; Humans; Research
PubMed: 27644739
DOI: 10.16288/j.yczz.16-305 -
JPMA. the Journal of the Pakistan... Feb 1980
Topics: Genetics, Medical; Genetics, Microbial; Humans
PubMed: 6770116
DOI: No ID Found -
Fungal Genetics and Biology : FG & B May 2016
Topics: Fungi; Genes, Fungal; Genetics, Microbial; Genome, Fungal; Plant Diseases
PubMed: 27038385
DOI: 10.1016/j.fgb.2016.03.005 -
JAMA Aug 1971
Topics: Genetics; Genetics, Microbial; Mutation; Radiation Genetics; Viruses
PubMed: 5109437
DOI: No ID Found -
FEMS Microbiology Reviews Oct 1998
Topics: Genes; Genetics, Microbial
PubMed: 9862120
DOI: 10.1111/j.1574-6976.1998.tb00367.x -
Current Opinion in Microbiology Feb 2015RNA sequencing has emerged as the premier approach to study bacterial transcriptomes. While the earliest published studies analyzed the data qualitatively, the data are... (Review)
Review
RNA sequencing has emerged as the premier approach to study bacterial transcriptomes. While the earliest published studies analyzed the data qualitatively, the data are readily digitized and lend themselves to quantitative analysis. High-resolution RNA sequence (RNA-seq) data allows transcriptional features (promoters, terminators, operons, among others) to be pinpointed on any bacterial transcriptome. Once the transcriptome is mapped, the activity of transcriptional features can be quantified. Here we highlight how quantitative transcriptome analysis can reveal biological insights and briefly discuss some of the challenges to be faced by the field of bacterial transcriptomics in the near future.
Topics: Bacteria; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genetics, Microbial; High-Throughput Nucleotide Sequencing; Molecular Biology
PubMed: 25483350
DOI: 10.1016/j.mib.2014.11.011