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Pediatric Dermatology Jun 1991Infantile myofibromatosis is part of a heterogeneous group of rare childhood fibromatoses characterized by the proliferation of myofibroblasts. It is not a common...
Infantile myofibromatosis is part of a heterogeneous group of rare childhood fibromatoses characterized by the proliferation of myofibroblasts. It is not a common condition and is frequently misdiagnosed. We present an unusual patient who had small, depressed, atrophic, skin lesions uncharacteristic of infantile myofibromatosis.
Topics: Atrophy; Diarrhea, Infantile; Female; Humans; Infant; Leiomyoma; Neoplasms, Multiple Primary; Skin; Skin Neoplasms
PubMed: 1923981
DOI: 10.1111/j.1525-1470.1991.tb00302.x -
Journal of Pediatric Hematology/oncology Apr 2015Although solitary presentations of infantile myofibromatosis tend toward spontaneous regression, multicentric forms fare worse. Previous case reports have depicted... (Review)
Review
Although solitary presentations of infantile myofibromatosis tend toward spontaneous regression, multicentric forms fare worse. Previous case reports have depicted observation, surgical resection, and systemic therapies as treatment options. This paper reports well-tolerated, successful outcomes in a series of patients with high-risk infantile myofibromatosis in need of life-sustaining interventions treated with a combination of vincristine and dactinomycin. The clinical presentation, pathology, and radiographic findings are described.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Humans; Infant; Infant, Newborn; Male; Myofibromatosis; Prognosis; Vincristine
PubMed: 25389917
DOI: 10.1097/MPH.0000000000000286 -
Journal of Pediatric Surgery Oct 1988Infantile myofibromatosis is a rare mesenchymal disorder in infants and children. We recently managed three children with this disorder; in this report we describe the...
Infantile myofibromatosis is a rare mesenchymal disorder in infants and children. We recently managed three children with this disorder; in this report we describe the cases and provide a review of the literature.
Topics: Female; Humans; Infant; Infant, Newborn; Leiomyoma; Male; Muscular Diseases; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Skin Neoplasms; Skull Neoplasms
PubMed: 3236168
DOI: 10.1016/s0022-3468(88)80398-1 -
Archives of Ophthalmology (Chicago,... Feb 1996An 11-day-old boy was found to have a lesion of the left lower eyelid and medial canthus. The mass was present at birth and subsequently enlarged, and was subtotally...
An 11-day-old boy was found to have a lesion of the left lower eyelid and medial canthus. The mass was present at birth and subsequently enlarged, and was subtotally excised when the child was 2 months old. Histopathologic examination disclosed a fascicular to slightly nodular pattern of predominantly spindle-shaped cells. Special stains demonstrated fibroblastic and smooth-muscle features in individual cells, and infantile myofibromatosis was diagnosed. Sixteen months postoperatively, no evidence of recurrence was noted. We believe this is the first case of infantile myofibromatosis of the solitary type involving the ocular adnexa of a neonate to be reported in the English literature. Infantile myofibromatosis of the solitary type appears to have an excellent prognosis and may be treated with conservative resection if the tumor infiltrates important adnexal structures.
Topics: Conjunctiva; Eyelid Neoplasms; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male; Myofibromatosis; Orbital Neoplasms
PubMed: 8573030
DOI: 10.1001/archopht.1996.01100130213022 -
Zeitschrift Fur Geburtshilfe Und... Jun 2013
Topics: Bone Neoplasms; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Premature; Myofibromatosis; Neoplasms, Multiple Primary; Skin Neoplasms
PubMed: 23967509
DOI: 10.1055/s-0033-1349977 -
Journal of Pediatric Hematology/oncology Oct 2023Infantile myofibromatosis (IM) is a rare benign tumor of infancy. Cases with solitary and multicentric disease usually spontaneously regress, but multicentric disease...
BACKGROUND
Infantile myofibromatosis (IM) is a rare benign tumor of infancy. Cases with solitary and multicentric disease usually spontaneously regress, but multicentric disease with visceral involvement carries a poor prognosis. Few cases of multicentric disease with central nervous system (CNS) involvement have been reported, and none report survival.
OBSERVATIONS
We present a newborn with multicentric IM with cutaneous, visceral, and CNS involvement. She was treated with vinblastine, methotrexate, and the novel addition of intrathecal methotrexate with treatment response after 1 year of therapy.
CONCLUSIONS
Multicentric IM with CNS involvement can be successfully treated with a multimodal approach of chemotherapy with the addition of intrathecal methotrexate and surgery.
Topics: Infant, Newborn; Female; Humans; Methotrexate; Myofibromatosis; Vinblastine
PubMed: 37526359
DOI: 10.1097/MPH.0000000000002717 -
Pediatric Blood & Cancer Jul 2012Infantile myofibromatosis is characterized by proliferation of benign fibrous tumors arising in skin, subcutaneous tissue, muscle, or bone. Solitary and multicentric... (Review)
Review
BACKGROUND
Infantile myofibromatosis is characterized by proliferation of benign fibrous tumors arising in skin, subcutaneous tissue, muscle, or bone. Solitary and multicentric forms are described. Few reports are available in the pediatric population.
PROCEDURE
To improve the knowledge of this rare tumor in infants, the authors present a series of all cases of infantile myofibromatosis treated in their institution over a 9-year period in order to propose treatment guidelines based on their experience and a review of the literature.
RESULTS
The authors report a series of 9 cases, 8 solitary forms and 1 multicentric form with visceral involvement treated from 2000 to 2009. Median age was 10 months (range: 2 days-14 years). Six patients with solitary forms underwent primary surgical resection leading to remission. Only biopsy was performed in 1 case, followed by tumor regression with no recurrence. The last patient with a solitary form was treated by chemotherapy and then surgery allowing remission. The patient with a multicentric form presented complete regression of tumors after 1 year of vinblastine and methotrexate combination chemotherapy.
CONCLUSIONS
Infantile myofibromatosis is a rare soft tissue tumor mainly concerning infants. Surgery is the treatment of choice for solitary forms when excision is possible. Close follow-up may be proposed in the case of inoperable sites. In multicentric life-threatening forms, chemotherapy promotes tumor regression and the vinblastine and methotrexate combination is effective with few long-term adverse effects.
Topics: Adolescent; Bone Neoplasms; Child; Female; Humans; Infant; Infant, Newborn; Male; Muscle Neoplasms; Myofibromatosis; Remission Induction; Retrospective Studies; Risk Factors; Skin Neoplasms
PubMed: 22038698
DOI: 10.1002/pbc.23387 -
Archives of Otolaryngology--head & Neck... Jan 1999To examine the clinical and pathological features of pediatric myofibroma of the head and neck and to discuss the challenges in diagnosis and treatment. (Review)
Review
OBJECTIVES
To examine the clinical and pathological features of pediatric myofibroma of the head and neck and to discuss the challenges in diagnosis and treatment.
DESIGN
A retrospective search of pathology department and clinical records to identify patients with myofibroma and a retrospective review of English-language medical publications.
SETTING
Academic medical center.
PATIENTS
Thirteen pediatric patients (aged from birth to 8 years old) diagnosed as having myofibroma of the head and neck.
RESULTS
Nine of 13 patients were cured with conservative surgical excision. Four patients (31%) had recurrence, requiring multiple surgical procedures. One third showed spontaneous regression clinically or by histological examination. The clinical course did not parallel the histological appearance, as high cellularity and mitotic figures were commonplace among the specimens. A misdiagnosis of malignancy was not unusual in this series, as 3 patients had an initial diagnosis of fibrosarcoma, which on review was revised to myofibroma.
CONCLUSIONS
Myofibromatosis is a distinct disorder among the great number of fibrous proliferations occurring in infants and children, with a particular predilection for the head and neck region. These lesions should be clearly distinguished from conventional adult-type fibromatoses (desmoid tumors), which are more aggressive. Most patients have solitary lesions that respond well to conservative surgical excision, whereas a few of these lesions behave more aggressively, requiring several surgical procedures for the management of recurrent or persistent tumor. Many of these lesions show spontaneous regression, suggesting that lesions not affecting vital functions, resulting in growth anomalies, or demonstrating rapid aggressive growth may be managed conservatively.
Topics: Biomarkers, Tumor; Cell Death; Child; Child, Preschool; Connective Tissue; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Myofibromatosis; Neoplasm Recurrence, Local; Neoplasm Regression, Spontaneous; Otorhinolaryngologic Neoplasms; Retrospective Studies
PubMed: 9932585
DOI: 10.1001/archotol.125.1.39 -
Pediatric Radiology 1993Infantile myofibromatosis is an unusual condition generally presenting in the newborn period. It may be solitary or multicentric. Sites involved include skin and... (Review)
Review
Infantile myofibromatosis is an unusual condition generally presenting in the newborn period. It may be solitary or multicentric. Sites involved include skin and subcutaneous tissues, muscle, bones and viscera. Nine cases are presented, including one case in an identical twin whose co-twin remained asymptomatic. The radiological features and differential diagnosis are discussed.
Topics: Bone Neoplasms; Diagnosis, Differential; Diseases in Twins; Female; Humans; Infant, Newborn; Leiomyoma; Male; Radiography; Soft Tissue Neoplasms
PubMed: 8332406
DOI: 10.1007/BF02013829 -
International Journal of Pediatric... Oct 1998Infantile myofibromatosis (IM) is a rare tumor of infancy and childhood, typically presenting as a firm, nodular mass involving soft tissue, bone or viscera....
Infantile myofibromatosis (IM) is a rare tumor of infancy and childhood, typically presenting as a firm, nodular mass involving soft tissue, bone or viscera. Approximately one-third of cases involve the head and neck. These tumors can be solitary or multicentric. Biopsy reveals tumor cells that resemble myofibroblasts. Spontaneous regression may occur. A high degree of suspicion is necessary to differentiate this entity from other more aggressive processes histiocytosis, fibrosarcoma, rhabdomyosarcoma. We describe the case of a male infant with multicentric myofibromatosis, presenting with multiple thoraco-abdominal subcutaneous nodules and lytic mass lesions of the temporal bone and calvarium. The characteristic clinical, radiologic and histopathologic features of this process are reviewed along with diagnostic and therapeutic options.
Topics: Humans; Infant; Male; Myofibromatosis
PubMed: 9865442
DOI: 10.1016/s0165-5876(98)00105-0