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International Journal of Molecular... Nov 2023The integration of molecular approaches in medicine allows for a more precise understanding of the mechanisms underlying infectious diseases, paving the way for targeted...
The integration of molecular approaches in medicine allows for a more precise understanding of the mechanisms underlying infectious diseases, paving the way for targeted therapies, personalized medicine, and the development of new diagnostic tools [...].
Topics: Humans; Molecular Medicine; Precision Medicine; Communicable Diseases
PubMed: 37958882
DOI: 10.3390/ijms242115899 -
Diagnostic Cytopathology Jan 2023In the era of personalized medicine, molecular testing plays a critical role in patient care. The rapid advance of molecular techniques, especially next-generation...
In the era of personalized medicine, molecular testing plays a critical role in patient care. The rapid advance of molecular techniques, especially next-generation sequencing, makes molecular diagnosis feasible in daily practice. Molecular testing can be used as a valuable ancillary test to increase diagnostic sensitivity and specificity, especially in small biopsy or cytology samples. In addition, molecular testing plays an important role in selecting patients for appropriate treatment by detecting therapeutic and predictive biomarkers in tissue or cytology samples. Molecular studies can be applied in all cytology samples, sometimes with better results than histology. As molecular testing has become essential for patient care and is often requested to be performed in cytology samples, it is critical for cytopathologists to understand the basics of molecular diagnostic methods, indications for molecular testing, and how to best utilize different cytologic samples for this purpose. In this special issue, experts in various areas of cytopathology and molecular pathology review the literature and discuss the basics of molecular techniques and the application of molecular testing in various types of cytology samples. It is our hope that after reading the articles in this special issue, the readers can know better about the possibilities of molecular cytology, a very exciting field of pathology.
Topics: Humans; Pathology, Molecular; Molecular Diagnostic Techniques
PubMed: 36367273
DOI: 10.1002/dc.25071 -
Clinical and Translational Medicine Mar 2021
Topics: Diagnostic Imaging; Humans; Molecular Imaging; Molecular Medicine; Spatio-Temporal Analysis
PubMed: 33784006
DOI: 10.1002/ctm2.347 -
International Journal of Molecular... Oct 2023The significant progress we have recently observed in the field of gastroenterology, both in the understanding of pathophysiological mechanisms and in the diagnosis and...
The significant progress we have recently observed in the field of gastroenterology, both in the understanding of pathophysiological mechanisms and in the diagnosis and treatment of diseases, is closely related to the improvement and discovery of new biomolecular techniques [...].
Topics: Gastroenterology; Molecular Medicine
PubMed: 37834355
DOI: 10.3390/ijms241914907 -
Advances in Cancer Research 2023Head and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers... (Review)
Review
Head and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). The TME consists of different subsets of immune cells that infiltrate the tumors and interact with the tumor cells or with each other. Understanding multiple pivotal factors in HNSCC tumorigenesis and tumor progression may help define novel targets and develop more effective therapies for patients. This review provides a comprehensive overview of the latest advances in the molecular biology of HNSCC and their effects on clinical oncology; it is meant for a broad readership in the head and neck cancers field.
Topics: Humans; Molecular Medicine; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Immunotherapy; Combined Modality Therapy; Tumor Microenvironment
PubMed: 37704289
DOI: 10.1016/bs.acr.2023.03.004 -
PloS One 2022Over the past two decades, graduate programs have sought to meet the rising need for cross-disciplinary biomedical and translational research training; however, among...
Over the past two decades, graduate programs have sought to meet the rising need for cross-disciplinary biomedical and translational research training; however, among program evaluation efforts, little is known about student satisfaction with these programs. We report survey results aimed at assessing the overall satisfaction of Molecular Medicine (MolMed) PhD program graduates with their training program and subsequent employment, their research productivity since graduation, and the program elements important for entering their diverse career choices. The survey consisted of quantitative and qualitative instruments and was deployed in June 2020 via email to 45 alumni who had graduated at least two years prior. Investigators assessed mean and median Likert scale data and they conducted a qualitative content analysis on all open-ended narrative survey data using inductive analysis to identify themes. Of the 45 contacted, 26 PhD graduates of the MolMed program responded to the survey. Overall, graduates felt the MolMed curriculum prepared them well for their current career (mean 3.4 out a 4-point Likert scale); and, knowing what they know now, they would likely pursue a PhD degree again (mean 3.7 out of 4). Four overarching themes emerged from the content analysis of the narrative survey data: curriculum and other training experiences; professional skills; importance of a strong advisor/mentor; and, networking and career development. Overall, alumni were satisfied with their MolMed Program experience. They found the curriculum to be strong and relevant, and they believed that it prepared them well for their careers. There may be opportunities to embed additional skills into the curriculum, and the program should continue to offer a strong mentoring and clinical experience, as well as train students for diverse career trajectories.
Topics: Humans; Molecular Medicine; Career Choice; Occupations; Curriculum; Mentors
PubMed: 36395255
DOI: 10.1371/journal.pone.0275996 -
Neuro-oncology Oct 2023
Topics: Humans; Precision Medicine; Pathology, Molecular; Neoplasms; Medical Oncology; Glioma
PubMed: 37503808
DOI: 10.1093/neuonc/noad132 -
Biological Chemistry Jun 2015
Topics: Animals; Humans; Molecular Medicine; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingolipids
PubMed: 25910400
DOI: 10.1515/hsz-2015-0163 -
The Journal of Molecular Diagnostics :... May 2022Developments in genomics are profoundly influencing medical practice. With increasing use of genetic and genomic testing across every aspect of the health care... (Review)
Review
Molecular Pathology Education: A Suggested Framework for Primary Care Resident Training in Genomic Medicine: A Report of the Association for Molecular Pathology Training and Education Committee.
Developments in genomics are profoundly influencing medical practice. With increasing use of genetic and genomic testing across every aspect of the health care continuum, patients and their families are increasingly turning to primary care physicians (PCPs) for discussion and advice regarding tests, implications, and results. Yet, with the rapid growth of information, technology, and applications, PCPs are finding it challenging to fill the gaps in knowledge and support the growing needs of their patients. A critical component in expanding PCP genomic literacy lies in the education of physicians in training and in practice. Although a framework for developing physician competencies in genomics has already been developed, the Association for Molecular Pathology is uniquely situated to actively utilize the skills of its members to engage and support PCPs in this effort. This report provides an overview and a suggested basic teaching framework, which can be used by molecular professionals in their individual institutions as a starting point for educational outreach.
Topics: Curriculum; Genomic Medicine; Humans; Pathology, Molecular; Primary Health Care
PubMed: 35304347
DOI: 10.1016/j.jmoldx.2021.12.013 -
The Journal of Thoracic and... Jul 2017
Topics: Humans; Molecular Medicine; Religion and Medicine; Reperfusion Injury; Transplantation, Autologous
PubMed: 28457535
DOI: 10.1016/j.jtcvs.2017.03.074