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Ear, Nose, & Throat Journal Aug 2005
Topics: Humans; Immunohistochemistry; Sarcoma, Myeloid
PubMed: 16220848
DOI: No ID Found -
Experimental Oncology Mar 2017Myeloid sarcomas (MS) are rare extramedullary tumors composed of blasts of myeloid lineage that either precede, follow or present concomitantly with acute myeloid... (Review)
Review
BACKGROUND
Myeloid sarcomas (MS) are rare extramedullary tumors composed of blasts of myeloid lineage that either precede, follow or present concomitantly with acute myeloid leukaemia (AML) or myeloproliferative neoplasms. The diagnosis of MS is especially challenging in patients without an antecedent history of leukemia.
METHODS
We present 2 cases of intraoral MS that presented as de novo lesions. A detailed review of cases of intraoral MS that either preceded or presented along with leukemia has been done with emphasis on diagnostic criteria used.
RESULTS
Two male patients aged 28 and 5 years presented with MS with one patient presenting with concomitant AML. A combination of morphological and immunohistochemical methods was used for diagnosis. A thorough review of world literature revealed 44 cases of intraoral MS that presented as de novo lesions.
CONCLUSION
Intraoral MS is a rare tumor with poor prognosis. It may be diagnostically challenging due to its protean clinical manifestations and histological overlap with other tumors.
Topics: Adult; Child, Preschool; Diagnosis, Differential; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; Male; Mouth Neoplasms; Peroxidase; Sarcoma, Myeloid
PubMed: 28361861
DOI: No ID Found -
BMJ Case Reports Jan 2019A 19-year-old woman presented to the outpatient department with occasional ocular pain and redness and a perilimbal mass, which she noticed 5 months ago in her left eye....
A 19-year-old woman presented to the outpatient department with occasional ocular pain and redness and a perilimbal mass, which she noticed 5 months ago in her left eye. She had no systemic complaints. Ultrasound biomicroscopy of the mass showed a hypoechoic lesion with uniform reflectivity. The patient underwent an excision biopsy and a histopathological analysis revealed features suggestive of a granulocytic sarcoma/myeloid sarcoma. Further haematopathological evaluation confirmed concurrent acute myeloid (myelomonocytic) leukaemia French American British classification M4. There was complete remission of the ocular surface lesion and leukaemia with systemic chemotherapy. At the last follow-up of 18 months post-treatment the patient is free of disease.
Topics: Aftercare; Biopsy; Drug Therapy; Eye Pain; Female; Humans; Leukemia, Myelomonocytic, Acute; Microscopy, Acoustic; Remission Induction; Sarcoma, Myeloid; Treatment Outcome; Young Adult
PubMed: 30642851
DOI: 10.1136/bcr-2018-226284 -
American Journal of Clinical Pathology Aug 2015This session of the 2013 Society of Hematopathology/European Association for Haematopathology workshop focused on extramedullary manifestations of myeloid neoplasms. (Review)
Review
OBJECTIVES
This session of the 2013 Society of Hematopathology/European Association for Haematopathology workshop focused on extramedullary manifestations of myeloid neoplasms.
METHODS
We divided the submitted cases into four subgroups: (1) isolated myeloid sarcoma (MS); (2) MS with concurrent acute myeloid leukemia (AML), with a focus on karyotypic and molecular findings; (3) extramedullary relapse of AML, including relapse in the posttransplant setting; and (4) blast phase/transformation of a myeloproliferative neoplasm or chronic myelomonocytic leukemia.
RESULTS
Establishing a diagnosis of isolated MS requires a high index of suspicion and use of immunophenotypic methods. Recurrent cytogenetic abnormalities or gene mutations that occur in MS mirror those known to occur in AML.
CONCLUSIONS
In the era of targeted therapy and sophisticated risk stratification, every attempt must be made to perform a complete workup on MS cases (or concurrent AML) since the diagnosis of MS, in itself, is no longer adequate for patient management. Cases of blastic plasmacytoid dendritic cell neoplasm were also included and discussed in this session.
Topics: Humans; Myeloproliferative Disorders; Sarcoma, Myeloid
PubMed: 26185307
DOI: 10.1309/AJCPO58YWIBUBESX -
British Journal of Haematology Sep 2008
Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Cranial Fossa, Middle; Craniotomy; Cytarabine; Female; Humans; Magnetic Resonance Imaging; Sarcoma, Myeloid; Skull Base Neoplasms
PubMed: 18477037
DOI: 10.1111/j.1365-2141.2008.07169.x -
Journal of Clinical Neuroscience :... Jul 2012The overwhelming majority of pineal region tumors are malignant germ cell tumors, pineal cell tumors, or glial tumors. To our knowledge we report the first patient with...
The overwhelming majority of pineal region tumors are malignant germ cell tumors, pineal cell tumors, or glial tumors. To our knowledge we report the first patient with myeloid sarcoma in the pineal region. Myeloid sarcomas are composed of immature granulocytic precursor cells and are associated with acute myelogenous leukemia. Thus, myeloid sarcoma should be considered in the differential diagnosis of pineal region masses in patients with a known history of acute myelogenous leukemia.
Topics: Aged; Humans; Hydrocephalus; Magnetic Resonance Imaging; Male; Pinealoma; Sarcoma, Myeloid
PubMed: 22560847
DOI: 10.1016/j.jocn.2011.11.014 -
BMC Ophthalmology Feb 2022Conjunctival myeloid sarcoma (MS) as an isolated presentation of acute myeloid leukemia (AML) relapse is rare. Here, we report a case of unilateral conjunctival MS...
BACKGROUND
Conjunctival myeloid sarcoma (MS) as an isolated presentation of acute myeloid leukemia (AML) relapse is rare. Here, we report a case of unilateral conjunctival MS revealed as a sign of AML relapse.
CASE PRESENTATION
A 50-year-old man with a history of AML in remission visited our clinic presenting with a left conjunctival injection persisting for 1 month. Diffuse subconjunctival thickening with conjunctival vascular engorgement was observed. Ultrasound biomicroscopy revealed a hyper-reflective, thickened conjunctiva in his left eye. During the incisional biopsy, the lesion was strongly attached to the underlying sclera; histopathologic examination revealed infiltration of leukemic blasts. The relapse of AML was confirmed by a successive bone marrow biopsy. The ocular lesion disappeared after allogeneic peripheral blood stem cell transplantation (PBSCT) and concomitant salvage radiotherapy on the left eye. The patient has remained in remission for 3 years after allogeneic PBSCT.
CONCLUSIONS
Incidental conjunctival lesions can indicate AML relapse in patients treated earlier for AML. An ophthalmologist may have a role in the early detection of AML when a patient presents with an atypical conjunctival lesion.
Topics: Conjunctiva; Conjunctival Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Sarcoma, Myeloid
PubMed: 35144564
DOI: 10.1186/s12886-022-02286-1 -
Orbit (Amsterdam, Netherlands) Jun 2016
Topics: Adult; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Orbital Neoplasms; Sarcoma, Myeloid; Transplantation, Homologous; Young Adult
PubMed: 27074545
DOI: 10.3109/01676830.2016.1139598 -
Blood Aug 2020
Topics: Adult; Antigens, CD; Biomarkers, Tumor; Bone Marrow Neoplasms; Disease Progression; Erythroblasts; Humans; Lymph Nodes; Male; Oncogene Proteins, Fusion; Sarcoma, Myeloid
PubMed: 32853379
DOI: 10.1182/blood.2019004410 -
Pathobiology : Journal of... 2023Myeloid sarcoma (MS) is a mass-forming proliferation of myeloid blasts. Frequently, it arises as blast phase of pre-existing myeloproliferative, myelodysplastic...
INTRODUCTION
Myeloid sarcoma (MS) is a mass-forming proliferation of myeloid blasts. Frequently, it arises as blast phase of pre-existing myeloproliferative, myelodysplastic disorders or consequent to bone marrow transplant. Its molecular characterization has become an increasingly important requirement for the diagnostic definition of this solid leukemia.
CASE PRESENTATION
Our case report concerns an MS arising in the breast of a woman with a previous diagnosis of JAK2-mutated essential thrombocythemia (Val617Phe exon 14p) mimicking, on histology, a lobular carcinoma of the breast. The immunohistochemical study of the neoplasm provided the key that solved the diagnostic doubt and the immunohistochemical evaluation of NPM protein expression, which turn out to be negative, provided a clear indication on the molecular status and prognosis of the disease. A year later, the neoplasm relapsed in the pelvic area.
DISCUSSION
This diagnostic challenge led us to review the literature of the past 10 years concerning MS of the breast. To the best of our knowledge, this was the first case of MS of the breast occurring in a patient with a history of essential thrombocythemia and recurred in the pelvic region.
Topics: Female; Humans; Thrombocythemia, Essential; Sarcoma, Myeloid; Blast Crisis; Leukemia; Exons; Janus Kinase 2
PubMed: 35850113
DOI: 10.1159/000525163