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The Lancet. Oncology Dec 2017
Topics: Europe; Female; Guidelines as Topic; Humans; Male; Medical Oncology; Molecular Medicine; Neoplasms; Precision Medicine; Societies, Medical
PubMed: 29153736
DOI: 10.1016/S1470-2045(17)30865-3 -
Briefings in Bioinformatics Sep 2013Today, Bioinformatics has become a scientific discipline with great relevance for the Molecular Biosciences and for the Omics sciences in general. Although developed... (Review)
Review
Today, Bioinformatics has become a scientific discipline with great relevance for the Molecular Biosciences and for the Omics sciences in general. Although developed countries have progressed with large strides in Bioinformatics education and research, in other regions, such as Central America, the advances have occurred in a gradual way and with little support from the Academia, either at the undergraduate or graduate level. To address this problem, the University of Costa Rica's Medical School, a regional leader in Bioinformatics in Central America, has been conducting a series of Bioinformatics workshops, seminars and courses, leading to the creation of the region's first Bioinformatics Master's Degree. The recent creation of the Central American Bioinformatics Network (BioCANET), associated to the deployment of a supporting computational infrastructure (HPC Cluster) devoted to provide computing support for Molecular Biology in the region, is providing a foundational stone for the development of Bioinformatics in the area. Central American bioinformaticians have participated in the creation of as well as co-founded the Iberoamerican Bioinformatics Society (SOIBIO). In this article, we review the most recent activities in education and research in Bioinformatics from several regional institutions. These activities have resulted in further advances for Molecular Medicine, Agriculture and Biodiversity research in Costa Rica and the rest of the Central American countries. Finally, we provide summary information on the first Central America Bioinformatics International Congress, as well as the creation of the first Bioinformatics company (Indromics Bioinformatics), spin-off the Academy in Central America and the Caribbean.
Topics: Agriculture; Animals; Biodiversity; Central America; Computational Biology; Costa Rica; Education, Graduate; Humans; Internet; Molecular Medicine; Societies, Scientific
PubMed: 23723382
DOI: 10.1093/bib/bbt033 -
Trends in Molecular Medicine Sep 2021
Topics: Humans; Molecular Medicine
PubMed: 34340934
DOI: 10.1016/j.molmed.2021.07.005 -
Trends in Molecular Medicine Jul 2021
Topics: Hematologic Neoplasms; Humans; Molecular Medicine; Regenerative Medicine; Translational Research, Biomedical
PubMed: 34052117
DOI: 10.1016/j.molmed.2021.05.002 -
Trends in Molecular Medicine Nov 2021
Topics: Humans; Molecular Medicine
PubMed: 34625337
DOI: 10.1016/j.molmed.2021.09.001 -
Clinics in Laboratory Medicine Jun 2018Molecular pathology techniques continue to evolve. Although polymerase chain reaction (PCR) remains the cornerstone methodology for nucleic acid amplification,... (Review)
Review
Molecular pathology techniques continue to evolve. Although polymerase chain reaction (PCR) remains the cornerstone methodology for nucleic acid amplification, improvements in nucleic acid detection methodologies (i.e. PCR) have increased the detection sensitivity by using fluorescent and bead based array technologies. Single base pair lesions can be detected via sequencing and related techniques to discern point mutations in disease pathogenesis. Novel technologies, such as high- resolution melting analysis, provide fast high throughput post PCR analysis of genetic mutations or variance in nucleic acid sequences. These and other technologies such as hybrid capture, fluorohore and chemiluminescence detections assays allow for rapid diagnosis and prognosis for expeditious and personalized patient management.
Topics: Communicable Diseases; Humans; Mass Spectrometry; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Pathology, Molecular
PubMed: 29776628
DOI: 10.1016/j.cll.2018.03.004 -
Current Molecular Medicine 2014
Topics: Biomedical Research; Humans; Molecular Medicine; Pharmacogenetics; Precision Medicine
PubMed: 25109800
DOI: 10.2174/1566524014666140811122704 -
Trends in Ecology & Evolution May 2020Pollinators have been declining worldwide, and pesticides have contributed to these declines. High-resolution approaches from molecular medicine can provide unparalleled...
Pollinators have been declining worldwide, and pesticides have contributed to these declines. High-resolution approaches from molecular medicine can provide unparalleled insight into organismal physiology and health. Applying these approaches to pollinators can significantly improve the efficiency and sensitivity of pesticide research and evaluation, and thus the sustainability of modern agriculture.
Topics: Agriculture; Molecular Medicine; Pesticides
PubMed: 32294420
DOI: 10.1016/j.tree.2019.12.012 -
Journal of Graduate Medical Education Feb 2020Medical innovation depends on translation, the process of applying clinical insights to solve biological problems, and vice versa, yet existing training programs provide...
BACKGROUND
Medical innovation depends on translation, the process of applying clinical insights to solve biological problems, and vice versa, yet existing training programs provide few opportunities for physician-scientists to integrate their clinical and research training.
OBJECTIVE
We developed and determined the feasibility and acceptability of a rotation on the Molecular Medicine Investigation Unit (MMIU), a novel program that engages trainees in the deliberate linkage of patient care and scientific inquiry to cultivate their interest and skills in translation.
METHODS
Between July 2017 and January 2019, fourth-year medical students and internal medicine residents were offered a 4-week elective rotation on the MMIU. Supervised by 2 part-time faculty, trainees evaluated patients with unusual and perplexing presentations with the goal of generating hypotheses and a research plan to elucidate the underlying mechanisms of disease. We tracked the development of research hypotheses and resulting projects and surveyed participants about their satisfaction with the program.
RESULTS
Over 18 months, 21 trainees (11 medical students and 10 residents) participated in the program and evaluated a total of 70 patients. Trainees generated a mechanistic hypothesis in 45 (64%) cases, and this resulted in a patient-centered research project in 38 (54%) cases. Trainees unanimously agreed that the program gave them an opportunity to integrate their clinical and research training, and many expressed that it reinforced their interests in translational research.
CONCLUSIONS
With modest funding support, it was feasible to deliver authentic experiences of translational inquiry for medical students and internal medical residents, and these experiences were valued by trainees.
Topics: Attitude of Health Personnel; Education, Medical, Undergraduate; Humans; Internship and Residency; Laboratory Personnel; Molecular Medicine; Physicians; Program Evaluation; Research; Research Personnel; San Francisco; Students, Medical
PubMed: 32089799
DOI: 10.4300/JGME-D-19-00507.1 -
Acta Paediatrica (Oslo, Norway : 1992) Jul 2023
Topics: Child; Humans; Lung; Pathology, Molecular; Polymerase Chain Reaction; Lung Diseases
PubMed: 37102398
DOI: 10.1111/apa.16797