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Child's Nervous System : ChNS :... 1997Infantile myofibromatosis (IM) is a proliferative disorder of infancy and early childhood characterized by the nodular or diffuse growth of lesions that are comprised of... (Review)
Review
Infantile myofibromatosis (IM) is a proliferative disorder of infancy and early childhood characterized by the nodular or diffuse growth of lesions that are comprised of a mixture of mesenchymal elements. Intracranial involvement is reportedly rare, only eight such patients having been reported to our knowledge. We report on a 4-year-old boy with intracranial IM with a mass in his left temporal bone. A previous report on intracranial IM proposed that the underlying dura mater should be resected because of the possibility of early recurrence. At surgery in this case, the tumor was noted to be located in the bone itself and did not arise from the underlying dura. Therefore, the underlying dura mater and venous sinus were preserved. The follow-up MRI showed no sign of recurrences. It may not to be necessary to resect the dura mater in patients with intracranial IM.
Topics: Child, Preschool; Humans; Magnetic Resonance Imaging; Male; Myofibromatosis; Skull Neoplasms; Temporal Bone; Tomography, X-Ray Computed
PubMed: 9454983
DOI: 10.1007/s003810050157 -
Pediatric Dermatology May 2022Infantile myofibroma (IM) commonly presents as a benign cutaneous fibrous tumor in infancy. Although the majority of solitary IM regress without any morbidity, some... (Review)
Review
Infantile myofibroma (IM) commonly presents as a benign cutaneous fibrous tumor in infancy. Although the majority of solitary IM regress without any morbidity, some cases have underlying bone or visceral involvement that can lead to both morbidity and mortality. In this report with review of the literature, we present two cases of solitary cutaneous IM with internal involvement and discuss screening cases of solitary IM with full body imaging.
Topics: Bone and Bones; Humans; Myofibroma; Myofibromatosis; Skin Neoplasms; Soft Tissue Neoplasms
PubMed: 35297087
DOI: 10.1111/pde.14975 -
Pediatric Blood & Cancer Jun 2023
Topics: Humans; Myofibromatosis; Tumor Suppressor Proteins
PubMed: 36861442
DOI: 10.1002/pbc.30278 -
The Journal of Dermatology Sep 2016We describe a case of CD34-positive infantile myofibromatosis with hemangiopericytoma-like pattern. A 2-day-old Japanese boy presented with multiple hemispherical... (Review)
Review
We describe a case of CD34-positive infantile myofibromatosis with hemangiopericytoma-like pattern. A 2-day-old Japanese boy presented with multiple hemispherical nodules on the extremities and back. There was a biphasic histological growth in the dermis, accompanied by a hemangiopericytoma-like pattern with antler-like branching vessels. Tumor cells were oval to spindle-shaped myoid cells with bland appearance. Immunohistochemically, vimentin, calponin and CD34 were positive, while α-smooth muscle actin, h-caldesmon, HHF35 and desmin were negative. Although CD34 was positive, the present case could be diagnosed as infantile myofibromatosis. Myopericytoma, myofibroma/myofibromatosis, glomus tumor, glomangiopericytoma and angioleiomyoma share a continuous spectrum of benign hemangiopericytoma-like pattern tumors. Myofibroma/myofibromatosis is nearly included in myopericytoma among pericytic (perivascular) tumors, and could be positive for CD34. Several immunohistochemical panels of smooth muscle markers are needed for the diagnosis of pericytic (perivascular) tumors.
Topics: Actins; Antigens, CD34; Apgar Score; Biomarkers, Tumor; Biopsy; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Desmin; Hemangiopericytoma; Humans; Immunohistochemistry; Infant, Low Birth Weight; Infant, Newborn; Magnetic Resonance Imaging; Male; Microfilament Proteins; Myofibromatosis; Soft Tissue Neoplasms; Vimentin; Calponins
PubMed: 27074874
DOI: 10.1111/1346-8138.13400 -
Skeletal Radiology Jul 2022Infantile myofibromatosis (IM) is the most common benign fibrous tumor of infancy, characterized by the development of single or multiple nodules in the skin, soft...
Infantile myofibromatosis (IM) is the most common benign fibrous tumor of infancy, characterized by the development of single or multiple nodules in the skin, soft tissues, bone, and/or viscera. Multicentric forms are less frequent and can affect different tissues simultaneously and their prognosis depends on their extension and visceral involvement. Rarely, these forms are limited to the skeleton, in which case the absence of extraosseous lesions makes it difficult to suspect this entity. We present the case of an infant with multiple radiolucent lesions involving the skull, ribs, spine, and long bones, discovered in a radiological study performed after a minor trauma. A broad differential diagnosis was considered based on the osteolytic and polyostotic nature of the lesions on imaging studies. This report details and illustrates the typical radiological findings in bony involvement of IM, which suggest this disorder over other diagnostic options.
Topics: Diagnosis, Differential; Humans; Infant; Myofibromatosis; Ribs; Soft Tissue Neoplasms
PubMed: 34865192
DOI: 10.1007/s00256-021-03968-5 -
Neuropathology : Official Journal of... Jun 2010An unusual case of intraparenchymal myofibromatosis of the brain occurring in a 29-year-old woman is described. Preoperative CT and MRI examinations revealed two... (Review)
Review
An unusual case of intraparenchymal myofibromatosis of the brain occurring in a 29-year-old woman is described. Preoperative CT and MRI examinations revealed two well-circumscribed nodular masses localized in the wall of the left lateral ventricle and right temporal lobe, respectively. Both masses were completely resected, and the patient remains disease-free 2 years post-surgery. Histopathologically, the lesions were characterized by stratification. From outer to inner, there was a reactive glial component, lamellated well-differentiated muscle-like cells, densely compact collagen fibers and cellular tumor with nodular and hemangiopericytoma-like patterns, respectively. The myofibroblastic nature of this tumor was verified by immunohistochemical staining and ultrastructural analysis. Intraparenchymal myofibromatosis may be confused with, and should be distinguished from, meningioma, myopericytoma, solitary fibrous tumor, leiomyoma and inflammatory myofibroblastic tumor for accurate diagnosis and optimal treatment.
Topics: Adult; Brain Neoplasms; Female; Humans; Myofibromatosis
PubMed: 19845864
DOI: 10.1111/j.1440-1789.2009.01065.x -
Zhonghua Zhong Liu Za Zhi [Chinese... Nov 1990Eight cases of infantile myofibromatosis, 5 male and 3 female, are reported. The ages ranged from 8 days to 3 years at diagnosis. The tumor was detected in 6 cases at...
Eight cases of infantile myofibromatosis, 5 male and 3 female, are reported. The ages ranged from 8 days to 3 years at diagnosis. The tumor was detected in 6 cases at birth and in 2 at the age of 3 and 11 months. The tumor occurred mostly in extremities, trunk, orbit, nose, soft tissue and bone. Spontaneous regression of all the tumor nodules was observed in 1 case of the multicentric type without evidence of visceral involvement within 3 years. Recurrence developed in 2/7 cases of solitary type 2 and 3 years after excision. Histologically, the tumor nodules were composed of myofibroblasts; blood vessel was abundant in a pericytoma-like pattern; and prominent necrosis or calcification was seen. By immunohistochemical stain for desmin, diffuse weak reactivity was shown in the tumor cells and granular cytoplasmic positivity in the actively proliferating tumor foci, suggesting the existence of muscle-specific intermediate filaments in the tumor cells.
Topics: Child, Preschool; Extremities; Female; Follow-Up Studies; Histocytochemistry; Humans; Infant; Infant, Newborn; Leiomyoma; Male; Neoplasm Recurrence, Local; Soft Tissue Neoplasms
PubMed: 2076639
DOI: No ID Found -
Child's Nervous System : ChNS :... May 2004We present a case of solitary myofibromatosis of the skull in a 4-year-old girl. Surgery was performed and the final diagnosis of myofibromatosis was made... (Review)
Review
CASE REPORT
We present a case of solitary myofibromatosis of the skull in a 4-year-old girl. Surgery was performed and the final diagnosis of myofibromatosis was made histopathologically.
DISCUSSION
Solitary myofibromatosis of the skull is rare and we found approximately 20 reported cases in the English-language literature. We reviewed eight well-described cases.
CONCLUSION
Neuroradiologically, common features such as a lytic lesion with a sclerotic rim on roentgenogram and intra-diploic lesion with periosteal new bone formation both in the outer and inner table of the skull on computed assisted tomography are noticed.
Topics: Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Myofibromatosis; Radionuclide Imaging; Skull Neoplasms; Tomography, X-Ray Computed
PubMed: 14722720
DOI: 10.1007/s00381-003-0874-2 -
The Journal of Dermatology Sep 1999Infantile myofibromatosis is an unusual condition generally presenting in the newborn period. The case being reported is that of a female newborn who had multiple... (Review)
Review
Infantile myofibromatosis is an unusual condition generally presenting in the newborn period. The case being reported is that of a female newborn who had multiple lesions that involved skin, subcutaneous tissue, skeletal muscles, bone, and lungs. The disease was diagnosed because of the easily palpable skin tumors and subcutaneous nodules that were obvious immediately after birth. The diagnosis was established by histopathological examination of one nodule that showed a spindle-celled mesenchymatogenic lesion demonstrating the morphological and immuno-phenotype characteristics of myofibroblastic differentiation. The histologic picture, combined with the clinical manifestations and the imaging findings, are consistent with infantile myofibromatosis. The physical condition of the newborn was excellent and remains so six months later. The tumors of the skin and the subcutaneous nodules have gradually regressed without therapy. At the age of six months, four (4) nodules are palpable; the infant is under continuous observation.
Topics: Bone Neoplasms; Female; Follow-Up Studies; Humans; Infant, Newborn; Lung Neoplasms; Myofibromatosis; Radiography; Remission, Spontaneous; Skin Neoplasms
PubMed: 10535254
DOI: No ID Found -
Dermatology Online Journal Nov 2021Infantile myofibromatosis is a rare myofibroblastic proliferative disorder characterized by firm, skin-colored to red-purple cutaneous and subcutaneous nodules; these...
Infantile myofibromatosis is a rare myofibroblastic proliferative disorder characterized by firm, skin-colored to red-purple cutaneous and subcutaneous nodules; these are the most prevalent fibrous tumors observed in infancy. A premature male infant presented at birth with multiple subcutaneous firm skin-colored nodules measuring about 1-2cm each. Full body MRI and excisional biopsy of the right chest nodule confirmed the diagnosis. We review the case of infantile myofibromatosis and discuss its highly heterogeneous presentation and clinical course, as well as histopathology, genetic testing, and approaches to management.
Topics: Head and Neck Neoplasms; Humans; Infant, Newborn; Infant, Premature; Male; Myofibromatosis; Photography; Scalp
PubMed: 35130404
DOI: 10.5070/D3271156092