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European Journal of Clinical... Nov 1994Mycobacterium haemophilum is emerging as a pathogen of immunocompromised patients particularly those with AIDS and organ transplants. Infection has also occurred in... (Review)
Review
Mycobacterium haemophilum is emerging as a pathogen of immunocompromised patients particularly those with AIDS and organ transplants. Infection has also occurred in healthy children. Adults usually present with cutaneous manifestations, septic arthritis or occasionally pneumonia. Children have perihilar, cervical or submandibular adenitis. The organism grows on mycobacterial media supplemented with ferric ammonium citrate or hemin, incubated at 30 degrees C to 32 degrees C, two to three weeks after inoculation. The most active antimicrobial agents in vitro are amikacin, ciprofloxacin, clarithromycin, rifabutin and rifampin. Development of resistance to the rifamycins has been demonstrated after patients were treated for several months with several antimycobacterial agents, including the rifamycins. Treatment for several months with at least two agents demonstrated to have low MICs for the organism has been shown to be effective.
Topics: Animals; Humans; Mycobacterium Infections; Mycobacterium haemophilum
PubMed: 7698118
DOI: 10.1007/BF02111493 -
Annals of Hematology Feb 2023
Topics: Humans; Alemtuzumab; Leukemia, Prolymphocytic, T-Cell; Mycobacterium haemophilum; Antineoplastic Agents; Mycobacterium Infections, Nontuberculous
PubMed: 36637475
DOI: 10.1007/s00277-022-05053-w -
Clinical Microbiology Reviews Oct 1996Reports of the association of Mycobacterium haemophilum with disease in humans have greatly increased. At least 64 cases have now been reported, with symptoms ranging... (Review)
Review
Reports of the association of Mycobacterium haemophilum with disease in humans have greatly increased. At least 64 cases have now been reported, with symptoms ranging from focal lesions to widespread, systemic disease. The organism is now known to cause primarily cutaneous and subcutaneous infection, septic arthritis, osteomyelitis, and pneumonitis in patients who are immunologically compromised and lymphadenitis in apparently immunocompetent children. Underlying conditions in the compromised patients have included AIDS; renal, bone marrow, and cardiac transplantation; lymphoma; rheumatoid arthritis; marrow hypoplasia; and Crohn's disease. Reports have originated from diverse geographic areas worldwide. The epidemiology of M. haemophilum remains poorly defined; there appears to be a genetic diversity between strains isolated from different regions. The organism is probably present in the environment, but recovery by sampling has not been successful. M. haemophilum has several unique traits, including predilection for lower temperatures (30 to 32 degrees C) and requirement for iron supplementation (ferric ammonium citrate or hemin). These may in the past have compromised recovery in the laboratory. Therapy has not been well elucidated, and the outcome appears to be influenced by the patient's underlying immunosuppression. The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Anti-Bacterial Agents; Antitubercular Agents; Arthritis, Rheumatoid; Bacteriological Techniques; Child; Child, Preschool; Chromatography, High Pressure Liquid; Coronary Artery Bypass; Crohn Disease; Culture Media; Female; Humans; Immunocompromised Host; Infant; Lymphoma; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium Infections; Mycobacterium haemophilum; Mycolic Acids; Transplantation
PubMed: 8894345
DOI: 10.1128/CMR.9.4.435 -
Journal Der Deutschen Dermatologischen... Oct 2020
PubMed: 32666629
DOI: 10.1111/ddg.14177 -
Journal Der Deutschen Dermatologischen... Nov 2023
Review
[Hautbeteiligung bei Infektionen mit Mycobacterium haemophilum: Zwei Fallberichte und eine aktualisierte Literaturübersicht: Mycobacterium haemophilum infection with cutaneous involvement: Two case reports and an updated literature review].
PubMed: 37946643
DOI: 10.1111/ddg.15163_g -
Journal of Clinical Rheumatology :... Jan 2021
Topics: Humans; Liver Transplantation; Mycobacterium haemophilum; Tenosynovitis
PubMed: 31880608
DOI: 10.1097/RHU.0000000000001232 -
BMC Infectious Diseases Jan 2021Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive... (Review)
Review
BACKGROUND
Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive effects, and may increase the risk of opportunistic infections. Here, we report a rare case of Cryptococcus neoformans and Mycobacterium haemophilum coinfection in a myelofibrosis patient who was receiving ruxolitinib.
CASE PRESENTATION
A 70-year-old Thai man who was diagnosed with JAK2V617F-mutation-positive primary myelofibrosis had been treated with ruxolitinib for 4 years. He presented with cellulitis at his left leg for 1 week. Physical examination revealed fever, dyspnea, desaturation, and sign of inflammation on the left leg and ulcers on the right foot. Blood cultures showed positive for C. neoformans. He was prescribed intravenous amphotericin B deoxycholate with a subsequent switch to liposomal amphotericin B due to the development of acute kidney injury. He developed new onset of fever after 1 month of antifungal treatment, and the lesion on his left leg had worsened. Biopsy of that skin lesion was sent for mycobacterial culture, and the result showed M. haemophilum. He was treated with levofloxacin, ethambutol, and rifampicin; however, the patient eventually developed septic shock and expired.
CONCLUSIONS
This is the first case of C. neoformans and M. haemophilum coinfection in a patient receiving ruxolitinib treatment. Although uncommon, clinicians should be aware of the potential for multiple opportunistic infections that may be caused by atypical pathogens in patients receiving ruxolitinib.
Topics: Aged; Amphotericin B; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Cellulitis; Coinfection; Cryptococcosis; Cryptococcus neoformans; Deoxycholic Acid; Drug Combinations; Fungemia; Humans; Male; Mycobacterium Infections; Mycobacterium haemophilum; Nitriles; Opportunistic Infections; Primary Myelofibrosis; Pyrazoles; Pyrimidines
PubMed: 33413168
DOI: 10.1186/s12879-020-05703-2 -
BMC Infectious Diseases Mar 2023Mycobacterium haemophilum is a slow-growing non-chromogenic nontuberculous Mycobacterium species that can cause skin infection or arthritis in an immunocompromised...
BACKGROUND
Mycobacterium haemophilum is a slow-growing non-chromogenic nontuberculous Mycobacterium species that can cause skin infection or arthritis in an immunocompromised population or in children. Primary infection of the healthy adult cornea is rare. The special requirements for culture make this pathogen difficult to diagnose. The study aims to report the clinical manifestation and treatment process of corneal infection and notify the awareness of M. Haemophilus keratitis among clinicians. This is the first case report of primary M. haemophilum infection in the cornea of healthy adults reported in the literature.
CASE PRESENTATION
A 53-year-old healthy goldminer presented with left eye redness and a history of vision loss for four months. The patient was misdiagnosed with herpes simplex keratitis until M. haemophilum was detected using high-throughput sequencing. Penetrating keratoplasty was performed, and a large number of mycobacteria were detected by Ziehl-Neelsen staining of the infected tissue. Three months later, the patient developed conjunctival and eyelid skin infections that manifested as caseous necrosis of the conjunctiva and skin nodules. After excision and debridement of the conjunctival lesions and systemic antituberculosis drug treatment for 10 months, the patient was cured.
CONCLUSION
M. haemophilum could cause primary corneal infection in healthy adults, which is an infrequent or rare infection. Owing to the need for special bacterial culture conditions, conventional culture methods do not provide positive results. High-throughput sequencing can rapidly identify the presence of bacteria, which aids in early diagnosis and timely treatment. Prompt surgical intervention is an effective treatment option for severe keratitis. Long-term systemic antimicrobial therapy is crucial.
Topics: Adult; Child; Humans; Middle Aged; Mycobacterium haemophilum; Cornea; Eye Infections; Nontuberculous Mycobacteria; Skin
PubMed: 36882753
DOI: 10.1186/s12879-023-08094-2 -
International Journal of Dermatology Sep 2021
Topics: Humans; Mycobacterium Infections; Mycobacterium haemophilum; Polymerase Chain Reaction; RNA, Ribosomal, 16S
PubMed: 33751550
DOI: 10.1111/ijd.15514 -
Annals of Neurology Mar 2024
Topics: Humans; Mycobacterium haemophilum; Myelitis
PubMed: 37953637
DOI: 10.1002/ana.26828