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Journal of Paediatrics and Child Health Mar 2018
Topics: Abscess; Child; Diabetes Mellitus, Type 1; Drug Contamination; Equipment Contamination; Humans; Injections; Insulin; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Recurrence; Risk Factors; Skin Diseases, Bacterial; Water Microbiology
PubMed: 29168906
DOI: 10.1111/jpc.13788 -
Indian Journal of Medical Microbiology Oct 2007We report a case of mycobacterial keratitis characterized by apparently spontaneous onset, delayed diagnosis, and eventually necessitating evisceration inspite of...
We report a case of mycobacterial keratitis characterized by apparently spontaneous onset, delayed diagnosis, and eventually necessitating evisceration inspite of systemic antibiotics and repeated corneal grafts.
Topics: Aged; Anti-Bacterial Agents; Corneal Transplantation; Humans; Keratitis; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Orbit Evisceration
PubMed: 18087102
DOI: 10.4103/0255-0857.37357 -
Revue Scientifique Et Technique... Dec 2010To ascertain the cause of tuberculous-like lesions in pigs slaughtered in a local abattoir in Ibadan (south-western Nigeria), a total of 516 pigs were inspected over a...
To ascertain the cause of tuberculous-like lesions in pigs slaughtered in a local abattoir in Ibadan (south-western Nigeria), a total of 516 pigs were inspected over a period of four months, 18 of which had gross lesions suggestive of tuberculosis at post-mortem. Mycobacterial culture and molecular typing (GenoType Mycobacterium CM [Common Mycobacteria] assay) analysis were used to identify and confirm the mycobacteria species responsible for these lesions. Results show that 2.3% (12/516) of the animals screened were infected with mycobacteria; Mycobacterium fortuitum was confirmed in 33.3% (4/12) of these cases. As far as the authors are aware, this is the first report confirming the isolation of M. fortuitum in slaughtered pigs in Nigeria. There is a need to improve on necessary preventive and control measures that will reduce potential sources of mycobacterial infections in pig-rearing herds. These infections may also have public health implications, especially to workers in the pig industry.
Topics: Abattoirs; Animals; Lymph Nodes; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Nigeria; Swine; Swine Diseases
PubMed: 21309469
DOI: 10.20506/rst.29.3.2008 -
Annals of Plastic Surgery Mar 2000Augmentation mammaplasty is a common operation performed in the United States. Postoperative wound infections are rare, but can be devastating. Most often, bacteria from... (Review)
Review
Augmentation mammaplasty is a common operation performed in the United States. Postoperative wound infections are rare, but can be devastating. Most often, bacteria from the normal skin flora cause these infections, but more atypical organisms can lead to similar situations. The authors present a case of a prosthetic breast implant infected with Mycobacterium fortuitum after augmentation mammaplasty. The patient, diagnosis, and treatment are discussed so that others may recognize and treat this entity successfully before encountering major complications. Although it is an infrequent occurrence, plastic surgeons, infectious disease specialists, and primary care doctors who may see postoperative wound infections should be aware of this potential pathogen. It is important in any postimplant infection and especially crucial in cases of unresolving or recurrent infections with unusual or even clear drainage. With proper identification through acid-fast smear and culture, multiagent therapy can be initiated early. Additional complications, including implant removal, may thus be avoided.
Topics: Adult; Breast Implants; Female; Humans; Mammaplasty; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Prosthesis-Related Infections
PubMed: 10735228
DOI: 10.1097/00000637-200044030-00014 -
The American Journal of Dermatopathology Mar 2023
Topics: Humans; Mycobacterium fortuitum; Skin Diseases, Bacterial; Mycobacterium Infections, Nontuberculous
PubMed: 36729795
DOI: 10.1097/DAD.0000000000002336 -
Applied Microbiology and Biotechnology Dec 2023Androst-4-ene-3,17-dione (AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) are important drug intermediates that can be biosynthesized from phytosterols. However,...
Androst-4-ene-3,17-dione (AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) are important drug intermediates that can be biosynthesized from phytosterols. However, the C9 hydroxylation of steroids via 3-ketosteroid 9α-hydroxylase (KSH) limits AD and 4-HBC accumulation. Five active KshAs, the oxidation component of KSH, were identified in Mycobacterium fortuitum ATCC 35855 for the first time. The deletion of kshAs indicated that the five KshA genes were jointly responsible for C9 hydroxylation during phytosterol biotransformation. MFKDΔkshA, the five KshAs deficient strain, blocked C9 hydroxylation and produced 5.37 g/L AD and 0.55 g/L 4-HBC. The dual function reductase Opccr knockout and 17β-hydroxysteroid dehydrogenase Hsd4A enhancement reduced 4-HBC content from 8.75 to 1.72% and increased AD content from 84.13 to 91.34%, with 8.24 g/L AD being accumulated from 15 g/L phytosterol. In contrast, hsd4A and thioesterase fadA5 knockout resulted in the accumulation of 5.36 g/L 4-HBC from 10 g/L phytosterol. We constructed efficient AD (MFKDΔkshAΔopccr_hsd4A) and 4-HBC (MFKDΔkshAΔhsd4AΔfadA5) producers and provided insights for further metabolic engineering of the M. fortuitum ATCC 35855 strain for steroid productions. KEY POINTS: • Five active KshAs were first identified in M. fortuitum ATCC 35855. • Deactivation of all five KshAs blocks the steroid C9 hydroxylation reaction. • AD or 4-HBC production was improved by Hsd4A, FadA5, and Opccr modification.
Topics: Phytosterols; Mycobacterium fortuitum; Mycobacterium; Mixed Function Oxygenases; Steroids; Biotransformation
PubMed: 37831185
DOI: 10.1007/s00253-023-12812-w -
Revista Da Sociedade Brasileira de... 2014Lymphadenitis caused by non-tuberculous mycobacteria is an uncommon manifestation in immunocompetent individuals. Here, we report a case of Mycobacterium fortuitum...
Lymphadenitis caused by non-tuberculous mycobacteria is an uncommon manifestation in immunocompetent individuals. Here, we report a case of Mycobacterium fortuitum infection in a previously healthy 9-year-old patient who developed cervical lymphadenitis evolving to a suppurative ulcer associated with a varicella-zoster virus infection. We discuss the relationship between the varicella-zoster virus and the immune response of the host as an explanation for the unusual progression of the case.
Topics: Child; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Lymphadenitis; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Skin Diseases, Bacterial
PubMed: 24603748
DOI: 10.1590/0037-8682-0166-2013 -
Journal of Infection and Chemotherapy :... Mar 2017Mycobacterium fortuitum is a rapidly growing mycobacterium (RGM) that is an uncommon cause of healthcare-associated infections. The most common infections caused by...
Mycobacterium fortuitum is a rapidly growing mycobacterium (RGM) that is an uncommon cause of healthcare-associated infections. The most common infections caused by M. fortuitum include skin, soft tissue, and catheter-related infections. Although occasionally cultured from sputum samples, M. fortuitum is a rare cause of pulmonary disease. We report a case of M. fortuitum empyema associated with an infected pleural catheter and review M. fortuitum pulmonary infections.
Topics: Aged; Catheter-Related Infections; Catheters, Indwelling; Cross Infection; Empyema; Humans; Lung Diseases; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Pleura; Respiratory Tract Infections
PubMed: 27890417
DOI: 10.1016/j.jiac.2016.08.016 -
Journal of the Medical Association of... Jun 2012A case of cutaneous Mycobacterium fortuitum infection after receiving an amateur tattoo is reported. A few days after tattooing, an otherwise healthy 25-year-old Thai...
A case of cutaneous Mycobacterium fortuitum infection after receiving an amateur tattoo is reported. A few days after tattooing, an otherwise healthy 25-year-old Thai male presented with multiple discrete erythematous papules confined to the tattoo area. He was initially treated with topical steroid and oral antihistamine without improvement. Skin biopsy was carried out, and the histopathology showed mixed cell granuloma with a foreign body reaction (tattoo color pigments). The acid-fast bacilli stain was positive. The tissue culture grew M. fortuitum two weeks later. He was treated with clarithromycin 1,000 mg/day and ciprofloxacin 1,000 mg/day for 10 months with complete response. From the clinical aspect, tattoo-associated rapidly growing mycobacterium infection might be difficult to differentiate from the pigment-based skin reactions. Skin biopsy for histopathology and tissue culture for Mycobacterium probably will be needed in arriving at the diagnosis.
Topics: Adult; Humans; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Skin Diseases, Bacterial; Tattooing
PubMed: 22774631
DOI: No ID Found -
The Journal of Infection Mar 2006There has been a marked increase in the frequency with which breast prosthesis are being used, both for reconstructive and cosmetic purposes. Although breast... (Review)
Review
There has been a marked increase in the frequency with which breast prosthesis are being used, both for reconstructive and cosmetic purposes. Although breast implant-related infections are uncommon, they are typically caused by bacterial skin flora, specifically Staphylococcus aureus and the coagulase negative staphylococci. There have been infrequent reports of breast implant infection caused by the atypical mycobacteria. This report summarizes the case of a young female who underwent augmentation mammoplasty who presented shortly thereafter with clinical evidence of an infected breast prosthesis. Despite a protracted course of empiric antibiotic therapy and multiple surgical interventions, she failed to improve. Additional microbiologic investigations allowed for a diagnosis of Mycobacterium fortuitum group breast implant infection to be established. A prolonged course of anti-mycobacterial therapy, based upon susceptibility results, allowed for eradication of the infection and subsequent successful re-implantation of the prosthesis.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Breast Implants; Ciprofloxacin; Female; Humans; Mycobacterium Infections, Nontuberculous; Mycobacterium fortuitum; Prosthesis-Related Infections
PubMed: 16171871
DOI: 10.1016/j.jinf.2005.07.004