-
Retina (Philadelphia, Pa.) Oct 2007Nontuberculous mycobacterial (NTM) infections are becoming an increasingly important complication in ophthalmology, particularly among immunocompromised patients. We...
Nontuberculous mycobacterial (NTM) infections are becoming an increasingly important complication in ophthalmology, particularly among immunocompromised patients. We report a case of NTM in a 66-year-old male immunosuppressed after cardiac transplantation. Chronic granulomatous iridocyclitis progressed to purulent endophthalmitis despite intraocular and systemic antimicrobial therapy. Direct immunoflourescent staining of the vitrectomy specimen revealed acid-fast bacilli. Biopsies of nodular skin lesions revealed non-caseating granulomas with acid-fast bacilli. Cultures of skin and eye biopsies yielded Mycobacterium haemophilum. Despite aggressive combination antimicrobial therapy, the eye was eventually enucleated. Resolution of systemic infection occurred with the addition of granulocyte macrophage-colony stimulating factor. This is the first reported case of M. haemophilum endophthalmitis.
Topics: Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Endophthalmitis; Eye Enucleation; Eye Infections, Bacterial; Graft Rejection; Granulocyte-Macrophage Colony-Stimulating Factor; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Mycobacterium Infections; Mycobacterium haemophilum; Skin Diseases, Bacterial; Vitreous Body
PubMed: 18040262
DOI: 10.1097/IAE.0b013e318030e622 -
The Journal of Dermatology May 2024
PubMed: 38801177
DOI: 10.1111/1346-8138.17273 -
FEMS Microbiology Letters May 2007In May 2005, a disease outbreak was investigated at a zebrafish (Danio rerio) research facility experiencing severe losses. Mycobacterium haemophilum was isolated from...
In May 2005, a disease outbreak was investigated at a zebrafish (Danio rerio) research facility experiencing severe losses. Mycobacterium haemophilum was isolated from these fish and the disease was subsequently recreated in experimentally infected zebrafish. Fish exhibited signs characteristic of mycobacteriosis, including granuloma formation and severe, diffuse, chronic inflammation. Bacteria were observed in multiple tissues, including the central nervous system. Biofilm samples from the outbreak facility were PCR positive for M. haemophilum, suggesting biofilms might act as a reservoir for infection. Zebrafish appear to be particularly vulnerable to M. haemophilum, and measures such as quarantine and treatment of incoming water should be implemented to minimize the likelihood of introduction of this bacterium to zebrafish research facilities. Zebrafish are already a well-established laboratory animal model for genetics, toxicology and disease, their susceptibility to M. haemophilum may make them useful for the study of this bacterium in the future.
Topics: Animals; Animals, Laboratory; Disease Models, Animal; Mycobacterium Infections; Mycobacterium haemophilum; Zebrafish
PubMed: 17326751
DOI: 10.1111/j.1574-6968.2007.00671.x -
Journal of Infection and Chemotherapy :... Sep 2001Mycobacterium haemophilum has been described as a pathogen that causes cutaneous lesions in immunocompromised patients. A specimen from a skin ulcer on the leg of a...
Mycobacterium haemophilum has been described as a pathogen that causes cutaneous lesions in immunocompromised patients. A specimen from a skin ulcer on the leg of a Japanese patient with acquired immunodeficiency syndrome yielded acid-fast bacilli on blood agar plates after 4 weeks of incubation at 30 degrees C, but the organism was not found on Ogawa egg slants. The organism was identified as M. haemophilum, on the basis of 16S rRNA gene sequence analysis. Prolonged culture in an optimal environment that includes an iron supplement, and growth temperatures at 28 degrees to 33 degrees C are necessary to grow M. haemophilum. Genotypic characterization of 16S rRNA is useful for a rapid diagnosis of this slowly growing mycobacterium.
Topics: AIDS-Related Opportunistic Infections; Base Sequence; DNA, Bacterial; Humans; Japan; Leg Ulcer; Male; Middle Aged; Molecular Sequence Data; Mycobacterium Infections; Mycobacterium haemophilum; RNA, Bacterial; RNA, Ribosomal, 16S; Sequence Homology, Nucleic Acid; Treatment Outcome
PubMed: 11810582
DOI: 10.1007/s101560100033 -
Canada Diseases Weekly Report = Rapport... Oct 1988
Topics: Acquired Immunodeficiency Syndrome; Adult; Child, Preschool; Female; Humans; Male; Mycobacterium; Mycobacterium Infections; Opportunistic Infections
PubMed: 3242895
DOI: No ID Found -
Transplantation Nov 1995The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow...
The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implementing the organism's unique requirements for growth. This report of the patients' clinical and immunologic course is based on a retrospective chart review. Two distinctly different presentations of M haemophilum infection were observed. Three patients presented with cutaneous lesions, typical of those seen in previous reports of the infection. Two others developed pulmonary disease only. All patients received directed therapy against M haemophilum, but respiratory failure developed in the patients with pneumonia and they died. The remaining 3 patients survived and are free of infection. These are the only reported cases of M haemophilum infection in bone marrow transplant recipients. Early diagnosis obtained through biopsy and special request for culture conditions conducive to the growth of the organism may decrease morbidity and mortality, particularly in patients with pulmonary disease.
Topics: Adult; Bone Marrow Transplantation; Female; Humans; Male; Mycobacterium Infections; Mycobacterium haemophilum; Postoperative Complications; Retrospective Studies
PubMed: 7491700
DOI: No ID Found -
Annals of the Academy of Medicine,... Jul 2004Mycobacterium haemophilum, a nontuberculous mycobacterium (NTM) that was first described in 1978, is a pathogen that can cause an array of symptoms in immunocompromised...
INTRODUCTION
Mycobacterium haemophilum, a nontuberculous mycobacterium (NTM) that was first described in 1978, is a pathogen that can cause an array of symptoms in immunocompromised patients, predominantly cutaneous.
CLINICAL PICTURE
We report our hospital's experience with the first 3 patients diagnosed with this infection from 1994 to 2002. All were women; one had systemic lupus erythematosus (SLE), one had mycosis fungoides and the last had Sjogren's syndrome with recurrent bacterial infections, although the specific nature of her immunocompromised state has not been defined. All were HIV negative. All 3 women presented with cutaneous lesions--the first with recurrent erythematous plaques on the limbs and back, the second with tender nodules and abscesses on the knees, and the third with papular eruptions on the cheek.
TREATMENT/OUTCOME
All responded to a combination of antibiotics and are presently still undergoing treatment and follow-up.
CONCLUSION
Infections caused by M. haemophilum occur mainly in immunocompromised patients. They can present with a variety of cutaneous manifestations, which require a high index of suspicion and coordination between the treating physician and the laboratory for diagnosis. Combination antibiotic treatment is recommended, and patients should be followed up after treatment to survey for possible relapse.
Topics: Adult; Clarithromycin; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Middle Aged; Mycobacterium Infections; Mycobacterium haemophilum; Singapore; Skin Diseases, Infectious
PubMed: 15329772
DOI: No ID Found -
Diagnostic Microbiology and Infectious... Apr 2014We present the case of a native Texan who was diagnosed with tuberculoid leprosy and later developed a cutaneous infection with M. haemophilum following iatrogenic...
We present the case of a native Texan who was diagnosed with tuberculoid leprosy and later developed a cutaneous infection with M. haemophilum following iatrogenic immunosuppression. To our knowledge, there are no such reports of M. haemophilum and M. leprae infection occurring simultaneously in the same host.
Topics: Adult; Coinfection; Histocytochemistry; Humans; Immunocompromised Host; Leprosy, Tuberculoid; Microscopy; Mycobacterium Infections; Mycobacterium haemophilum; Mycobacterium leprae; Skin; Skin Diseases, Bacterial
PubMed: 24439137
DOI: 10.1016/j.diagmicrobio.2013.09.003 -
Clinical Infectious Diseases : An... Feb 2011We report a Mycobacterium haemophilum outbreak after permanent make-up of the eyebrows performed by the same freelance artist. Twelve patients presented an eyebrow...
We report a Mycobacterium haemophilum outbreak after permanent make-up of the eyebrows performed by the same freelance artist. Twelve patients presented an eyebrow lesion and cervical lymphadenitis. All were treated with antibiotics. Surgery was required in 10 cases. M. haemophilum DNA was identified in the make-up ink.
Topics: Disease Outbreaks; Eyebrows; Female; Humans; Middle Aged; Mycobacterium Infections; Mycobacterium haemophilum; Tattooing; Tuberculosis, Lymph Node
PubMed: 21258102
DOI: 10.1093/cid/ciq191 -
Case Reports in Plastic Surgery & Hand... Oct 2020We report a case of purulent flexor tenosynovitis caused by in an immunosuppressed patient who received renal transplantation. Three synovial debridements and multiple...
We report a case of purulent flexor tenosynovitis caused by in an immunosuppressed patient who received renal transplantation. Three synovial debridements and multiple antimicrobial administrations with clarithromycin, rifampicin, and moxifloxacin have been performed. No apparent recurrence has been observed two years after the final operation.
PubMed: 33134429
DOI: 10.1080/23320885.2020.1830775