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Journal of Clinical Pathology May 1965Myco. fortuitum was isolated from subcutaneous abscesses of two patients who had been inoculated with B.C.G. and one patient who had iron injections. The organisms were...
Myco. fortuitum was isolated from subcutaneous abscesses of two patients who had been inoculated with B.C.G. and one patient who had iron injections. The organisms were resistant to a wide range of anti-tuberculous drugs. They were highly virulent for mice in which they produced symptoms of spinning disease. It is thought that the infections originated from contamination of syringes or skin.
Topics: Abscess; Animals; BCG Vaccine; Culture Media; Drug Resistance; Drug Resistance, Microbial; Humans; Injections; Male; Mice; Mycobacterium; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous; Mycobacterium bovis; Mycobacterium fortuitum; Tuberculosis; Vaccination
PubMed: 14304242
DOI: 10.1136/jcp.18.3.307 -
The Journal of Arthroplasty Aug 2008Periprosthetic infections after total joint arthroplasty are infrequent but potentially devastating complications. Gram-positive bacteria is the typical causative... (Review)
Review
Periprosthetic infections after total joint arthroplasty are infrequent but potentially devastating complications. Gram-positive bacteria is the typical causative organism. However, uncommon sources such as Mycobacterium fortuitum have been documented in the literature. We report a case, the first to our knowledge, of bilateral infections involving this organism after total knee arthroplasty. M. fortuitum is notoriously resistant to many standard antibacterial medications, and a delay in initial diagnosis due to inadequate incubation time has been reported. In poor surgical candidates, long-term antibiotic suppression may be a viable alternative.
Topics: Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Knee; Humans; Knee Joint; Knee Prosthesis; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Prosthesis-Related Infections; Reoperation
PubMed: 18534520
DOI: 10.1016/j.arth.2007.07.010 -
The Indian Journal of Medical Research Mar 2001During a six week period in 1999, seven patients who underwent laparoscopic tubectomies at small town health centres near Chandigarh developed chronic discharging...
During a six week period in 1999, seven patients who underwent laparoscopic tubectomies at small town health centres near Chandigarh developed chronic discharging sinuses at the site of incision. Mycobacterium fortuitum was isolated from wound discharge of the five patients by standard methods and two patients were smear positive. Environmental samples e.g., tap water, and a variety of fluids did not yield any mycobacteria and swabs from different parts of the laparoscope were sterile. All patients responded to ciprofloxacin and amikacin therapy. Our observation demonstrates that M. fortuitum is a clinically important nosocomial pathogen in setting of surgical wound infection in our country.
Topics: Amikacin; Ciprofloxacin; Cross Infection; Humans; Laparoscopy; Mycobacterium Infections; Mycobacterium fortuitum; Surgical Wound Infection
PubMed: 11525156
DOI: No ID Found -
Indian Journal of Medical Microbiology 2010We report a case of dual nontuberculous mycobacterial infections complicating an open distal radius and ulna fracture after polytrauma in a 35-year-old man. There was... (Review)
Review
We report a case of dual nontuberculous mycobacterial infections complicating an open distal radius and ulna fracture after polytrauma in a 35-year-old man. There was persistent wound discharge after definitive fixation of this fracture, but microbiological cultures did not yield any organism. The patient underwent multiple debridement, and subsequent tissue grew Mycobacterium chelonae and Mycobacterium fortuitum. Despite appropriate chemotherapy and surgical debridement the infection persisted until radical bone excision and tissue debridement were done. This case indicates that nontuberculous mycobacterial infections should be considered when conventional microbiological assays fail to identify the infecting agent in suspected osteomyelitis following open fracture. A combination of radical debridement, including removal of infected bone, and prolonged antimicrobial therapy are required to eradicate the infection completely.
Topics: Adult; Anti-Infective Agents; Debridement; Fractures, Open; Humans; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium chelonae; Mycobacterium fortuitum; Radiography; Radius; Ulna
PubMed: 20644316
DOI: 10.4103/0255-0857.66488 -
Medicine Dec 2023Injection-related abscesses are a common complication in clinical practice, but the identification of infected bacteria might be difficult.
RATIONALE
Injection-related abscesses are a common complication in clinical practice, but the identification of infected bacteria might be difficult.
PATIENT CONCERNS
A 51-year-old female patient was admitted to the hospital due to a lump on her right buttock that emerged after receiving intramuscular injections to treat left shoulder joint pain. The lump gradually enlarged into a 3.0 to 4.5 cm mass at the time of admission with symptoms such as skin redness, itching, and pain.
DIAGNOSES
The patient received ultrasonic and other laboratory examinations. Laboratory results from the drainage indicated that the infection was caused by a rapidly growing mycobacteria and was confirmed as Mycobacterium fortuitum by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.
INTERVENTIONS
The patient was treated with antibiotics for 12 days after incision and drainage of the abscess in the right buttock. Local dressings were changed regularly. A migration lesion that appeared 3 days after treatment was drained and cleaned when it matured.
OUTCOMES
The lesion substantially decreased in size and the patient was discharged after 2 months of treatment.
LESSONS
Rapidly growing mycobacteria are rare but important pathogens that should be considered in patients with injection-related abscesses. Early identification and appropriate treatment can result in a favorable prognosis.
Topics: Humans; Female; Middle Aged; Mycobacterium fortuitum; Abscess; Mycobacterium Infections; Mycobacterium; Muscles; Pain; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
PubMed: 38050215
DOI: 10.1097/MD.0000000000036060 -
BMJ Case Reports Apr 2019We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt...
We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt revision surgeries. Eventually was isolated and the patient improved after specific treatment. is a rapidly growing, non-tuberculous mycobacterium (NTM). NTMs are associated with postsurgical, post-trauma and device-related infections. Most of the present-day surgical equipment, catheters, prostheses and indwelling devices comprised silicone, stainless steel, polyvinyl chloride and polycarbonate, on which NTMs have the tendency to form biofilms. Central nervous system infection caused by NTM carries a high mortality rate (ranging from 35% to 70%), especially in immune-compromised patients. Indwelling device removal along with prolonged treatment with a combination regimen is recommended in such cases.
Topics: Adolescent; Anti-Bacterial Agents; Central Nervous System Infections; Female; Humans; Immunocompetence; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Reoperation; Ventriculoperitoneal Shunt
PubMed: 30992281
DOI: 10.1136/bcr-2018-226900 -
Veterinary Pathology Mar 2015A 1-year old female spayed German Shepherd dog was evaluated for acute onset of dyspnea. Pyogranulomatous inflammation and green globoid structures were present on...
A 1-year old female spayed German Shepherd dog was evaluated for acute onset of dyspnea. Pyogranulomatous inflammation and green globoid structures were present on aspirates of the affected lung. Impression smears and histopathology confirmed pyogranulomatous pneumonia, with large amounts of lipid corresponding to the green structures noted cytologically, and identified poorly staining bacterial rods within lipid vacuoles. Special stains confirmed the presence of acid-fast bacterial rods, and polymerase chain reaction and DNA sequencing identified the organism as Mycobacterium fortuitum. M. fortuitum pneumonia is well described in humans and has previously been reported in 4 dogs and 1 cat. Lipid was a prominent cytologic and histologic feature, as is often described in humans and in the single feline case report. Additionally, this case highlights the variable cytologic appearance of lipid, as well as Mycobacterium spp, which are classically nonstaining with Wright-Giemsa.
Topics: Animals; Base Sequence; Dog Diseases; Dogs; Fatal Outcome; Female; Molecular Sequence Data; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Pneumonia, Lipid; Polymerase Chain Reaction; Sequence Analysis, DNA
PubMed: 24788402
DOI: 10.1177/0300985814531497 -
Biochemical and Biophysical Research... Jan 2020Mycobacterium fortuitum has emerged as a nosocomial infectious agent and biofilm formation attributed for the presence of this bacterium in hospital environment....
Mycobacterium fortuitum has emerged as a nosocomial infectious agent and biofilm formation attributed for the presence of this bacterium in hospital environment. Transposon random mutagenesis was used to identify membrane-proteins for biofilm formation in M. fortuitum. Ten mutants were shortlisted from a library of 450 mutants for examine their biofilm forming ability. Comparative biofilm ability with respect to wild type M. fortuitum ATCC 6841 showed an altered and delayed biofilm formation in one mutant namely, MT721. Sequence analysis revealed mutation in anthranilate phosphoribosyl transferase (MftrpD), which is associated with tryptophan operon. Functional interaction study of TrpD protein through STRING showed its interaction with chorismate utilizing proteins, majorly involved in synthesis of aromatic amino acid and folic acid, suggesting that biofilm establishment and maintenance requires components of central metabolism. Our study indicates important role of MftrpD in establishment and maintenance of biofilm by M. fortuitum, which may further be explored for drug discovery studies against mycobacterial infections.
Topics: Anthranilate Phosphoribosyltransferase; Bacterial Proteins; Biofilms; Chorismic Acid; DNA Transposable Elements; Mutagenesis, Insertional; Mutation; Mycobacterium fortuitum; Protein Interaction Mapping; Protein Structure, Secondary
PubMed: 31727369
DOI: 10.1016/j.bbrc.2019.11.021 -
La Tunisie Medicale Mar 2018The association between achalasia and no tuberculosis mycobacterial lung infection is well described in the literature. MycobactériumFortuitum is often responsible,...
The association between achalasia and no tuberculosis mycobacterial lung infection is well described in the literature. MycobactériumFortuitum is often responsible, and the clinical's presentation is an aspiration pneumonia resistant to usual antibiotic therapy. We report the case of a 15 year-old patient with the history of Allgrove syndrome. The chest imaging showed right lung congestion; the diagnosis was bacteriological and MycobactériumFortuitum resistant to rifampicin, isoniazid, pyrazinamide and ethambutol was isolated. The patient was treated by the association cotrimoxazole, ciprofloxacin and clarithromycin for 12 months and the clinical, radiological and bacteriological outcomes were favorable. To prevent the recurrence the patient benefited from a cardiomyotomy.
Topics: Adolescent; Adrenal Insufficiency; Esophageal Achalasia; Female; Humans; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Pneumonia, Aspiration; Tuberculosis, Pulmonary
PubMed: 30325493
DOI: No ID Found -
Journal of Investigative Medicine High... 2022Pyomyositis is a bacterial infection occurring mainly in skeletal muscles. It is most commonly caused by with initial symptoms including muscle pain, swelling, and site...
Pyomyositis is a bacterial infection occurring mainly in skeletal muscles. It is most commonly caused by with initial symptoms including muscle pain, swelling, and site tenderness. When available, the most accurate technique to determine the extent and the specific location of disease is the magnetic resonance imaging. Successful management includes early recognition, timely surgical debridement or drainage, and appropriate antibiotic therapy. This case report describes a case of pyomyositis in an elderly male associated with challenges of successful diagnosis.
Topics: Aged; Anti-Bacterial Agents; Humans; Male; Mycobacterium fortuitum; Pyomyositis; Staphylococcal Infections; Staphylococcus aureus
PubMed: 35073772
DOI: 10.1177/23247096211069766