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Bioconjugate Chemistry 2003Chlorambucil, an aromatic nitrogen mustard, has been conjugated to putrescine- and spermidine-based scaffolds bearing one, two, and four persulfated cholic acid units....
Chlorambucil, an aromatic nitrogen mustard, has been conjugated to putrescine- and spermidine-based scaffolds bearing one, two, and four persulfated cholic acid units. Those conjugates bearing two or four sterols show improved hydrolytic stability and water solubility relative to chlorambucil. A similar conjugate that contained only one sterol unit shows negligible improvement in hydrolytic stability but a significant increase in water solubility. Qualitatively, the hydrolytic stability within this series of conjugates parallels the shielding effects that have previously been found for related conjugates bearing a pendant, hydrophobic fluorescent probe. In vitro studies indicate that these conjugates possess modest to moderate activity against certain human lymphoblastic leukemia and human colon carcinoma cells.
Topics: Cell Line, Tumor; Chlorambucil; Drug Stability; Humans; Hydrolysis; Nitrogen Mustard Compounds; Solubility; Water
PubMed: 12757393
DOI: 10.1021/bc034007s -
New York State Journal of Medicine May 1947
Topics: Ethylamines; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds
PubMed: 20295029
DOI: No ID Found -
Nature Aug 1951
Topics: Mechlorethamine; Nitrogen; Nitrogen Mustard Compounds; Proteins
PubMed: 14875068
DOI: 10.1038/168251b0 -
Acta Pathologica Et Microbiologica... 1950
Topics: Animals; Leukemia; Mechlorethamine; Mice; Mustard Gas; Nitrogen Mustard Compounds
PubMed: 15406238
DOI: 10.1111/j.1699-0463.1950.tb05187.x -
The Medical Journal of Australia Dec 1956
Topics: Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds
PubMed: 13386582
DOI: 10.5694/j.1326-5377.1956.tb57372.x -
Arzneimittel-Forschung Oct 1958
Topics: Chlorine; Mechlorethamine; Mustard Plant; Nitrogen Mustard Compounds
PubMed: 13607287
DOI: No ID Found -
The Journal of Experimental Zoology Oct 1946
Topics: Amphibians; Mechlorethamine; Nitrogen Mustard Compounds
PubMed: 20275389
DOI: 10.1002/jez.1401030102 -
Journal of the American Medical... Jun 1946
Topics: Gas Poisoning; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds
PubMed: 20984885
DOI: 10.1001/jama.1946.02870250010003 -
Neoplasma 1965
Topics: Animals; Cyclophosphamide; Mannitol; Mannomustine; Mechlorethamine; Neoplasm Transplantation; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Rats; Research; Sarcoma; Sarcoma, Yoshida; Thymine
PubMed: 14278323
DOI: No ID Found -
Cancer Research Jan 1947
Topics: Ethylamines; Mechlorethamine; Nitrogen Mustard Compounds
PubMed: 20278229
DOI: No ID Found