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The American Journal of Dermatopathology Aug 2000
Topics: Biomarkers, Tumor; Histocytochemistry; Humans; Male; Middle Aged; Myoepithelioma; Neoplasm Proteins; Skin Neoplasms
PubMed: 10949461
DOI: 10.1097/00000372-200008000-00009 -
Head & Neck May 2004Extraglandular myoepitheliomas are neoplasms that seldom occur in the soft tissue of the head and neck region. Misdiagnosis of these neoplasms as more aggressive tumors... (Review)
Review
BACKGROUND
Extraglandular myoepitheliomas are neoplasms that seldom occur in the soft tissue of the head and neck region. Misdiagnosis of these neoplasms as more aggressive tumors can lead to unnecessary treatment.
METHODS
We describe a myoepithelioma of cervical soft tissue. The histopathology of the tumor, its immunophenotype, its differential diagnosis, and a review of the literature are presented.
RESULTS
Histopathologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and eccentric nuclei arranged in cords and files. On immunohistochemical analysis, the cells expressed cytokeratin 14, calponin, glial fibrillary acid protein, and p63 and showed focal positivity for S-100 protein. Together, these markers identified the cells as myoepithelial type. A literature review identified only five cases of myoepithelioma in the soft tissue of the head and neck region in which detailed clinical information was provided.
CONCLUSIONS
Myoepitheliomas can have cells with variable morphology arranged in different histologic patterns. Immunohistochemical analysis is crucial for unequivocal diagnosis when myoepitheliomas occur in extraglandular locations.
Topics: Biopsy, Needle; Follow-Up Studies; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Myoepithelioma; Risk Assessment; Soft Tissue Neoplasms; Treatment Outcome
PubMed: 15122665
DOI: 10.1002/hed.20044 -
Head and Neck Pathology Jul 2013Myoepithelial neoplasms are tumors composed almost exclusively of cells with myoepithelial differentiation. They frequently contain spindle, plasmacytoid or epithelioid... (Review)
Review
Myoepithelial neoplasms are tumors composed almost exclusively of cells with myoepithelial differentiation. They frequently contain spindle, plasmacytoid or epithelioid shaped cells and may have oncocytic or clear cytoplasmic features. They are uncommon, accounting for 1.5 % of all salivary gland tumors and for 2.2-5.7 % of major and minor salivary gland tumors, respectively. Recently this author, together with several colleagues, have described three unusual myoepithelial tumors, two benign and one malignant that contained abundant intracellular mucin material, which they termed the mucinous variant of myoepithelioma. This represents a unique, previously undescribed subtype that does not fit in the current classification system. A literature review revealed several similar cases reported as "signet ring-cell" adenocarcinomas of salivary gland, which stained for myoepithelial markers, in addition to containing intracellular mucin material, that are more accurately classified as mucinous myoepithelioma. To date, there are 17 reported mucinous myoepitheliomas; four were classified as benign and 13 as malignant. Thirteen arose in minor salivary glands and four in the parotid gland. One patient presented with a lymph node metastasis. With minimal follow-up currently available, this appears to be a benign to low-grade malignancy.
Topics: Biomarkers, Tumor; Cystadenocarcinoma, Mucinous; Humans; Immunohistochemistry; Myoepithelioma; Salivary Gland Neoplasms
PubMed: 23821216
DOI: 10.1007/s12105-013-0464-x -
Lung Cancer (Amsterdam, Netherlands) Apr 1998Myoepithelial tumors occur mainly in the salivary glands, the sweat glands or the breast, but uncommonly in the lung. Herein, we describe two cases of myoepithelioma of... (Review)
Review
Myoepithelial tumors occur mainly in the salivary glands, the sweat glands or the breast, but uncommonly in the lung. Herein, we describe two cases of myoepithelioma of the lung. Both patients were 58-year-old men, in whom the tumors were located in the right-upper bronchus and in the left-upper bronchus, respectively, with endobronchial growth pattern. Surgery was performed, but metastasis occurred into the forearm and hip muscles in the former case, and into the liver in the latter. Histologically, the tumor in the former was a spindle-plasmacytoid type, and that in the latter was a plasmacytoid type in part with squamous differentiation. Based on histochemical, immunohistochemical and ultrastructural analyses, both were compatible with myoepithelioma. The clinicopathological uniqueness of this neoplasm is discussed, together with a review of reports of this disease in the literature.
Topics: Fatal Outcome; Humans; Immunohistochemistry; Lung Neoplasms; Male; Microscopy, Electron; Middle Aged; Myoepithelioma
PubMed: 9699187
DOI: 10.1016/s0169-5002(98)00006-3 -
Virchows Archiv. A, Pathological... 1993Malignant myoepithelioma of the salivary gland is discussed in terms of its clinical behaviour, morphological features and the frequent pre-existence of a pleomorphic... (Review)
Review
Malignant myoepithelioma of the salivary gland is discussed in terms of its clinical behaviour, morphological features and the frequent pre-existence of a pleomorphic adenoma. The study comprised six female and four male patients aged 14-63 years (mean age 38.9 years). Two tumours presented as intraoral lesions and eight were located in the parotid gland. Tumour cells displayed a morphological spectrum ranging from round epithelioid cells to spindle-shaped and stellate cells. Most cells displayed reactivity for high molecular weight keratins and in four tumours there was strong immunoreactivity for smooth muscle actin. Malignant myoepithelioma seems to arise in two different clinical settings: either de novo or in a recurrent pleomorphic adenoma. De novo malignant myoepitheliomas arise in normal salivary gland, tend to be more aggressive and have a short clinical history. Recurrences may not develop or may occur as a single event within a short time interval, and metastases develop in the lungs. Malignant myoepitheliomas arising in recurrent pleomorphic adenomas have a long clinical history, are characterized by multiple recurrences and have to be distinguished from aggressive carcinomas arising in these adenomas. In contrast, the tumours described in the present series arising in pleomorphic adenomas showed local aggressiveness and metastases did not occur until decades after the first treatment. The general opinion that all malignant tumours that arise from pleomorphic adenomas are highly aggressive is not confirmed by the present study.
Topics: Adenoma, Pleomorphic; Adolescent; Adult; Female; Follow-Up Studies; Humans; Immunohistochemistry; Longitudinal Studies; Male; Middle Aged; Myoepithelioma; Neoplasms, Second Primary; Salivary Gland Neoplasms
PubMed: 8116228
DOI: 10.1007/BF01607152 -
Clinical Imaging May 2020The spectrum of myoepithelial tumors usually occur in the salivary glands, and occasionally in the skin, breast, upper aero-digestive tract, and soft tissues. The... (Review)
Review
The spectrum of myoepithelial tumors usually occur in the salivary glands, and occasionally in the skin, breast, upper aero-digestive tract, and soft tissues. The myoepithelial tumors have no sex predominance and usually present within a wide range of age of distribution around the third and fifth decades. We describe a 12 year old male patient with primary malignant myoepithelial tumor in the foot plantar soft tissues. Including this tumor with unusual location, and age of presentation is essential in the differential diagnosis for soft tissue tumors in the pediatric population.
Topics: Biomarkers, Tumor; Child; Diagnosis, Differential; Humans; Male; Myoepithelioma; Plantar Plate; Sarcoma; Soft Tissue Neoplasms
PubMed: 32000118
DOI: 10.1016/j.clinimag.2019.11.014 -
Chest Jul 2011Myoepitheliomas have been described most commonly in salivary glands and have been reported elsewhere but are rare in the lung, with only six previously reported cases....
Myoepitheliomas have been described most commonly in salivary glands and have been reported elsewhere but are rare in the lung, with only six previously reported cases. To our knowledge, this represents the first endotracheal myoepithelioma. These tumors have characteristic features that distinguish them from other tumors, and the diagnosis is a pathologic one, based on the morphology and supported by immunohistochemistry. Myoepitheliomas should be considered in the diagnosis of any pulmonary nodule.
Topics: Actins; Aged; Biopsy; Bronchi; Bronchoscopy; Diagnosis, Differential; Humans; Immunohistochemistry; Lung Neoplasms; Male; Myoepithelioma; Tomography, X-Ray Computed
PubMed: 21729896
DOI: 10.1378/chest.10-2976 -
The American Journal of Surgical... Feb 2021
Topics: Forkhead Box Protein O1; Forkhead Box Protein O3; Hand; Humans; Myoepithelioma; Neoplasms
PubMed: 32649321
DOI: 10.1097/PAS.0000000000001539 -
Breast (Edinburgh, Scotland) Dec 2004Primary clear cell tumors of the breast are uncommon and often present a diagnostic challenge. We describe an extremely rare case of glycogen-rich clear cell malignant... (Review)
Review
Primary clear cell tumors of the breast are uncommon and often present a diagnostic challenge. We describe an extremely rare case of glycogen-rich clear cell malignant myoepithelioma in a 43-year-old woman. Histologically, this tumor is composed of clear cells with abundant cytoplasmic glycogen particles. Immunohistochemically, these tumor cells show co-expression of vimentin, smooth muscle actin, epithelial membrane antigen, S-100 protein, and cytokeratin as evidence of myoepithelial cell tumor. The pathological staging of the patient is IIB (pT3N0M0) and the nuclear grading is 2. The patient demonstrated no evidence of recurrence or metastasis over a period of 42 months. We suggest that glycogen-rich clear cell malignant myoepithelioma be included in the histological differential diagnosis of clear cell tumors of the breast.
Topics: Breast Neoplasms; Combined Modality Therapy; Cytoplasm; Female; Glycogen; Humans; Immunohistochemistry; Myoepithelioma
PubMed: 15563859
DOI: 10.1016/j.breast.2004.07.003 -
Spine Nov 2014Case report and review of the relevant literature. (Review)
Review
STUDY DESIGN
Case report and review of the relevant literature.
OBJECTIVE
To present a case of primary spinal myoepithelioma and discuss its clinical, radiological and histopathological characteristics. We report a long-term follow-up of 5 years.
SUMMARY OF BACKGROUND DATA
Myoepithelial neoplasms, represent a diverse morphological and biological spectrum of tumors, composed of epithelial and myoepithelial elements. Primary myoepithelioma of the bone is extremely rare and very few cases of spinal myoepitheliomas have been reported till date.
METHODS
A 50-year male, presenting with complaints of paraparesis and difficulty in walking, was diagnosed to have an expansile lytic lesion involving the D10 vertebral body with paraspinal extension. The patient underwent D10 laminectomy and gross total resection of the tumor. Patient's power improved postoperatively, and he returned to his full functional status.
RESULTS
Long-term follow-up of 5 years reveals 2 recurrences, despite gross total resection at the initial surgery followed by radiotherapy. Histopathology, at the third surgery, documents the transformation of myoepithelioma into myoepithelial carcinoma.
CONCLUSION
Primary myoepithelioma of spine is very rare. Gross total resection with wide resection margins in the paraspinal region should be used to tackle this rare entity as the role of adjuvant therapy is doubtful. Long-term follow-up is a must.
Topics: Carcinoma; Cell Transformation, Neoplastic; Humans; Laminectomy; Male; Middle Aged; Myoepithelioma; Radiography; Radiotherapy, Adjuvant; Recurrence; Spinal Neoplasms; Thoracic Vertebrae
PubMed: 25188604
DOI: 10.1097/BRS.0000000000000564