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Pediatrics in Review Jan 2020
Review
Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Child; Humans; Lung; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Radiography, Thoracic
PubMed: 31894069
DOI: 10.1542/pir.2018-0016 -
Yonsei Medical Journal 1986
Topics: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Male; Pneumonia; Pneumonia, Mycoplasma
PubMed: 3564543
DOI: 10.3349/ymj.1986.27.4.300 -
The Lancet. Microbe Oct 2023
Topics: Humans; Mycoplasma pneumoniae; Pneumonia, Mycoplasma
PubMed: 37393927
DOI: 10.1016/S2666-5247(23)00182-9 -
The Clinical Respiratory Journal Dec 2018Mycoplasmal pneumonia is a common type of adult community-acquired pneumonia in China, but round/spherical pneumonia caused by mycoplasma pneumoniae has rarely been...
BACKGROUND
Mycoplasmal pneumonia is a common type of adult community-acquired pneumonia in China, but round/spherical pneumonia caused by mycoplasma pneumoniae has rarely been reported. Here, we report an outbreak of mycoplasmal round pneumonia in a military dormitory in China.
METHODS
We analysed epidemiological, clinical, imaging and laboratory data from a series of adults affected by an outbreak of mycoplasmal round pneumonia in the dormitory of a military hospital (Fuzhou General Hospital) in Fuzhou, China. The dormitory included 2 separate buildings. Mycoplasma antibody was detected using a passive agglutination assay.
RESULTS
The first case in our series, a 23-year-old male intern, presented on July 16, 2015 with a 3-day history of low-grade fever, dizziness, fatigue and chest tightness. Chest computed tomography revealed spherical masses. Over the following 4 days, 11 individuals who had been in close contact with the first patient were found to have similar masses. All 12 cases were mildly symptomatic or asymptomatic, and fever was the only sign visible upon physical examination. Chest radiology revealed single, round consolidations in 3 cases and multiple round consolidations in 9 cases; consolidations ranged in size from 0.2 to 2.9 cm. Most cases had normal blood cell count, erythrocyte sedimentation rate and C reactive protein level. Nasopharyngeal swabs from all cases tested negative for 25 pathogens, including Mycoplasma pneumoniae, in a PCR-based assay performed on August 1, 2015. All 12 patients showed a 4-fold increase in the titre of anti-mycoplasmal pneumonia antibody in paired sera on August 13, 2015. Patients were given the antibiotic moxifloxacin or symptomatic treatment, and 11 of the 12 cases showed complete resolution of round pneumonia lesions within 4 weeks.
CONCLUSION
This case series illustrates the diversity of clinical manifestations as well as imaging findings for mycoplasmal pneumonia, to which clinicians should pay more attention. Mycoplasmal round pneumonia should be included in differential diagnosis of multiple pulmonary nodules in adults in order to enable accurate clinical identification of disease and successful treatment and resolution.
Topics: Agglutination Tests; Anti-Bacterial Agents; China; Community-Acquired Infections; Diagnosis, Differential; Disease Outbreaks; Humans; Male; Moxifloxacin; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Tomography, X-Ray Computed; Treatment Outcome; Young Adult
PubMed: 30417557
DOI: 10.1111/crj.12972 -
The Tokai Journal of Experimental and... Aug 1988Characteristic of patients with mycoplasmal pneumonia has been stated reviewing 124 children and 78 adults who were hospitalized in Tokai University Hospital during the... (Review)
Review
Characteristic of patients with mycoplasmal pneumonia has been stated reviewing 124 children and 78 adults who were hospitalized in Tokai University Hospital during the period from 1975 to 1987. Differences in clinical features between pediatric and adult cases have also been stated. As another epidemic may appear in this year, 1988, because the last previous epidemic was four years ago, it may be worth it to stress the importance of epidemiological and clinical knowledge of the disease.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Japan; Male; Middle Aged; Pneumonia, Mycoplasma; Seasons; Sex Factors
PubMed: 3075822
DOI: No ID Found -
Journal of Korean Medical Science Oct 2018
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Child; Doxycycline; Humans; Levofloxacin; Macrolides; Mycoplasma pneumoniae; Pneumonia, Mycoplasma
PubMed: 30344464
DOI: 10.3346/jkms.2018.33.e281 -
Clinical Microbiology Reviews Oct 2004Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of... (Review)
Review
Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur.
Topics: Asthma; Humans; Mycoplasma pneumoniae; Pneumonia, Mycoplasma
PubMed: 15489344
DOI: 10.1128/CMR.17.4.697-728.2004 -
CRC Critical Reviews in Diagnostic... 1980M. pneumoniae is a common cause of pneumonia. The diagnosis is suspected when the patient presents with symptoms suggesting primary atypical pneumonia including cough,... (Review)
Review
M. pneumoniae is a common cause of pneumonia. The diagnosis is suspected when the patient presents with symptoms suggesting primary atypical pneumonia including cough, fever, chills, headache, and malaise in association with a segmental or subsegmental pulmonary infiltrate(s), the white blood cell count is normal or only slightly elevated, and the Gram stain of the sputum (if any can be obtained) reveals polymorphonuclear leukocytes and few bacteria. The diagnosis is more difficult when the patient presents with symptoms not suggestive of pneumonia including lethargy, dyspnea, and a 1- to 4-week history of shortness of breath without cough or fever in association with diffuse reticulonodular or interstitial pulmonary infiltrates. The disease in the previously healthy host is usually benign and self-limiting. However, the course is shortened by the administration of tetracycline derivatives or erythromycin. M. pneumoniae pneumonia can occur in association with other diseases including sickle cell anemia, sarcoidosis, systemic lupus erythematosus, Hodgkin's disease, and various other immunodeficiency states. In these patients mycoplasma pneumonia can be very serious. Although there is no pathognomonic clinical or radiographic presentation, careful consideration of epidemiologic, clinical, laboratory, and radiographic data are usually sufficient to suggest the diagnosis in most patients.
Topics: Adolescent; Adult; Agglutinins; Anti-Bacterial Agents; Autoantibodies; Child; Child, Preschool; Cold Temperature; Complement Fixation Tests; Female; History, 19th Century; History, 20th Century; Humans; Male; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Radiography
PubMed: 6767579
DOI: No ID Found -
The Veterinary Clinics of North... Jul 1985Infectious calf pneumonia is a high-mortality pneumonia of housed dairy-type calves. Viruses are important etiologic agents and infection with bovine respiratory... (Review)
Review
Infectious calf pneumonia is a high-mortality pneumonia of housed dairy-type calves. Viruses are important etiologic agents and infection with bovine respiratory syncytial virus (RSV) and parainfluenza type 3 virus (PI-3 virus) may result in extensive, and sometimes fatal, lung damage. Respiratory viral infections are frequently followed by mycoplasmal and secondary bacterial invasion of the lower respiratory tract, which increases the extent and severity of lung damage. Bad housing, particularly bad ventilation, will increase the severity of pneumonia outbreaks. Although the source of respiratory viral infections is not always obvious, it is likely that a proportion of calves acquired infection from their dams early in life. The possibility of cross-infections from other domestic animals and from humans must also be considered. Diagnosis of respiratory virus infections necessitates submission of suitable respiratory tract specimens that are taken at an early stage in the outbreak together with paired sera. Various therapeutic and prophylactic regimens for the control of calf pneumonia are described.
Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Colostrum; Female; Housing, Animal; Pneumonia; Pneumonia, Mycoplasma; Pneumonia, Viral; Pregnancy; Vaccination
PubMed: 3907774
DOI: 10.1016/s0749-0720(15)31326-8 -
Chest Mar 1989
Review
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Laboratory Techniques; Female; Humans; Infant; Male; Middle Aged; Pneumonia, Mycoplasma; Radiography; Retrospective Studies
PubMed: 2646077
DOI: 10.1378/chest.95.3.639