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British Journal of Haematology Jul 2021
Topics: Adult; Bone Marrow; Female; Humans; Karyotype; Leukemia, Myeloid, Acute; Point Mutation; Wolman Disease
PubMed: 33694176
DOI: 10.1111/bjh.17389 -
American Journal of Hematology Feb 2017
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leukemia, Myeloid, Acute; Male; Mutation; Nuclear Proteins; Nucleophosmin; Prognosis; Recurrence; Remission Induction
PubMed: 27813149
DOI: 10.1002/ajh.24601 -
Medicine and Health, Rhode Island Jan 2011
Topics: Aged; Farnesyltranstransferase; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Prognosis; Risk Assessment; fms-Like Tyrosine Kinase 3
PubMed: 21290987
DOI: No ID Found -
The Pan African Medical Journal 2021Myeloid sarcoma is a rare ocular manifestation of acute myeloid leukemia. Bilateral manifestation preceding any clinical signs of leukemia is even rarer. We here report...
Myeloid sarcoma is a rare ocular manifestation of acute myeloid leukemia. Bilateral manifestation preceding any clinical signs of leukemia is even rarer. We here report the case of a 16-month-old patient with rapidly progressive, inflammatory, acute bilateral exophthalmos associated with exposure keratitis. Computed tomography (CT) scan of the orbit and of the brain showed bilateral tissue-like infiltration into the orbital cavity. Blood tests showed biologic inflammatory syndrome, bicytopenia and circulating blasts 83%. Myelogram was performed based on the presence of circulating blasts; it showed acute myeloid leukemia (grade 4). Clinicians should suspect myeloid sarcoma in patients with bilateral exophthalmos and conduct a careful interpretation of blood test results.
Topics: Exophthalmos; Humans; Infant; Leukemia, Myeloid, Acute; Male; Myelography; Orbital Neoplasms; Sarcoma, Myeloid; Tomography, X-Ray Computed
PubMed: 34527161
DOI: 10.11604/pamj.2021.39.145.25242 -
Leukemia Research Jul 2012
Topics: Cell Differentiation; Cell Shape; Cytogenetics; Disease Progression; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Staging; Phenotype; Prognosis
PubMed: 22483069
DOI: 10.1016/j.leukres.2012.03.004 -
Journal of the College of Physicians... Jun 2016Myeloid sarcoma (MS) is an extramedullary solid tumor composed of leukemic myeloid cells. MS is an uncommon tumor complicating acute myeloid leukemia (AML), or less...
Myeloid sarcoma (MS) is an extramedullary solid tumor composed of leukemic myeloid cells. MS is an uncommon tumor complicating acute myeloid leukemia (AML), or less often myelodysplestic syndrome (MDS) and myeloproliferative disorders. Rarely, MS may precede the systemic onset of AML, which usually follows within months. We report a 36 year-old lady who presented with a cervical-uterine mass, which proved to be MS. Initially, she had no systemic AMLand was treated with hysterectomy and systemic chemotherapy. She developed bilateral-flank pain and renal impairment after 9 months. Imaging revealed a soft-tissue mass in the para-aortic and peri-sacral region with bilateral hydronephrosis. Biopsy from the mass confirmed recurrence of MS. Bone marrow (BM) biopsy revealed 20% blasts consistent with AML. She was treated with aggressive chemotherapy and local radiotherapy. Despite these measures, she died of progressive disease. MS should be considered and treated as systemic AML, rather than an isolated mass; and we discuss management issues in such patients.
Topics: Adult; Fatal Outcome; Female; Humans; Leukemia, Myeloid, Acute; Sarcoma, Myeloid; Uterine Neoplasms; Uterus
PubMed: 27376223
DOI: No ID Found -
Blood Mar 1970
Topics: Adult; Antineoplastic Agents; Autopsy; Biopsy; Breast Neoplasms; Cheek; Diagnosis, Differential; Facial Neoplasms; Female; Humans; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Sarcoma; Thoracic Neoplasms
PubMed: 4908654
DOI: No ID Found -
The American Journal of Case Reports Apr 2019BACKGROUND Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before,...
BACKGROUND Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before, concurrently with, or following acute myeloid leukemia presentation. Few reports have focused on the imaging findings in cases of myeloid sarcoma of the breast, and the existing findings are variable and nonspecific; the present case report aimed to bridge this gap. CASE REPORT A 24-year-old female presented with a palpable lump at the upper outer quadrant of her right breast. She had noticed the mass 2 days prior to presentation. She was first diagnosed with acute myelogenous leukemia 18 months before the lump presentation and had undergone haploidentical stem cell transplantation 6 months prior. At the time of the breast lump presentation, she was undergoing chemotherapy for relapsed acute myeloid leukemia. Ultrasonography of her right breast revealed a circumscribed, oval mass corresponding to the palpable lump. Ultrasonography-guided 14-gauge core needle biopsy was performed on the breast mass, leading to a pathological diagnosis of myeloid sarcoma. CONCLUSIONS We reported a case of myeloid sarcoma involving the breast. On sonography, although the internal echotexture resembled that of breast hamartoma, the observed hard elasticity and high vascularity raised suspicions of malignancy.
Topics: Breast Neoplasms; Female; Humans; Image-Guided Biopsy; Leukemia, Myeloid, Acute; Sarcoma, Myeloid; Stem Cell Transplantation; Ultrasonography, Mammary; Young Adult
PubMed: 31030205
DOI: 10.12659/AJCR.915453 -
Acta Dermato-venereologica May 2013We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52...
We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52 years. Diagnosis of myeloid sarcoma in the skin was difficult due to the low frequency of myeloperoxidase and/or CD34+ cases (56% and 19% of tested cases, respectively). Seventy-one of the 83 patients (86%) had ≥ 1 bone marrow biopsy. Twenty-eight (39%) had acute myeloid leukemia with monocytic differentiation. Twenty-three had other de novo acute myeloid leukemia subtypes. Thirteen patients had other myeloid neoplasms, of which 4 ultimately progressed to an acute myeloid leukemia. Seven had no bone marrow malignancy. Ninety-eight percent of the patients received chemotherapy, and approximately 89% died of causes related to their disease. Cutaneous myeloid sarcoma in most cases represents an aggressive manifestation of acute myeloid leukemia. Diagnosis can be challenging due to lack of myeloblast-associated antigen expression in many cases, and difficulty in distinguishing monocyte-lineage blasts from neoplastic and non-neoplastic mature monocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents; Biopsy; Bone Marrow Examination; Chi-Square Distribution; Child; Child, Preschool; Female; Flow Cytometry; Humans; Immunohistochemistry; Infant; Infant, Newborn; Karyotyping; Leukemia, Myeloid, Acute; Male; Middle Aged; Missouri; Predictive Value of Tests; Retrospective Studies; Sarcoma, Myeloid; Skin; Skin Neoplasms; Tertiary Care Centers; Time Factors; Treatment Outcome; Young Adult
PubMed: 23165700
DOI: 10.2340/00015555-1458 -
Lancet (London, England) Sep 1979Identification of a "cluster" of cases of acute myeloid leukaemia and chronic myeloproliferative disorders in Lytham St. Annes, Lancashire, prompted an analysis of the...
Identification of a "cluster" of cases of acute myeloid leukaemia and chronic myeloproliferative disorders in Lytham St. Annes, Lancashire, prompted an analysis of the incidence of myeloid leukaemias in Lancashire (excluding Ormskirk Health District), as recorded by the Manchester Cancer Registry. Although statistically there was no significant difference in the trend of incidence between the whole former borough of Lytham St. Annes and the other districts studied, the reported incidence of these diseases in the area as a whole had almost doubled, and in two districts nearly trebled, between two consecutive 6 year periods, beginning in 1965. This represents a substantially larger increase than mortality data suggests has occurred nationally in the same period, and is unlikely to be due solely to more accurate diagnosis or reporting.
Topics: England; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Space-Time Clustering
PubMed: 89557
DOI: 10.1016/s0140-6736(79)91613-1