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Nihon Ketsueki Gakkai Zasshi : Journal... Feb 1976
Topics: Bencyclane; Blood Platelets; Cyclic AMP; Cycloheptanes; Humans; In Vitro Techniques; Mopidamol; Platelet Aggregation; Pyrimidines; Serotonin; Vasodilator Agents
PubMed: 183446
DOI: No ID Found -
Journal of Medicine 1987Red cell deformability was found to be impaired in SS- and SC-genotype and to a lesser extent SA-genotype red blood cells as compared with those of AA-genotype. RA-233...
Studies on the vasoocclusive crisis of sickle cell disease. III. In vitro and in vivo effect of the pyrimido-pyrimidine derivative, RA-233: studies on its mechanism of action.
Red cell deformability was found to be impaired in SS- and SC-genotype and to a lesser extent SA-genotype red blood cells as compared with those of AA-genotype. RA-233 in vitro improved deformability according to a bell-shaped dose-response curve. RA-233 also prevented experimental vasoocclusive crisis in Macaca arctoides. Deoxygenation of SS-genotype red cells resulted in sickle shape transformation, ATP depletion, potassium efflux, and attachment of hemoglobin molecules to the membrane. These changes were prevented by RA-233. Suspending SS-genotype red blood cells in potassium rich tris-buffer also prevented potassium efflux during deoxygenation and also decreased cellular deformability. RA-233 had no effect on osmotic fragility of SS-genotype red blood cells.
Topics: Adult; Anemia, Sickle Cell; Animals; Antisickling Agents; Child; Child, Preschool; Erythrocyte Deformability; Female; Genotype; Humans; Macaca; Male; Mopidamol; Osmotic Fragility; Platelet Aggregation; Potassium; Pyrimidines
PubMed: 3480932
DOI: No ID Found -
Life Sciences Nov 1975
Relative potencies of dipyridamole and related agents as inhibitors of cyclic nucleotide phosphodiesterases: possible explanation of mechansim of inhibition of platelet function.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Blood Platelets; Cyclic GMP; Dipyridamole; Humans; Mopidamol; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Adhesiveness; Platelet Aggregation; Pyrimidines
PubMed: 173959
DOI: 10.1016/0024-3205(75)90170-8 -
Neoplasma 1986In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice... (Comparative Study)
Comparative Study
In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline). Flurbiprofen decreased significantly spontaneous metastases formation in a dose-depending manner. From the results obtained, it appears that the treatment with flurbiprofen, either on days 1-8 or days 1-21, was similarly effective. In mopidamole treated groups the number of animals with lung metastases was significantly decreased. This effect was not observed after treatment with dipyridamole or pentoxifylline.
Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mopidamol; Neoplasm Metastasis; Pentoxifylline; Platelet Aggregation; Propionates; Pyrimidines; Theobromine
PubMed: 3762804
DOI: No ID Found -
Progress in Clinical and Biological... 1982
Topics: Animals; Blood Platelets; Female; Humans; Male; Mice; Mopidamol; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Neoplastic Cells, Circulating; Pentoxifylline; Platelet Aggregation; Pyrimidines; Rats; Transplantation, Heterologous
PubMed: 7111311
DOI: No ID Found -
[Rinsho Ketsueki] the Japanese Journal... Apr 1975
Topics: Anti-Inflammatory Agents; Bencyclane; Blood Platelets; Halofenate; Humans; Imipramine; In Vitro Techniques; Mopidamol; Platelet Adhesiveness; Platelet Aggregation; Thrombelastography
PubMed: 1170359
DOI: No ID Found -
Die Medizinische Welt Jan 1976
Comparative Study
Topics: Animals; Blood Coagulation; Carcinoma 256, Walker; Dipyridamole; Dose-Response Relationship, Drug; Ketones; Mopidamol; Neoplastic Cells, Circulating; Rats; Surface Properties; Xanthines
PubMed: 1250120
DOI: No ID Found