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Radiology Mar 2013
Topics: Catheter Ablation; Female; Humans; Lung Neoplasms; Male; Microwaves
PubMed: 23431232
DOI: 10.1148/radiol.12122238 -
International Journal of Hyperthermia :... Nov 2004Interstitial microwave thermal therapy may be an effective alternative to surgery for the treatment of some solid tumours. Arrays of helical antennae can produce complex... (Review)
Review
Interstitial microwave thermal therapy may be an effective alternative to surgery for the treatment of some solid tumours. Arrays of helical antennae can produce complex heating patterns which when combined with active cooling of normal tissue structures can provide conformal heating for thermal coagulation of tumours. The development of a clinical protocol involving phantom and animal model studies, treatment planning, tissue property measurement and methods for on-line treatment monitoring is reviewed. The technology developed has been applied to the problem of recurrent prostate cancer following failed radiation treatment where available curative options are associated with high normal tissue morbidity. The purpose was to develop a treatment option for this group of patients with a very low side-effect profile that would not preclude further treatment if the disease progressed. Results of a Phase I/II trial demonstrate safety, promising efficacy and a low complication rate. As the technology for delivering this treatment matures, larger multi-institutional trials should be considered.
Topics: Humans; Hyperthermia, Induced; Male; Microwaves; Neoplasm Recurrence, Local; Prostatic Neoplasms
PubMed: 15675670
DOI: 10.1080/02656730410001734146 -
British Journal of Sports Medicine Dec 1990
Review
Topics: Diathermy; Humans; Microwaves; Physical Therapy Modalities
PubMed: 2097017
DOI: 10.1136/bjsm.24.4.212 -
Oncology 2002Treatment of hepatocellular carcinoma (HCC) is different from that of other solid tumors, in that surgery plays a limited role while nonsurgical therapies are very... (Review)
Review
Treatment of hepatocellular carcinoma (HCC) is different from that of other solid tumors, in that surgery plays a limited role while nonsurgical therapies are very instrumental. At our institute, 90% of previously untreated patients have received image-guided percutaneous tumor ablations, such as percutaneous ethanol injection therapy (PEIT), percutaneous microwave coagulation therapy (PMCT) and radiofrequency ablation (RFA). We performed PEIT in 756 patients with HCC. Their survival rates were 89% at 1 year, 64% at 3 years, 39% at 5 years, and 18% at 10 years. With PMCT, survival rates of 122 new patients with HCC were 90% at 1 year, 87% at 2 years, and 68% at 3 years. We performed RFA in 324 patients. RFA required fewer treatment sessions and a shorter hospital stay than PEIT or PMCT to achieve complete necrosis of the lesions. By virtue of their local curability, minimal effect on liver function, and easy repeatability for recurrence, image-guided percutaneous tumor ablations, especially RFA, will be increasingly important in the treatment of HCC.
Topics: Administration, Cutaneous; Blood Coagulation; Carcinoma, Hepatocellular; Catheter Ablation; Ethanol; Humans; Liver Neoplasms; Microwaves
PubMed: 11868788
DOI: 10.1159/000048278 -
The Medical Journal of Australia Jun 1985
Topics: Aged; Combined Modality Therapy; Humans; Hyperthermia, Induced; Microwaves; Middle Aged; Otorhinolaryngologic Neoplasms
PubMed: 4010595
DOI: No ID Found -
Surgical Technology International Nov 2020Hepatocellular carcinoma (HCC) and secondary hepatic malignancies, most often arising from colorectal cancer, are a leading cause of morbidity and cancer-related deaths... (Review)
Review
Hepatocellular carcinoma (HCC) and secondary hepatic malignancies, most often arising from colorectal cancer, are a leading cause of morbidity and cancer-related deaths worldwide. In lieu of first-line surgical resection, which is precluded in more than 75% of cases due to underlying comorbid conditions or locally advanced disease, several minimally-invasive transarterial and thermal ablation procedures have emerged as safe and effective alternative therapies in select patients. Among the thermal ablative techniques, microwave ablation (MWA) has become the preferred treatment modality because of its operational convenience and superior heating profile, allowing for larger ablation zones and reduced treatment times while maintaining high technical success rates. To date, MWA has been demonstrated to provide equivalent, and in some cases improved, clinical outcomes compared to radiofrequency ablation (RFA) in patients with inoperable HCC or oligometastatic disease. Active areas of investigation include the comparison of MWA and transarterial therapies, such as transarterial chemoembolization (TACE), as well as combined multimodality therapies. Here we review the emerging topic of MWA for the treatment of hepatic malignancies by examining staging and treatment strategies, available technologies, procedural protocol and technique, and clinical outcomes.
Topics: Carcinoma, Hepatocellular; Catheter Ablation; Chemoembolization, Therapeutic; Humans; Liver Neoplasms; Microwaves; Radiofrequency Ablation; Treatment Outcome
PubMed: 32681731
DOI: No ID Found -
Expert Review of Medical Devices Mar 2013Microwave ablation is one of the several options in the ablation armamentarium for the treatment of malignancy, offering several potential benefits when compared with... (Review)
Review
Microwave ablation is one of the several options in the ablation armamentarium for the treatment of malignancy, offering several potential benefits when compared with other ablation, radiation, surgical and medical treatment modalities. The basic microwave system consists of the generator, power distribution system and antennas. Often under image (computed tomography or ultrasound) guidance, a needle-like antenna is inserted percutaneously into the tumor, where local microwave electromagnetic radiation is emitted from the probe's active tip, producing frictional tissue heating, capable of causing cell death by coagulation necrosis. Half of the microwave ablation systems use a 915 MHz generator and the other half use a 2450 MHz generator. To date, there are no completed clinical trials comparing microwave devices head-to-head. Prospective comparisons of microwave technology with other treatment alternatives, as well as head-to-head comparison with each microwave device, is needed if this promising field will garner more widespread support and use in the oncology community.
Topics: Adult; Aged; Aged, 80 and over; Animals; Catheter Ablation; Catheters; Equipment Design; Female; Humans; Male; Microwaves; Middle Aged; Neoplasms; Treatment Outcome
PubMed: 23480091
DOI: 10.1586/erd.12.77 -
ACS Nano Oct 2023Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and...
Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone and gas. However, microwave (MW) is not selective against tumors, and residual tumors after incomplete ablation will generate immunosuppression, ultimately making tumors prone to recurrence and metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) is proposed to reverse the immunosuppression and reactivate the antitumor immune effect through responsively releasing HS in tumor cells for improving MWTT. Under MW irradiation, BMCPH will mediate MWTT to ablate tumors and release l-cysteine (l-Cys) to react with the highly expressed cystathionine β-synthase in tumor to generate HS. The generated HS can inhibit the accumulation of myeloid-derived suppressor cells (MDSCs) and promote the expression of cytotoxic T lymphocytes (CTLs). Moreover, Bi-MOF can also scavenge reactive oxygen species (ROS), a major means of MDSCs-mediated immunosuppression, to further weaken the immunosuppressive effect. Simultaneously, the surface-covered HA will gather CTLs around the tumor to enhance the immune response. This nano gas immunomodulator provides an idea for the sensitive and tunable release of unstable gas molecules at tumor sites. The strategy of HS gas to reverse immunosuppression and reactivate antitumor immune response introduces a direction to reduce the risk of tumor recurrence and metastasis after thermal ablation.
Topics: Humans; Microwaves; Immunosuppression Therapy; Neoplasms; Immunity; Immune Tolerance; Tumor Microenvironment
PubMed: 37781935
DOI: 10.1021/acsnano.3c05936 -
Radiographics : a Review Publication of... Oct 2005Microwave ablation is the most recent development in the field of tumor ablation. The technique allows for flexible approaches to treatment, including percutaneous,... (Review)
Review
Microwave ablation is the most recent development in the field of tumor ablation. The technique allows for flexible approaches to treatment, including percutaneous, laparoscopic, and open surgical access. With imaging guidance, the tumor is localized, and a thin (14.5-gauge) microwave antenna is placed directly into the tumor. A microwave generator emits an electromagnetic wave through the exposed, noninsulated portion of the antenna. Electromagnetic microwaves agitate water molecules in the surrounding tissue, producing friction and heat, thus inducing cellular death via coagulation necrosis. The main advantages of microwave technology, when compared with existing thermoablative technologies, include consistently higher intratumoral temperatures, larger tumor ablation volumes, faster ablation times, and an improved convection profile. Microwave ablation has promising potential in the treatment of primary and secondary liver disease, primary and secondary lung malignancies, renal and adrenal tumors, and bone metastases. The technology is still in its infancy, and future developments and clinical implementation will help improve the care of patients with cancer.
Topics: Adolescent; Aged; Aged, 80 and over; Electrocoagulation; Equipment Design; Female; Humans; Male; Microwaves; Middle Aged; Neoplasms
PubMed: 16227498
DOI: 10.1148/rg.25si055501 -
Best Practice & Research. Clinical... Dec 2007Microwave endometrial ablation is an effective treatment for heavy menstrual loss that achieves high satisfaction rates, is acceptable to patients, and is recommended by... (Review)
Review
Microwave endometrial ablation is an effective treatment for heavy menstrual loss that achieves high satisfaction rates, is acceptable to patients, and is recommended by the National Institute of Clinical Excellence. It has been evaluated extensively in randomized trials against first- and second-generation endometrial ablative techniques. Its simplicity of use and short treatment time make it suitable for outpatient treatments, whilst it can also treat larger and irregular cavities. This article reviews the available clinical research and scientific basis of this endometrial ablation technique.
Topics: Adult; Contraindications; Endometrium; Evidence-Based Medicine; Female; Humans; Menorrhagia; Microwaves; Middle Aged; Short-Wave Therapy
PubMed: 17574926
DOI: 10.1016/j.bpobgyn.2007.03.016