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Deutsche Medizinische Wochenschrift... Mar 1958
Topics: Animals; Cyclophosphamide; Mechlorethamine; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats
PubMed: 13537667
DOI: 10.1055/s-0028-1114243 -
Science (New York, N.Y.) Mar 1965Uracil mustard, injected intraperitoneally, increased the incidence and average number of pulmonary tumors in A/J mice. In comparison to a typical alkylating agent,...
Uracil mustard, injected intraperitoneally, increased the incidence and average number of pulmonary tumors in A/J mice. In comparison to a typical alkylating agent, nitrogen mustard, or to urethan, uracil mustard (on a molar basis) was considerably more carcinogenic.
Topics: DNA; Lung Neoplasms; Mechlorethamine; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; RNA; Research; Toxicology; Uracil Mustard; Urethane
PubMed: 14268720
DOI: 10.1126/science.147.3664.1443 -
Journal Des Praticiens; Revue Generale... Mar 1951
Topics: Carcinoma; Mechlorethamine; Neoplasms; Neoplasms, Glandular and Epithelial; Nitrogen Mustard Compounds
PubMed: 14832803
DOI: No ID Found -
Annals of Surgery Mar 1953
Topics: Arteries; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds
PubMed: 13031467
DOI: 10.1097/00000658-195303000-00011 -
Cancer Research Oct 1957
Topics: Animals; Benzimidazoles; Mechlorethamine; Neoplasms, Experimental; Nitrogen Mustard Compounds
PubMed: 13472682
DOI: No ID Found -
Cancer Chemotherapy Reports Jan 1963
Topics: Data Collection; Mechlorethamine; Nitrogen Mustard Compounds
PubMed: 14015018
DOI: No ID Found -
Texas State Journal of Medicine Apr 1963
Topics: Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds
PubMed: 14026496
DOI: No ID Found -
Journal of Chromatography Jun 1970
Topics: Chromatography, Thin Layer; Glycosides; Mustard Compounds; Solvents
PubMed: 5426329
DOI: 10.1016/s0021-9673(00)93642-2 -
Acta Radiologica Apr 1953
Topics: Mechlorethamine; Nitrogen Mustard Compounds
PubMed: 13057641
DOI: 10.3109/00016925309136719 -
Bioconjugate Chemistry 2003Chlorambucil, an aromatic nitrogen mustard, has been conjugated to putrescine- and spermidine-based scaffolds bearing one, two, and four persulfated cholic acid units....
Chlorambucil, an aromatic nitrogen mustard, has been conjugated to putrescine- and spermidine-based scaffolds bearing one, two, and four persulfated cholic acid units. Those conjugates bearing two or four sterols show improved hydrolytic stability and water solubility relative to chlorambucil. A similar conjugate that contained only one sterol unit shows negligible improvement in hydrolytic stability but a significant increase in water solubility. Qualitatively, the hydrolytic stability within this series of conjugates parallels the shielding effects that have previously been found for related conjugates bearing a pendant, hydrophobic fluorescent probe. In vitro studies indicate that these conjugates possess modest to moderate activity against certain human lymphoblastic leukemia and human colon carcinoma cells.
Topics: Cell Line, Tumor; Chlorambucil; Drug Stability; Humans; Hydrolysis; Nitrogen Mustard Compounds; Solubility; Water
PubMed: 12757393
DOI: 10.1021/bc034007s