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Infection 1976The pathogenicity of mycoplasmas is caused by several factors, e.g. exotoxin, toxic properties of membrane components, exoenzymes, peroxide, and immunological factors.... (Review)
Review
The pathogenicity of mycoplasmas is caused by several factors, e.g. exotoxin, toxic properties of membrane components, exoenzymes, peroxide, and immunological factors. The absence of a rigid cell wall and the small genome tend to influence the interactions between mycoplasmas and host tissue. Mycoplasmas do not have a cell wass and are therefore resistant to the action of the host's lysozymes. They appear in some patients to be immunologically inconspicuous and in other patients they have been reported to have an immuno-suppressive effect. Recently there have been reports of central nervous system disorders due to mycoplasma. The pathogenic factors involved in these reactions have not been elucidated. Other aspects of Mycoplasma pneumoniae pathogenicity are also discussed.
Topics: Animals; Humans; Mycoplasma; Toxins, Biological
PubMed: 783049
DOI: 10.1007/BF01638414 -
Antonie Van Leeuwenhoek 1956
Topics: Mycoplasma; Mycoplasmataceae; Pleuropneumonia
PubMed: 13395347
DOI: 10.1007/BF02538350 -
International Journal of Infectious... Jun 2023Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum commonly colonize the human urogenital tract, which may cause urogenital infections. However, infection... (Review)
Review
Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum commonly colonize the human urogenital tract, which may cause urogenital infections. However, infection by M. hominis, U. parvum, or U. urealyticum is rarely reported in patients with peritoneal dialysis (PD)-associated peritonitis. Herein, we reported four cases of PD-associated peritonitis caused by these pathogens, along with a review of the literature. The four cases were female patients with recurrent "culture-negative" PD-associated peritonitis and were related to menstruation. M. hominis, U. parvum, or U. urealyticum was detected in the PD fluid of the patients by metagenomic next-generation sequencing. All four patients were cured by intraperitoneal tigecycline combined with oral azithromycin or minocycline. M. hominis, U. parvum, and U. urealyticum should be paid more attention in female patients with recurrent culture-negative PD-associated peritonitis, especially when the peritonitis is related to menstruation, sexual intercourse, or urogenital tract operation. Moreover, metagenomic next-generation sequencing can provide a reasonable method to identify the pathogen for culture-negative PD-associated peritonitis.
Topics: Humans; Female; Male; Ureaplasma urealyticum; Ureaplasma; Mycoplasma hominis; Mycoplasma Infections; Peritoneal Dialysis
PubMed: 36948449
DOI: 10.1016/j.ijid.2023.03.032 -
Clinical Infectious Diseases : An... Aug 2021
Topics: Humans; Mycoplasma genitalium; Mycoplasma hominis; Ureaplasma
PubMed: 33493329
DOI: 10.1093/cid/ciab065 -
Annals of the New York Academy of... Oct 2006Several organisms from a number of prokaryotic and eukaryotic groups have presented problems for systematists for a long time. Both phenotypic and genotypic methods for...
Several organisms from a number of prokaryotic and eukaryotic groups have presented problems for systematists for a long time. Both phenotypic and genotypic methods for sorting out these relationships have been employed. There are limitations with each method when taken alone. Since the purpose of systematics is to determine the correct genealogical relationships among biological organisms, it is necessary to use all available means to arrive at consensus associations, and polyphasic taxonomy, which takes into consideration both methods, is a rational approach. In this short article, we provide a number of examples where polyphasic taxonomy is serving as the means of arriving at the desired consensus.
Topics: Animals; Ehrlichia; Genotype; Ixodidae; Mycoplasmataceae; Phenotype; Phylogeny; Piroplasmida; Species Specificity
PubMed: 17135557
DOI: 10.1196/annals.1373.073 -
Methods in Molecular Biology (Clifton,... 1998
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Bioengineered 2012
Topics: Algorithms; Computer Simulation; Models, Biological; Mycoplasma genitalium; Systems Biology
PubMed: 23099453
DOI: 10.4161/bioe.22367 -
International Journal of Systematic and... Jan 2006
Topics: Animals; Bacterial Typing Techniques; Mycoplasma; Mycoplasmataceae; RNA, Bacterial; RNA, Ribosomal, 16S; Sequence Analysis, RNA; Species Specificity
PubMed: 16403858
DOI: 10.1099/ijs.0.63998-0 -
Journal of Ultrastructure Research Feb 1960
Topics: Mycoplasma; Mycoplasma hominis; Mycoplasmataceae; Pleuropneumonia
PubMed: 14405991
DOI: 10.1016/s0022-5320(60)80015-9 -
The Yale Journal of Biology and Medicine 1983Mycoplasma attachment to glass in a protein-containing environment requires energization of the cells, probably to provide more accessibility of binding sites. The... (Review)
Review
Mycoplasma attachment to glass in a protein-containing environment requires energization of the cells, probably to provide more accessibility of binding sites. The substance mediating attachment is of protein nature. Studies with monoclonal antibodies on M. pneumoniae suggest a concentration of the binding sites at the tip structure.
Topics: Adhesiveness; Binding Sites; Biophysical Phenomena; Biophysics; Cell Membrane; Energy Metabolism; Glass; Mycoplasma; Mycoplasma pneumoniae
PubMed: 6433576
DOI: No ID Found