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The New England Journal of Medicine Dec 1974
Review
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Division; Cells, Cultured; Clone Cells; DNA; Feedback; Granulocytes; Growth Inhibitors; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Leukocytes; Neutropenia; Neutrophils
PubMed: 4279336
DOI: 10.1056/NEJM197412262912606 -
Internal Medicine Journal Oct 2006Extramedullary relapse of acute myeloid leukaemia may occur in sites such as the central nervous system, testes, and skin. Presentations in the female genital tract are...
Extramedullary relapse of acute myeloid leukaemia may occur in sites such as the central nervous system, testes, and skin. Presentations in the female genital tract are uncommon and usually asymptomatic. In contrast, symptomatic uterine myeloid sarcoma is very rare. Treatment of this is generally unsuccessful, but is improved when systemic therapies are used. We study a case of a uterine relapse of acute myeloid leukaemia presenting as vaginal bleeding and successfully managed by local irradiation. The mechanism of preferential infiltration of uterine tissue requires further study.
Topics: Diagnosis, Differential; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; Pregnancy; Sarcoma, Myeloid; Uterine Hemorrhage; Uterine Neoplasms
PubMed: 16958646
DOI: 10.1111/j.1445-5994.2006.01177.x -
Current Problems in Pediatric and... Feb 2002
Comparative Study Review
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Cytogenetics; Disease-Free Survival; Down Syndrome; Forecasting; Humans; Immunophenotyping; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Risk Factors; Time Factors; Tumor Lysis Syndrome
PubMed: 11951090
DOI: 10.1067/mps.2002.121791 -
Blood Oct 2011Extramedullary (EM) manifestations of acute leukemia include a wide variety of clinically significant phenomena that often pose therapeutic dilemmas. Myeloid sarcoma...
Extramedullary (EM) manifestations of acute leukemia include a wide variety of clinically significant phenomena that often pose therapeutic dilemmas. Myeloid sarcoma (MS) and leukemia cutis (LC) represent 2 well-known EM manifestations with a range of clinical presentations. MS (also known as granulocytic sarcoma or chloroma) is a rare EM tumor of immature myeloid cells. LC specifically refers to the infiltration of the epidermis, dermis, or subcutis by neoplastic leukocytes (leukemia cells), resulting in clinically identifiable cutaneous lesions. The molecular mechanisms underlying EM involvement are not well defined, but recent immunophenotyping, cytogenetic, and molecular analysis are beginning to provide some understanding. Certain cytogenetic abnormalities are associated with increased risk of EM involvement, potentially through altering tissue-homing pathways. The prognostic significance of EM involvement is not fully understood. Therefore, it has been difficult to define the optimal treatment of patients with MS or LC. The timing of EM development at presentation versus relapse, involvement of the marrow, and AML risk classification help to determine our approach to treatment of EM disease.
Topics: Chromosome Aberrations; Drug Therapy; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Leukemic Infiltration; Mutation; Prognosis; Sarcoma, Myeloid; Skin
PubMed: 21795742
DOI: 10.1182/blood-2011-04-347229 -
Immunity Jun 2020The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide,... (Review)
Review
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
Topics: Animals; Betacoronavirus; COVID-19; Coronavirus Infections; Disease Susceptibility; Humans; Immunity, Innate; Immunologic Memory; Inflammation; Lymphocytes; Myeloid Cells; Pandemics; Pneumonia, Viral; SARS-CoV-2
PubMed: 32505227
DOI: 10.1016/j.immuni.2020.05.002 -
Vnitrni Lekarstvi Sep 1981
Review
Topics: Chromosomes, Human, 21-22 and Y; Humans; Leukemia, Myeloid
PubMed: 7027606
DOI: No ID Found -
Acta Dermato-venereologica Nov 2012
Topics: Aclarubicin; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 7; Cytarabine; Humans; Leukemia, Myeloid, Acute; Male; Sarcoma, Myeloid; Skin; Skin Neoplasms; Skin Pigmentation; Translocation, Genetic; Treatment Outcome
PubMed: 22278733
DOI: 10.2340/00015555-1312 -
Hematological Oncology 1987
Review
Topics: Age Factors; Bone Marrow Transplantation; Combined Modality Therapy; Graft Survival; Graft vs Host Disease; Humans; Infertility; Leukemia, Myeloid; Neoplasm Recurrence, Local; Radiation Injuries; Tissue Donors
PubMed: 3319867
DOI: 10.1002/hon.2900050405 -
British Journal of Haematology Feb 1998
Review
Topics: Apoptosis; Cell Cycle; Cell Division; Genes, ras; Humans; Leukemia, Myeloid
PubMed: 9488611
DOI: 10.1046/j.1365-2141.1998.00554.x -
Clinics in Haematology Feb 1986
Review
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Graft vs Host Disease; Granulocytes; HLA-DR Antigens; Hematopoietic Stem Cells; Histocompatibility Antigens Class II; Humans; Leukemia, Myeloid, Acute; Melphalan; Time Factors; Transplantation Immunology; Transplantation, Autologous; Whole-Body Irradiation
PubMed: 3516488
DOI: 10.1016/s0308-2261(86)80010-8