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Annals of Laboratory Medicine Sep 2013Mycobacterium longobardum is a slow-growing, nontuberculous mycobacterium that was first characterized from the M. terrae complex in 2012. We report a case of M....
Mycobacterium longobardum is a slow-growing, nontuberculous mycobacterium that was first characterized from the M. terrae complex in 2012. We report a case of M. longobardum induced chronic osteomyelitis. A 71-yr-old man presented with inflammation in the left elbow and he underwent a surgery under the suspicion of tuberculous osteomyelitis. The pathologic tissue culture grew M. longobardum which was identified by analysis of the 65-kDa heat shock protein and full-length 16S rRNA genes. The patient was cured with the medication of clarithromycin and ethambutol without further complications. To the best of our knowledge, this is the first report of a M. longobardum infection worldwide.
Topics: Aged; Anti-Bacterial Agents; Bacterial Proteins; Chaperonin 60; Clarithromycin; Elbow; Ethambutol; Humans; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Osteomyelitis; RNA, Ribosomal, 16S; Treatment Outcome
PubMed: 24003427
DOI: 10.3343/alm.2013.33.5.356 -
BMJ Case Reports Oct 2021is a member of the complex (MTC) that is implicated in bone and joint infections, among others. This group of environmental pathogens can be found in soil, reclaimed...
is a member of the complex (MTC) that is implicated in bone and joint infections, among others. This group of environmental pathogens can be found in soil, reclaimed and drinking water systems, rodents, fish tanks and bioaerosols in duck houses. Interestingly, while is genotypically closely related to the other agents in the MTC, antibiotic susceptibility of these mycobacteria can vary widely and empiric antibiotic therapy is controversial. Our case report contributes to the very limited literature on tenosynovitis-as only six cases have been reported since 2008-and sheds light on different courses of treatment. While previous cases have been successfully treated, a streamlined course of therapy for tenosynovitis is still needed.
Topics: Humans; Mycobacteriaceae; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Tenosynovitis
PubMed: 34667040
DOI: 10.1136/bcr-2021-245130 -
International Journal of Infectious... Jul 2009To date, few cases of human joint infection caused by the Mycobacterium terrae complex have been reported. Because M. terrae infection is a relatively uncommon problem,...
To date, few cases of human joint infection caused by the Mycobacterium terrae complex have been reported. Because M. terrae infection is a relatively uncommon problem, it can be mistaken for a noninfectious inflammatory joint condition. The most common presentation of M. terrae complex infection is tenosynovitis of the hand; infections in bones other than those of the hands are rarely reported. Here, we describe a patient with arthritis of the knee caused by M. terrae and review data from other cases reported in the medical literature.
Topics: Adult; Anti-Bacterial Agents; Arthritis, Rheumatoid; Azithromycin; Drug Therapy, Combination; Ethambutol; Humans; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Ofloxacin; Treatment Outcome
PubMed: 18986820
DOI: 10.1016/j.ijid.2008.09.002 -
Expert Review of Anti-infective Therapy Oct 2013Pulmonary disease (PD) caused by nontuberculous mycobacteria is an emerging infection mainly in countries where the incidence of tuberculosis is in decline. It affects... (Review)
Review
Pulmonary disease (PD) caused by nontuberculous mycobacteria is an emerging infection mainly in countries where the incidence of tuberculosis is in decline. It affects an elderly population, often with underlying chronic lung diseases, but its epidemiology shows significant regional variation. Guidelines and recommendations for treatment of these infections exist, but build strongly on expert opinion, as very few good quality clinical trials have been performed in this field. Only for the most frequent causative agents, the Mycobacterium avium complex, Mycobacterium kansasii and Mycobacterium abscessus, a reasonable number of trials and case series is now available. For the less frequent causative agents of pulmonary nontuberculous mycobacterial (NTM) disease (Mycobacterium xenopi, Mycobacterium malmoense, Mycobacterium fortuitum, Mycobacterium chelonae) data is mostly limited to a few very small case series. Within this review, we have collected and combined evidence from all available trials and case series. From the data of these trials and case series, we reconstruct a more evidence-based overview of possible drug treatment regimens and their outcomes.
Topics: Aged; Anti-Bacterial Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Dosage Calculations; Evidence-Based Medicine; Humans; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Survival Analysis; Treatment Outcome
PubMed: 24124798
DOI: 10.1586/14787210.2013.830413 -
The Pediatric Infectious Disease Journal May 2017Mycobacterium gordonae is a slow growing, pigmented, nontuberculous mycobacterium. It is commonly associated with environmental contamination of clinical specimens, but...
Mycobacterium gordonae is a slow growing, pigmented, nontuberculous mycobacterium. It is commonly associated with environmental contamination of clinical specimens, but it is also a recognized pathogen in immunocompromised hosts. We describe an immunocompetent child with a spontaneously occurring skin ulcer on the face caused by M. gordonae infection.
Topics: Anti-Bacterial Agents; Child, Preschool; Clarithromycin; Dermatologic Surgical Procedures; Ethambutol; Face; Humans; Immunocompetence; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Rifampin; Skin
PubMed: 28403059
DOI: 10.1097/INF.0000000000001549 -
Journal of the Formosan Medical... Jun 2020Great progress has recently been made in methodologies for identifying nontuberculous mycobacteria (NTM). Recommendations for drug susceptibility testing (DST) of NTM... (Review)
Review
Great progress has recently been made in methodologies for identifying nontuberculous mycobacteria (NTM). Recommendations for drug susceptibility testing (DST) of NTM have been expanded and updated by the Clinical and Laboratory Standards Institute and are crucial in the management of NTM infections. This article summarizes the clinically relevant molecular methods used to discriminate NTM species and updates the information on DST. Furthermore, recent progress on new antimicrobials against NTM infections is reviewed.
Topics: Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Mycobacterium tuberculosis; Nontuberculous Mycobacteria
PubMed: 32423573
DOI: 10.1016/j.jfma.2020.05.002 -
Journal of Applied Microbiology Jan 2018Non-Tuberculous Mycobacteria (NTM) are ubiquitous in nature. The data on prevalence of NTM under the RNTCP is scarce. Many NTM species have clinical significance, and...
AIMS
Non-Tuberculous Mycobacteria (NTM) are ubiquitous in nature. The data on prevalence of NTM under the RNTCP is scarce. Many NTM species have clinical significance, and hence their identification and speciation are important.
METHODS AND RESULTS
It is a cross-sectional study conducted at the five RNTCP accredited culture and drug susceptibility testing (CDST) laboratory. The culture isolates from AFB positive but Immunochromatographic test negative samples were taken for identification and speciation using HPLC. Of the total 266 isolates only 164 isolates had a second sample received at the laboratory. The speciation was done using HPLC for those isolates. The type of species identified are: 26·8% (44) were Mycobacterium chelonae, 12·8% (21) were Mycobacterium fortuitum, 9% (15) were Mycobacterium gordonae, 9% (15) were Mycobacterium tuberculosis complex, 6·1% (10) were Mycobacterium kansasii, 4·9% (8) were Mycobacterium simiae, 2·4% (4) were Mycobacterium thermophile, 1·2% (2) were Mycobacterium gastri, 0·6% (1) were Mycobacterium scrofulaceum, 0·6% (1) were Mycobacterium avium and 4·9% (8) isolates had chromatogram which was un-interpretable.
CONCLUSION
Identification and its speciation of NTM are not routinely done under TB control programme. Since HPLC could identify 95% of isolates belonging to 10 species, the speciation of NTM using HPLC should gain importance in the diagnosis of disease caused by NTM.
SIGNIFICANCE AND IMPACT OF STUDY
NTM are emerging as important causative agents of pulmonary and extra pulmonary disease, the ability to recognize disease caused by NTM and subsequently treat such disease has become increasingly important. The identification of NTM up to its species level should gain importance in all TB reference Laboratories.
Topics: Bacterial Typing Techniques; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Humans; India; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria
PubMed: 28990320
DOI: 10.1111/jam.13604 -
Journal of Cystic Fibrosis : Official... Jan 2015
Topics: Cystic Fibrosis; Female; Humans; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria
PubMed: 25487786
DOI: 10.1016/j.jcf.2014.12.002 -
Klinicheskaia Laboratornaia Diagnostika Apr 2021Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is... (Review)
Review
Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M. fortuitum group, as the main pathogens among the group of fast-growing mycobacteria. The data on the modern classification based on the use of molecular genetic studies are indicated. The M. fortuitum group includes: Mycobacterium fortuitum, M. peregrinum, M. senegalense, M. porcinum, M. houstonense, M. neworleansense, M. boenickei, M. conceptionense, M. septicum, M. alvei. According to the new data, mycobacteria were divided into 5 clades (Abscessus-Chelonae, Fortuitum-Vaccae, Terrae, Triviale, Tuberculosis-Simiae), and based on molecular genetic studies, new genera in the Mycobacteriaceae family were isolated: Mycolicibacter spp., Mycolicibacillus spp., Mycolicibacillus spp., Mycobacteroides spp., Mycolicibacterium spp. In accordance with the new classification, representatives of the Mycobacterium fortuitum group belong to the genus Mycolicibacterium. The main epidemiological features of the main sources of the spread of mycobacteria, factors and ways of their transmission are indicated. Due to their wide distribution in the environment, representatives of the M. fortuitum group are capable of causing diseases of the pulmonary and extrapulmonary localization. The distinctive features of pathogenicity factors, due to which the course of the disease is determined, are noted. The article also indicates the main difficulties and features of determining the sensitivity to antimicrobial chemotherapy drugs, provides data on the main features of antibiotic resistance of M.fortuitum group. In preparing the review, literature sources obtained from international and domestic databases were used: Scopus, Web of Science, Springer, RSCI.
Topics: Drug Resistance, Microbial; Humans; Mycobacterium; Mycobacterium Infections; Mycobacterium fortuitum; Nontuberculous Mycobacteria
PubMed: 33878244
DOI: 10.51620/0869-2084-2021-66-4-223-228 -
BMJ Case Reports May 2013Infections are a significant cause of morbidity and mortality in patients with sickle cell disease. Loss of splenic function in these patients makes them highly...
Infections are a significant cause of morbidity and mortality in patients with sickle cell disease. Loss of splenic function in these patients makes them highly susceptible to some bacterial infections. Non-tuberculous mycobacterial infections in patients with sickle cell disease are extremely rare and only two cases have been reported previously. We describe a case of sepsis caused by non-tuberculous mycobacterium, Mycobacterium terrae complex in a patient with febrile sickle cell disease. M terrae complex is a rare clinical pathogen and this is the first reported case of sepsis secondary to this organism in a patient with sickle cell disease. The patient responded to imipenem and amikacin therapy.
Topics: Adult; Anemia, Sickle Cell; Anti-Bacterial Agents; Female; Humans; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Sepsis
PubMed: 23645646
DOI: 10.1136/bcr-2013-009159