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Antimicrobial Agents and Chemotherapy Jun 2019The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were...
The understanding of species distribution and inducible macrolide resistance in the complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were , followed by , , , and Most , , and isolates were inducibly resistant to clarithromycin, whereas two-thirds of the isolates were clarithromycin susceptible. Clarithromycin-resistant isolates exhibited common mutations of (39), potentially involved in clarithromycin resistance.
Topics: Anti-Bacterial Agents; Clarithromycin; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium fortuitum
PubMed: 30885902
DOI: 10.1128/AAC.02331-18 -
BMJ Case Reports Oct 2016Mycobacterium fortuitum is a non-tuberculous mycobacterium found in the soil and water of most regions of the world, and it can cause disease in immunocompetent and...
Mycobacterium fortuitum is a non-tuberculous mycobacterium found in the soil and water of most regions of the world, and it can cause disease in immunocompetent and immunocompromised hosts. We present a 52-year-old man who developed a scalp abscess under a free flap for cranium coverage after a motor vehicle accident. Culture of material drained from the abscess grew M. fortuitum.
Topics: Anti-Bacterial Agents; Humans; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Scalp Dermatoses; Skin Transplantation; Surgical Flaps; Surgical Wound Infection; Tuberculosis, Cutaneous; Vancomycin
PubMed: 27797799
DOI: 10.1136/bcr-2016-216968 -
Otolaryngology--head and Neck Surgery :... Dec 1997
Topics: Adolescent; Female; Humans; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Otitis Externa; Otitis Media
PubMed: 9419126
DOI: 10.1016/S0194-59989770080-9 -
Hinyokika Kiyo. Acta Urologica Japonica Nov 2008A 70-year-old male who complained of urinary frequency and a feeling of incomplete emptying was admitted to our hospital. Imaging findings showed dilation of the left... (Review)
Review
A 70-year-old male who complained of urinary frequency and a feeling of incomplete emptying was admitted to our hospital. Imaging findings showed dilation of the left renal pelvis and ureter. He was diagnosed as having urinary tuberculosis because a positive urinary Mycobacterium tuberculosis result was obtained by polymerase chain reaction (PCR). He was treated with a combination of the antituberculosis agents isoniazid, rifampicin, pyrazinamide and ethambutol for six months. The symptoms and pyuria disappeared and M. tuberculosis was negative by PCR; however, Mycobacterium fortuitum was isolated by culture. Due to asymptomatic urinary tract infection by the multidrug resistant M. fortuitum, he was followed up with observation. Currently, he remains unchanged with regard to symptoms and imaging examination. M. fortuitum is a nontubercular mycobacterium, and clinical relevance between urinary tract infection and M. fortuitum has rarely emerged. However, we should be aware that nontubercular mycobacteria such as M. fortuitum can infect the urinary tract, especially in immunocompromised patients.
Topics: Aged; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Humans; Immunocompromised Host; Male; Mycobacterium fortuitum; Mycobacterium tuberculosis; Tuberculosis; Urinary Tract Infections
PubMed: 19068730
DOI: No ID Found -
BioMed Research International 2018Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an...
OBJECTIVE
Nontuberculous mycobacteria (NTM) cause various diseases in humans and animals. Recently, the prevalence of NTM-related disease has been on the rise, becoming an emerging public health problem. The aim of this study was to determine the antibiotic susceptibility profiles of clinical isolates of . We performed susceptibility tests on 37 clinical NTM isolates to 30 antibiotics with the microdilution method recommended by the Clinical and Laboratory Standards Institute.
RESULTS
Both and were highly resistant to antitubercular drugs such as isoniazid, rifampin, ethambutol, clofazimine, ethionamide, and rifabutin. showed the lowest resistant rates to cefoxitin (10%), azithromycin (10%), amikacin (10%), and clarithromycin (20%) and very high resistant to sulfamethoxazole, vancomycin, oxacillin, clindamycin, and all fluoroquinolones. showed low resistance to tigecycline (0%), tetracycline (0%), cefmetazole (12%), imipenem (12%), linezolid (18%), and the aminoglycosides amikacin (0%), tobramycin (0%), neomycin (0%), and gentamycin (24%).
CONCLUSION
Amikacin, cefoxitin, and azithromycin have the highest activity against . Isolates of need to be individually evaluated for drug susceptibility before choosing an effective antimicrobial regimen for treatment of infections.
Topics: Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Mycobacterium abscessus; Mycobacterium fortuitum
PubMed: 30687747
DOI: 10.1155/2018/4902941 -
Dermatology Online Journal Jun 2014We report an uncommon case of a cutaneous infection with Mycobacterium fortuitum arising in a new tattoo. A 29-year-old man presented with a several month history of a...
We report an uncommon case of a cutaneous infection with Mycobacterium fortuitum arising in a new tattoo. A 29-year-old man presented with a several month history of a non-pruritic papular eruption within a tattoo; the papules developed 1-to-2 weeks after the tattoo procedure. He denied similar symptoms with previous tattoos. He had been treated unsuccessfully with cephalexin. Histopathologic examination revealed perifollicular chronic and granulomatous inflammation, consistent with chronic folliculitis. Acid-fast bacilli culture identified Mycobacterium fortuitum complex. The patient was treated with a 2-month course of oral trimethoprim-sulfamethoxazole (160mg/800mg twice daily) and ciprofloxacin (250 mg twice daily), with clinical improvement at follow up after three weeks of the antibiotic regimen. Rapidly growing mycobacteria have emerged as a cause of tattoo-associated cutaneous infection in recent years. Diagnosis and treatment can be difficult without clinical suspicion. M. fortuitum and other rapidly growing mycobacteria should be considered in the differential diagnosis of tattoo-associated dermatologic complications.
Topics: Adult; Anti-Bacterial Agents; Cephalexin; Ciprofloxacin; Clarithromycin; Cosmetic Techniques; Drug Therapy, Combination; Humans; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Tattooing; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 24945647
DOI: No ID Found -
Harefuah Aug 2020Non-Tuberculous Mycobacteria (NTM) are opportunistic environmental pathogens that can produce a wide range of diseases, including infection of the skin and soft tissues....
Non-Tuberculous Mycobacteria (NTM) are opportunistic environmental pathogens that can produce a wide range of diseases, including infection of the skin and soft tissues. Mycobacterium fortuitum is a predominant causative agent of postsurgical wound infection, especially in breast surgery. Peri-prosthetic infection due to Mycobacterium fortuitum are uncommon, but increasingly reported. This report summarizes the case of a young healthy female who underwent bilateral breast mastopexy with insertion of silicone implants. Shortly after the procedure she presented with clinical signs of wound infection that failed to heal completely in spite of repeated drainage and empiric antibiotic therapy. Additional microbiological investigation allowed for a diagnosis of Mycobacterium fortuitum. A prolonged course of anti-mycobacterial therapy, combined with removal of the implants initiated eradication of the infection and enabled re-implantation of the prosthesis. This case report underscores the importance of awareness to this type of pathogen especially in cases of exudative infection with sterile cultures. Timely identification can lead to prompt therapy of patients preventing further complications, costs and remaining aesthetic damage.
Topics: Anti-Bacterial Agents; Breast Implants; Female; Humans; Mammaplasty; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum
PubMed: 32852158
DOI: No ID Found -
Biofouling Sep 2021In this study, the effects of agitation, temperature, and pH on biofilm formation by were studied and quantified through response surface modeling. The microtiter plate...
In this study, the effects of agitation, temperature, and pH on biofilm formation by were studied and quantified through response surface modeling. The microtiter plate assay was optimized to achieve conditions favoring maximum mycobacterial biofilm quantification. Optical density (OD) measurement using a crystal violet assay was performed to estimate the amount of biofilm formed. Response surface methodology (RSM) results revealed an value of 96.18%, exhibiting a maximum OD of 2.119 (λ) at a temperature of 37 °C and pH 7.0, under a static environment. The conditions were experimentally validated. Statistically significant results showed that the maximum biofilm was produced 96 h after mycobacterial inoculation. Thus, the results provide a basis for using RSM as an efficient optimization method for . biofilm assays. This approach can also be incorporated into strategies for screening anti-biofilm compounds, synthetic chemicals, drugs, or inhibitors against pathogenic mycobacteria.
Topics: Biofilms; Mycobacterium fortuitum
PubMed: 34503352
DOI: 10.1080/08927014.2021.1974846 -
Clinical Infectious Diseases : An... Mar 2000
Review
Topics: Endocarditis, Bacterial; Female; Heart Valve Diseases; Humans; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum
PubMed: 10722456
DOI: 10.1086/313695 -
Bone Marrow Transplantation Oct 2001Reports of cases of mycobacterial infections after SCT are rare. We report a 30-year-old female with a cutaneous infection of Mycobacterium fortuitum 30 months after... (Review)
Review
Reports of cases of mycobacterial infections after SCT are rare. We report a 30-year-old female with a cutaneous infection of Mycobacterium fortuitum 30 months after allogeneic bone marrow transplantation for acute lymphoblastic leukemia. The patient was successfully treated with surgical debridement followed by oral minocycline and clarithromycin. Mycobacterial infections should be considered in SCT patients with undiagnosed refractory chronic cutaneous infection, and surgical debridement is useful for the diagnosis and treatment of such infections.
Topics: Adult; Bone Marrow Transplantation; Clarithromycin; Combined Modality Therapy; Cyclosporine; Debridement; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Minocycline; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Skin Ulcer; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous
PubMed: 11704796
DOI: 10.1038/sj.bmt.1703211