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Journal of Veterinary Diagnostic... Jan 2022Two aborted Chester White pig fetuses were presented to a veterinary diagnostic laboratory in Illinois. Postmortem examination identified no gross abnormalities....
Two aborted Chester White pig fetuses were presented to a veterinary diagnostic laboratory in Illinois. Postmortem examination identified no gross abnormalities. Histologic evaluation revealed multifocal necrosis of chorionic epithelial cells, coalescing areas of mineralization in the placenta, and focal accumulations of viable and degenerate neutrophils in the lung. Intra- and extracellular acid-fast bacilli were identified in the lesions in both the placenta and lungs. Bacterial culture of stomach contents yielded heavy growth of , a rapidly growing nontuberculous mycobacterium (NTM), which was further confirmed through whole-genome sequencing. NTM are opportunistic pathogens commonly found in the soil and in contaminated water supplies. In animals, is typically introduced through cutaneous wounds leading to infections limited to the skin, with systemic infection being uncommon. To our knowledge, abortion caused by has not been reported previously.
Topics: Animals; Calcinosis; Cell Count; Epithelial Cells; Female; Mycobacterium fortuitum; Nontuberculous Mycobacteria; Swine; Swine Diseases
PubMed: 34448422
DOI: 10.1177/10406387211042289 -
Pediatrics International : Official... Jan 2022
Topics: Candidiasis, Chronic Mucocutaneous; Humans; Mutation; Mycobacterium Infections; Mycobacterium fortuitum
PubMed: 35438220
DOI: 10.1111/ped.15166 -
Journal of Basic Microbiology Dec 2022The fatty acid biosynthesis pathway is crucial for the formation of the mycobacterial cell envelope. The fatty acid synthase type-II (FAS-II) components are attractive...
The fatty acid biosynthesis pathway is crucial for the formation of the mycobacterial cell envelope. The fatty acid synthase type-II (FAS-II) components are attractive targets for designing anti-biofilm inhibitors. Literature review, bioinformatics analysis, cloning, and sequencing led to the identification of a novel Mycobacterium fortuitum FAS-II gene MFfabG4 which interacts with mycobacterial proteins involved in biofilm formation. A manually curated M. fortuitum fatty acid biosynthesis pathway has been proposed exploiting functional studies from the Kyoto Encyclopedia of Genes and Genomes and Mycobrowser databases for MFFabG4. M. fortuitum MFfabG4 knockdown strain (FA) was constructed and validated by quantitative polymerase chain reaction. The FA strain displayed unstructured smooth colony architecture, correlating with decreased pathogenicity and virulence. MFfabG4 knockdown resulted in diminished pellicle and attenuated biofilm formation, along with impaired sliding motility, and reduced cell sedimentation. The FA strain showed lowered cell surface hydrophobicity, indicating attenuation in M. fortuitum intracellular infection-causing ability. Stress survival studies showed the requirement of MFfabG4 for survival in a nutrient-starved environment. The results indicate that MFfabG4 maintains the physiology of the cell envelope and is required for the formation of M. fortuitum pellicle and biofilm. The study corroborates the role of MFfabG4 as a pellicle- and biofilm-specific drug target and a potential diagnostic marker for M. fortuitum and related pathogenic mycobacteria.
Topics: Mycobacterium fortuitum; Biofilms; Virulence; Fatty Acids
PubMed: 35736669
DOI: 10.1002/jobm.202200230 -
Journal of Infection in Developing... Oct 2022Mycobacterium fortuitum infections of the musculoskeletal system are commonly missed, given their rarity and the absence of systemic symptoms. In this study, we isolated... (Review)
Review
Mycobacterium fortuitum infections of the musculoskeletal system are commonly missed, given their rarity and the absence of systemic symptoms. In this study, we isolated the M. fortuitum from the skin sinus tract of a traffic accident patient's right medial knee surgical incision (over the open fracture wound), and confirmed by Morphological analysis, MALDI-TOF MS, 16S rRNA gene sequencing, and mNGS. Then we adjusted the treatment plan and treated the patient with cefoxitin, amikacin, and doxycycline. At three months follow-up review, his wound had completely healed. This report may provide a reference for the clinical treatment of Mycobacterium fortuitum infection in patients with open fractures.
Topics: Humans; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Leg; RNA, Ribosomal, 16S; Amikacin; Mycobacterium Infections
PubMed: 36332221
DOI: 10.3855/jidc.16635 -
Canadian Family Physician Medecin de... Jan 2014
Review
Topics: Abscess; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Body Piercing; Breast Diseases; Debridement; Female; Humans; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Pregnancy; Pregnancy Complications, Infectious; Trimethoprim, Sulfamethoxazole Drug Combination; Wound Infection; Young Adult
PubMed: 24452562
DOI: No ID Found -
American Review of Tuberculosis Jul 1955
Topics: Humans; Mycobacterium; Mycobacterium fortuitum
PubMed: 14388208
DOI: 10.1164/artpd.1955.72.1.53 -
Microbiology Spectrum Aug 2023We evaluated the clinical characteristics and treatment outcomes of 35 patients diagnosed with Mycobacterium fortuitum-pulmonary disease (M. fortuitum-PD). Prior to...
We evaluated the clinical characteristics and treatment outcomes of 35 patients diagnosed with Mycobacterium fortuitum-pulmonary disease (M. fortuitum-PD). Prior to treatment, all isolates were sensitive to amikacin and 73% and 90% were sensitive to imipenem and moxifloxacin, respectively. Approximately two-thirds of the patients (24 of 35) remained stable without antibiotic treatment. Of 11 patients requiring antibiotic treatment, the majority (81%, 9 of 11) achieved a microbiological cure with susceptible antibiotics. Mycobacterium fortuitum (M. fortuitum) is a rapidly growing mycobacterium that causes M. fortuitum-pulmonary disease (PD). It is common among individuals with preexisting lung conditions. Limited data exist regarding treatment and prognosis. Our study examined patients with M. fortuitum-PD. Two-thirds of them remained stable without antibiotics. Among those requiring treatment, 81% achieved a microbiological cure with suitable antibiotics. In many cases, M. fortuitum-PD follows a stable course without antibiotics, and when necessary, a favorable treatment response can be achieved with the appropriate antibiotics.
Topics: Humans; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Anti-Bacterial Agents; Treatment Outcome; Microbial Sensitivity Tests; Lung Diseases
PubMed: 37428038
DOI: 10.1128/spectrum.02051-23 -
Travel Medicine and Infectious Disease 2021
Topics: Animals; Beloniformes; Diving; Humans; Mycobacterium Infections; Mycobacterium fortuitum
PubMed: 33831551
DOI: 10.1016/j.tmaid.2021.102056 -
Klinicheskaia Laboratornaia Diagnostika Apr 2021Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is... (Review)
Review
Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M. fortuitum group, as the main pathogens among the group of fast-growing mycobacteria. The data on the modern classification based on the use of molecular genetic studies are indicated. The M. fortuitum group includes: Mycobacterium fortuitum, M. peregrinum, M. senegalense, M. porcinum, M. houstonense, M. neworleansense, M. boenickei, M. conceptionense, M. septicum, M. alvei. According to the new data, mycobacteria were divided into 5 clades (Abscessus-Chelonae, Fortuitum-Vaccae, Terrae, Triviale, Tuberculosis-Simiae), and based on molecular genetic studies, new genera in the Mycobacteriaceae family were isolated: Mycolicibacter spp., Mycolicibacillus spp., Mycolicibacillus spp., Mycobacteroides spp., Mycolicibacterium spp. In accordance with the new classification, representatives of the Mycobacterium fortuitum group belong to the genus Mycolicibacterium. The main epidemiological features of the main sources of the spread of mycobacteria, factors and ways of their transmission are indicated. Due to their wide distribution in the environment, representatives of the M. fortuitum group are capable of causing diseases of the pulmonary and extrapulmonary localization. The distinctive features of pathogenicity factors, due to which the course of the disease is determined, are noted. The article also indicates the main difficulties and features of determining the sensitivity to antimicrobial chemotherapy drugs, provides data on the main features of antibiotic resistance of M.fortuitum group. In preparing the review, literature sources obtained from international and domestic databases were used: Scopus, Web of Science, Springer, RSCI.
Topics: Drug Resistance, Microbial; Humans; Mycobacterium; Mycobacterium Infections; Mycobacterium fortuitum; Nontuberculous Mycobacteria
PubMed: 33878244
DOI: 10.51620/0869-2084-2021-66-4-223-228 -
Italian Journal of Dermatology and... Dec 2022
Topics: Humans; Mycobacterium fortuitum; Hair Removal; Skin Diseases, Bacterial
PubMed: 36651205
DOI: 10.23736/S2784-8671.22.07206-1