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The Journal of Pediatrics Sep 2020
Topics: Alopecia; Child, Preschool; Hair; Humans; Male; Monilethrix
PubMed: 32446725
DOI: 10.1016/j.jpeds.2020.05.024 -
CMAJ : Canadian Medical Association... Jul 2018
Topics: Alopecia; Child, Preschool; Dermoscopy; Female; Hair; Humans; Monilethrix
PubMed: 30061326
DOI: 10.1503/cmaj.180273 -
Journal of the American Academy of... Mar 2021Although topical minoxidil is an effective treatment option for hair loss, many patients are poorly compliant because of the necessity to apply the medication twice a... (Review)
Review
BACKGROUND
Although topical minoxidil is an effective treatment option for hair loss, many patients are poorly compliant because of the necessity to apply the medication twice a day, undesirable hair texture, and scalp irritation.
OBJECTIVE
In recent years, oral minoxidil at low dose has been proposed as a safe alternative. This study reviewed articles in which oral minoxidil was used to treat hair loss to determine its efficacy and safety as an alternative to topical minoxidil.
METHODS
PubMed searches were performed to identify articles discussing oral minoxidil as the primary form of treatment for hair loss published up to April 2020.
RESULTS
A total of 17 studies with 634 patients were found discussing the use of oral minoxidil as the primary treatment modality for hair loss. Androgenetic alopecia was the most studied condition, but other conditions included telogen effluvium, lichen planopilaris, loose anagen hair syndrome, monilethrix, alopecia areata, and permanent chemotherapy-induced alopecia.
LIMITATIONS
Larger randomized studies comparing the efficacy/safety of different doses with standardized objective measurements will be needed to clarify the best treatment protocol.
CONCLUSION
Oral minoxidil was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.
Topics: Administration, Oral; Alopecia; Drug Administration Schedule; Humans; Medication Adherence; Minoxidil; Treatment Outcome
PubMed: 32622136
DOI: 10.1016/j.jaad.2020.06.1009 -
Journal of Cytology 2022
PubMed: 36605870
DOI: 10.4103/joc.joc_25_22 -
International Journal of Trichology Oct 2013
PubMed: 24778539
DOI: 10.4103/0974-7753.130423 -
The Journal of Pediatrics Dec 2012
Topics: Child; Female; Humans; Monilethrix
PubMed: 22884362
DOI: 10.1016/j.jpeds.2012.06.033 -
Journal of Structural Biology Mar 2021Utilising the AFM nanoindentation technique for the study of hair cross- and longitudinal sections, the mechanical anisotropy of human hair fibres affected by a rare...
Utilising the AFM nanoindentation technique for the study of hair cross- and longitudinal sections, the mechanical anisotropy of human hair fibres affected by a rare congenital condition, Monilethrix, has been investigated for the first time. Supported by X-ray microdiffraction data, and applying a model based on an ideal composite material consisting of rods (KIFs) and matrix (KAPs) to Monilethrix affected fibres, it has been shown that the results could be grouped into clearly different classes, namely: almost isotropic behaviour for Monilethrix affected hairs and anisotropic behaviour for Control hair. Moreover, AFM nanoindentation of hair cross sections has demonstrated, also for the first time that hairs affected by Monilethrix have a continuous, and not periodic, weakness within the cortex. This has been attributed to disruptions in the KIF-KIF, KIF-intermacrofibrillar matrix or KIF-desmosome complexes within the hair shaft, as suggested by X-ray microdiffraction examination. Hairs from a patient exhibiting no obvious phenotype exhibited similar mechanical weakness despite the otherwise normal visual appearance of the fibre. This further supports a hypothesis that the beaded appearance of Monilethrix hair is a secondary factor, unrelated to the inherent structural weakness.
Topics: Hair; Humans; Monilethrix; Phenotype; X-Rays
PubMed: 33309724
DOI: 10.1016/j.jsb.2020.107679 -
Proceedings of the Royal Society of... Jun 1929
PubMed: 19987037
DOI: No ID Found -
The Ulster Medical Journal Nov 1956
Topics: Hair; Hair Diseases; Humans; Monilethrix
PubMed: 13401564
DOI: No ID Found