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Acta Veterinaria Scandinavica 2003
Topics: Animals; Mycoplasma; Swine
PubMed: 14650549
DOI: 10.1186/1751-0147-44-103 -
International Journal of Molecular... Dec 2023species ( spp.) are commonly found as commensals in the human urogenital tracts, although their overgrowth can lead to infection in the urogenital tract and at distal...
species ( spp.) are commonly found as commensals in the human urogenital tracts, although their overgrowth can lead to infection in the urogenital tract and at distal sites. Furthermore, ureaplasmas lack a cell wall and do not synthesize folic acid, which causes all β-lactam and glycopeptide antibiotics, and sulfonamides and diaminopyrimidines, to be of no value. The antibiotics used in therapy belong to the fluoroquinolone, tetracycline, chloramphenicol and macrolide classes. However, the growing incidence of antibiotic-resistant spp. in the population becomes a problem. Thus, there is a need to search for new drugs effective against these bacteria. Since 1951, the FDA-approved, well-tolerated, inexpensive, orally administered drug disulfiram (DSF) has been used in the treatment of chronic alcoholism, but recently, its antimicrobial effects have been demonstrated. The main biological metabolite of DSF, i.e., N,N-diethyldithiocarbamate (DDC), is generally believed to be responsible for most of the observed pharmacological effects of DSF. In the presented studies, the effect of DDC at concentrations of 2 µg/mL, 20 µg/mL and 200 µg/mL on the growth and survival of and was tested for the first time. The results indicated that all the used DDC concentrations showed both bacteriostatic and bactericidal activity against both tested strains.
Topics: Humans; Ureaplasma urealyticum; Ureaplasma; Ditiocarb; Anti-Bacterial Agents; Sulfanilamide
PubMed: 38203213
DOI: 10.3390/ijms25010040 -
Archiv Fur Geschwulstforschung 1968
Review
Topics: Culture Techniques; Female; Humans; L Forms; Lung; Male; Meninges; Mouth; Mycoplasma; Mycoplasma Infections; Neoplasms; Urogenital System
PubMed: 4878146
DOI: No ID Found -
Nihon Saikingaku Zasshi. Japanese... May 1998
Review
Topics: Genome, Bacterial; Mycoplasma; Plant Diseases
PubMed: 9654944
DOI: 10.3412/jsb.53.443 -
Sub-cellular Biochemistry 1993
Review
Topics: Adhesins, Bacterial; Animals; Bacterial Adhesion; Bacterial Proteins; Humans; Multigene Family; Mycoplasma; Mycoplasma pneumoniae; Sequence Homology, Amino Acid
PubMed: 8378992
DOI: 10.1007/978-1-4615-2924-8_9 -
Medycyna Wieku Rozwojowego 2006Mycoplasmas comprise a big group of organisms consisting of one hundred eighty species which are found in nature as parasites of humans, other mammals, reptiles, fishes... (Review)
Review
Mycoplasmas comprise a big group of organisms consisting of one hundred eighty species which are found in nature as parasites of humans, other mammals, reptiles, fishes and plants, or living as commensals. The group commonly referred to as genital mycoplasmas comprise species most often found in the genitourinary tract of sexually active adults as common commensal inhabitants, or pathogens which can cause many different infections. The species we are most interested in this work are called: Mycoplasma genitalium, Mycoplasma hominis and Ureaplasma urealyticum. There is no doubt that they can cause non-gonococcal urethritis (NGU) in both men and women and bacterial vaginosis (BV), cervicitis, endometritis. Infection can spread to the upper port of female genital tract and it can lead to pelvic inflammatory disease, or if it happens during pregnancy--to chorioamnionitis and further pregnancy complications. Even though mycoplasmas have been known and described since 1898, the problem of their morbidity and the possible influence they have on human fertility is still not clear. Similar to research from 30 years ago, connecting Chlamydia trachomatis with infertility, new scientific work as well as the dynamic development of diagnostics procedure, especially more common use of PCR method, may be helpful in discovering the potential role genital mycoplasmas play in infertility.
Topics: Female; Humans; Infertility, Female; Male; Mycoplasma; Mycoplasma Infections; Mycoplasma genitalium; Mycoplasma hominis; Sexually Transmitted Diseases, Bacterial; Ureaplasma urealyticum; Urethritis
PubMed: 17401188
DOI: No ID Found -
Antonie Van Leeuwenhoek 1956
Topics: Humans; Mycoplasma; Mycoplasmataceae; Pleuropneumonia; Virulence
PubMed: 13395348
DOI: 10.1007/BF02538351 -
Science (New York, N.Y.) May 1981A new spiroplasma isolated from Ixodes pacificus collected in Oregon was serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could...
A new spiroplasma isolated from Ixodes pacificus collected in Oregon was serologically and morphologically distinct from known spiroplasmas. The new spiroplasma could also be isolated in tick cell cultures. Discovery of a new fastidious mycoplasma in ticks offers opportunities to explore the possible role of these agents in human and animal diseases.
Topics: Animals; Humans; Mycoplasma; Ticks
PubMed: 7233197
DOI: 10.1126/science.7233197 -
Journal of Bacteriology Aug 1963
Topics: Culture Media; Mycoplasma; Mycoplasma pneumoniae; Research
PubMed: 14058962
DOI: 10.1128/jb.86.2.339-339.1963 -
Journal of Bacteriology Feb 1962Gill, James W. (University of New Hampshire, Durham). Culture and metabolism of Mycoplasma gallisepticum. J. Bacteriol. 83:213-218. 1962.-Mycoplasma gallisepticum A5969,...
Gill, James W. (University of New Hampshire, Durham). Culture and metabolism of Mycoplasma gallisepticum. J. Bacteriol. 83:213-218. 1962.-Mycoplasma gallisepticum A5969, a strong-growing pleuropneumonia-like organism pathogenic for poultry, was found to be intolerant of extremes of temperature and potassium ion concentration. It ferments glucose to the benefit of cell yield, but glycolysis appears not to be essential to growth. Anaerobic growth can be maintained if pyruvate is added as a hydrogen recipient.A transamination system between glutamic acid and aspartic acid, more rapid toward the formation of aspartic acid, was found in a frozen-cell preparation. Two small peptides were observed to be produced by the organism and liberated into the medium under normal growth conditions. The composition of the peptides shows a relationship to the cell wall of certain bacteria.
Topics: Glucose; Mycoplasma; Mycoplasma Infections; Mycoplasma gallisepticum; Pyruvates
PubMed: 13898603
DOI: 10.1128/jb.83.2.213-218.1962