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Journal of Foot and Ankle Research Jun 2023Plantar warts, or verrucae plantaris, are common lesions causing considerable pain during weightbearing activity. Although current treatment modalities have low success...
BACKGROUND
Plantar warts, or verrucae plantaris, are common lesions causing considerable pain during weightbearing activity. Although current treatment modalities have low success rates, microwave therapy has been introduced as a promising intervention. This study aimed to determine the effectiveness of microwave therapy for the treatment of plantar warts and to determine the clinical factors associated with plantar wart resolution.
METHODS
A retrospective analysis of 150 plantar warts from 45 patients treated with microwave therapy was undertaken. Binomial regression was conducted to explore clinical characteristics (age, gender, immunosuppression, impaired healing, multiple vs single wart, location of lesion, lesion diameter) associated with lesion resolution.
RESULTS
Of the total 150 plantar warts treated with microwave therapy, 125 (83.3%) warts resolved and 25 (17%) warts did not resolve. The mean (SD) total treatment sessions for resolved lesions was 2.8 (1.0). Decreasing age (P = 0.046) was the only clinical characteristic associated with resolution.
CONCLUSIONS
This retrospective study has shown that plantar warts may be resolved with two to three sessions of microwave therapy, which may be more successful in younger populations.
Topics: Humans; Retrospective Studies; Microwaves; Warts; Foot Diseases; Pain Management; Treatment Outcome
PubMed: 37322512
DOI: 10.1186/s13047-023-00638-8 -
Minimally Invasive Therapy & Allied... Apr 2020We aim to evaluate the efficacy, safety and survival time of microwave ablation (MWA) with adjuvant antiangiogenic therapy-endostatin in animal models. A total of 40...
We aim to evaluate the efficacy, safety and survival time of microwave ablation (MWA) with adjuvant antiangiogenic therapy-endostatin in animal models. A total of 40 rabbits successfully implanted with VX2 tumors were randomly assigned to four experimental groups: Group A underwent only microwave ablation of the tumors; Group B received only antiangiogenic drugs endostatin; Group C received endostatin immediately after MWA; Group D followed up without treatment. Two months post-treatment, tumor sizes of Group A and Group C were reduced to 1.936 ± 0.373 cm and 1.592 ± 0.382 cm, respectively. However, tumors grew to 15.091 ± 1.735 cm and 47.825 ± 7.664 cm in Group B and the control group. Three months post-treatment, tumor sizes in Group A and Group C maintained as 1.395 ± 0.394 cm and 1.482 ± 0.305 cm, significantly smaller than Group B (35.277 ± 6.019 cm). All animals in the control group died, while four (40%) survived in Group B (Endo Group). The numbers of survivals in Groups A and C were seven (70%) and eight (80%), respectively. The lowest metastasis rate (2/10, 20%) was observed in Group C (combination therapy). The combination of MWA and antiangiogenic therapy triggered a significant reduction in the growth rate and metastases of tumors and may potentially improve survivals.
Topics: Angiogenesis Inhibitors; Animals; Combined Modality Therapy; Microwaves; Neoplasms; Rabbits
PubMed: 30987497
DOI: 10.1080/13645706.2019.1601632 -
Henry Ford Hospital Medical Journal 1981
Clinical Trial Review
Topics: Clinical Trials as Topic; Humans; Hyperthermia, Induced; Microwaves; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Radiotherapy; Temperature
PubMed: 7024209
DOI: No ID Found -
Nihon Hinyokika Gakkai Zasshi. the... May 1992Microwave energy had become a valuable component in the electromagnetic spectrum. Because of its unique energy source, the microwave radiation can penetrate several... (Review)
Review
Microwave energy had become a valuable component in the electromagnetic spectrum. Because of its unique energy source, the microwave radiation can penetrate several centimeters into biologic tissue. The energy is absorbed and converted into heat within the tissue. Clinical applications of microwave irradiation fall into two categories; thermotherapy and hyperthermia. Microwave therapy has generated great interest in the field of urology because of its safety, efficiency, and its simplicity as a surgical tool. This review analyses the fundamentals of the science of microwave energy as a therapy and presents an in-depth discussion of its theoretical principles, unique characteristics, appropriateness of application, and its potentiality as a long-term modality for the treatment of urologically-related diseases.
Topics: Animals; Female Urogenital Diseases; Humans; Hyperthermia, Induced; Male Urogenital Diseases; Microwaves
PubMed: 1495198
DOI: 10.5980/jpnjurol1989.83.589 -
Current Pharmaceutical Design 2011There are several different ways for cancer treatment including operation, radiation therapy, chemotherapy, gene therapy, immunotherapy, ablation and hyperthermia.... (Review)
Review
There are several different ways for cancer treatment including operation, radiation therapy, chemotherapy, gene therapy, immunotherapy, ablation and hyperthermia. Techniques utilizing temperature elevation over the tumor region are usually called as thermal therapies. In this paper, we will focus on hyperthermia which is one of the promising cancer treatments utilizing the difference of thermal sensitivity between the tumor and normal tissue. In addition, microwave energy is a heating source used for localized hyperthermia. Depending on the position and size of the target tumor, several types of antennas, which radiate microwave energy to the target, can be selected. This paper describes two types of heating schemes which can be used with microwave energy, and provides brief explanations of the basic engineering involved. In addition, methods used for evaluations of antenna performance are described.
Topics: Animals; Computer Simulation; Electrodes; Equipment Design; Humans; Hyperthermia, Induced; Microwaves; Models, Biological; Neoplasms
PubMed: 21736543
DOI: 10.2174/138161211797052538 -
The Journal of Surgical Research Jan 2014The present study compares the efficacy of 915- and 2450-MHz contrast-enhanced ultrasound (CEUS)-guided percutaneous microwave coagulation with that of CEUS-guided...
BACKGROUND
The present study compares the efficacy of 915- and 2450-MHz contrast-enhanced ultrasound (CEUS)-guided percutaneous microwave coagulation with that of CEUS-guided thrombin injection for the treatment of trauma-induced spleen hemorrhage.
MATERIALS AND METHODS
In a canine splenic artery hemorrhage model with two levels of arterial diameter (A, <1 mm and B, between 1 and 2 mm), hemostatic therapy was performed using 915- and 2450-MHz microwaves and drug injection. Therapy efficacy was measured by comparing bleeding rate, hemostatic time, bleeding index, bleeding volume, and pathology.
RESULTS
The most efficient technique was CEUS-guided 915-MHz percutaneous microwave coagulation therapy in terms of action time and total blood loss. The success rate of the 915-MHz microwave group was higher than that of the 2450-MHz microwave and the drug injection groups (except A level, P < 0.05). Hemostatic time, bleeding index, and bleeding volume were significantly less in the 915-MHz microwave group than those in the 2450-MHz microwave and drug injection groups (P < 0.05). Obvious degeneration and necrosis of parenchyma and large intravascular thrombosis were observed in the cavity of larger vessels in the 915-MHz microwave group, but pathologic changes of light injury could be seen in the other groups.
CONCLUSIONS
The present study provides evidence that microwave coagulation therapy is more efficient than thrombin injection for the treatment of splenic hemorrhage. Furthermore, treatment with 915-MHz microwaves stops bleeding more rapidly and generates a wider cauterization zone than does treatment with 2450-MHz microwaves.
Topics: Animals; Contrast Media; Dogs; Hemorrhage; Hemostatic Techniques; Injections; Microwaves; Spleen; Ultrasonography, Interventional
PubMed: 23992856
DOI: 10.1016/j.jss.2013.07.038 -
Abdominal Radiology (New York) Apr 2016Surveillance programs and widespread use of medical imaging have increased the detection of hepatic tumors. When feasible, surgical resection is widely accepted as the... (Review)
Review
Surveillance programs and widespread use of medical imaging have increased the detection of hepatic tumors. When feasible, surgical resection is widely accepted as the curative treatment of choice, but surgical morbidity and mortality has spurred the development of minimally invasive ablative technologies over the last 2 decades. Microwave ablation has emerged as a promising thermal ablation modality with improving oncologic efficacy due to technical improvements and image guidance strategies. This article provides an overview of microwave application in liver tumors, and we discuss currently available equipment, clinical efficacy, and safety and provide comparisons with other commonly used therapies. This article also introduces advanced ablative techniques and combination therapies that may help achieve precise ablation and further enhance the efficacy of microwave ablation.
Topics: Catheter Ablation; Diagnostic Imaging; Equipment Safety; Humans; Imaging, Three-Dimensional; Liver Neoplasms; Microwaves; Patient Safety; Radiography, Interventional; Surgery, Computer-Assisted
PubMed: 26880177
DOI: 10.1007/s00261-016-0662-6 -
Modern Veterinary Practice Oct 1977
Topics: Animals; Diathermy; Dog Diseases; Dogs; Microwaves
PubMed: 927424
DOI: No ID Found -
Journal of Evidence-based Medicine May 2015To assess the efficacy and safety of focused ultrasound therapy (FU) and microwave therapy (MW) for cervical ectopy (CE). (Meta-Analysis)
Meta-Analysis Review
OBJECTIVES
To assess the efficacy and safety of focused ultrasound therapy (FU) and microwave therapy (MW) for cervical ectopy (CE).
METHODS
We searched PubMed, EMbase, the Cochrane Library, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journals Database (VIP), China Academic Journals Full-text Database (CNKI), and WanFang Data for randomized controlled trials (RCTs) comparing FU with MW for women with symptomatic CE from inception to 30 August 2014. Two review authors (Tang XL and Gao Z) independently screened for eligible studies according to the inclusion and exclusion criteria, extracted data and assessed risk of bias of included RCTs. Then, meta-analysis was performed using the RevMan 5.2 software. Funnel plots were used to evaluate publication bias.
RESULTS
A total of 33 RCTs with 11,759 participants were included. All studies had high risk of bias. The results of meta-analysis indicated that compared to MW, FU significantly reduced the risk of vaginal bleeding (RR = 0.09, 95%CI 0.05 to 0.17, P < 0.00001) and vaginal discharge (RR = 0.10, 95%CI 0.04 to 0.24, P < 0.00001), increased the cure rate (RR = 1.10, 95%CI 1.05 to 1.15, P < 0.0001) and the total effectiveness rate (RR = 1.04, 95%CI 1.02 to 1.06, P = 0.0005), and decreased the recurrence rate (RR = 0.13, 95%CI 0.02 to 1.00, P = 0.05); however, this last difference was not statistically significant.
CONCLUSION
Current available evidence suggests that FU is safer and more effective than MW for treating CE. However, some limitations will reduce the reliability of our results. Further well-designed clinical trials are needed to provide further clarification.
Topics: Endometriosis; Female; Humans; Microwaves; Ultrasonic Therapy; Uterine Cervical Diseases
PubMed: 25954850
DOI: 10.1111/jebm.12150 -
Biomaterials Apr 2022Microwave thermal therapy (MWTT) shows great prospect in cancer treatments due to its non-invasive or minimally invasive nature and deep penetration through the tissue....
Microwave thermal therapy (MWTT) shows great prospect in cancer treatments due to its non-invasive or minimally invasive nature and deep penetration through the tissue. However, incomplete ablation and elevated expression of many pro-tumor angiogenesis after MWTT (e.g., vascular endothelial growth factor, VEGF) induced tumor recurrence still remains an obstacle, especially in some tumors prone to recurrence and metastasis, such as colorectal cancer. Herein, we propose a nanocapsule of covalent organic framework cladding metal organic framework (MOF@COF) with microwave (MW) thermal-dynamic sensitization and co-action of tumor anti-angiogenesis. The MOF of Bi-Mn-porphyrin (BM) is designed as MW sensitizer to generate cytotoxic O and heat for microwave dynamic therapy (MWDT) synergistic MWTT. The COF is covalently coated on BM for further augmenting these two sensitization properties, as well as loading hydrophobic inhibitor of Apatinib to downregulate the expression of VEGF for inhibiting tumor recurrence. Furthermore, the contained Bi and porphyrin endow system with CT and fluorescence imaging (FI) capabilities. In vivo experiments verify that this combination therapy significantly impairs the growth of colorectal cancer with no recurrent carcinoma. Therefore, our work presents an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
Topics: Colorectal Neoplasms; Humans; Microwaves; Nanocapsules; Neoplasm Recurrence, Local; Vascular Endothelial Growth Factor A
PubMed: 35313274
DOI: 10.1016/j.biomaterials.2022.121472