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Infectious Disease Reports Jan 2022There are few reports of bacteremia caused by in the literature. We present a review of the literature in addition to a case study.
BACKGROUND
There are few reports of bacteremia caused by in the literature. We present a review of the literature in addition to a case study.
METHOD
We describe the case of an 82-year-old patient who underwent gastrointestinal surgery and subsequently presented with dehydration, nausea, and hyperkalemia secondary to diarrhea. Further clinical work included blood cultures, and the patient was started empirically on piperacillin/tazobactam.
RESULTS
After five days, the blood culture bottle showed growth of a gram-variable, curved rod-shaped organism. After culture under anaerobic conditions on sheep blood agar, the organism was identified as by MALDI-TOF mass spectrometry and enzymatic technology. A review of the literature reveals five additional cases of bacteremia.
CONCLUSIONS
This is the sixth case in the literature describing species bacteremia. This organism is rarely identified in blood culture and is most often thought of in the context of bacterial vaginosis. However, the reported cases of bacteremia show gastrointestinal symptoms and presumed gastrointestinal source of infection. The pathogenesis of infection of this organism requires further investigation.
PubMed: 35076503
DOI: 10.3390/idr14010009 -
Clinical Microbiology Reviews Apr 2016Bacterial vaginosis (BV) is the most commonly reported microbiological syndrome among women of childbearing age. BV is characterized by a shift in the vaginal flora from... (Review)
Review
Bacterial vaginosis (BV) is the most commonly reported microbiological syndrome among women of childbearing age. BV is characterized by a shift in the vaginal flora from the dominant Lactobacillus to a polymicrobial flora. BV has been associated with a wide array of health issues, including preterm births, pelvic inflammatory disease, increased susceptibility to HIV infection, and other chronic health problems. A number of potential microbial pathogens, singly and in combinations, have been implicated in the disease process. The list of possible agents continues to expand and includes members of a number of genera, including Gardnerella, Atopobium, Prevotella, Peptostreptococcus, Mobiluncus, Sneathia, Leptotrichia, Mycoplasma, and BV-associated bacterium 1 (BVAB1) to BVAB3. Efforts to characterize BV using epidemiological, microscopic, microbiological culture, and sequenced-based methods have all failed to reveal an etiology that can be consistently documented in all women with BV. A careful analysis of the available data suggests that what we term BV is, in fact, a set of common clinical signs and symptoms that can be provoked by a plethora of bacterial species with proinflammatory characteristics, coupled to an immune response driven by variability in host immune function.
Topics: Bacteria; DNA, Bacterial; Female; Humans; Microbiota; Vaginosis, Bacterial
PubMed: 26864580
DOI: 10.1128/CMR.00075-15 -
Anaerobe Apr 2008Mobiluncus curtisii was isolated from the blood of a 35-year-old man with a medical history of ulcerative colitis who was admitted unconscious to the Intensive Care Unit...
Mobiluncus curtisii was isolated from the blood of a 35-year-old man with a medical history of ulcerative colitis who was admitted unconscious to the Intensive Care Unit (ICU). A CT scan revealed massive intracerebral hemorrhage in the left hemisphere. Temperature remained constant over 38.5 degrees C; therefore, two sets of blood cultures were collected. One anaerobic bottle BacT/ALERT SN (bioMerieux, France) was detected as positive after 5 days of incubation and a Gram stain confirmed a gram variable curved-shaped rod. The patient died 18 h after being admitted to the hospital.
Topics: Actinomycetales Infections; Adult; Bacteremia; Blood; Brain; Cerebral Hemorrhage; Colitis, Ulcerative; Fatal Outcome; Humans; Male; Mobiluncus; Radiography
PubMed: 18242106
DOI: 10.1016/j.anaerobe.2007.12.003 -
The Journal of Infection Sep 1998We present the case of a 54-year-old female with life-threatening septicaemia due to Mobiluncus curtisii subsp. curtisii. Her admission was complicated by septic shock,... (Review)
Review
We present the case of a 54-year-old female with life-threatening septicaemia due to Mobiluncus curtisii subsp. curtisii. Her admission was complicated by septic shock, renal failure, disseminated intravascular coagulation, the adult respiratory distress syndrome and spontaneous splenic rupture. The patient survived with full intensive care support and intravenous ceftriaxone. Extra-genital infection with Mobiluncus species is rarely diagnosed and has been confined to breast abscesses and non-life-threatening bacteraemia. A review of extra-genital infections with Mobiluncus species is presented.
Topics: Bacteroidaceae Infections; Female; Humans; Middle Aged; Mobiluncus; Multiple Organ Failure; Respiratory Distress Syndrome; Sepsis
PubMed: 9821100
DOI: 10.1016/s0163-4453(98)80180-1 -
APMIS : Acta Pathologica,... Nov 1991Mobiluncus is an anaerobic motile rod associated with bacterial vaginosis. In this work, luminol-enhanced chemiluminescence was used to study the ability of Mobiluncus...
Mobiluncus is an anaerobic motile rod associated with bacterial vaginosis. In this work, luminol-enhanced chemiluminescence was used to study the ability of Mobiluncus spp. from the vaginas of women with bacterial vaginosis to induce, in the presence of normal adult serum, oxidative metabolism of polymorphonuclear leukocytes, which is an indirect measure of phagocytic activity. M. curtisii induced a significantly (p less than 0.05) lower response than M. mulieris, which indicates that M. curtisii escapes phagocytosis more easily. Indirect immunofluorescence assays showed IgG antibodies to M. curtisii at significantly (p less than 0.01) higher titres than to M. mulieris in women with bacterial vaginosis. The titres were higher in patients with bacterial vaginosis than in women without vaginosis and healthy men. No antibodies to Mobiluncus spp. of secretory IgA type were found in vaginal washings. These results indicate that M. curtisii is a more virulent species than M. mulieris, and agree with reports of M. curtisii found in postoperative and extragenital infections.
Topics: Adult; Antibodies, Bacterial; Antigens, Bacterial; Bacteria, Anaerobic; Female; Fluorescent Antibody Technique; Humans; Luminescent Measurements; Male; Neutrophils; Phagocytosis; Reference Values; Vaginosis, Bacterial
PubMed: 1958349
DOI: No ID Found -
Diagnostic Microbiology and Infectious... Nov 1994Mobiluncus species are uncommonly isolated from nongenital sites. We report a case of abdominal abscess with associated Mobiluncus mulieris bacteremia and review the... (Review)
Review
Mobiluncus species are uncommonly isolated from nongenital sites. We report a case of abdominal abscess with associated Mobiluncus mulieris bacteremia and review the literature on extragenital infections due to Mobiluncus species.
Topics: Bacteroidaceae Infections; Diabetic Ketoacidosis; Female; Humans; Middle Aged; Mobiluncus
PubMed: 7874884
DOI: 10.1016/0732-8893(94)90111-2 -
Frontiers in Cellular and Infection... 2021The cervicovaginal microbiome plays an important role in protecting women from dysbiosis and infection caused by pathogenic microorganisms. In healthy reproductive-age...
The cervicovaginal microbiome plays an important role in protecting women from dysbiosis and infection caused by pathogenic microorganisms. In healthy reproductive-age women the cervicovaginal microbiome is predominantly colonized by protective spp. The loss of these protective bacteria leads to colonization of the cervicovaginal microenvironment by pathogenic microorganisms resulting in dysbiosis and bacterial vaginosis (BV). and sp. are two of the many anaerobes that can contribute to BV, a condition associated with multiple adverse obstetric and gynecological outcomes. has been linked to high Nugent scores (relating to BV morphotypes) and preterm birth (PTB), whilst some bacterial members of the family are highly prevalent in BV, and identified in ~85-95% of cases. The functional impact of and sp. in BV is still poorly understood. To determine the individual immunometabolic contributions of sp. and within the cervicovaginal microenvironment, we utilized our well-characterized human three-dimensional (3-D) cervical epithelial cell model in combination with multiplex immunoassays and global untargeted metabolomics approaches to identify key immune mediators and metabolites related to and sp. infections. We found that infection with significantly elevated multiple proinflammatory markers (IL-6, IL-8, TNF-α and MCP-1) and altered metabolites related to energy metabolism (nicotinamide and succinate) and oxidative stress (cysteinylglycine, cysteinylglycine disulfide and 2-hydroxygluatrate). sp. infection significantly elevated multiple sphingolipids and glycerolipids related to epithelial barrier function, and biogenic amines (putrescine and cadaverine) associated with elevated vaginal pH, vaginal amine odor and vaginal discharge. Our study elucidated that elevated multiple proinflammatory markers relating to PTB and STI acquisition, as well as altered energy metabolism and oxidative stress, whilst sp. upregulated multiple biogenic amines associated with the clinical diagnostic criteria of BV. Future studies are needed to evaluate how these bacteria interact with other BV-associated bacteria within the cervicovaginal microenvironment.
Topics: Female; Humans; Infant, Newborn; Microbiota; Mobiluncus; Pregnancy; Premature Birth; Vagina; Vaginosis, Bacterial
PubMed: 35004344
DOI: 10.3389/fcimb.2021.759697 -
Antimicrobial Agents and Chemotherapy Jul 2020Here, the antimicrobial susceptibility, resistance mechanisms, and clonality of sp. isolates recovered from gynecological outpatients in China were investigated....
Here, the antimicrobial susceptibility, resistance mechanisms, and clonality of sp. isolates recovered from gynecological outpatients in China were investigated. Compared to , exhibited higher antimicrobial resistance to metronidazole, clindamycin, and tetracycline. Whole-genome sequencing indicated that the clindamycin resistance gene (X) was located on a transposable element, Tn, which was composed of two IS sequences. Phylogenetic analysis indicated that spp. had high diversity, with isolates being grouped into several sporadic clades.
Topics: Anti-Bacterial Agents; China; Clindamycin; Microbial Sensitivity Tests; Mobiluncus; Phylogeny
PubMed: 32513795
DOI: 10.1128/AAC.00780-20 -
The Journal of Reproductive Medicine Oct 1991Vaginitis is a prevalent disorder requiring a thorough understanding by primary care physicians. An in-depth understanding of candidiasis, trichomoniasis and bacterial... (Review)
Review
Vaginitis is a prevalent disorder requiring a thorough understanding by primary care physicians. An in-depth understanding of candidiasis, trichomoniasis and bacterial vaginosis provides the basis for effective treatment. An accurate initial diagnosis is needed in the evaluation of recurrent, chronic vaginitis. A simple office evaluation is usually sufficient and should include a careful microscopic evaluation of the vaginal secretions for hyphae, budding yeast forms, clue cells, trichomonads and Lactobacillus forms; a quantitative assessment of the white blood cells and non-Lactobacillus organisms; and an assessment of the presence of the newly described Mobiluncus species. Assessing the vaginal pH is also important in the evaluation. Vaginal cultures are necessary when the microscopic evaluation does not provide a clear etiology.
Topics: Adult; Female; Humans; Vagina; Vaginitis
PubMed: 1956016
DOI: No ID Found -
Acta Obstetricia Et Gynecologica... 1989Women attending our Department for a first-trimester abortion were examined for the presence of Mobiluncus species. C. trachomatis or clue cells in vaginal discharge in...
Women attending our Department for a first-trimester abortion were examined for the presence of Mobiluncus species. C. trachomatis or clue cells in vaginal discharge in an attempt to identify risk groups for development of pelvic inflammatory disease (PID) after first-trimester abortion. A correlation was found between the presence of Mobiluncus and clue cells in vaginal discharge and the incidence of PID after first-trimester abortions. These women were also older than those in whom C. trachomatis was identified. Our study indicates that screening for C. trachomatis and clue cells in vaginal discharge will identify two different risk groups for developing PID after first-trimester abortion.
Topics: Abortion, Induced; Bacteria, Anaerobic; Chlamydia trachomatis; Female; Humans; Leukorrhea; Pelvic Inflammatory Disease; Pregnancy; Pregnancy Trimester, First; Prognosis; Risk Factors; Vaginal Smears
PubMed: 2618604
DOI: 10.3109/00016348909020992