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Cardiovascular and Interventional... Feb 2023
Topics: Humans; Microwaves; Radiofrequency Ablation
PubMed: 36175654
DOI: 10.1007/s00270-022-03285-x -
International Journal of Hyperthermia :... Feb 2017Approximately 30% of early stage lung cancer patients are not surgical candidates due to medical co-morbidities, poor cardiopulmonary function and advanced age. These... (Review)
Review
Approximately 30% of early stage lung cancer patients are not surgical candidates due to medical co-morbidities, poor cardiopulmonary function and advanced age. These patients are traditionally offered chemotherapy and radiation, which have shown relatively modest improvements in mortality. For over a decade, percutaneous image-guided ablation has emerged as a safe, cost-effective, minimally invasive treatment alternative for patients who would otherwise not qualify for surgery. Although radiofrequency ablation (RFA) is currently the most extensively studied and widely utilised technique in the treatment of lung malignancies, there is a growing body of evidence that microwave ablation (MWA) has several unique benefits over RFA and cryoablation in the lung. This article reviews our institution's clinical experiences in the treatment of lung malignancies with MWA including patient selection, procedural technique, imaging follow-up, treatment outcomes and comparison of ablation techniques.
Topics: Ablation Techniques; Humans; Hyperthermia, Induced; Lung Neoplasms; Microwaves
PubMed: 27411731
DOI: 10.1080/02656736.2016.1204630 -
International Journal of Hyperthermia :... 2022Microwave ablation (MWA) is becoming an increasingly important minimally invasive treatment option for localized tumors in many organ systems due to recent advancements... (Review)
Review
Microwave ablation (MWA) is becoming an increasingly important minimally invasive treatment option for localized tumors in many organ systems due to recent advancements in microwave technology that have conferred many advantages over other tumor ablation modalities. Despite these improvements in technology and development of applicators for site-specific tumor applications, the vast majority of commercially available MWA applicators are generally designed to create large-volume, symmetric, ellipsoid or spherically-shaped treatment zones and often lack the consistency, predictability, and spatial control needed to treat tumor targets near critical structures that are vulnerable to inadvertent thermal injury. The relatively new development and ongoing translation of directional microwave ablation (DMWA) technology, however, has the potential to confer an added level of control over the treatment zone shape relative to applicator position, and shows great promise to expand MWA's clinical applicability in treating tumors in challenging locations. This paper presents a review of the industry-standard commercially available MWA technology, its clinical applications, and its limitations when used for minimally-invasive tumor treatment in medical practice followed by discussion of new advancements in experimental directional microwave ablation (DMWA) technology, various techniques and approaches to its use, and examples of how this technology may be used to treat tumors in challenging locations that may otherwise preclude safe treatment by conventional omni-directional MWA devices.
Topics: Ablation Techniques; Humans; Microwaves; Neoplasms; Radiofrequency Ablation
PubMed: 35465811
DOI: 10.1080/02656736.2021.1991012 -
Der Urologe. Ausg. A Nov 2018
Review
Topics: Diathermy; Humans; Male; Microwaves; Prostatic Hyperplasia
PubMed: 30259061
DOI: 10.1007/s00120-018-0779-z -
International Journal of Hyperthermia :... Feb 2017The use of microwaves (MW) for thermal cancer treatment began in the late 1970s. At first, hyperthermia was induced by using single antennas applied interstitially. This... (Review)
Review
The use of microwaves (MW) for thermal cancer treatment began in the late 1970s. At first, hyperthermia was induced by using single antennas applied interstitially. This was followed by arrays of multiple interstitial antennas driven synchronously at 915 or 2450 MHz. This early work focused on hyperthermia as an adjuvant therapy, but more recently has evolved into a thermally ablative monotherapy. Increased power required to thermally ablate tissues required additional developments such as internally cooled antennas. Larger tumours have also been ablated with MW antenna arrays activated synchronously or non-synchronously. Numerical modelling has provided clinical treatment planning guidance and device design insight throughout this history. MW thermal therapy systems, treatment planning, navigation and image guidance continue to evolve to provide better tools and options for clinicians and patients in order to provide targeting optimisation with the goal of improved treatment for the patient and durable cancer eradication. This paper reviews the history and related technological developments, including antenna design, of MW heating for both hyperthermia and ablation.
Topics: Ablation Techniques; Animals; Equipment Design; Humans; Hyperthermia, Induced; Microwaves; Neoplasms
PubMed: 27492859
DOI: 10.1080/02656736.2016.1214884 -
Nihon Geka Gakkai Zasshi May 2001We evaluated the efficacy of local ablation therapy in 40 patients with liver metastases from colorectal cancer. Radiofrequency ablation (RFA) and/or microwave... (Review)
Review
We evaluated the efficacy of local ablation therapy in 40 patients with liver metastases from colorectal cancer. Radiofrequency ablation (RFA) and/or microwave coagulation therapy (MCT) were used. Ablation therapies were performed in percutaneous, endoscopic, and operative procedures. The regional recurrence rate at the therapeutic sites was 15% (median follow-up period of 2.5 years). The average surgical margin in the operative ablation group was 11 mm. The cumulative 5-year survival rates were 37% in the local ablation, 41% in the hepatic resection, and 5% in the regional chemotherapy groups. Major complications occurred in only two patients (one biliary fistula and one liver abscess). Together these observations indicate that local ablation therapy is a radical and safe locoregional therapy that provides adequate local control and contributes to long survival.
Topics: Catheter Ablation; Colorectal Neoplasms; Electrocoagulation; Humans; Liver Neoplasms; Microwaves
PubMed: 11394002
DOI: No ID Found -
European Urology Feb 1999The present status of transurethral microwave thermotherapy (TUMT) in the low (LE) and high energy (HE) version is given as an overview. (Review)
Review
OBJECTIVES AND METHODS
The present status of transurethral microwave thermotherapy (TUMT) in the low (LE) and high energy (HE) version is given as an overview.
RESULTS
With LE software, approximately 75% of patients will note significant improvement with 65% reduction in symptom scores and a 35-40% improvement in peak flow rate. Sham studies have shown statistically significant improvement in treated patients compared to sham. Randomized studies between TUMT and TURP show similar improvements in symptom scores with TURP producing higher flow rates, as expected. Long-term studies have been reported to 5 years showing durability, although 10-20% of patients subsequently undergo TURP. The clinical efficacy of HE-TUMT 2.5 has been documented in recently completed studies. Approximately 37% of patients develop cavitation with HE-TUMT. The symptomatic improvement is similar between low and high energy while the flow rates with high energy improve by approximately 65%. Pressure flow studies have documented relief of obstruction in most of those patients who had obstruction prior to treatment. The morbidity of HE-TUMT in terms of retrograde ejaculation and posttreatment retention is higher compared to the LE version.
CONCLUSIONS
TUMT is a 1-hour out-patient, local anesthetic procedure, minimally invasive treatment option for benign prostatic hyperplasia that encompasses microwave radiative heating and water conductive cooling. TUMT has been proven both safe and efficacious for relieving benign prostatic hyperplasia symptoms in several large-scale controlled studies. The existence of low and high energy versions offers the opportunity to select patients according to obstruction grade.
Topics: Diathermy; Humans; Male; Microwaves; Patient Selection; Prostatic Hyperplasia; Urodynamics
PubMed: 9933806
DOI: 10.1159/000019833 -
Seminars in Respiratory and Critical... Aug 2008Recent years have witnessed the refinement and significant growth of several new, minimally invasive approaches for the nonsurgical treatment of primary lung... (Review)
Review
Recent years have witnessed the refinement and significant growth of several new, minimally invasive approaches for the nonsurgical treatment of primary lung malignancies. For select patients, these technologies offer an attractive treatment option given their availability in the outpatient setting and low associated morbidity and mortality. Microwave ablation represents the most recent addition to the growing armamentarium of available ablative technologies. Administered in a manner similar to radiofrequency ablation, the lung tumor is localized under imaging guidance, and a microwave antenna is placed directly into the tumor bed. In contrast to existing thermoablative technologies, however, microwave treatment offers several key theoretical advantages. These include consistently higher intratumoral temperatures, larger ablation volumes, reduced treatment times, and improved convection profile. As a nascent technology, efficacy and outcomes data for microwave ablation of pulmonary malignancies remain relatively lacking compared with other thermoablative techniques; however, early trials have demonstrated promising results. It is hoped that further refinements in the clinical application of this technology will continue to improve the care of patients with lung cancer.
Topics: Catheter Ablation; Humans; Lung Neoplasms; Microwaves; Radiography, Interventional; Tomography, X-Ray Computed
PubMed: 18651356
DOI: 10.1055/s-2008-1081281 -
Radiologic Clinics of North America Sep 2004The integration of imaging and thermal therapy can provide a minimally invasive or even noninvasive alternative to breast surgery for small tumors. Ongoing trials seek... (Review)
Review
The integration of imaging and thermal therapy can provide a minimally invasive or even noninvasive alternative to breast surgery for small tumors. Ongoing trials seek to show safety and efficacy for laser, radiofrequency, microwave, cryoablation, and focused ultrasound surgery. To be successful, these therapies must achieve equivalent or even greater efficacy as surgical outcomes and must demonstrate total ablation of the dominant lesion with negative margins, while sparing normal tissue beyond the target tissue. Procedures have been validated by histopathology subsequent to resection.
Topics: Breast; Breast Neoplasms; Catheter Ablation; Cryosurgery; Female; Humans; Laser Therapy; Magnetic Resonance Imaging; Mastectomy, Segmental; Microwaves; Ultrasonic Therapy
PubMed: 15337427
DOI: 10.1016/j.rcl.2004.05.003 -
International Journal of Molecular... Jun 2020Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide and its incidence is rising. Percutaneous locoregional therapies, such... (Review)
Review
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide and its incidence is rising. Percutaneous locoregional therapies, such as radiofrequency ablation and microwave ablation, are widely used as curative treatment options for patients with small HCC, but their effectiveness remains restricted because of the associated high rate of recurrence, occurring in about 70% of patients at five years. These thermal ablation techniques have the particularity to induce immunomodulation by destroying tumours, although this is not sufficient to raise an effective antitumour immune response. Ablative therapies combined with immunotherapies could act synergistically to enhance antitumour immunity. This review aims to understand the different immune changes triggered by radiofrequency ablation and microwave ablation as well as the interest in using immunotherapies in combination with thermal ablation techniques as a tool for complementary immunomodulation.
Topics: Carcinoma, Hepatocellular; Clinical Trials as Topic; Combined Modality Therapy; Humans; Immunotherapy; Liver Neoplasms; Microwaves; Neoplasm Recurrence, Local; Radiofrequency Ablation; Treatment Outcome
PubMed: 32575734
DOI: 10.3390/ijms21124398