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Journal of Stomatology, Oral and... Dec 2020Mucoepidermoid Carcinoma (MEC) is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. A review of the literature was... (Review)
Review
OBJECTIVE
Mucoepidermoid Carcinoma (MEC) is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. A review of the literature was conducted in order to determine trends in presentation, diagnostic features, treatment, and outcomes.
METHODS
A PubMed, Embase, and Scopus search was carried out. The search process was performed by 2 independent reviewing authors and inclusion criteria included systematic reviews, meta-analyses, case-controls studies, cohort studies, comparative studies, clinical trials, cross-sectional studies, descriptive studies, experimental studies, case reports, case series studies, and human studies evaluating MEC.
RESULTS
Females were more affected (54.5%) and the average age was 48.8 years. The most common location of MEC was the parotid glands (56.8%) followed by hard palate (18%). The most frequent clinical presentation was mass (65.2%) followed by ulcer (29.4%) with pressure as their main symptom (64.4%). The most frequent histologic presentation was Low grade (46.7%) followed by Intermediate grade (27.3%) and the most used treatment was surgery (76.2%). The average follow up was 138.5months, and recurrence was reported at 8.5%.
CONCLUSION
MEC showed a strong predilection for the parotid glands is frequently painful, most frequently presents as a mass and most commonly has a low-grade histologic presentation.
Topics: Carcinoma, Mucoepidermoid; Cross-Sectional Studies; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Parotid Gland; Salivary Gland Neoplasms
PubMed: 32565266
DOI: 10.1016/j.jormas.2020.06.003 -
Mayo Clinic Proceedings Sep 2023
Topics: Humans; Carcinoma, Mucoepidermoid
PubMed: 37661153
DOI: 10.1016/j.mayocp.2023.07.018 -
Expert Review of Respiratory Medicine Mar 2018Primary mucoepidermoid carcinomas (MEC) of the lung are rare and represent a diagnostic challenge. MEC in the lung is under the umbrella of primary salivary gland type... (Review)
Review
Primary mucoepidermoid carcinomas (MEC) of the lung are rare and represent a diagnostic challenge. MEC in the lung is under the umbrella of primary salivary gland type tumors of the lung. Areas covered: In general, salivary gland type tumors are represented by malignant neoplasms that may range from low to intermediate to high-grade type of malignancy sharing similar histopathological features as those in salivary glands. The focus in this review will be on one tumor in particular - mucoepidermoid carcinoma. Clinical, radiological, histopathological, and molecular diagnostic features will be highlighted in order to provide an insight on this unusual tumor in the lung. In addition, the treatment of these tumors will be discussed. Expert commentary: It is important to stress that in the majority of cases, the proper use of histopathological assessment is the most important step in arriving at an accurate diagnosis. It is also important to recognized that there are other unusual primary tumoral conditions of the lung, which may pose a significant challenge in the differential diagnosis. The importance of proper recognition of mucoepidermoid carcinoma and its grading will be highlighted in order to assess clinical outcome.
Topics: Carcinoma, Mucoepidermoid; Diagnosis, Differential; Humans; Lung Neoplasms
PubMed: 29338644
DOI: 10.1080/17476348.2018.1428563 -
Radiology Oct 2022
Topics: Breast; Carcinoma, Mucoepidermoid; Humans
PubMed: 35787204
DOI: 10.1148/radiol.220128 -
Ophthalmic Plastic and Reconstructive...
Topics: Adolescent; Carcinoma, Mucoepidermoid; Eyelid Neoplasms; Eyelids; Humans
PubMed: 35561114
DOI: 10.1097/IOP.0000000000002083 -
European Archives of... Apr 2015Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are... (Review)
Review
Clinicopathological features, prognosis and therapeutic strategies for mucoepidermoid carcinoma originating in salivary and salivary-type glands of the head and neck are reviewed. We emphasise histopathological aspects, appraise the value of histochemistry, electron microscopy, immunohistochemistry and cytophotometry, and discuss histogenesis and characteristic gene translocations. We additionally consider possible diagnostic difficulties, problems related to histological grading and accuracy of existing literature, and areas of controversy or uncertainty which may benefit from further investigations.
Topics: Biopsy, Fine-Needle; Carcinoma, Mucoepidermoid; Disease Management; Head and Neck Neoplasms; Humans; Immunohistochemistry; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Salivary Gland Neoplasms
PubMed: 24771140
DOI: 10.1007/s00405-014-3053-z -
The Laryngoscope May 2018Identify the effect of patient characteristics, disease traits, and treatment modality on patient outcomes in the rare disease process of intraosseous mucoepidermoid... (Review)
Review
OBJECTIVE
Identify the effect of patient characteristics, disease traits, and treatment modality on patient outcomes in the rare disease process of intraosseous mucoepidermoid carcinoma.
STUDY DESIGN
Retrospective review of institutional case records and literature.
METHODS
This study includes one case report, a literature review of the MEDLINE database from 1950 through June 2017 using keywords "intraosseous" and "mucoepidermoid," and a query of the University of California, Los Angeles, Department of Pathology database for all documented cases of intraosseous mucoepidermoid carcinoma of the head and neck.
RESULTS
Indicators of poorer prognosis were male gender (P = 0.0071) and higher histological grade (P = 0.0095). Lesion site, size, association with odontogenic cyst, and treatment type did not have a statistically significant correlation with patient outcomes. There also was no statistically significant correlation observed between treatment modality and recurrent or progressive disease when stratified by histological grade of the cancer.
CONCLUSION
This study identified male gender and high histological tumor grade as poor prognostic indicators; however, it did not reveal a statistically significant relationship between treatment modality and patient outcomes. Data regarding patient outcomes following treatment was limited due to loss to follow-up, suggesting that further investigation is required. Based on this review, decisions regarding treatment should be clinically guided and individually tailored to the patient's baseline health, disease severity, and the patient's treatment goals. A multi-disciplinary conference, as was utilized in the presented case report, may be the best approach to treatment planning for these patients at this time.
LEVEL OF EVIDENCE
4. Laryngoscope, 128:1083-1092, 2018.
Topics: Aged; Carcinoma, Mucoepidermoid; Female; Head and Neck Neoplasms; Humans; Mandibular Neoplasms; Mandibular Reconstruction; Prognosis; Risk Factors
PubMed: 28833169
DOI: 10.1002/lary.26832 -
Journal of Cancer Research and... 2019A 58-year-old male presented with redness for 1 year and dimness of vision for 2 years in his left eye. Excision biopsy from an inferotemporal conjunctival mass revealed... (Review)
Review
A 58-year-old male presented with redness for 1 year and dimness of vision for 2 years in his left eye. Excision biopsy from an inferotemporal conjunctival mass revealed high-grade mucoepidermoid carcinoma (MEC) with lymphovascular invasion and positive margins. The tumor bed was irradiated to 80 Gy using strontium 90 β-applicator. After 13 months, fine-needle aspiration cytology from a suspicious preauricular lymphadenopathy found metastatic cells. Ipsilateral supra-omohyoid neck dissection showed three positive nodes out of 15, and the left neck was irradiated. He is disease free at present, 12 months from external beam radiation therapy completion. With 48 cases reported in the literature, conjunctival MEC remains a rare condition, possibly in part due to clinicopathological underdiagnosis. This is unfortunate, given that this cancer is more aggressive, has a poorer prognosis, and warrants more vigorous treatment than squamous cell carcinoma, which it may be misdiagnosed as in the absence of appropriate staining and pathological review.
Topics: Biopsy; Carcinoma, Mucoepidermoid; Combined Modality Therapy; Conjunctival Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Treatment Outcome
PubMed: 31169248
DOI: 10.4103/jcrt.JCRT_926_17 -
International Journal of Surgical... Oct 2020Mucoepidermoid carcinoma is one of the most common malignancies in salivary glands. In comparison, breast mucoepidermoid carcinoma is a very rare entity, with limited... (Review)
Review
Mucoepidermoid carcinoma is one of the most common malignancies in salivary glands. In comparison, breast mucoepidermoid carcinoma is a very rare entity, with limited reports and understanding of its clinical behaviors to date. In this article, we report a case of low-grade breast mucoepidermoid carcinoma of a 60-year-old female patient. Histologic and immunohistochemical patterns were demonstrated. Fluorescence in situ hybridization test was also conducted to identify rearrangement in this case, indicating a similar molecular abnormality as mucoepidermoid carcinoma in the salivary gland. Five-year follow-up of the patient showed no local recurrence or distant metastasis of the carcinoma, indicating the indolent behavior of low-grade breast mucoepidermoid carcinoma. Besides, a 40-year literature review from 1979 to 2019 was also performed to better characterize the prognosis and molecular abnormalities of the lesion.
Topics: Breast Neoplasms; Carcinoma, Mucoepidermoid; Female; Gene Rearrangement; Humans; Middle Aged; Trans-Activators
PubMed: 32362174
DOI: 10.1177/1066896920916779 -
Journal of Cranio-maxillo-facial... Jan 2018To integrate the available data published on central mucoepidermoid carcinoma (CMC) into a comprehensive analysis of its clinical aspects, histology, treatment, and... (Review)
Review
OBJECTIVE
To integrate the available data published on central mucoepidermoid carcinoma (CMC) into a comprehensive analysis of its clinical aspects, histology, treatment, and prognostic factors.
METHODS
An electronic search was undertaken in July 2017. Eligibility criteria for publications included having clinical, histological, treatment, and time of follow-up data to confirm the diagnosis.
RESULTS
In addition, gender, histological grade, conservative treatment, and lymph node metastasis were significant independent prognostic factors.
CONCLUSION
Male patients with histological grade III CMC of the jaw bone, who used conservative treatment as the main treatment, and presented with lymph node metastasis, were more likely to have a worse prognosis.
Topics: Adult; Carcinoma, Mucoepidermoid; Female; Humans; Jaw Neoplasms; Male; Prognosis
PubMed: 29198377
DOI: 10.1016/j.jcms.2017.10.020