-
Pediatric Dermatology 2023Cutaneous myeloid sarcoma is rarely present prior to the diagnosis of congenital acute myeloid leukemia (AML); the former is typically diagnosed with or after the...
Cutaneous myeloid sarcoma is rarely present prior to the diagnosis of congenital acute myeloid leukemia (AML); the former is typically diagnosed with or after the leukemia. We report a 2-day-old male born with multiple cutaneous red to violaceous nodules. Histopathologic and immunohistochemistry findings from a skin nodule were suspicious for myeloid sarcoma. Bone marrow biopsy was initially negative for aberrant blasts; however, at age 4 months, AML with a KMT2A gene rearrangement was identified via bone marrow biopsy.
Topics: Humans; Infant; Infant, Newborn; Male; Bone Marrow; Leukemia, Myeloid, Acute; Sarcoma, Myeloid; Skin; Skin Neoplasms
PubMed: 37029447
DOI: 10.1111/pde.15313 -
Archives of Pathology & Laboratory... Aug 2005Myeloid sarcoma is a neoplasm of immature myeloid cells involving an extramedullary anatomic site that is usually, although not always, associated with acute myeloid...
CONTEXT
Myeloid sarcoma is a neoplasm of immature myeloid cells involving an extramedullary anatomic site that is usually, although not always, associated with acute myeloid leukemia. Any extramedullary site can be involved by myeloid sarcoma, but involvement of the cecal appendix is uncommon, and symptoms mimicking acute appendicitis as a result of appendiceal involvement are rare.
OBJECTIVE
To describe the clinicopathologic features of 2 patients with myeloid sarcoma involving the appendix who presented with right lower quadrant pain suggestive of acute appendicitis and prompting appendectomy.
DESIGN
Clinical information for both patients was obtained from the medical record. Routine hematoxylin-eosin-stained slides, naphthol-ASD-chloroacetate stain, and immunohistochemical stains for myeloid, B-cell, and T-cell antigens were prepared.
RESULTS
Peripheral blood and bone marrow were infiltrated by coexistent acute myeloid leukemia in case 1 but were negative for leukemia in case 2. In case 2, the patient had a history of acute myeloid leukemia that had been treated by an allogenic bone marrow transplant 7 months earlier. Histologic examination of the appendix revealed poorly differentiated myeloid sarcoma in both cases. Each neoplasm was positive for chloroacetate esterase, myeloperoxidase, lysozyme, and CD43 and was negative for CD3 and CD20.
CONCLUSIONS
Myeloid sarcoma involving the appendix can rarely cause pain or other symptoms mimicking acute appendicitis. A high index of suspicion combined with the use of cytochemical and immunohistochemical studies are helpful in establishing the diagnosis.
Topics: Abdomen; Adult; Appendicitis; Appendix; Biomarkers, Tumor; Chemotherapy, Adjuvant; Child; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Leukemia, Myeloid; Male; Palliative Care; Radiotherapy; Retrospective Studies; Sarcoma, Myeloid; Treatment Outcome; Ultrasonography
PubMed: 16048393
DOI: 10.5858/2005-129-1027-MSOAMA -
Haematologica Apr 2011
Topics: Humans; Karyotyping; Leukemia, Myeloid, Acute; Monosomy; Prognosis
PubMed: 21454879
DOI: 10.3324/haematol.2011.043208 -
Pediatric Hematology and Oncology Nov 2011
Topics: Cytogenetic Analysis; Developing Countries; Follow-Up Studies; Humans; India; Leukemia, Myeloid, Acute
PubMed: 21875321
DOI: 10.3109/08880018.2011.601435 -
BMJ Case Reports Oct 2017
Topics: Adult; Eyelids; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Orbit; Orbital Neoplasms; Sarcoma, Myeloid; Whole Body Imaging
PubMed: 28978612
DOI: 10.1136/bcr-2017-222659 -
Nihon Naika Gakkai Zasshi. the Journal... Jul 2013
Review
Topics: Adult; Age Factors; Cytokines; Humans; Leukemia, Myeloid, Acute; Prognosis; Risk Factors; Secondary Prevention
PubMed: 23947230
DOI: 10.2169/naika.102.1687 -
Turkish Journal of Haematology :... Nov 2019
Topics: Child; Diagnosis, Differential; Female; Humans; Leukemia, Myeloid, Acute; Mediastinal Neoplasms; Nuclear Proteins; Nucleophosmin; Sarcoma, Myeloid
PubMed: 30859798
DOI: 10.4274/tjh.galenos.2019.2018.0434 -
Haematologica Mar 1999
Topics: China; Humans; Leukemia, Myeloid, Acute
PubMed: 10189404
DOI: No ID Found -
Hematology. American Society of... 2008
Topics: Autopsy; Bone Marrow Transplantation; Granulocytes; History, 19th Century; History, 20th Century; Humans; Leukemia, Myeloid, Acute; Platelet Transfusion
PubMed: 19074115
DOI: 10.1182/asheducation-2008.1.390 -
Diagnostic Cytopathology Oct 2013Acute myeloid leukemia (AML) may be associated with extramedullary tumor growth, which is commonly known as myeloid sarcoma. Although AML with leukemic pleural effusion...
Acute myeloid leukemia (AML) may be associated with extramedullary tumor growth, which is commonly known as myeloid sarcoma. Although AML with leukemic pleural effusion is considered rare, the true incidence is not clear. We report three cases of AML involving pleural effusion in this study. The cases were encountered in a single institute within two years, suggesting that leukemic effusion is more common than previously reported. Leukemic cells showed evidence of monocytic differentiation in all cases. Two patients presented with advanced AML. Both had concurrent myeloid sarcoma. Both were ineligible for intensive treatment and died soon after diagnosis of myeloid sarcoma. The third patient had pleural effusion upon diagnosis of AML. Remission was achieved and the effusion disappeared after treatment. We conclude leukemic effusion may become more common in an era of improved care and prolonged survival for AML patients. The prognostic impact is unclear and patients should be given standard AML treatment whenever possible.
Topics: Aged; Female; Humans; Leukemia, Myeloid, Acute; Male; Pleural Effusion, Malignant; Radiography; Sarcoma, Myeloid
PubMed: 22550016
DOI: 10.1002/dc.22859