-
BMJ Case Reports Mar 2013Mycobacterium haemophilum is a slow growing, aerobic, fastidious mycobacterium requiring hemin and a temperature of 30-32° C for optimal growth that is ubiquitous in...
Mycobacterium haemophilum is a slow growing, aerobic, fastidious mycobacterium requiring hemin and a temperature of 30-32° C for optimal growth that is ubiquitous in nature. Disease in immunocompromised adults typically manifests as skin lesions such as papules, pustules and ulcerations. This organism also causes lymphadenitis in immunocompetent children. Antitumour necrosis factor-α (anti-TNF-α) therapy with agents such as infliximab, etanercept and adalimumab is increasingly being used for immunosuppression in patients with various autoimmune conditions. These agents are known to place patients at increased risk for tuberculosis and other granulomatous diseases. However, little is known about illness caused by M haemophilum in patients on immunosuppression with anti-TNF-α therapy. We describe a case of disseminated M haemophilum manifesting as skin lesions in a 72-year-old man with rheumatoid arthritis on infliximab and methotrexate.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Male; Mycobacterium Infections; Mycobacterium haemophilum
PubMed: 23505273
DOI: 10.1136/bcr-2012-008034 -
Journal of Clinical Microbiology Jan 1987Mycobacterium haemophilum was isolated from wrist and ankle aspirates as the organism responsible for tenosynovitis in a patient with acquired immune deficiency...
Mycobacterium haemophilum was isolated from wrist and ankle aspirates as the organism responsible for tenosynovitis in a patient with acquired immune deficiency syndrome. Mycobacterium isolates recovered from synovial fluid were identified as hemin requiring by their failure to grow on subculture unless the medium was supplemented with hemin. M. haemophilum is of low virulence and rarely associated with infections in humans. This is the first documented case of M. haemophilum infection in a patient with acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Mycobacterium; Mycobacterium Infections; Opportunistic Infections; Tenosynovitis
PubMed: 3793874
DOI: 10.1128/jcm.25.1.186-190.1987 -
Transplant Infectious Disease : An... Feb 2011Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium that can cause disease in both immunocompetent and immunocompromised patients. The most common...
Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium that can cause disease in both immunocompetent and immunocompromised patients. The most common clinical presentations of infection are the appearance of suppurative and ulcerated skin nodules. For the diagnosis, samples collected from suspected cases must be processed under the appropriate conditions, because M. haemophilum requires lower incubation temperatures and iron supplementation in order to grow in culture. In this case report, we describe the occurrence of skin lesions in a kidney transplant recipient, caused by M. haemophilum, associated with acupuncture treatment. The diagnosis was established by direct smear and culture of material aspirated from cutaneous lesions. Species identification was achieved by characterization of the growth requirements and by partial sequencing of the hsp65 gene. The patient was successfully treated with clarithromycin and ciprofloxacin for 12 months. Considering that the number of patients receiving acupuncture treatment is widely increasing, the implications of this potential complication should be recognized, particularly in immunosuppressed patients.
Topics: Acupuncture Therapy; Anti-Bacterial Agents; Ciprofloxacin; Clarithromycin; Humans; Immunocompromised Host; Kidney Transplantation; Male; Middle Aged; Mycobacterium Infections; Mycobacterium haemophilum; Skin Diseases, Bacterial
PubMed: 20534038
DOI: 10.1111/j.1399-3062.2010.00522.x -
Clinical Imaging 2014We report a case of chiasmitis caused by a rare nontuberculous mycobacterium in an immunocompromised patient. A 44-year-old man with a history of AIDS presented with...
We report a case of chiasmitis caused by a rare nontuberculous mycobacterium in an immunocompromised patient. A 44-year-old man with a history of AIDS presented with recurrent vision loss and headache. Magnetic resonance imaging (MRI) demonstrated an enhancing mass involving the optic chiasm. Histopathologic and microbiological evaluation revealed infection with Mycobacterium haemophilum. While combination antimicrobial and steroid therapy contributed to improvement in his vision, the patient's symptoms recurred. Follow-up MRI showed extension of infection to the hypothalamus and leptomeninges, indicative of basilar meningitis. MRI is a valuable tool for early diagnosis of chiasmitis as well as for monitoring infection progression and treatment response.
Topics: Adult; Diagnosis, Differential; Eye Infections, Bacterial; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Male; Mycobacterium Infections; Mycobacterium haemophilum; Optic Chiasm; Optic Nerve Diseases; Recurrence
PubMed: 24908366
DOI: 10.1016/j.clinimag.2014.02.012 -
International Journal of Dermatology Aug 2021
Topics: Aged; Dermatitis; Forearm; Humans; Mycobacterium Infections; Mycobacterium haemophilum; Skin Diseases, Bacterial
PubMed: 33650117
DOI: 10.1111/ijd.15484 -
Emerging Infectious Diseases Sep 2008The database of a major microbiology laboratory in Israel was searched to determine the prevalence of nontuberculous mycobacterial lymphadenitis in immunocompetent...
The database of a major microbiology laboratory in Israel was searched to determine the prevalence of nontuberculous mycobacterial lymphadenitis in immunocompetent children. We observed a 4-fold increase in nontuberculous mycobacteria isolates during 1985-2006, which was attributable mainly to increased detection of Mycobacterium haemophilum starting in 1996.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Immunocompetence; Infant; Israel; Lymphadenitis; Male; Mycobacterium Infections; Mycobacterium avium Complex; Mycobacterium haemophilum
PubMed: 18760014
DOI: 10.3201/eid1409.070917 -
Journal of Clinical Microbiology Jul 2010We describe a case and summarize six additional cases of cervical lymphadenitis in otherwise healthy adults caused by Mycobacterium haemophilum. The organism causes...
We describe a case and summarize six additional cases of cervical lymphadenitis in otherwise healthy adults caused by Mycobacterium haemophilum. The organism causes cervicofacial lymphadenitis in healthy children and severe disease in immunocompromised patients but has not been previously reported to cause cervical lymphadenitis in nonimmunocompromised, healthy adults.
Topics: Adult; Aged; Antibiotics, Antitubercular; Female; Histocytochemistry; Humans; Lymph Node Excision; Male; Middle Aged; Mycobacterium haemophilum; Tuberculosis, Lymph Node; Wounds and Injuries
PubMed: 20484607
DOI: 10.1128/JCM.00814-10 -
Internal Medicine Journal Oct 2015Disseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated...
Disseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. We describe a case of disseminated Mycobacterium haemophilum skeletal infection due to anti IFN-γ autoantibodies in a 71-year-old Cambodian man. He responded to a combination of anti-mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN-γ deficiency due to IFN-γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM.
Topics: Aged; Asian People; Autoantibodies; Cambodia; Humans; Interferon-gamma; Magnetic Resonance Imaging; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium haemophilum; Tuberculosis, Osteoarticular
PubMed: 26429217
DOI: 10.1111/imj.12875 -
Journal of Clinical Microbiology Jan 2018
Topics: Aged; Anti-Bacterial Agents; Exanthema; Fatal Outcome; Female; Humans; Kidney Transplantation; Mycobacterium Infections; Mycobacterium haemophilum; Thailand; Transplant Recipients
PubMed: 29279349
DOI: 10.1128/JCM.00561-17 -
Pathology Jul 1993A case of osteomyelitis resulting from infection with Mycobacterium haemophilum in a patient with the Acquired Immunodeficiency Syndrome (AIDS) and Hodgkin's disease is... (Review)
Review
A case of osteomyelitis resulting from infection with Mycobacterium haemophilum in a patient with the Acquired Immunodeficiency Syndrome (AIDS) and Hodgkin's disease is described. The clinical features and response to therapy are examined and compared to previous reported cases. Mycobacterium haemophilum infection in immunocompromised patients usually results in cutaneous lesions but osteomyelitis may be the presenting feature. Tissue samples should be obtained early for microbiological examination and treatment should consist of surgical debridement and appropriate antimicrobial therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Hodgkin Disease; Humans; Male; Mycobacterium Infections; Osteomyelitis
PubMed: 8265253
DOI: 10.3109/00313029309066595